TWAS hub - GTF3C2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0650	0.0230	1.5e-08	0.091	0.078	0.075	0.078	0.079	3.4e-11	9.4e-10	1.9e-09	9.6e-10	7.2e-10
2	GTEx	Thyroid	0.1670	0.0540	7.7e-07	0.072	NA	0.083	NA	0.083	3.4e-06	NA	6.4e-07	NA	6.1e-07
3	TCGA	Breast Invasive Carcinoma	0.0209	0.0137	9.4e-03	0.012	0.008	0.006	NA	0.010	1.2e-03	7.5e-03	2.0e-02	NA	2.9e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Triglycerides	52.5	86.0	249.6	15.8	0.2	-2.9
Gout (self-reported)	19.3	26.4	66.4	8.2	2.8	2.2
Fasting Glucose	15.8	18.9	54.6	-7.4	-1.4	-0.1
Medication: Allopurinol	13.3	17.7	44.1	6.6	2.4	1.8
High cholesterol (Self-reported)	11.6	20.5	60.5	7.8	0.5	-0.8
Had menopause	11.2	14.0	29.4	-5.4	-3.1	-1.8
Alcohol intake frequency.	9.8	22.7	66.6	8.2	0.8	-0.9
Blood Platelet Count	8.7	100.7	282.2	16.8	4.2	1.5
Medication: Atorvastatin	7.7	9.5	26.9	5.2	1.3	0.2
Blood White Count	7.4	54.7	158.8	12.6	2.3	0.4
Ever used hormone-replacement therapy (HRT)	6.6	8.5	10.3	-3.2	-3.1	-2.4
Type 2 Diabetes (T2D) (2018)	6.4	11.9	33.4	-5.8	-1.4	-0.7
Diabetes diagnosed by doctor	5.6	9.1	26.9	-5.2	-0.1	0.7
Diabetes (self-reported)	5.5	8.4	23.6	-4.9	0.3	1.2
Alcohol intake versus 10 years previously	5.2	7.7	18.9	4.3	1.8	1.0
Age when periods started (menarche)	5.1	12.3	16.7	-2.3	-4.1	-3.9
Pulse rate, automated reading	5.1	16.5	48.4	7.0	0.1	-1.0
Cholesterol lowering medication	5.0	7.3	21.7	4.7	0.3	-0.3
Medication: Cholesterol lowering	4.9	7.7	22.7	4.8	0.6	-0.2
Lupus	4.8	7.3	8.4	2.5	2.9	2.7
Medication for pain relief, constipation, heartburn	4.4	7.5	13.2	-3.6	-2.4	-2.0
Number of treatments/medications taken	4.3	7.7	17.4	4.2	2.0	1.3
Diverticular disease/diverticulitis (self-reported)	4.3	5.1	7.2	2.7	2.1	2.0
Number of self-reported non-cancer illnesses	4.1	7.1	17.5	4.2	1.4	1.4
Crohns Disease (2017)	3.8	8.3	17.6	4.2	2.0	1.8
Medication: Metformin	3.8	5.4	16.1	-4.0	-0.3	0.3
Hayfever, allergic rhinitis or eczema	3.8	8.3	15.4	3.9	2.4	2.0
Supplements: Vitamin C	3.8	4.5	7.0	0.9	2.4	2.6
Medication: Ibuprofen (e.g. Nurofen)	3.6	4.6	5.2	2.3	2.0	2.1
Irritable Bowel Disease (IBD)	3.4	8.2	18.9	4.3	1.9	1.5
Trunk fat-free mass	3.4	19.3	56.7	-7.5	-1.0	0.1
Trunk predicted mass	3.4	19.5	57.5	-7.6	-1.0	0.1
Eye problems/disorders: Cataract	3.4	3.9	11.4	3.4	0.6	-0.0
Vitamin and mineral supplements	3.3	4.5	8.9	-3.0	-1.7	-1.3
Arm fat-free mass (right)	3.3	17.2	50.4	-7.1	-1.0	0.0
Unable to work because of sickness or disability	3.3	4.3	4.7	-2.2	-2.0	-2.1
Schizophrenia vs Biploar Disorder	3.2	4.3	11.8	-3.4	-0.9	-0.4
Cardiovascular Disease	3.2	10.7	26.8	5.2	2.0	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	3.2	4.2	6.2	-1.3	-2.5	-2.1
Illnesses of siblings	3.1	4.4	5.2	-2.3	-2.1	-1.8
Pulse rate	3.1	5.2	14.9	3.9	0.7	0.1
