Hub : Genes

FLJ10661

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.1030	0.0430	4.4e-10	0.159	0.116	0.137	NA	0.153	2.1e-13	4.6e-10	1.2e-11	NA	6.1e-13
2	TCGA	Cervical Squamous Cell Carcinoma	0.3290	0.1060	9.6e-05	0.089	0.089	0.086	NA	0.070	3.8e-05	3.7e-05	5.1e-05	NA	2.5e-04
3	TCGA	Colon Adenocarcinoma	0.1520	0.0590	5.1e-12	0.257	0.224	0.213	NA	0.226	4.9e-15	3.8e-13	1.8e-12	NA	3.0e-13
4	TCGA	Esophageal Carcinoma	0.1980	0.0690	7.2e-08	0.233	0.221	0.228	NA	0.233	5.5e-08	1.3e-07	7.8e-08	NA	5.5e-08
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0734	0.0281	3.7e-13	0.143	0.114	0.134	NA	0.137	1.0e-15	1.0e-12	8.1e-15	NA	3.7e-15
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0650	0.0334	8.8e-04	0.006	0.018	0.023	NA	0.032	6.2e-02	3.4e-03	1.1e-03	NA	1.6e-04
7	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0670	0.0370	1.9e-03	0.024	0.038	0.022	NA	0.030	1.6e-02	2.9e-03	2.0e-02	NA	7.6e-03
8	TCGA	Brain Lower Grade Glioma	0.2080	0.0647	0.0e+00	0.264	0.293	0.296	NA	0.299	7.0e-30	1.4e-33	6.2e-34	NA	2.3e-34
9	TCGA	Liver Hepatocellular Carcinoma	0.0930	0.0480	1.2e-03	0.066	0.069	0.059	NA	0.065	4.9e-04	3.6e-04	9.2e-04	NA	5.2e-04
10	TCGA	Lung Adenocarcinoma	0.0598	0.0316	8.0e-05	0.049	0.032	0.035	NA	0.038	1.9e-06	1.1e-04	5.0e-05	NA	2.4e-05
11	TCGA	Lung Squamous Cell Carcinoma	0.1185	0.0475	1.1e-09	0.085	0.071	0.069	NA	0.077	6.6e-10	1.6e-08	2.8e-08	NA	4.7e-09
12	TCGA	Ovarian Serous Cystadenocarcinoma	0.1140	0.0530	2.1e-04	0.060	0.058	0.068	NA	0.067	6.7e-05	9.1e-05	2.3e-05	NA	2.6e-05
13	TCGA	Pancreatic Adenocarcinoma	0.1710	0.0710	4.3e-06	0.109	0.144	0.159	NA	0.132	2.7e-05	1.2e-06	3.3e-07	NA	3.7e-06
14	TCGA	Pheochromocytoma and Paraganglioma	0.2490	0.0870	4.9e-08	0.184	0.134	0.123	NA	0.165	8.4e-08	5.5e-06	1.4e-05	NA	4.2e-07
15	TCGA	Soft Tissue Sarcoma	0.1160	0.0720	5.6e-03	0.000	-0.004	-0.004	NA	-0.005	3.2e-01	6.9e-01	7.9e-01	NA	8.9e-01
16	TCGA	Stomach Adenocarcinoma	0.0820	0.0390	8.0e-06	0.048	0.070	0.068	NA	0.060	2.0e-04	9.3e-06	1.2e-05	NA	3.5e-05
