Hub : Genes

FUT1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1500	0.0430	6.7e-06	0.132	0.030	0.143	0.125	0.146	9.8e-16	0.00014	4.5e-17	5.7e-15	2.1e-17
2	METSIM	Adipose	0.0363	0.0151	4.5e-03	0.015	0.004	0.004	0.004	0.019	2.2e-03	0.07600	8.0e-02	6.3e-02	6.9e-04
3	TCGA	Liver Hepatocellular Carcinoma	0.1540	0.0680	8.9e-03	0.078	0.026	0.055	NA	0.080	1.5e-04	0.02100	1.4e-03	NA	1.3e-04
4	TCGA	Thyroid Carcinoma	0.0410	0.0240	9.2e-03	0.035	0.024	0.026	NA	0.034	2.3e-04	0.00190	1.4e-03	NA	2.7e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	1.0	3.9	0.0	-2.0	0.0	0.0
Bipolar Disorder or Schizophrenia	0.7	1.8	7.1	0.0	-2.7	0.0	0.0
Depressed Affect (Nagel 2018)	0.6	1.2	2.0	-1.2	0.7	0.8	1.4
Depression (Nagel 2018)	1.6	2.4	5.3	-1.4	0.7	2.3	1.4
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.6	0.1	-0.7	-0.8	-0.2
Neuroticism (Nagel 2018)	0.1	0.2	0.3	-0.3	-0.1	0.5	0.5
Schizophrenia (2018)	0.5	1.0	4.0	0.0	-2.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.0	-0.5	0.0	0.0
Worry (Nagel 2018)	0.0	0.0	0.1	0.2	-0.1	0.4	-0.2
Alzheimer’s Disease (in mother)	1.1	1.3	1.7	1.3	-0.8	-1.2	-1.2
Alzheimer’s Disease (in father)	0.3	0.3	0.5	-0.6	0.6	0.7	0.3
Alzheimer’s Disease (including proxy)	0.3	0.4	0.6	0.8	-0.4	-0.5	-0.7
Crohns Disease (2017)	2.5	5.5	16.0	1.9	-4.0	-0.2	-1.6
Irritable Bowel Disease (IBD)	1.0	2.4	7.7	1.1	-2.8	0.3	-0.7
Ulcerative Colitis (UC)	0.2	0.3	0.6	-0.1	-0.8	0.6	0.5
Major Depression (MDD)	0.0	0.0	0.1	0.0	-0.3	0.0	0.0
Reaction Time	0.2	0.3	1.0	0.4	-0.1	1.0	-0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.3	-0.2	-0.6	0.4	0.1
Breast Cancer	0.3	0.6	2.1	-0.4	1.4	-0.1	0.5
Ovarian Cancer	0.7	0.9	2.1	-0.5	0.9	1.4	0.6
Prostate Cancer	2.5	3.6	5.3	2.2	-2.0	-0.3	-2.3
Age at First Birth	0.3	0.4	1.3	0.3	-1.1	0.2	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.7	2.3	2.9	-1.5	1.5	1.7	1.3
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	4.4	7.1	17.6	2.5	-4.2	0.0	-2.1
Mean Putamen Volume	1.7	2.0	3.7	1.9	-0.9	0.0	-1.9
Fasting Glucose	0.4	0.5	1.8	0.2	-0.3	1.4	-0.0
HbA1C	2.5	2.8	4.3	-1.9	1.0	2.1	1.6
HDL Cholesterol	0.5	0.9	2.2	0.2	0.9	-1.5	-0.7
LDL Cholesterol	8.1	12.9	28.2	3.7	-5.3	-1.4	-2.8
Lupus	4.5	6.8	10.0	-2.3	3.2	2.6	2.2
Neuroticism (2016)	0.2	0.3	0.6	-0.5	-0.4	0.8	0.4
Primary Biliary Cirrhosis	0.5	0.7	1.0	0.9	-0.9	0.0	-1.0
Rheumatoid Arthritis	1.0	1.4	2.2	-1.4	1.3	0.2	1.5
Schizophrenia (2014)	0.9	2.1	4.8	0.0	-2.2	-1.9	0.0
Triglycerides	1.4	2.2	7.6	0.9	-2.8	-0.5	-0.4
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.2	0.3	1.2	0.0	-1.1	0.0	0.0
Blood Eosinophil Count	0.7	5.4	10.6	2.5	-3.2	-0.2	-2.2
