TWAS hub - INHBC

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Brain Lower Grade Glioma	0.0324	0.0177	0.0010	0.029	0.020	0.015	NA	0.021	0.0003	0.0024	0.0069	NA	0.0016
2	TCGA	Prostate Adenocarcinoma	0.0353	0.0239	0.0048	0.002	0.013	0.014	NA	0.009	0.1600	0.0150	0.0120	NA	0.0310

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Gout (self-reported)	19.3	26.5	52.4	7.2	-0.8
Medication: Allopurinol	14.2	18.9	37.8	6.1	0.1
Triglycerides	10.5	17.1	34.2	5.9	-0.1
HDL Cholesterol	7.4	12.4	21.3	-4.6	-1.9
Heart attack	6.1	7.8	14.5	3.8	1.0
Heart attack/myocardial infarction (self-reported)	5.6	7.2	13.7	3.7	0.8
Chest pain or discomfort	5.4	7.9	8.4	-2.9	2.7
High blood pressure (mother)	5.3	7.5	11.7	3.4	-1.8
High blood pressure (siblings)	5.1	7.4	8.4	2.9	-2.5
Relative age of first facial hair	4.7	9.6	19.0	-0.5	4.4
Mineral and other dietary supplements	4.6	6.2	9.4	-3.1	-1.8
Suffer from ‘nerves’	4.4	6.9	9.5	-3.1	2.1
Schizophrenia vs Biploar Disorder	4.2	5.5	10.4	0.8	-3.2
Heart disease (mother)	4.2	5.2	8.2	2.9	-1.5
Supplements: Fish oil (including cod liver oil)	4.1	5.3	9.4	3.1	1.1
Blood Platelet Count	4.0	46.1	67.4	5.0	8.2
Eye problems/disorders: Cataract	4.0	4.6	4.7	2.1	-2.2
Illnesses of mother	3.8	4.7	8.9	-3.0	0.8
Diabetes (mother)	3.7	4.7	5.3	2.3	-2.0
Chronic bronchitis/emphysema (father)	3.7	4.4	8.0	-2.8	0.9
Wheeze or whistling in the chest in last year	3.6	6.4	8.5	-2.9	2.1
LDL Cholesterol	3.5	5.5	10.8	3.3	0.5
Ulcerative Colitis	3.5	5.0	5.5	-2.1	-2.3
Angina	3.4	4.4	8.5	0.5	2.9
Sitting height	3.4	24.2	39.8	2.9	-6.3
Mouth/teeth dental problems	3.4	5.3	7.3	2.7	-1.8
Angina (self-reported)	3.3	4.3	8.4	0.5	2.9
Asthma	3.2	6.4	11.9	-3.4	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.2	3.8	7.6	-0.1	2.8
Respiratory disease	3.1	6.9	12.1	-3.5	-1.3
Medication: Cholesterol lowering	3.1	4.8	9.6	3.1	-0.2
Migraine (self-reported)	3.1	3.8	5.3	-1.5	2.3
Asthma (self-reported)	3.1	6.1	11.7	-3.4	-0.7
Allergy	3.0	6.9	13.4	3.7	-0.6
Illnesses of siblings	2.9	4.0	4.2	-2.1	1.9
Neck or shoulder pain in last month	2.9	4.1	5.6	-1.6	2.4
Chronotype (morning person)	2.7	6.3	11.0	1.2	3.3
Taking other prescription medications	2.7	4.2	4.7	-2.2	1.9
Medication: Simvastatin	2.7	3.9	7.5	2.7	-0.5
Illnesses of father: Heart disease	2.7	3.7	6.7	2.6	0.8
Body Mass Index (BMI) (2010)	2.6	3.5	5.3	-2.3	-1.3
Age at first live birth	2.5	4.4	5.2	2.3	-1.9
Medication: Gliclazide	2.5	2.8	3.3	-1.8	1.5
Intelligence (Savage-Jansen 2018)	2.4	7.5	13.5	3.7	-1.2
Medication: Levothyroxine sodium	2.4	4.0	8.0	-0.0	-2.8
Alzheimer’s Disease (including proxy)	2.3	3.3	6.2	-0.6	-2.5
Neuroticism (2016)	2.3	3.4	3.9	1.7	2.0
Ever used hormone-replacement therapy (HRT)	2.3	3.0	5.8	-2.4	-0.4
Health satisfaction	2.3	3.0	6.0	-2.5	0.2
Eye problems/disorders: None of the above	2.3	2.6	4.5	-0.9	2.1
Systolic blood pressure, automated reading	2.2	6.3	12.0	3.5	-0.8
Past tobacco smoking	2.2	4.0	4.7	2.2	-1.8