Arm predicted mass (right)	3.1	15.8	46.6	-6.8	-0.8	0.2
Whole body water mass	3.1	17.5	51.8	-7.2	-0.8	0.2
Medication: Simvastatin	3.0	4.4	11.9	3.5	-0.6	-1.0
Whole body fat-free mass	3.0	17.2	51.0	-7.1	-0.7	0.4
Arm fat-free mass (left)	3.0	15.1	44.4	-6.7	-1.0	0.1
Arm predicted mass (left)	3.0	15.2	44.6	-6.7	-1.0	0.0
Ulcerative Colitis	2.9	4.2	9.7	3.1	1.5	0.9
Allergy or Eczema	2.9	7.7	15.1	3.9	2.2	1.8
Alcohol drinker status: Never	2.9	3.5	6.1	0.9	-1.8	-2.5
Average weekly beer plus cider intake	2.9	4.2	5.8	-1.5	-2.1	-2.4
Major Depression (MDD)	2.7	3.2	4.9	-1.3	-2.2	-1.8
Taking other prescription medications	2.7	4.2	5.9	2.4	1.9	1.8
Alcohol usually taken with meals	2.7	4.4	6.6	2.6	1.8	1.9
Qualifications: nursing, teaching	2.7	4.2	4.5	2.0	2.1	2.1
Medication for cholesterol	2.7	4.0	10.5	-3.2	-1.1	-0.6
Osteoporosis (self-reported)	2.7	3.3	8.1	2.8	1.0	0.9
Ever taken oral contraceptive pill	2.7	3.0	5.6	-0.3	1.9	2.4
Qualifications: O levels/GCSEs or equivalent	2.6	4.1	6.4	0.9	2.5	2.3
High blood pressure (siblings)	2.6	3.8	6.6	2.6	1.6	1.4
Basal metabolic rate	2.6	14.2	42.2	-6.5	-0.6	0.3
Fractured/broken bones in last 5 years	2.6	3.4	3.6	1.9	1.8	1.9
Number of children fathered	2.5	2.8	4.2	-0.9	-2.0	-1.8
Handedness (chirality/laterality): Left-handed	2.5	3.0	4.7	-0.9	-2.2	-1.9
Sitting height	2.4	17.0	45.8	-6.8	-2.0	-1.1
Health satisfaction	2.4	3.1	6.4	2.5	1.5	0.8
Comparative height size at age 10	2.4	13.0	34.6	-5.9	-1.9	-0.9
Bilateral oophorectomy (both ovaries removed)	2.3	2.6	7.0	2.6	0.7	0.6
Medication: Paracetamol	2.3	3.8	9.8	3.1	1.1	0.4
Commuting to job workplace: Public transport	2.3	2.8	3.9	-1.3	-2.0	-1.7
Bipolar Disorder (2011)	2.2	2.1	6.0	2.5	0.2	-0.5
Leg fat-free mass (left)	2.2	11.8	35.2	-5.9	-0.3	0.5
Relative age voice broke	2.2	3.3	5.5	2.3	1.7	1.3
Stomach or abdominal pain in last month	2.2	2.7	7.7	2.8	0.1	-0.6
Leg predicted mass (left)	2.2	11.7	34.7	-5.9	-0.2	0.6
Standing height	2.2	22.2	54.5	-7.4	-3.1	-1.6
Medication for cholesterol, blood pressure or diabetes	2.2	3.6	9.3	-3.0	-1.1	-0.6
Medication: Ibuprofen	2.2	2.6	2.7	1.6	1.6	1.6
Leg predicted mass (right)	2.2	11.5	34.2	-5.8	-0.1	0.6
Systolic blood pressure, automated reading	2.1	6.1	9.9	3.1	2.2	1.9
Diabetes (father)	2.1	2.5	7.3	-2.7	-0.2	0.5
Headache pain in last month	2.1	3.5	8.5	2.9	1.4	0.6
Leg fat-free mass (right)	2.1	11.4	33.8	-5.8	-0.1	0.6
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	5.8	2.4	-0.8	-1.2
Comparative body size at age 10	2.0	5.5	11.2	3.4	1.9	1.2
Ever had bowel cancer screening	2.0	2.3	2.9	1.7	1.4	1.4
Medication: Gliclazide	2.0	2.2	6.5	-2.5	-0.4	0.3
Systolic Blood Pressure	1.9	9.6	20.2	4.5	2.3	1.8
Townsend deprivation index at recruitment	1.9	2.6	3.3	-1.8	-1.8	-1.2
Heart attack	1.9	2.4	3.6	0.9	1.7	1.9