Blood Platelet Count	3.4	39.2	54.5	6.2	-7.4	-5.2	-6.1
Blood Red Count	0.3	3.1	5.8	-1.9	2.4	0.6	1.7
Blood White Count	0.1	1.0	3.9	0.1	-2.0	0.5	-0.0
Heel T-Score	0.1	0.4	0.6	-0.8	0.6	0.5	0.8
BMI	1.4	8.0	10.4	-3.2	1.8	2.9	3.2
Height	0.6	11.2	20.5	-3.0	4.5	2.3	3.2
Waist Hip Ratio (WHR)	3.9	17.6	19.9	4.4	-4.0	-3.9	-4.5
Systolic Blood Pressure	3.5	17.7	29.8	4.3	-5.5	-2.8	-3.8
Smoking Status	0.6	1.5	1.9	-1.3	1.0	1.2	1.4
Allergy or Eczema	0.2	0.5	1.1	-0.6	0.3	1.0	0.6
Cardiovascular Disease	4.3	14.2	25.1	3.6	-5.0	-2.6	-3.5
Hypothyroidism (self reported)	4.2	9.7	13.6	3.1	-3.7	-2.3	-3.2
Respiratory disease	1.0	2.3	3.0	-1.6	1.7	1.3	1.4
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.6	-0.6	1.6	-0.3	0.4
Lung FEV1/FVC ratio	2.6	13.2	21.9	-3.5	4.7	2.8	3.3
Lung FVC	0.6	2.9	3.7	1.8	-1.9	-0.9	-1.9
Neuroticism	0.1	0.2	0.3	-0.4	0.6	0.3	0.3
Chronotype (morning person)	1.4	3.3	5.1	-1.4	2.3	1.8	1.6
Hair Pigment	0.1	2.4	3.7	-1.5	1.9	1.4	1.3
Tanning	0.0	0.4	0.9	0.8	-0.4	-0.0	-1.0
Hand grip strength (left)	0.0	0.0	0.1	0.1	-0.2	0.2	-0.0
Number of treatments/medications taken	1.6	2.9	5.2	1.8	-2.3	-0.4	-1.7
Average weekly spirits intake	4.9	6.1	7.8	-2.6	2.8	2.0	2.4
Sensitivity / hurt feelings	0.2	0.3	0.6	-0.1	-0.8	-0.6	0.3
Frequency of depressed mood in last 2 weeks	0.8	1.1	1.3	-1.1	0.9	1.2	1.0
Hearing difficulty/problems: Yes	1.9	2.8	3.5	-1.6	1.9	1.6	1.6
Relative age of first facial hair	1.6	3.4	5.0	1.4	-2.2	-2.0	-1.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.5	0.7	-0.7	0.2	-0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	0.6	0.4	0.2	-1.0
Ever had hysterectomy (womb removed)	0.6	0.7	1.6	-0.8	0.5	0.3	1.3
Systolic blood pressure, automated reading	1.7	5.0	10.4	2.2	-3.2	-0.8	-2.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.5	0.5	0.1	1.2	-0.0
Angina	1.2	1.6	2.4	-1.3	1.5	0.8	1.3
Medication for hormone replacement therapy	5.8	6.5	9.8	3.1	-2.7	-0.7	-2.9
Vitamin and mineral supplements	1.0	1.4	2.3	1.3	-1.5	-0.7	-1.1
Supplements: Zinc	0.4	0.4	1.1	0.6	-1.1	0.3	-0.2
Medication: Co-codamol	1.0	1.2	1.5	-1.2	1.2	0.7	1.2
Medication: Metformin	0.2	0.3	0.4	-0.4	0.7	-0.4	0.6
Diabetes (father)	2.7	3.3	5.8	-1.8	2.4	1.1	1.7
Diabetes (mother)	1.8	2.3	2.5	-1.6	1.4	1.5	1.5
Severe depression (siblings)	5.3	5.9	8.3	2.9	-2.6	-1.3	-2.6
Pack years adult smoking proportion	1.6	2.5	3.8	1.6	-0.3	-1.9	-1.8
Impedance of leg (right)	1.4	7.0	9.9	3.1	-1.9	-2.2	-3.1
Leg fat-free mass (left)	3.0	16.0	21.5	-4.5	3.8	2.8	4.6
Trunk fat percentage	1.2	4.6	5.8	-2.4	1.8	2.1	2.3
Hand grip strength (right)	0.0	0.1	0.4	0.0	-0.6	0.1	0.1
Townsend deprivation index at recruitment	0.8	1.1	1.3	1.2	-1.1	-0.8	-1.1