Mouth/teeth dental problems: Loose teeth	2.2	2.6	4.7	-2.2	-0.7
Alzheimer’s Disease (in mother)	2.1	2.5	4.9	0.4	-2.2
Hypothyroidism (self reported)	2.1	4.7	9.2	0.5	-3.0
Supplements: Glucosamine	2.1	2.7	4.5	0.9	2.1
Pulse wave peak to peak time	2.1	2.5	5.0	2.2	-0.1
Ever smoked	2.1	3.7	3.8	-1.9	2.0
Number of live births	2.0	2.9	5.6	-2.4	0.4
Pulse wave Arterial Stiffness index	2.0	2.4	4.8	-2.2	-0.2
Mouth/teeth dental problems: Bleeding gums	2.0	2.5	3.0	-1.4	1.7
Shortness of breath walking on level ground	2.0	2.3	4.2	-2.0	-0.7
Age at last live birth	2.0	3.0	4.2	1.3	-2.0
Irritability	2.0	3.3	6.0	0.8	2.5
Mean Putamen Volume	1.9	2.2	2.3	1.5	-1.5
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.5	4.9	2.2	0.3
Comparative height size at age 10	1.9	10.5	20.9	0.3	-4.6
Handedness (chirality/laterality): Left-handed	1.9	2.3	3.3	-1.1	-1.8
Alzheimer’s Disease (in father)	1.8	1.9	3.5	-1.9	0.5
Allergy or Eczema	1.8	4.8	6.0	-2.4	1.9
Vitamin and mineral supplements	1.8	2.4	2.5	-1.6	-1.5
Hayfever, allergic rhinitis or eczema	1.8	3.9	5.8	-2.4	1.4
Reaction Time	1.7	3.2	5.2	1.1	-2.3
Qualifications: College or University degree	1.7	5.5	5.7	2.4	-2.3
Medication: Aspirin	1.7	2.3	4.5	2.1	-0.3
Miserableness	1.7	3.0	3.9	1.5	2.0
Mother’s age at death	1.7	2.2	3.4	-1.0	1.9
Fractured/broken bones in last 5 years	1.7	2.2	4.3	-0.3	-2.1
Depressed Affect (Nagel 2018)	1.6	3.4	6.6	0.4	2.6
Smoking Status	1.6	3.9	5.1	-1.7	2.3
Qualifications: A levels/AS levels or equivalent	1.6	3.5	3.6	1.9	-1.8
Medication: Omeprazole	1.6	1.9	3.8	-0.3	-1.9
Mean time to correctly identify matches	1.6	3.1	5.1	1.1	-2.3
Cholesterol lowering medication	1.6	2.4	4.7	2.2	-0.4
HbA1C	1.5	1.6	2.8	1.7	0.7
Time employed in main current job	1.5	1.7	2.8	-0.8	-1.7
Medication: Aspirin	1.5	2.0	3.9	2.0	0.2
Sensitivity / hurt feelings	1.4	2.3	4.7	0.1	2.2
Supplements: Zinc	1.4	1.5	2.4	1.6	0.7
Waist circumference	1.4	5.1	10.2	-3.2	-0.1
Impedance of arm (right)	1.4	6.7	10.7	1.6	-3.3
Worrier / anxious feelings	1.4	2.7	4.4	-2.1	1.0
Headache pain in last month	1.4	2.5	4.8	-0.3	2.2
Mood swings	1.4	2.5	4.8	0.3	2.2
Schizophrenia (2018)	1.3	2.8	4.1	-1.2	-2.0
Ulcerative Colitis (UC)	1.3	2.4	2.8	-1.4	-1.7
Blood Red Count	1.3	13.0	26.0	-5.1	-0.0
Systolic Blood Pressure	1.3	6.3	12.7	3.6	0.0
Hip circumference	1.3	5.4	9.6	-3.1	-1.1
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	4.8	-0.6	-2.2
Exposure to tobacco smoke outside home	1.3	1.7	2.5	1.6	0.9
Overall health rating	1.3	2.8	5.1	-2.3	-0.7
High cholesterol (Self-reported)	1.3	2.3	4.5	2.1	0.3
Primary Biliary Cirrhosis	1.2	1.7	1.8	1.3	-1.3
Ever had hysterectomy (womb removed)	1.2	1.3	2.7	-1.6	-0.0
Impedance of leg (right)	1.2	5.6	8.9	3.0	-1.5
Medication: Atenolol	1.2	1.5	1.9	1.0	1.4
Number of incorrect matches in round	1.2	1.9	3.6	-0.5	-1.9
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	2.6	-1.6	1.1
Birth weight	1.2	2.7	5.0	0.6	-2.2
Number of full brothers	1.2	1.5	2.6	-0.6	-1.6