17	TCGA	Testicular Germ Cell Tumors	0.2360	0.0770	8.9e-11	0.359	0.329	0.348	NA	0.345	1.5e-13	2.5e-12	4.1e-13	NA	5.7e-13
18	TCGA	Thyroid Carcinoma	0.0750	0.0460	6.0e-03	0.002	0.007	0.014	NA	0.007	1.8e-01	5.8e-02	1.4e-02	NA	5.9e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Bipolar Disorder (2018)	2.6	4.1	6.2	2.2	1.2	2.3	2.0	2.2	1.9	2.0	-2.5	2.4	1.7	1.9	1.9	2.2	-2.1	1.4	2.0	2.2	1.4
Bipolar Disorder or Schizophrenia	7.0	17.1	22.0	4.6	3.8	4.7	4.2	4.6	3.9	4.3	-4.7	4.3	4.2	4.1	4.1	4.1	-4.4	3.0	4.3	4.4	2.0
Depressed Affect (Nagel 2018)	2.9	6.1	10.2	-3.2	-1.8	-3.1	-2.2	-3.1	-2.5	-2.3	2.8	-2.5	-2.3	-2.2	-2.4	-2.5	2.4	-1.8	-2.5	-2.8	-1.5
Depression (Nagel 2018)	2.3	3.5	6.5	-2.0	-0.8	-1.8	-1.6	-1.9	-2.2	-1.6	1.6	-2.2	-1.2	-1.6	-2.1	-2.5	1.3	-2.3	-1.4	-1.9	-2.5
Intelligence (Savage-Jansen 2018)	0.3	0.8	3.3	-0.4	-0.5	-0.4	-0.5	-0.5	-1.8	-0.4	0.5	-1.0	0.4	-0.4	-0.9	-1.5	0.4	-1.6	-0.0	-0.3	-1.7
Neuroticism (Nagel 2018)	2.6	6.1	8.9	-3.0	-1.8	-3.0	-2.2	-2.9	-2.3	-2.3	3.0	-2.8	-2.9	-2.4	-2.1	-2.7	2.4	-1.1	-2.7	-2.8	-0.8
Schizophrenia (2018)	6.2	12.8	17.2	4.1	3.8	4.1	3.7	4.1	0.0	3.8	-4.0	3.6	4.0	3.8	3.7	3.4	-4.0	2.6	3.8	3.8	1.3
Schizophrenia vs Biploar Disorder	2.8	3.7	8.2	2.1	2.9	2.2	1.9	2.1	0.0	2.0	-2.1	1.8	2.4	2.2	1.9	1.8	-1.9	1.2	1.9	1.8	0.5
Worry (Nagel 2018)	1.4	3.0	7.7	-2.0	-2.3	-2.1	-1.4	-1.9	-1.6	-1.7	2.0	-1.4	-2.8	-1.5	-1.0	-1.1	1.7	-0.0	-2.1	-1.7	0.6
Alzheimer’s Disease (in mother)	0.3	0.4	2.7	0.5	0.0	0.4	0.6	0.5	-1.6	0.2	-0.2	0.1	0.8	0.7	0.4	0.3	-0.3	0.3	0.6	0.3	-0.8
Alzheimer’s Disease (in father)	0.5	0.6	4.0	-0.6	-1.2	-0.7	-0.3	-0.6	-2.0	-0.6	0.6	-0.4	0.1	-0.3	-0.2	-0.4	0.5	-1.0	-0.6	-0.6	-0.5
Alzheimer’s Disease (including proxy)	0.3	0.5	5.1	0.4	-0.1	0.3	0.4	0.4	-2.3	-0.2	0.1	-0.2	0.5	0.4	0.3	0.1	-0.2	-0.5	0.3	0.1	-1.3
Crohns Disease (2017)	0.7	1.6	3.8	0.9	0.7	1.0	1.8	1.0	0.8	1.6	-1.3	1.3	1.2	1.1	1.2	1.0	-1.7	1.9	1.5	1.1	0.2
Irritable Bowel Disease (IBD)	0.2	0.4	1.7	0.3	0.5	0.5	0.8	0.4	0.8	0.8	-0.7	0.6	0.5	0.1	0.2	0.2	-0.8	1.3	0.8	0.5	-0.0
Ulcerative Colitis (UC)	0.1	0.1	0.3	-0.3	-0.1	-0.2	-0.4	-0.3	0.5	-0.2	0.1	0.0	-0.3	-0.6	-0.5	-0.2	0.3	0.4	-0.2	-0.2	0.3