Current tobacco smoking	1.2	1.9	5.5	-1.2	2.4	-0.3	0.7
Average weekly fortified wine intake	1.1	1.3	2.2	-0.8	1.1	1.5	1.0
Maternal smoking around birth	0.4	0.6	1.5	0.5	-1.2	0.8	-0.0
Fed-up feelings	0.2	0.4	1.6	-0.1	0.3	1.3	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.9	1.5	-0.8	0.9	1.2	0.7
Relative age voice broke	1.8	2.7	4.9	1.7	-2.2	-0.7	-1.6
Taking other prescription medications	0.8	1.3	2.4	1.2	-0.4	-1.6	-1.1
Age when periods started (menarche)	2.2	5.3	5.8	2.2	-2.4	-2.3	-2.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.5	0.6	-1.2	0.5	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.3	-0.1	0.6	0.4	0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	0.2	0.7	-0.2	-0.4
Qualifications: CSEs or equivalent	0.2	0.3	0.6	-0.1	-0.5	0.8	0.5
Serious illness, injury or assault to yourself	0.2	0.3	0.5	0.7	-0.6	-0.4	-0.4
High blood pressure	1.0	2.7	4.2	1.5	-2.0	-1.5	-1.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.1	-0.2	0.3	1.5	0.4
Multivitamins +/- minerals	0.6	0.8	1.3	-0.9	1.1	0.7	0.7
Stomach or abdominal pain in last month	1.0	1.2	2.4	0.9	-0.2	-1.6	-1.3
Supplements: Glucosamine	0.3	0.4	0.5	-0.7	-0.0	0.6	0.7
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.7	-0.8	0.3	-1.7	0.7
Medication: Atenolol	0.0	0.0	0.1	0.0	-0.2	-0.3	0.1
Medication: Levothyroxine sodium	4.4	7.4	8.8	2.9	-3.0	-1.9	-2.9
Sitting height	1.7	12.3	16.8	-3.5	4.1	2.8	3.5
Chronic bronchitis/emphysema (father)	1.0	1.1	3.4	0.9	-1.8	-0.1	-0.6
High blood pressure (mother)	1.3	1.8	4.0	1.3	-2.0	-1.0	-0.8
Body mass index (BMI)	2.0	8.5	12.0	-3.5	2.2	2.4	3.3
Impedance of leg (left)	1.4	6.7	10.1	3.1	-1.9	-1.9	-3.2
Leg predicted mass (left)	3.1	16.3	21.9	-4.5	3.8	2.8	4.7
Trunk fat mass	2.1	9.0	11.1	-3.3	2.9	2.6	3.2
Waist circumference	1.6	6.0	8.1	-2.8	2.5	1.5	2.7
Number of incorrect matches in round	0.9	1.4	3.3	-0.9	1.8	0.8	1.0
Past tobacco smoking	1.0	1.9	2.6	1.6	-0.9	-1.3	-1.6
Alcohol usually taken with meals	2.5	4.1	5.2	1.9	-2.3	-1.7	-2.1
Nervous feelings	0.5	0.9	1.8	1.0	-1.3	0.6	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.5	-1.1	1.2	0.2	1.0
Hearing difficulty/problems with background noise	0.2	0.3	0.6	-0.5	0.5	0.8	0.3
Hair/balding pattern: Pattern 2	1.4	1.8	3.1	-1.6	1.2	0.4	1.7
Had menopause	0.3	0.4	0.7	0.6	0.4	0.6	-0.8
Had other major operations	1.7	2.1	2.9	-1.6	1.7	0.6	1.5
Forced vital capacity (FVC)	0.1	0.2	0.3	-0.5	0.5	0.3	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.1	0.2	-0.2	0.3	0.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.4	-0.1	-0.4	-0.4
Qualifications: None of the above	0.0	0.0	0.1	0.3	-0.1	-0.2	-0.2