Knee pain experienced in last month	1.2	1.8	3.4	-0.4	1.8
Smoking status: Previous	1.2	1.8	2.7	-1.6	1.0
Medication: Bendroflumethiazide	1.2	1.9	3.8	-1.9	-0.0
Number of operations (self-reported)	1.2	1.7	3.5	1.9	-0.1
Bipolar Disorder (2018)	1.1	1.7	1.7	-1.3	1.3
Neuroticism	1.1	2.6	4.1	1.0	2.0
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	1.4	1.2	1.0
Standing height	1.1	11.2	21.9	-0.7	-4.7
Loud music exposure frequency	1.1	1.2	1.8	-1.3	0.8
Medication: Atorvastatin	1.1	1.4	2.4	1.5	0.6
Risk taking	1.1	1.6	3.2	-0.0	1.8
Irritable Bowel Disease (IBD)	1.0	2.3	3.2	-1.2	-1.8
Blood White Count	1.0	7.3	9.9	3.1	2.2
Current tobacco smoking	1.0	1.6	2.7	-0.8	1.6
Pulse rate	1.0	1.7	3.5	-1.9	-0.0
Hair/balding pattern: Pattern 4	1.0	2.3	2.5	1.5	1.6
Peak expiratory flow (PEF)	1.0	2.2	2.5	-1.4	-1.6
Medication: Ibuprofen	1.0	1.2	2.4	1.5	0.1
Had major operations	1.0	1.2	2.1	1.4	-0.6
Commuting to job workplace: Walk	1.0	1.1	2.0	1.4	0.3
Smoking status: Current	1.0	1.6	3.1	-0.3	1.8
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.8	1.9	-0.7
Heel T-Score	0.9	7.1	8.1	-2.5	2.9
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.3	-1.5	0.1
Medication for hormone replacement therapy	0.9	1.0	1.7	-1.3	0.6
Average weekly fortified wine intake	0.9	1.0	2.0	-0.4	1.4
Maternal smoking around birth	0.9	1.3	2.3	-1.5	0.6
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	1.9	-0.5	1.4
Trunk fat mass	0.9	3.7	4.8	-2.2	-1.6
Pain all over the body in last month	0.9	1.0	1.9	-1.4	0.1
Fluid intelligence score	0.9	1.9	2.6	1.6	-1.1
Neuroticism score	0.9	1.8	3.2	0.7	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	1.7	-0.7	1.3
Wears glasses or contact lenses	0.9	1.1	1.8	-1.4	0.6
Ever depressed for a whole week	0.9	1.1	1.8	0.6	1.3
Pain experienced in last month	0.9	1.5	3.0	0.0	-1.7
Neuroticism (Nagel 2018)	0.8	1.9	3.8	-0.1	2.0
Crohns Disease (2012)	0.8	1.3	2.4	0.4	-1.6
Rheumatoid Arthritis	0.8	1.2	2.1	-0.5	-1.4
BMI	0.8	4.5	7.7	-2.8	1.2
Height	0.8	16.1	30.6	-1.3	-5.5
Frequency of depressed mood in last 2 weeks	0.8	1.1	1.8	1.4	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	1.8	-1.3	1.3
Weight	0.8	3.9	5.8	-2.4	-1.4
Noisy workplace	0.8	1.0	2.0	-0.2	1.4
Medication: Lansoprazole	0.8	0.9	1.6	-1.3	-0.5
Forced vital capacity (FVC), Best measure	0.8	3.0	4.3	1.3	-2.1
Medication for pain relief, constipation, heartburn	0.8	1.4	2.4	-1.6	-0.6
Pulse rate, automated reading	0.8	2.5	4.6	-2.1	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	1.1	-1.0	0.9
Leg fat-free mass (right)	0.8	4.4	5.7	-2.4	-1.8
Loneliness, isolation	0.8	1.1	2.3	-0.1	1.5
Osteoarthritis (self-reported)	0.8	1.0	2.0	-1.4	0.2
Illnesses of father: None of the above (group 1)	0.8	1.0	2.0	-1.4	0.2
Leg predicted mass (right)	0.8	4.3	5.5	-2.4	-1.7
Myopia	0.8	1.2	2.1	1.5	0.5
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.4	-0.7	-1.2
Bipolar Disorder or Schizophrenia	0.7	1.8	3.1	-1.8	-0.7
Major Depression (MDD)	0.7	0.8	1.1	0.7	-1.1