Medication: Amlodipine	1.9	2.7	4.8	0.2	2.2	1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	6.0	2.5	0.3	-0.1
Height	1.8	34.2	92.7	-9.6	-3.0	-1.1
Pulse wave reflection index	1.8	2.3	2.7	-1.6	-1.4	-1.5
Medication: Ventolin 100micrograms inhaler	1.8	2.4	4.2	2.0	1.3	1.2
Age at first live birth	1.8	3.3	3.7	1.7	1.9	1.8
Allergy	1.7	3.9	7.5	-2.7	-1.5	-1.4
Suffer from ‘nerves’	1.7	2.7	4.1	-0.6	-1.9	-2.0
Average weekly red wine intake	1.7	2.5	4.3	-1.0	1.5	2.1
Illnesses of father: High blood pressure	1.7	2.1	2.9	1.3	1.7	1.3
Heart attack/myocardial infarction (self-reported)	1.7	2.3	3.3	0.9	1.6	1.8
Ulcerative Colitis (UC)	1.6	2.9	8.0	2.8	0.8	0.5
Primary Biliary Cirrhosis	1.6	2.3	6.1	2.5	0.7	0.5
Impedance of arm (left)	1.6	7.2	14.8	3.9	-1.6	-2.0
Eye problems/disorders: None of the above	1.6	1.8	5.3	-2.3	-0.4	0.2
Medication: Aspirin	1.6	2.0	2.6	1.1	1.6	1.5
Medication: Paracetamol	1.6	2.4	6.8	2.6	0.7	0.2
Supplements: Zinc	1.5	1.6	3.0	-0.2	1.4	1.7
Glaucoma (self-reported)	1.5	1.7	2.7	-0.5	-1.6	-1.5
Overall health rating	1.5	3.3	8.8	3.0	-0.1	-1.0
Illnesses of siblings: Diabetes	1.5	1.8	2.1	-1.1	1.4	1.4
Number of operations (self-reported)	1.5	2.3	5.9	2.4	0.5	0.8
Impedance of whole body	1.5	7.6	15.1	3.9	-1.8	-2.2
Schizophrenia (2018)	1.4	3.0	4.3	-2.1	-1.5	-1.5
Crohns Disease (2012)	1.4	2.3	4.5	2.1	1.1	1.1
Hand grip strength (left)	1.4	3.8	9.3	-3.0	-1.2	-0.8
Relative age of first facial hair	1.4	2.8	7.0	2.6	-0.7	-1.0
Diabetes (mother)	1.4	1.8	4.5	-2.1	0.5	0.9
Medication: Ramipril	1.4	1.8	2.7	0.5	1.5	1.6
Weight	1.4	7.0	20.9	-4.6	-0.5	-0.0
Impedance of arm (right)	1.4	6.5	15.6	4.0	-1.1	-1.7
Hypertension (Self-reported)	1.4	3.8	5.4	2.3	1.9	1.5
Illnesses of father: Heart disease	1.4	1.9	5.5	2.3	0.3	-0.3
Bipolar Disorder (2018)	1.3	2.1	6.2	2.5	0.1	-0.2
Alzheimer’s Disease (in mother)	1.3	1.5	2.3	1.5	-1.0	-1.0
Prostate Cancer	1.3	1.8	2.8	-0.8	-1.4	-1.7
Neuroticism (2016)	1.3	1.8	2.8	-0.2	-1.6	-1.7
Average weekly spirits intake	1.3	1.6	2.5	1.0	-1.1	-1.6
Hand grip strength (right)	1.3	3.4	8.3	-2.9	-1.2	-0.7
Supplements: Glucosamine	1.3	1.7	2.2	-0.8	-1.5	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.6	2.9	-1.7	0.7	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	3.1	1.8	-0.7	-1.0
Pain experienced in last month	1.3	2.2	4.0	-2.0	-1.3	-1.0
Reaction Time	1.2	2.3	2.9	1.2	1.6	1.7
Waist Hip Ratio (WHR)	1.2	5.5	8.5	-0.3	-2.8	-2.9
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	3.8	2.0	0.6	0.6
Forced expiratory volume in 1-second (FEV1)	1.2	3.9	5.7	-1.1	-2.2	-2.4
Family relationship satisfaction	1.2	1.4	4.2	-2.1	-0.2	-0.1
Alcohol drinker status: Previous	1.2	1.3	2.1	0.5	1.3	1.4
Impedance of leg (right)	1.1	5.4	6.6	2.6	-2.0	-2.3
High blood pressure	1.1	3.0	6.3	2.5	1.4	0.9
Multivitamins +/- minerals	1.1	1.4	4.2	2.0	0.3	-0.2