Financial difficulties in last 2 years	0.0	0.0	0.1	0.4	0.0	0.1	-0.2
Mouth/teeth dental problems	3.9	5.9	8.6	-2.7	2.9	1.5	2.4
Heart attack	1.8	2.3	3.4	-1.6	1.9	0.3	1.8
Allergy	0.4	0.8	1.6	0.8	-0.7	-1.3	-0.7
Pain all over the body in last month	0.5	0.5	0.8	0.7	-0.9	-0.6	-0.7
Diabetes (self-reported)	0.5	0.7	2.4	0.1	0.7	-1.6	0.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	0.5	-0.3	0.8	-0.4
Medication: Ramipril	0.4	0.6	1.3	0.5	-0.2	-1.1	-0.8
Medication: Simvastatin	4.5	6.6	7.5	2.5	-2.5	-2.6	-2.7
Fluid intelligence score	0.1	0.2	0.3	0.3	-0.6	0.3	-0.4
Illnesses of siblings	0.1	0.1	0.5	-0.2	-0.1	0.7	-0.2
Neuroticism score	0.2	0.4	0.5	-0.6	0.6	0.7	0.6
Weight	3.5	17.3	21.6	-4.7	4.0	3.2	4.6
Impedance of arm (right)	2.3	10.7	15.2	3.9	-2.9	-2.3	-3.7
Arm fat percentage (right)	1.1	4.3	5.3	-2.3	1.6	2.2	2.2
Trunk fat-free mass	3.1	17.8	20.7	-4.5	4.5	3.1	4.5
Hip circumference	5.4	23.0	26.2	-5.1	4.9	4.1	5.0
Time employed in main current job	1.0	1.2	1.6	-1.3	1.3	-0.8	1.0
Alcohol intake versus 10 years previously	3.5	5.3	12.0	-2.2	3.5	0.9	1.9
Father’s age at death	0.3	0.3	0.9	0.7	0.2	-0.2	-0.9
Worrier / anxious feelings	0.0	0.1	0.2	-0.2	-0.2	0.4	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.2	0.0	-0.4	1.1	-0.1
Falls in the last year	0.5	0.6	1.6	0.3	0.9	1.3	-0.0
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.1	0.5	-0.9	-0.0
Number of live births	0.6	0.9	2.7	-0.7	1.7	-0.0	0.6
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	3.7	-1.4	1.9	1.3	1.3
Pulse rate	1.1	1.9	4.5	1.2	-2.1	-0.4	-1.2
Happiness	0.2	0.2	0.4	-0.1	-0.5	0.7	0.2
Noisy workplace	0.1	0.2	0.2	0.5	-0.3	-0.5	-0.2
Qualifications: A levels/AS levels or equivalent	0.9	1.9	3.6	1.2	-1.0	-1.9	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.9	0.1	-1.4	1.1	-0.1
Mouth/teeth dental problems: Dentures	1.5	2.6	8.1	0.6	-1.2	-2.9	-0.7
Asthma	0.7	1.3	2.0	-1.4	1.0	0.8	1.3
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.2	1.2	-0.3	-1.4	-1.5
Medication: Cholesterol lowering	6.8	10.6	12.1	3.3	-3.5	-2.8	-3.3
Depression (self-reported)	1.5	1.8	3.5	1.9	-0.7	0.2	-1.7
Medication: Lansoprazole	3.1	3.6	4.5	-2.1	2.1	1.2	1.9
Prospective memory result	0.3	0.4	1.2	-0.4	-0.1	-1.1	0.3
Lung cancer (father)	0.9	1.1	1.5	1.2	-1.1	0.9	-1.0
Illnesses of mother	0.6	0.8	1.8	-0.9	1.4	-0.3	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.6	-0.8	1.1	1.3	0.8
Pulse wave Arterial Stiffness index	2.1	2.4	3.8	-2.0	1.8	0.3	1.6
Impedance of arm (left)	1.5	7.1	10.6	3.2	-2.3	-1.9	-3.0
Arm fat mass (right)	2.1	8.8	11.1	-3.3	2.7	2.6	3.2
Trunk predicted mass	3.2	18.4	21.3	-4.6	4.6	3.2	4.6