Schizophrenia (2014)	0.7	1.4	1.9	-1.0	-1.4
Average weekly spirits intake	0.7	0.9	1.3	1.1	0.7
Leg fat-free mass (left)	0.7	3.6	3.7	-1.9	-1.9
Trunk fat percentage	0.7	2.7	4.0	-2.0	-1.2
Alcohol intake versus 10 years previously	0.7	1.1	1.3	1.2	0.9
Depression (self-reported)	0.7	0.8	1.3	-1.1	0.6
Comparative body size at age 10	0.7	2.0	3.4	-1.9	0.8
Emphysema/chronic bronchitis	0.7	0.8	1.5	-1.2	-0.4
Medication: Seretide 50 evohaler	0.7	0.8	1.4	-1.2	-0.3
Supplements: Vitamin C	0.7	0.9	1.6	1.3	0.4
Breast cancer (self-reported)	0.7	0.9	1.7	-1.3	0.0
Guilty feelings	0.7	1.1	2.0	0.3	1.4
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.5	1.2	-0.3
Average weekly beer plus cider intake	0.7	1.0	1.7	-1.3	0.4
Commuting to job workplace: Cycle	0.7	0.9	1.8	1.3	-0.2
Impedance of whole body	0.7	3.6	5.0	1.5	-2.2
Number of treatments/medications taken	0.6	1.1	1.7	0.8	1.3
Serious illness, injury or assault to yourself	0.6	0.7	1.4	-0.1	-1.2
Multivitamins +/- minerals	0.6	0.8	1.2	1.1	0.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.4	0.3	-1.2
Leg predicted mass (left)	0.6	3.3	3.4	-1.8	-1.9
Forced vital capacity (FVC)	0.6	2.5	4.8	0.4	-2.2
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	4.1	-0.2	-2.0
Mouth/teeth dental problems: Dentures	0.6	1.0	1.2	-1.1	0.9
Impedance of arm (left)	0.6	2.7	4.6	0.9	-2.1
Arm fat mass (right)	0.6	2.4	4.2	-2.1	-0.7
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.3	0.8	1.2
Medication: Ventolin 100micrograms inhaler	0.6	0.7	0.8	-0.9	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	1.2	-0.2	-1.1
Whole body fat mass	0.6	2.6	4.2	-2.0	-1.0
Alcohol intake frequency.	0.6	1.3	2.4	0.4	1.6
Commuting to job workplace: Public transport	0.6	0.7	1.1	-0.5	-1.1
Eye problems/disorders: Glaucoma	0.6	0.7	1.2	1.1	-0.5
Basal metabolic rate	0.6	3.4	3.6	-1.8	-1.9
Diastolic blood pressure, automated reading	0.6	1.8	3.5	1.9	-0.1
Leg fat mass (left)	0.6	2.2	4.2	-2.0	-0.5
Body mass index (BMI)	0.5	2.2	3.8	-2.0	0.7
Impedance of leg (left)	0.5	2.6	3.4	1.8	-1.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.3	0.3	1.1
Falls in the last year	0.5	0.7	1.3	-1.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.8	2.8	0.9	-1.7
Medication: Paracetamol	0.5	0.9	1.8	-0.0	1.3
Body fat percentage	0.5	1.9	3.5	-1.9	-0.6
Whole body fat-free mass	0.5	2.9	3.4	-1.6	-1.8
Arm fat percentage (left)	0.5	2.0	3.9	-2.0	0.2
Long-standing illness, disability or infirmity	0.5	0.8	1.5	-1.2	-0.5
Whole body water mass	0.5	2.8	2.9	-1.6	-1.7
Arm fat mass (left)	0.5	2.1	4.0	-2.0	-0.3
Number of self-reported non-cancer illnesses	0.5	0.9	1.8	-1.3	0.1
Financial situation satisfaction	0.5	0.6	0.7	-0.7	0.9
Medication: Blood pressure	0.5	0.9	1.1	-0.9	1.1
Medication: Paracetamol	0.5	0.8	1.5	0.1	1.2
Illnesses of father: High blood pressure	0.5	0.6	0.8	0.9	-0.7
Arm fat-free mass (left)	0.5	2.5	2.7	-1.6	-1.5
Worry (Nagel 2018)	0.4	0.8	1.2	-1.1	0.5
Hair Pigment	0.4	10.2	16.2	-4.0	-2.1