Medication: Levothyroxine sodium	1.1	1.8	2.6	0.7	1.6	1.5
High blood pressure (mother)	1.1	1.5	4.4	2.1	0.4	0.2
Impedance of leg (left)	1.1	5.2	7.9	2.8	-1.8	-2.2
Pain all over the body in last month	1.1	1.1	3.4	1.9	-0.0	0.0
Worrier / anxious feelings	1.1	2.1	2.9	1.7	1.4	1.2
Birth weight of first child	1.1	2.1	5.5	-2.3	-0.7	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.0	1.7	0.8	0.5
Loneliness, isolation	1.1	1.5	2.7	1.6	-0.8	-1.1
Guilty feelings	1.1	1.6	2.6	-0.4	-1.4	-1.6
Body Mass Index (BMI) (2010)	1.0	1.3	3.3	-1.8	-0.7	-0.4
Neuroticism score	1.0	2.1	3.1	1.4	-1.2	-1.8
Mouth/teeth dental problems: Loose teeth	1.0	1.2	1.7	0.6	-1.2	-1.3
Medication: Seretide 50 evohaler	1.0	1.2	2.1	-0.2	1.1	1.5
Heart disease (mother)	1.0	1.2	3.3	1.8	0.6	0.0
Chest pain or discomfort	1.0	1.5	2.5	1.6	-0.9	-1.1
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.9	-0.0	1.4	1.3
Smoking status: Previous	1.0	1.4	2.9	-0.1	1.2	1.7
Ever depressed for a whole week	1.0	1.2	2.3	-0.3	-1.1	-1.5
Vascular/heart problems diagnosed by doctor	1.0	2.7	6.2	-2.5	-1.1	-0.8
Coronary Artery Disease (CAD)	0.9	1.1	1.8	1.0	0.8	1.3
LDL Cholesterol	0.9	1.4	2.2	1.0	-1.0	-1.5
Schizophrenia (2014)	0.9	2.1	3.2	-1.8	-1.2	-1.2
Type 2 Diabetes (T2D) (2012)	0.9	1.1	1.9	-0.5	1.0	1.4
Current tobacco smoking	0.9	1.5	2.0	0.8	-1.4	-1.4
Forced vital capacity (FVC)	0.9	3.4	3.7	-1.8	-1.9	-1.8
Mouth/teeth dental problems	0.9	1.5	2.3	-0.2	1.4	1.5
Father’s age at death	0.9	1.2	1.6	0.7	1.2	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	1.7	1.3	-0.9	-1.3
Hair/balding pattern: Pattern 3	0.9	1.3	3.4	-1.8	-0.6	-0.3
Tense / ‘highly strung’	0.9	1.5	2.3	0.8	-1.2	-1.5
Exposure to tobacco smoke outside home	0.9	1.2	2.6	-0.1	-0.9	-1.6
Mean time to correctly identify matches	0.9	1.8	2.8	0.9	1.3	1.7
Medication: Aspirin	0.9	1.2	1.6	1.0	1.3	1.1
Smoking status: Current	0.9	1.5	2.4	0.5	-1.5	-1.4
Financial situation satisfaction	0.9	1.1	1.8	0.5	1.3	1.2
Neuroticism	0.8	2.0	5.1	2.3	-0.4	-0.9
Hair Pigment	0.8	22.0	56.0	7.5	2.9	1.3
Angina	0.8	1.0	2.4	1.6	-0.6	-0.5
Fed-up feelings	0.8	1.5	2.7	0.9	-1.0	-1.6
Waist circumference	0.8	2.8	6.6	-2.6	-0.9	-0.9
Number of incorrect matches in round	0.8	1.3	2.0	-0.5	1.3	1.4
Hearing difficulty/problems with background noise	0.8	1.3	1.8	1.4	0.9	1.1
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.1	0.6	1.8	1.4
Lung cancer (father)	0.8	0.9	1.2	0.8	-1.0	-1.1
Illnesses of mother	0.8	0.9	2.4	-1.5	0.4	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.7	0.3	-1.3	-1.3
Number of full brothers	0.8	1.0	2.0	-1.4	-0.8	-0.6
Medication: Blood pressure	0.8	1.3	2.0	1.1	1.4	0.9
Mood swings	0.8	1.5	4.0	2.0	-0.1	-0.7
Miserableness	0.8	1.4	3.9	2.0	-0.1	-0.5
Heart disease (siblings)	0.8	1.0	2.4	1.5	-0.5	-0.7