Standing height	0.9	9.0	15.4	-2.8	3.9	2.0	3.0
Length of working week for main job	0.8	0.9	1.7	-0.5	1.3	-1.2	0.2
Exposure to tobacco smoke at home	0.8	0.9	1.3	1.2	-0.9	0.1	-1.1
Breastfed as a baby	2.4	2.9	4.7	1.9	-1.7	-0.9	-2.2
Tense / ‘highly strung’	0.1	0.1	0.2	0.5	-0.1	-0.3	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.9	-0.1	0.9	0.2	-0.1
Hair/balding pattern: Pattern 4	0.5	1.2	3.3	-0.8	0.4	1.8	0.9
Birth weight of first child	4.2	7.6	12.5	-3.0	3.5	0.8	2.9
Peak expiratory flow (PEF)	1.8	4.2	8.3	-2.1	2.9	0.6	2.0
Pulse wave reflection index	1.8	2.3	3.2	-1.8	1.7	0.6	1.6
Ever highly irritable/argumentative for 2 days	3.4	4.1	6.6	-2.1	2.6	1.5	1.8
Loud music exposure frequency	1.0	1.1	2.2	-0.8	-0.4	1.5	1.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.4	-0.6	0.6	0.3	0.5
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	1.9	1.4	-1.1	1.0	-1.4
Blood clot in the leg (DVT)	0.2	0.3	0.8	0.4	-0.3	0.9	-0.3
Medication: Paracetamol	0.3	0.5	1.1	-0.6	0.3	1.0	0.6
Headache pain in last month	0.1	0.2	0.5	0.7	-0.0	0.4	-0.6
Medication for cholesterol, blood pressure or diabetes	3.9	6.4	9.5	-2.5	3.1	2.0	2.5
Glaucoma (self-reported)	0.1	0.1	0.3	-0.2	-0.2	0.6	0.3
Gout (self-reported)	0.9	1.2	1.8	1.3	-0.0	-1.2	-1.3
Hypothyroidism/myxoedema (self-reported)	3.6	7.1	9.2	2.7	-3.0	-1.8	-2.9
Medication: Amlodipine	0.5	0.7	1.7	0.2	-1.3	-1.0	0.0
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.3	-0.7	-0.2	0.7	1.2
Birth weight	4.1	9.0	15.4	-3.2	3.9	1.8	2.6
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.9	0.6	-0.1	-1.7	-0.7
High blood pressure (siblings)	0.0	0.1	0.2	0.4	-0.1	-0.0	-0.2
Forced vital capacity (FVC), Best measure	0.0	0.1	0.2	0.4	-0.5	0.3	-0.3
Body fat percentage	1.0	4.1	5.3	-2.3	1.7	1.8	2.1
Leg fat percentage (right)	1.1	4.0	5.5	-2.3	2.0	1.4	2.1
Arm fat-free mass (right)	4.3	22.2	27.1	-5.2	4.9	3.3	5.2
Exposure to tobacco smoke outside home	0.6	0.8	2.4	0.5	-0.5	-1.6	-0.5
Comparative body size at age 10	3.1	8.4	9.1	-2.9	3.0	2.9	2.8
Number of full brothers	0.1	0.1	0.3	-0.5	-0.1	-0.4	0.4
Worry too long after embarrassment	0.3	0.5	1.3	-0.4	-0.3	1.1	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.1	1.0	-0.2	-0.2	-1.0
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	0.4	-0.1	-0.6	-0.5
Number of children fathered	2.8	3.2	4.4	-2.0	2.1	1.1	1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.1	1.1	-1.5	-0.3	-1.0
Age at first live birth	1.7	3.0	5.9	1.4	-2.4	-1.7	-1.3
Pulse wave peak to peak time	1.5	1.7	3.1	1.7	-1.4	0.1	-1.4
Health satisfaction	0.4	0.5	0.6	-0.7	0.6	0.7	0.8
Shortness of breath walking on level ground	1.2	1.5	2.0	-1.1	1.2	1.0	1.4