Major Depression (MDD)	0.3	0.4	2.8	-0.6	-0.0	-0.7	-0.3	-0.5	-1.7	-0.6	1.0	-0.4	-0.0	0.3	0.2	0.0	0.6	-0.0	-0.5	-0.7	0.2
Reaction Time	0.5	1.0	2.3	-1.2	-1.5	-1.3	-0.8	-1.1	-1.1	-0.8	1.5	-1.1	-1.1	-0.7	-0.3	-0.8	0.9	0.4	-1.0	-0.8	0.8
Verbal and Numeric Reasoning (VNR)	1.0	2.3	4.8	-1.5	-1.2	-1.3	-1.3	-1.5	-1.7	-1.2	1.2	-1.6	-0.9	-1.8	-2.0	-2.1	1.0	-2.1	-0.9	-1.3	-2.2
Breast Cancer	1.9	4.5	8.5	2.7	2.9	2.6	2.1	2.6	1.6	2.8	-1.9	0.7	2.4	1.9	1.9	0.2	-2.2	2.4	2.3	2.1	-0.6
Ovarian Cancer	0.6	0.8	1.5	0.9	1.1	1.0	1.0	0.9	0.5	1.2	-1.0	-0.1	1.2	0.7	0.7	0.0	-1.0	0.4	0.8	0.7	-1.0
Prostate Cancer	0.9	1.3	2.3	1.5	1.1	1.5	0.9	1.4	1.0	1.2	-1.4	1.1	1.3	1.1	0.9	0.7	-0.8	0.7	1.1	1.4	0.3
Age at First Birth	0.8	1.2	2.0	-1.4	-1.4	-1.4	-1.0	-1.4	-0.7	-0.8	1.2	-1.2	-1.4	-0.9	-0.7	-1.1	1.1	0.1	-1.2	-1.2	-0.0
Bipolar Disorder (2011)	0.2	0.2	0.8	0.5	-0.1	0.6	0.5	0.5	0.0	0.4	-0.9	0.8	0.0	0.3	0.2	0.5	-0.6	0.1	0.6	0.6	0.2
Body Mass Index (BMI) (2010)	3.9	5.3	8.8	2.4	1.1	2.4	2.4	2.4	0.5	3.0	-2.2	1.6	2.6	2.9	3.0	2.1	-2.2	2.7	2.3	2.6	1.5
Coronary Artery Disease (CAD)	0.3	0.3	2.8	-0.5	0.5	-0.4	0.3	-0.4	0.0	-0.2	0.2	0.8	-0.5	0.2	0.5	0.7	-0.3	0.6	-0.1	-0.3	1.7
Crohns Disease (2012)	0.8	1.3	2.3	1.3	0.9	1.4	1.5	1.4	0.8	1.1	-1.5	1.4	1.2	0.9	0.7	0.7	-1.4	0.7	1.4	1.1	-0.5
Mean Putamen Volume	0.2	0.2	0.9	-0.0	0.4	0.1	0.6	0.1	-0.3	-0.2	-0.1	0.9	0.4	0.3	-0.0	0.7	-0.6	-0.3	0.6	-0.0	-0.7
Fasting Glucose	0.5	0.6	2.0	0.7	-0.1	0.8	1.4	0.7	0.8	1.0	-1.1	0.9	0.7	0.6	0.8	0.6	-1.1	-0.0	0.6	0.7	-0.2
HbA1C	0.9	1.0	3.9	0.3	-0.6	0.6	1.3	0.5	-2.0	1.2	-0.9	0.3	1.6	1.3	1.2	0.6	-1.1	0.3	0.9	0.9	-0.0
HDL Cholesterol	0.7	1.2	2.9	-0.5	0.2	-0.8	-1.7	-0.7	0.7	-1.3	1.3	-1.2	-1.6	-1.0	-1.1	-1.0	1.6	-0.9	-1.3	-1.0	0.4
LDL Cholesterol	0.1	0.2	0.5	0.4	0.6	0.5	0.0	0.4	0.0	0.5	-0.7	0.2	0.6	-0.0	-0.0	-0.1	-0.3	-0.1	0.4	0.5	0.4
Lupus	9.3	14.1	18.1	4.2	2.9	4.2	4.0	4.2	3.0	3.8	-4.0	4.2	4.0	3.5	3.9	3.8	-4.2	3.1	3.9	4.0	1.9
Neuroticism (2016)	24.4	35.2	48.6	-6.3	-5.4	-6.3	-5.7	-6.3	-7.0	-6.3	6.3	-6.1	-5.0	-5.5	-6.0	-5.8	6.1	-6.0	-5.8	-6.2	-4.2
