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chr8:8,092,025-8,939,373

Best TWAS P=2.94e-10 · Best GWAS P=7.18e-12 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Brain Cerebellar Hemisphere	FAM86B3P	0.28	0.27	lasso	8	0.28	5.4e-08	-6.5	6.0	1.7e-09	-0.83	0.06	0.93	FALSE
2	GTEx	Brain Cerebellum	FAM86B3P	0.19	0.14	lasso	5	0.16	1.8e-05	-5.4	5.7	9.8e-09	-0.85	0.07	0.92	FALSE
3	GTEx	Brain Cortex	FAM86B3P	0.14	0.05	enet	9	0.07	5.1e-03	-5.5	5.3	8.9e-08	-0.80	0.04	0.84	FALSE
4	GTEx	Brain Frontal Cortex BA9	FAM86B3P	0.16	0.13	enet	27	0.10	1.1e-03	-5.6	5.4	8.0e-08	-0.72	0.08	0.81	FALSE
5	GTEx	Cells Transformed fibroblasts	FAM86B3P	0.23	0.33	lasso	11	0.38	8.4e-30	-4.9	-5.7	1.2e-08	0.82	0.65	0.35	FALSE
6	GTEx	Colon Transverse	FAM86B3P	0.13	0.04	lasso	8	0.04	4.4e-03	-5.4	-5.3	1.2e-07	0.78	0.12	0.58	FALSE
7	GTEx	Esophagus Mucosa	FAM86B3P	0.22	0.17	lasso	8	0.19	1.7e-12	-4.9	-5.8	5.8e-09	0.80	0.67	0.33	FALSE
8	GTEx	Testis	FAM86B3P	0.15	0.14	lasso	7	0.13	2.2e-06	-5.5	5.6	2.4e-08	-0.78	0.17	0.83	FALSE
9	GTEx	Thyroid	SGK223	0.19	0.35	enet	16	0.36	1.1e-28	-6.8	6.3	2.9e-10	-0.95	0.00	1.00	TRUE
10	ROSMAP	Brain Pre-frontal Cortex	FAM86B3P	0.19	0.27	bslmm	331	0.27	5.6e-35	-5.5	5.2	1.6e-07	-0.65	0.87	0.13	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	FAM85B	0.16	0.23	enet	18	0.22	1.8e-28	-4.9	5.3	1.2e-07	-0.79	0.97	0.03	FALSE
12	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FLJ10661	0.10	0.16	lasso	1	0.15	6.1e-13	-5.4	-5.4	5.4e-08	0.74	0.02	0.98	FALSE
13	The Cancer Genome Atlas	Colon Adenocarcinoma	FLJ10661	0.15	0.26	lasso	4	0.23	3.0e-13	-5.4	-5.5	4.8e-08	0.76	0.02	0.98	FALSE
14	The Cancer Genome Atlas	Esophageal Carcinoma	FLJ10661	0.20	0.23	lasso	2	0.23	5.6e-08	-5.6	-5.5	4.2e-08	0.74	0.01	0.99	FALSE
15	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FLJ10661	0.07	0.14	lasso	3	0.14	3.7e-15	-5.4	-5.5	3.9e-08	0.75	0.02	0.98	FALSE
16	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FLJ10661	0.07	0.02	blup	42	0.04	2.9e-03	-4.8	-5.8	6.8e-09	0.75	0.02	0.79	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	FLJ10661	0.21	0.26	lasso	9	0.30	2.3e-34	-4.9	5.3	1.2e-07	-0.77	0.04	0.95	FALSE
18	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FLJ10661	0.11	0.06	enet	5	0.07	2.3e-05	-5.4	-5.1	2.8e-07	0.70	0.01	0.95	FALSE
19	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FLJ10661	0.25	0.18	lasso	4	0.16	4.2e-07	-5.6	5.9	4.7e-09	-0.76	0.00	0.99	FALSE
20	The Cancer Genome Atlas	Soft Tissue Sarcoma	FLJ10661	0.12	0.00	blup	42	0.00	6.9e-01	-5.4	-6.0	1.7e-09	0.64	0.01	0.51	FALSE
21	The Cancer Genome Atlas	Stomach Adenocarcinoma	FLJ10661	0.08	0.05	blup	42	0.07	9.3e-06	-4.8	-5.7	1.0e-08	0.75	0.02	0.98	FALSE
22	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FLJ10661	0.24	0.36	enet	8	0.35	4.1e-13	-5.4	-5.5	3.7e-08	0.75	0.02	0.98	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	SGK223	0.16	0.20	enet	14	0.22	6.1e-21	4.1	5.3	1.3e-07	-0.77	0.82	0.17	FALSE