Qualifications: College or University degree	0.5	1.7	2.6	1.1	-1.6	-1.4	-1.1
Eye problems/disorders: None of the above	1.3	1.5	2.5	-1.6	1.3	-0.0	1.3
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.0	1.7	-0.8	-0.6	-1.6
Emphysema/chronic bronchitis	1.2	1.3	2.2	1.0	-0.1	-1.5	-1.4
Medication for pain relief, constipation, heartburn	0.4	0.6	0.8	-0.7	0.7	0.9	0.9
Neck or shoulder pain in last month	1.3	1.9	6.0	-0.6	0.6	2.5	0.9
Medication: Blood pressure	1.2	2.0	3.8	1.2	-2.0	-1.3	-1.1
Angina (self-reported)	1.4	1.8	2.7	-1.4	1.6	1.0	1.4
Migraine (self-reported)	1.0	1.2	1.5	-1.2	1.1	0.9	1.2
Medication: Ibuprofen	2.9	3.5	5.8	2.2	-1.0	-1.6	-2.4
Medication: Allopurinol	0.6	0.8	1.2	1.1	-0.6	-0.9	-0.8
Medication: Omeprazole	2.4	2.9	5.9	1.2	-1.6	-2.4	-1.3
Medication: Seretide 50 evohaler	0.2	0.2	0.5	0.4	-0.7	0.3	-0.3
Mean time to correctly identify matches	0.1	0.2	0.8	0.1	0.3	0.9	0.2
Heart disease (mother)	0.3	0.4	0.4	0.6	-0.7	-0.6	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	2.5	1.4	-1.6	-0.4	-1.4
Whole body fat mass	2.1	8.6	10.6	-3.2	2.9	2.4	3.1
Leg fat mass (right)	2.0	7.6	10.1	-3.2	2.6	2.1	3.0
Arm predicted mass (right)	4.1	20.8	25.5	-5.0	4.8	3.1	5.0
Pulse rate, automated reading	0.6	2.1	5.4	1.1	-2.3	0.2	-1.2
Alcohol intake frequency.	6.5	15.0	24.3	-3.7	4.9	3.2	3.5
Comparative height size at age 10	1.9	10.6	19.7	-3.1	4.4	1.4	3.3
Number of full sisters	0.2	0.2	0.8	-0.3	-0.1	0.9	0.2
Suffer from ‘nerves’	0.4	0.7	1.4	-0.3	1.0	1.2	0.3
Overall health rating	0.1	0.1	0.3	0.5	-0.3	0.2	-0.4
Chest pain or discomfort	0.3	0.5	0.9	0.6	-0.9	-0.6	-0.4
Had major operations	0.8	0.9	2.3	-1.0	1.5	-0.3	0.6
Age at last live birth	2.8	4.0	7.5	1.6	-1.9	-2.7	-1.6
Family relationship satisfaction	0.1	0.1	0.2	-0.3	-0.1	0.1	0.4
Leg pain on walking	0.8	1.0	2.9	-0.6	1.7	-0.2	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	2.3	-1.3	1.1	1.3	1.5
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.3	0.3	0.4	-0.6	-0.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	0.9	-0.3	-0.4	-1.0
Medication: Aspirin	0.1	0.1	0.6	0.0	0.0	-0.7	-0.0
Supplements: Vitamin C	2.1	2.4	3.4	-1.8	1.8	0.9	1.5
Knee pain experienced in last month	0.4	0.6	1.3	1.1	-0.1	-0.1	-1.0
Hypertension (Self-reported)	1.5	4.1	6.4	1.8	-2.5	-1.9	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.1	0.6	-0.5	-0.5	-1.1
Illnesses of father: Heart disease	1.2	1.7	2.7	-1.5	0.9	1.0	1.6
Illnesses of siblings: Diabetes	0.6	0.7	1.0	1.0	0.3	-0.8	-1.0
Smoking status: Previous	1.4	2.1	3.0	-1.6	0.4	1.7	1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.6	0.1	-0.8	0.6	0.3