Verbal and Numeric Reasoning (VNR)	0.7	1.7	2.7	-1.6	-1.2	-1.0
Ovarian Cancer	0.7	1.0	2.9	1.7	0.2	0.1
Chronotype (morning person)	0.7	1.7	2.5	-0.3	-1.6	-1.6
Serious illness, injury or assault to yourself	0.7	0.8	2.2	1.5	0.4	0.3
Financial difficulties in last 2 years	0.7	0.9	1.4	-0.3	-1.1	-1.2
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	1.7	0.7	0.9	1.3
Fluid intelligence score	0.7	1.5	3.8	-2.0	-0.6	-0.5
Falls in the last year	0.7	1.0	2.2	1.5	0.6	0.5
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.5	0.4	-0.9	-1.2
Chronic bronchitis/emphysema (mother)	0.7	0.8	0.9	0.9	0.9	0.8
Angina (self-reported)	0.7	0.9	1.9	1.4	-0.7	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.0	1.0	0.9	0.8
Irritability	0.7	1.1	2.2	1.5	-0.6	-0.8
Depressed Affect (Nagel 2018)	0.6	1.2	2.1	1.5	-0.6	-1.1
Tanning	0.6	7.7	20.3	-4.5	0.5	1.6
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.9	1.4	-0.6	-0.6
Hearing difficulty/problems: Yes	0.6	0.9	2.5	1.6	-0.2	-0.2
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.1	-1.0	0.8	0.6
Hair/balding pattern: Pattern 2	0.6	0.7	1.1	0.8	-0.7	-1.0
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.6	0.1	-0.9	-1.3
Time employed in main current job	0.6	0.7	1.3	0.2	1.1	0.9
Happiness	0.6	0.7	1.1	0.7	1.1	0.7
Mouth/teeth dental problems: Dentures	0.6	1.1	3.1	-1.8	-0.3	-0.2
Prospective memory result	0.6	0.8	1.1	-0.4	1.0	1.0
Peak expiratory flow (PEF)	0.6	1.5	2.5	0.3	-1.4	-1.6
Had major operations	0.6	0.7	1.1	1.0	-0.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.2	-1.8	-0.2	0.4
Medication: Blood pressure	0.6	1.2	2.6	1.6	0.8	0.7
Diastolic blood pressure, automated reading	0.6	1.9	2.9	1.0	1.7	1.3
Supplements: Calcium	0.6	0.6	1.3	1.2	0.5	0.6
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	1.2	0.4	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	2.7	-1.6	-0.2	0.6
Trunk fat mass	0.5	2.3	6.2	-2.5	-0.7	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	2.0	-1.1	-1.3	-1.4
Length of working week for main job	0.5	0.6	0.8	-0.7	-0.9	-0.6
Exposure to tobacco smoke at home	0.5	0.5	0.8	0.2	0.9	0.9
Hair/balding pattern: Pattern 4	0.5	1.2	3.1	-1.8	-0.6	0.2
Forced vital capacity (FVC), Best measure	0.5	1.9	2.8	-1.7	-1.3	-1.2
Wheeze or whistling in the chest in last year	0.5	1.0	2.3	1.5	0.5	0.5
Qualifications: College or University degree	0.5	1.6	1.9	1.2	1.4	1.2
Emphysema/chronic bronchitis	0.5	0.6	1.1	-0.6	-1.0	-0.5
Leg fat mass (right)	0.5	1.9	5.6	-2.4	-0.2	-0.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	0.8	0.9	0.9	0.6
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.1	1.5	0.2	0.2
Mother’s age at death	0.5	0.7	1.3	-1.1	-0.1	0.8
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.9	1.0	0.4	0.7
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.5	-1.2	-0.5	-0.4