Primary Biliary Cirrhosis	0.3	0.4	1.1	0.8	0.5	0.9	0.5	0.8	1.0	0.4	-1.1	1.1	0.4	0.0	0.2	0.3	-1.0	-0.4	0.4	0.6	0.1
Rheumatoid Arthritis	0.1	0.2	0.7	0.3	-0.4	0.2	0.8	0.4	-0.5	0.3	-0.2	0.4	0.3	0.3	0.5	0.4	-0.7	0.5	0.2	0.1	-0.1
Schizophrenia (2014)	9.6	21.2	27.7	4.9	4.3	5.1	4.8	4.9	3.6	4.5	-5.3	5.2	5.0	4.9	4.3	4.9	-4.8	3.2	5.0	4.9	1.9
Triglycerides	6.8	11.1	14.4	-3.8	-2.8	-3.8	-3.1	-3.7	-3.5	-3.5	3.7	-3.5	-3.0	-3.1	-3.3	-3.3	3.3	-3.0	-3.6	-3.8	-1.8
Type 2 Diabetes (T2D) (2012)	3.1	3.5	7.0	2.0	1.7	2.1	2.3	2.1	0.0	2.2	-2.0	1.9	1.6	1.4	1.6	1.4	-2.6	2.0	2.2	2.0	0.2
Ulcerative Colitis	1.1	1.6	2.9	-1.0	0.3	-1.1	-1.6	-1.1	0.6	-1.5	1.5	-1.2	-1.6	-1.6	-1.6	-1.7	1.4	-0.6	-1.3	-1.3	-0.5
Blood Eosinophil Count	0.0	0.3	1.3	-0.7	-1.2	-0.4	-0.3	-0.6	-0.7	0.0	-0.1	0.5	0.8	-0.7	-0.1	0.5	-0.1	-0.9	-0.2	-0.0	0.6
Blood Platelet Count	0.0	0.4	1.6	0.6	-0.5	0.4	0.4	0.5	-1.3	0.1	-0.4	0.3	0.8	1.3	0.6	0.8	0.5	-0.2	0.5	0.7	0.2
Blood Red Count	0.1	0.9	5.2	-0.5	2.3	-0.4	0.5	-0.4	-0.9	0.1	1.0	-1.4	1.3	0.4	0.0	-0.8	-0.6	-0.5	-0.1	-1.2	-1.6
Blood White Count	0.1	0.5	3.2	-0.7	-1.8	-0.5	-0.3	-0.6	-0.4	0.5	-0.2	0.6	0.2	-0.5	0.1	0.3	0.0	1.2	0.2	0.6	1.5
Heel T-Score	0.2	1.5	7.1	0.6	0.8	0.7	1.7	0.7	0.1	-0.8	-1.2	2.7	0.8	1.2	0.3	2.3	-1.4	-1.5	0.8	0.1	-0.7
BMI	0.1	0.3	1.4	-1.0	-0.7	-0.8	0.2	-0.9	-1.2	-0.1	0.3	-0.5	0.3	-0.2	-0.3	-0.1	-0.0	-0.4	-0.3	-0.7	-0.5
Height	0.1	1.1	3.2	-0.8	0.0	-0.7	-0.6	-0.8	0.7	-1.3	0.2	0.2	-1.6	-1.4	-1.7	-0.9	0.0	-1.8	-0.3	-1.2	-1.6
Waist Hip Ratio (WHR)	0.3	1.4	2.7	1.0	-0.8	1.1	1.3	1.0	-0.4	1.4	-1.6	1.2	1.5	1.1	1.1	1.2	-1.2	0.7	1.2	1.5	0.7
Systolic Blood Pressure	0.5	2.4	6.1	-1.8	-1.3	-1.8	-1.8	-1.8	0.6	-1.4	1.6	-0.8	-2.5	-2.2	-0.9	-0.9	1.2	-0.1	-2.0	-1.5	1.8
Smoking Status	1.3	3.1	6.3	-2.5	-0.0	-2.2	-2.0	-2.5	-0.3	-2.2	1.7	-1.1	-1.9	-2.1	-2.4	-1.1	1.2	-1.7	-1.4	-2.1	-0.9
Allergy or Eczema	0.7	1.9	4.6	0.5	-1.4	0.6	1.4	0.6	-1.3	0.8	-1.3	2.0	2.1	1.8	1.4	2.1	-0.8	0.4	1.1	1.4	1.7
Cardiovascular Disease	1.1	3.6	8.6	-2.4	-1.4	-2.3	-1.8	-2.3	-0.0	-2.1	1.9	-1.1	-2.9	-2.6	-2.1	-1.6	1.2	-1.1	-1.9	-2.2	-0.2