Medication: Metformin	0.4	0.6	1.2	-1.1	-0.2
Diabetes (father)	0.4	0.5	0.9	-0.2	-0.9
Severe depression (siblings)	0.4	0.5	0.6	-0.8	-0.6
Fed-up feelings	0.4	0.8	1.3	0.5	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.9	0.9	-0.4
Relative age voice broke	0.4	0.5	1.0	-0.3	1.0
Hair/balding pattern: Pattern 2	0.4	0.5	0.8	0.5	0.9
Medication: Ramipril	0.4	0.6	0.6	-0.7	-0.8
Arm fat percentage (right)	0.4	1.4	2.8	-1.7	-0.2
Trunk fat-free mass	0.4	2.2	3.3	-1.0	-1.8
Hair/balding pattern: Pattern 3	0.4	0.7	0.7	0.8	-0.8
Trunk predicted mass	0.4	2.2	3.4	-1.0	-1.9
Tense / ‘highly strung’	0.4	0.7	1.1	-1.0	0.5
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.9	-0.3	1.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.2	-1.1	0.3
Leg fat mass (right)	0.4	1.7	3.3	-1.8	-0.3
Arm predicted mass (right)	0.4	1.8	2.7	-1.6	-1.0
Leg pain on walking	0.4	0.4	0.7	0.8	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	0.8	0.8	-0.9
Ever had bowel cancer screening	0.4	0.4	0.8	0.3	0.9
Medication: Lisinopril	0.4	0.5	0.7	0.5	0.9
Alcohol drinker status: Never	0.4	0.5	0.8	-0.9	0.5
Unable to work because of sickness or disability	0.4	0.5	1.0	0.4	-1.0
Heart disease (siblings)	0.4	0.5	0.9	-0.0	1.0
Pack years of smoking	0.4	0.6	0.6	-0.7	-0.8
Arm predicted mass (left)	0.4	2.2	2.3	-1.4	-1.5
Fasting Glucose	0.3	0.3	0.3	0.6	-0.6
Lupus	0.3	0.4	0.7	0.8	-0.3
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.5	-0.5	-0.7
Blood Eosinophil Count	0.3	2.5	3.6	-1.9	1.1
Cardiovascular Disease	0.3	0.9	0.9	0.9	0.9
Tanning	0.3	3.9	4.3	-2.1	1.8
Hearing difficulty/problems: Yes	0.3	0.4	0.6	-0.5	-0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.5	-0.7	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	0.2	1.0
Arm fat-free mass (right)	0.3	1.7	2.6	-1.6	-0.9
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.4	-0.6	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.6	0.4	-0.8
Illnesses of siblings: Diabetes	0.3	0.3	0.6	0.8	-0.3
Average weekly red wine intake	0.3	0.4	0.8	-0.9	-0.1
Friendships satisfaction	0.3	0.4	0.7	-0.9	0.2
Leg fat percentage (left)	0.3	1.1	2.1	-1.4	0.3
Crohns Disease (2017)	0.2	0.5	1.1	0.0	-1.0
Coronary Artery Disease (CAD)	0.2	0.2	0.4	-0.1	0.6
Waist Hip Ratio (WHR)	0.2	1.1	2.0	-1.4	0.5
Lung FEV1/FVC ratio	0.2	1.3	1.8	-1.3	0.9
Hand grip strength (left)	0.2	0.5	0.6	-0.6	-0.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.5	-0.7	-0.0
Medication: Co-codamol	0.2	0.2	0.2	-0.4	0.5
Pack years adult smoking proportion	0.2	0.3	0.3	-0.6	-0.6
Townsend deprivation index at recruitment	0.2	0.3	0.5	-0.7	0.2
Qualifications: CSEs or equivalent	0.2	0.2	0.4	-0.1	0.6
Financial difficulties in last 2 years	0.2	0.3	0.6	-0.7	0.1
Diabetes (self-reported)	0.2	0.3	0.5	-0.4	-0.7
Prospective memory result	0.2	0.2	0.4	0.2	-0.6
Length of working week for main job	0.2	0.2	0.4	0.6	-0.2
Pulse wave reflection index	0.2	0.2	0.5	0.0	-0.7
Glaucoma (self-reported)	0.2	0.2	0.3	0.5	-0.4
