Best TWAS P=6.84e-26 · Best GWAS P=4.51e-21 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | NRXN2 | 0.11 | 0.05 | enet | 21 | 0.05 | 3.4e-05 | 8.0 | 8.0 | 1.3e-15 | 0.75 | 0.53 | 0.46 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | MAP3K11 | 0.08 | 0.08 | lasso | 4 | 0.05 | 1.7e-03 | 5.8 | 5.5 | 3.4e-08 | 0.06 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Artery Tibial | NRXN2 | 0.17 | 0.12 | lasso | 5 | 0.12 | 6.9e-10 | 7.9 | 7.4 | 1.4e-13 | 0.80 | 0.79 | 0.21 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | NRXN2 | 0.15 | 0.05 | lasso | 4 | 0.06 | 2.0e-05 | 8.0 | 8.3 | 1.1e-16 | 0.84 | 0.09 | 0.91 | TRUE |
| 5 | GTEx | Colon Sigmoid | MAP3K11 | 0.23 | 0.05 | enet | 8 | 0.08 | 6.5e-04 | 5.2 | 5.4 | 5.6e-08 | 0.10 | 0.01 | 0.98 | FALSE |
| 6 | GTEx | Esophagus Mucosa | CCDC88B | 0.18 | 0.04 | lasso | 3 | 0.05 | 2.9e-04 | -3.1 | 5.4 | 5.8e-08 | 0.23 | 0.17 | 0.05 | TRUE |
| 7 | GTEx | Lung | NRXN2 | 0.18 | 0.13 | enet | 40 | 0.12 | 1.2e-09 | 7.9 | 6.2 | 5.0e-10 | 0.50 | 1.00 | 0.00 | TRUE |
| 8 | GTEx | Lung | MAP3K11 | 0.08 | 0.08 | lasso | 5 | 0.07 | 4.4e-06 | 4.4 | 5.2 | 2.1e-07 | 0.08 | 0.06 | 0.93 | FALSE |
| 9 | GTEx | Muscle Skeletal | VEGFB | 0.19 | 0.00 | enet | 31 | 0.04 | 1.7e-04 | 9.0 | -7.3 | 3.0e-13 | -0.56 | 0.07 | 0.31 | TRUE |
| 10 | GTEx | Nerve Tibial | NRXN2 | 0.08 | 0.05 | lasso | 4 | 0.07 | 2.0e-05 | 7.8 | 7.5 | 4.3e-14 | 0.76 | 0.60 | 0.30 | FALSE |
| 11 | GTEx | Skin Not Sun Exposed Suprapubic | NRXN2 | 0.10 | 0.07 | enet | 6 | 0.05 | 7.8e-04 | 7.9 | 7.9 | 3.8e-15 | 0.74 | 0.43 | 0.44 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | NRXN2 | 0.11 | 0.05 | enet | 27 | 0.08 | 7.0e-07 | 8.0 | 7.5 | 6.1e-14 | 0.73 | 0.43 | 0.56 | FALSE |
| 13 | GTEx | Spleen | NRXN2 | 0.46 | 0.12 | lasso | 5 | 0.10 | 1.3e-03 | 7.9 | 7.7 | 1.5e-14 | 0.74 | 0.32 | 0.07 | FALSE |
| 14 | GTEx | Thyroid | MAP3K11 | 0.20 | 0.19 | lasso | 8 | 0.21 | 4.4e-16 | 4.4 | 5.4 | 5.5e-08 | 0.09 | 0.49 | 0.50 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | OVOL1 | 0.16 | 0.24 | lasso | 2 | 0.24 | 1.3e-30 | 5.8 | 5.8 | 5.1e-09 | 0.08 | 0.00 | 1.00 | TRUE |
| 16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NRXN2 | 0.01 | 0.02 | lasso | 3 | 0.01 | 5.1e-04 | 7.9 | 7.9 | 3.3e-15 | 0.75 | 0.09 | 0.30 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC22A12 | 0.02 | 0.02 | blup | 38 | 0.02 | 4.3e-03 | 9.4 | 10.5 | 6.8e-26 | 0.93 | 0.01 | 0.88 | TRUE |
| 18 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SLC22A12 | 0.05 | 0.02 | blup | 38 | 0.03 | 6.3e-03 | 6.9 | 10.0 | 1.9e-23 | 0.92 | 0.01 | 0.63 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SLC22A12 | 0.04 | 0.02 | blup | 38 | 0.01 | 3.3e-02 | 8.1 | 6.4 | 1.6e-10 | 0.86 | 0.04 | 0.30 | FALSE |
| 20 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SLC22A11 | 0.06 | 0.03 | blup | 42 | 0.04 | 1.2e-03 | 9.1 | -10.0 | 1.1e-23 | -0.72 | 0.04 | 0.71 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NRXN2 | 0.03 | 0.03 | enet | 23 | 0.03 | 7.2e-04 | 7.9 | 5.9 | 4.6e-09 | 0.56 | 0.16 | 0.27 | FALSE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC22A11 | 0.05 | 0.03 | lasso | 5 | 0.02 | 2.8e-03 | 9.2 | -9.4 | 4.3e-21 | -0.37 | 0.03 | 0.61 | TRUE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC22A11 | 0.04 | 0.01 | blup | 42 | 0.03 | 8.5e-04 | 2.0 | -6.3 | 2.8e-10 | -0.72 | 0.03 | 0.48 | FALSE |