Leg fat mass (left)	0.5	1.9	5.7	-2.4	0.0	0.1
Bipolar Disorder or Schizophrenia	0.4	1.0	1.7	-0.1	-1.1	-1.3
Depression (Nagel 2018)	0.4	0.7	1.3	1.1	-0.5	-0.7
Age at First Birth	0.4	0.6	0.8	0.8	0.9	0.7
HDL Cholesterol	0.4	0.6	1.5	-1.2	0.4	0.3
Blood Eosinophil Count	0.4	3.2	4.1	2.0	1.8	1.5
Lung FEV1/FVC ratio	0.4	2.2	3.3	-0.4	-1.8	-1.8
Lung FVC	0.4	1.9	4.4	2.1	0.9	0.6
Past tobacco smoking	0.4	0.7	1.8	0.0	-0.6	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.5	1.2	-0.1	-0.4
Had other major operations	0.4	0.4	0.7	0.9	0.5	0.5
Qualifications: None of the above	0.4	0.8	0.9	-0.9	-1.0	-0.8
Hip circumference	0.4	1.9	5.2	-2.3	0.3	0.6
Number of live births	0.4	0.6	0.9	1.0	0.6	0.6
Arm fat mass (right)	0.4	1.7	5.0	-2.2	-0.0	0.1
Pulse wave peak to peak time	0.4	0.5	1.1	-1.0	0.2	0.7
Whole body fat mass	0.4	1.6	4.7	-2.2	-0.3	-0.3
Age at last live birth	0.4	0.6	0.7	0.8	0.8	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	1.0	0.4	0.6
Arm fat mass (left)	0.4	1.6	4.8	-2.2	-0.1	-0.1
Eye problems/disorders: Glaucoma	0.4	0.5	0.7	-0.4	-0.9	-0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.5	1.2	0.4	0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	1.0	0.3	0.7
Neuroticism (Nagel 2018)	0.3	0.8	1.4	-0.2	-1.0	-1.2
Alzheimer’s Disease (in father)	0.3	0.3	0.5	-0.2	0.7	0.7
Alzheimer’s Disease (including proxy)	0.3	0.4	0.5	0.6	-0.7	-0.7
Blood Red Count	0.3	2.7	4.5	0.2	2.1	1.9
BMI	0.3	1.8	4.6	-2.1	0.6	0.5
Medication: Co-codamol	0.3	0.4	0.9	0.3	-0.5	-1.0
Qualifications: CSEs or equivalent	0.3	0.4	0.5	-0.5	0.7	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.5	-1.2	-0.5	0.2
Pulse wave Arterial Stiffness index	0.3	0.3	0.6	0.5	-0.4	-0.8
Birth weight	0.3	0.7	0.9	0.6	0.9	1.0
Shortness of breath walking on level ground	0.3	0.3	0.5	-0.5	-0.7	-0.4
Medication: Omeprazole	0.3	0.4	0.7	0.3	0.5	0.8
Long-standing illness, disability or infirmity	0.3	0.5	0.8	0.4	0.8	0.9
Asthma (self-reported)	0.3	0.7	0.9	0.6	0.9	0.9
Average weekly champagne plus white wine intake	0.3	0.4	0.6	-0.6	0.3	0.8
Wears glasses or contact lenses	0.3	0.4	0.5	0.7	0.5	0.6
Hearing aid user	0.3	0.3	0.8	0.9	0.3	0.2
Medication: Bendroflumethiazide	0.3	0.4	0.7	0.2	-0.7	-0.8
Myopia	0.3	0.4	0.7	-0.4	-0.6	-0.9
Pack years of smoking	0.3	0.5	0.7	-0.5	-0.8	-0.8
Intelligence (Savage-Jansen 2018)	0.2	0.7	0.7	-0.7	-0.9	-0.8
Worry (Nagel 2018)	0.2	0.4	0.9	-0.0	-0.5	-0.9
Breast Cancer	0.2	0.5	0.6	0.8	-0.5	-0.7
Mean Putamen Volume	0.2	0.2	0.3	0.3	-0.4	-0.6
Rheumatoid Arthritis	0.2	0.3	0.7	-0.8	-0.2	0.2
Heel T-Score	0.2	1.4	3.4	-1.9	-0.9	-0.2
Medication for hormone replacement therapy	0.2	0.2	0.3	0.4	-0.3	-0.6
Pack years adult smoking proportion	0.2	0.3	0.6	0.0	-0.6	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.4	0.4	-0.6	-0.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.6	-0.5	-0.3