Medication: Amlodipine	0.2	0.3	0.3	-0.5	0.5
Number of full sisters	0.2	0.2	0.4	0.6	0.3
Family relationship satisfaction	0.2	0.2	0.4	-0.3	0.6
Diabetes diagnosed by doctor	0.2	0.3	0.6	-0.1	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	-0.5	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.3	-0.6
Back pain experienced in last month	0.2	0.3	0.4	-0.7	0.4
Average weekly champagne plus white wine intake	0.2	0.3	0.4	0.4	-0.6
Age started oral contraceptive pill	0.2	0.2	0.4	-0.6	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.9	-0.9	-0.1
Basal cell carcinoma (self-reported)	0.2	0.3	0.3	0.6	0.4
Depression (Nagel 2018)	0.1	0.1	0.2	0.4	-0.1
Age at First Birth	0.1	0.1	0.2	0.1	0.4
Lung FVC	0.1	0.7	1.4	1.2	0.3
Hand grip strength (right)	0.1	0.4	0.7	-0.2	-0.8
Age when periods started (menarche)	0.1	0.2	0.3	-0.6	0.3
Stomach or abdominal pain in last month	0.1	0.1	0.1	0.4	0.4
Alcohol usually taken with meals	0.1	0.2	0.2	0.5	0.5
Hearing difficulty/problems with background noise	0.1	0.2	0.4	-0.6	0.1
Had menopause	0.1	0.2	0.3	-0.6	-0.1
Had other major operations	0.1	0.2	0.2	0.3	0.4
Father’s age at death	0.1	0.2	0.2	-0.4	-0.5
Happiness	0.1	0.1	0.2	0.4	0.3
Lung cancer (father)	0.1	0.1	0.1	-0.3	0.2
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.1	0.4
Breastfed as a baby	0.1	0.1	0.3	-0.0	0.5
Birth weight of first child	0.1	0.1	0.2	0.4	-0.1
Blood clot in the leg (DVT)	0.1	0.2	0.2	-0.3	0.5
Leg fat percentage (right)	0.1	0.4	0.7	-0.9	0.2
Worry too long after embarrassment	0.1	0.2	0.2	0.3	-0.5
Number of children fathered	0.1	0.1	0.2	-0.4	0.3
Medication: Blood pressure	0.1	0.2	0.4	0.2	-0.6
Qualifications: nursing, teaching	0.1	0.2	0.3	0.3	-0.5
Medication for cholesterol	0.1	0.1	0.2	-0.2	-0.5
Osteoporosis (self-reported)	0.1	0.1	0.1	-0.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.4	0.6	0.3
Ever taken oral contraceptive pill	0.1	0.2	0.2	-0.4	-0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.2	0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	0.4	0.2
Supplements: Calcium	0.1	0.1	0.1	-0.3	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.1	0.4
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.1	-0.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.0	0.0	0.0	0.1	0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	0.1	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.1	-0.2	0.4
High blood pressure	0.0	0.0	0.0	-0.0	0.2
Nervous feelings	0.0	0.1	0.1	-0.3	0.3
Qualifications: None of the above	0.0	0.0	0.1	-0.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.0	-0.1	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	-0.1	-0.2
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	-0.1	-0.1
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	0.0	0.1
Hypertension (Self-reported)	0.0	0.0	0.0	-0.1	0.0
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	-0.2	0.1
Hearing aid user	0.0	0.0	0.1	0.1	-0.3

Hub : Genes

INHBC

Models

Trait associations