Whole body fat-free mass	3.3	19.1	23.4	-4.8	4.4	3.3	4.8
Leg fat-free mass (right)	3.1	16.3	21.8	-4.5	3.8	3.0	4.7
Arm fat percentage (left)	1.1	4.5	5.8	-2.4	1.7	2.1	2.2
Average weekly red wine intake	0.3	0.4	0.8	0.8	-0.3	-0.3	-0.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.7	-0.7	1.3	0.3	0.6
Mood swings	0.1	0.3	0.4	-0.4	0.5	0.4	0.7
Loneliness, isolation	0.2	0.2	0.5	-0.1	0.7	-0.7	-0.2
Long-standing illness, disability or infirmity	0.5	0.8	1.4	-0.9	0.3	1.0	1.2
Ever had bowel cancer screening	0.3	0.4	0.6	0.8	-0.6	0.3	-0.7
Diabetes diagnosed by doctor	0.2	0.4	0.8	-0.2	0.9	-0.6	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	2.6	-1.4	1.6	-1.0	1.0
Friendships satisfaction	0.7	0.8	1.6	0.8	-1.3	-0.5	-0.9
Qualifications: nursing, teaching	1.3	2.0	3.0	-1.3	1.7	1.2	1.4
Commuting to job workplace: Walk	0.7	0.7	1.5	0.9	-1.2	0.1	-0.7
Eye problems/disorders: Cataract	1.3	1.5	4.9	-0.7	0.5	2.2	0.7
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.9	1.0	-1.7	0.9	-0.6
Medication for cholesterol	2.0	3.0	4.2	-2.1	2.0	0.4	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.4	1.0	-1.2	0.4	-1.0
Back pain experienced in last month	1.2	1.7	2.9	-1.2	1.7	0.3	1.5
Mineral and other dietary supplements	0.2	0.3	0.7	0.5	0.4	-0.8	-0.3
Breast cancer (self-reported)	0.3	0.4	0.9	0.8	-0.3	-0.0	-0.9
Asthma (self-reported)	0.7	1.5	2.1	-1.4	0.9	0.9	1.4
Osteoporosis (self-reported)	0.8	1.0	1.6	1.2	-1.3	-0.2	-1.0
Osteoarthritis (self-reported)	3.2	4.1	6.1	-1.6	2.5	2.3	1.6
Medication: Aspirin	0.3	0.4	1.3	0.3	-0.3	-1.1	-0.2
Medication: Gliclazide	0.8	0.9	2.3	-0.6	1.5	-0.4	0.8
Illnesses of father: None of the above (group 1)	0.2	0.3	0.8	-0.4	0.9	0.2	0.4
Smoking status: Current	1.1	1.8	5.1	-1.2	2.3	-0.4	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	3.0	1.5	-0.9	-0.7	-1.7
Whole body water mass	3.2	18.1	22.4	-4.7	4.3	3.1	4.7
Leg predicted mass (right)	3.0	16.0	21.4	-4.4	3.7	3.0	4.6
Arm fat mass (left)	2.2	9.1	11.2	-3.4	2.6	2.9	3.2
Number of self-reported non-cancer illnesses	3.1	5.4	6.5	2.5	-2.5	-1.9	-2.3
Average weekly champagne plus white wine intake	0.5	0.6	1.6	0.4	-1.3	-0.7	-0.6
Miserableness	0.1	0.3	0.5	0.1	-0.6	0.7	0.3
Guilty feelings	0.5	0.7	2.5	0.3	-0.5	1.6	-0.1
Wears glasses or contact lenses	0.4	0.5	0.9	0.5	0.7	0.6	-0.9
Ever taken oral contraceptive pill	0.1	0.1	0.4	-0.2	0.6	-0.2	0.1
Hearing aid user	3.1	3.4	4.6	-2.1	1.8	1.2	2.1
Mother’s age at death	0.1	0.2	0.4	0.3	-0.0	0.7	-0.4
Financial situation satisfaction	0.3	0.4	1.1	0.4	-0.5	1.1	-0.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.7	0.7	-0.7	-0.4	-0.8