Body mass index (BMI)	0.2	1.0	1.5	-1.2	0.9	0.7
Asthma	0.2	0.3	0.4	0.3	0.6	0.7
Medication: Lansoprazole	0.2	0.2	0.4	0.6	-0.1	-0.4
Breastfed as a baby	0.2	0.3	0.6	-0.8	-0.1	0.3
Loud music exposure frequency	0.2	0.2	0.5	-0.7	-0.0	-0.1
Migraine (self-reported)	0.2	0.2	0.6	0.8	-0.2	-0.2
Leg pain on walking	0.2	0.3	0.5	-0.5	-0.2	-0.7
Knee pain experienced in last month	0.2	0.2	0.7	-0.8	-0.2	-0.1
Back pain experienced in last month	0.2	0.3	0.6	0.8	-0.0	-0.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	0.6	0.2	0.4
Commuting to job workplace: Cycle	0.2	0.2	0.4	-0.6	-0.2	-0.4
Hypothyroidism (self reported)	0.1	0.2	0.5	0.3	0.7	0.3
Severe depression (siblings)	0.1	0.2	0.2	0.0	0.5	0.5
Average weekly fortified wine intake	0.1	0.1	0.3	-0.5	-0.1	-0.1
Chronic bronchitis/emphysema (father)	0.1	0.2	0.4	0.7	-0.2	-0.2
Nervous feelings	0.1	0.2	0.4	-0.3	-0.4	-0.6
Worry too long after embarrassment	0.1	0.1	0.3	0.6	-0.1	-0.3
Friendships satisfaction	0.1	0.1	0.1	0.4	0.2	0.2
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.5	-0.0	0.1
Mineral and other dietary supplements	0.1	0.1	0.2	-0.5	0.2	0.4
Breast cancer (self-reported)	0.1	0.1	0.2	0.4	0.4	0.3
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.2	0.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	0.7	0.4	0.2
Medication: Lisinopril	0.1	0.2	0.4	0.3	0.6	0.4
Ever smoked	0.1	0.2	0.6	-0.2	0.3	0.8
Age started oral contraceptive pill	0.1	0.2	0.3	0.5	-0.1	0.4
Basal cell carcinoma (self-reported)	0.1	0.2	0.4	0.7	-0.0	-0.2
HbA1C	0.0	0.0	0.1	-0.2	0.1	0.3
Smoking Status	0.0	0.1	0.1	0.3	-0.3	0.1
Respiratory disease	0.0	0.1	0.1	0.3	0.1	0.3
Sensitivity / hurt feelings	0.0	0.0	0.1	0.3	0.0	0.2
Trunk fat percentage	0.0	0.1	0.3	-0.2	-0.4	-0.5
Maternal smoking around birth	0.0	0.0	0.1	0.0	-0.2	-0.0
Medication: Atenolol	0.0	0.0	0.0	0.0	-0.1	-0.1
Arm fat percentage (right)	0.0	0.1	0.2	0.1	0.4	0.1
Noisy workplace	0.0	0.1	0.1	-0.3	-0.1	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	-0.0	-0.1	0.2
Depression (self-reported)	0.0	0.1	0.1	0.2	0.2	0.3
Blood clot in the leg (DVT)	0.0	0.0	0.1	0.1	-0.0	0.4
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	0.1	0.2	0.2
Body fat percentage	0.0	0.1	0.2	0.1	-0.2	-0.5
Leg fat percentage (right)	0.0	0.0	0.0	0.1	0.1	-0.2
Neck or shoulder pain in last month	0.0	0.0	0.1	0.2	-0.1	0.0
Number of full sisters	0.0	0.0	0.1	-0.1	-0.3	-0.1
Arm fat percentage (left)	0.0	0.0	0.1	-0.0	0.2	-0.1
Illnesses of father: None of the above (group 1)	0.0	0.0	0.0	-0.0	-0.1	0.0
Leg fat percentage (left)	0.0	0.0	0.1	0.1	0.3	0.0
Risk taking	0.0	0.1	0.2	-0.4	0.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	0.0	-0.2	0.2

Hub : Genes

GTF3C2

Models

Trait associations