Commuting to job workplace: Public transport	2.0	2.3	3.5	-1.8	1.9	0.1	1.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	-0.4	0.7	0.3	0.3
Medication: Blood pressure	0.4	0.7	0.9	0.8	-1.0	-0.8	-0.7
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.9	-0.3	-0.0	1.4	0.6
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.9	-0.8	-0.4	1.7	0.6
High cholesterol (Self-reported)	11.9	21.0	30.0	4.8	-5.5	-2.9	-4.8
Medication: Bendroflumethiazide	3.4	5.2	6.2	2.4	-2.5	-1.8	-2.4
Medication: Paracetamol	0.1	0.1	0.4	-0.1	-0.3	0.6	0.3
Medication: Lisinopril	0.1	0.2	0.5	-0.3	-0.2	-0.7	0.3
Medication: Atorvastatin	3.6	4.5	8.6	2.4	-2.9	-0.8	-1.8
Illnesses of father: High blood pressure	0.2	0.2	0.6	0.2	-0.8	0.1	0.2
Alcohol drinker status: Never	0.4	0.4	0.7	-0.5	0.8	-0.9	0.4
Ever smoked	1.1	2.0	3.5	-1.4	1.9	1.0	1.2
Basal metabolic rate	3.5	19.2	23.7	-4.8	4.4	3.2	4.9
Leg fat percentage (left)	1.2	4.4	5.9	-2.4	2.1	1.6	2.2
Arm fat-free mass (left)	4.1	20.8	24.8	-5.0	4.6	3.6	5.0
Number of operations (self-reported)	0.5	0.7	1.8	-0.8	1.4	-0.2	0.5
Average weekly beer plus cider intake	0.5	0.7	2.1	0.6	-1.5	0.4	-0.4
Irritability	0.4	0.7	2.2	0.6	0.2	-1.5	-0.4
Risk taking	0.0	0.0	0.1	-0.1	-0.4	0.0	0.2
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.9	-0.1	0.7	-1.0	-0.2
Fractured/broken bones in last 5 years	5.2	6.7	7.6	-2.5	2.6	2.8	2.5
Age started oral contraceptive pill	1.1	1.3	2.3	-1.0	1.5	0.9	1.1
Diastolic blood pressure, automated reading	0.5	1.5	5.2	0.6	-2.3	0.1	-0.5
Ever depressed for a whole week	0.0	0.1	0.1	0.3	-0.0	-0.2	-0.3
Unable to work because of sickness or disability	2.4	3.1	4.5	-1.6	2.1	1.7	1.6
Commuting to job workplace: Cycle	1.4	1.6	3.1	1.7	-1.0	-0.4	-1.5
Myopia	0.2	0.3	0.5	-0.5	0.7	0.5	0.6
Vascular/heart problems diagnosed by doctor	0.9	2.6	3.7	-1.5	1.9	1.5	1.5
Cholesterol lowering medication	0.8	1.2	2.7	1.0	-1.6	-0.6	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.8	0.2	-0.4	-1.7	-0.4
Pain experienced in last month	0.2	0.4	0.6	-0.8	0.6	-0.6	0.4
Supplements: Calcium	0.1	0.1	0.2	0.2	-0.4	-0.1	-0.2
Basal cell carcinoma (self-reported)	0.2	0.3	0.4	0.6	0.1	-0.6	-0.6
Heart attack/myocardial infarction (self-reported)	1.8	2.3	3.4	-1.6	1.8	0.5	1.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.8	0.3	-0.5	0.9	-0.2
Heart disease (siblings)	0.7	0.9	2.0	-1.2	0.4	0.1	1.4
Alcohol drinker status: Previous	0.7	0.8	1.9	-0.3	1.0	1.4	0.2
Pack years of smoking	1.2	1.7	2.9	1.3	-0.0	-1.7	-1.5
Impedance of whole body	1.6	8.2	11.8	3.4	-2.4	-2.1	-3.3
Leg fat mass (left)	1.9	7.5	9.7	-3.1	2.6	2.2	2.9
Arm predicted mass (left)	4.1	21.1	25.4	-5.0	4.6	3.6	5.0