Hypothyroidism (self reported)	2.9	6.6	14.0	-2.6	-2.2	-2.7	-3.3	-2.8	-2.4	-2.9	2.2	-1.8	-2.0	-1.8	-2.7	-1.8	3.7	-3.6	-2.9	-2.5	-0.2
Respiratory disease	1.7	3.8	7.9	1.5	0.6	1.9	2.7	1.7	0.2	2.0	-2.8	2.4	2.7	1.9	1.5	1.8	-2.8	0.7	2.2	1.9	-0.4
Type 2 Diabetes (T2D) (2018)	1.0	1.8	6.2	-1.3	-1.1	-1.0	-0.7	-1.2	-1.3	-0.9	0.2	-0.7	-0.6	-2.1	-1.9	-1.5	-0.0	-2.2	-0.6	-1.2	-2.5
Lung FEV1/FVC ratio	1.6	8.2	14.3	-2.5	-0.9	-2.6	-3.5	-2.7	-1.6	-2.4	2.9	-3.8	-2.8	-3.1	-3.3	-3.6	3.1	-2.9	-3.0	-3.1	-2.5
Lung FVC	0.6	3.2	7.4	2.1	2.0	2.0	2.7	2.2	0.0	1.7	-1.7	0.8	2.0	2.2	1.8	0.6	-2.2	1.3	1.9	1.5	-1.4
Neuroticism	0.1	0.2	0.8	-0.3	0.0	-0.4	0.1	-0.2	-0.6	-0.3	0.8	-0.9	-0.7	-0.0	0.1	-0.5	0.2	0.6	-0.5	-0.5	-0.5
Chronotype (morning person)	1.0	2.2	4.4	2.0	-0.6	1.9	1.7	2.0	0.4	1.9	-2.1	1.3	1.4	1.1	1.6	0.8	-1.6	0.8	1.2	2.0	0.1
Hair Pigment	0.0	0.7	2.9	-0.6	-1.1	-0.8	-0.3	-0.6	-0.8	-0.3	0.5	-0.2	-0.9	1.1	0.4	0.6	1.4	1.3	-0.5	0.0	1.7
Tanning	0.2	2.7	6.0	2.0	2.5	2.0	2.1	2.1	2.0	1.0	-1.6	1.8	1.0	1.5	1.3	1.1	-2.2	0.9	1.6	1.1	-0.4
Hand grip strength (left)	0.4	1.1	3.4	1.3	1.8	1.2	1.1	1.3	0.9	1.0	-0.6	0.5	1.1	0.9	0.9	0.8	-1.1	1.0	1.3	0.9	-0.6
Number of treatments/medications taken	0.6	1.0	3.3	0.6	-0.9	0.7	0.7	0.6	0.1	1.2	-1.0	0.8	0.9	1.0	1.2	1.1	-0.6	1.3	0.7	1.3	1.8
Average weekly spirits intake	2.2	2.8	4.8	-1.5	-0.9	-1.5	-1.9	-1.6	-0.7	-1.9	1.5	-1.6	-1.7	-1.8	-2.2	-1.8	1.8	-2.2	-1.7	-1.7	-1.3
Sensitivity / hurt feelings	12.6	21.6	30.0	-4.6	-3.3	-4.8	-4.5	-4.6	-4.8	-4.8	5.5	-5.5	-4.5	-4.4	-4.3	-5.3	4.8	-3.9	-4.9	-5.1	-3.3
Frequency of depressed mood in last 2 weeks	8.6	12.1	15.8	-3.6	-2.5	-3.6	-3.3	-3.6	-3.2	-3.6	3.7	-3.8	-3.2	-3.6	-3.6	-4.0	3.3	-3.5	-3.5	-3.8	-2.7
Hearing difficulty/problems: Yes	0.1	0.2	0.5	-0.6	-0.6	-0.6	-0.2	-0.5	-0.4	-0.7	0.5	0.1	-0.5	-0.2	-0.1	0.3	0.3	-0.4	-0.5	-0.5	0.5
Relative age of first facial hair	0.3	0.5	1.7	-0.5	-0.4	-0.5	-0.6	-0.5	0.7	-0.8	0.3	-0.4	-1.3	-1.3	-0.9	-1.2	0.3	-0.4	-0.7	-0.7	-0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.9	-0.9	-1.2	-0.9	-0.8	-0.9	-1.0	-0.3	0.8	-1.4	-0.6	-0.7	-0.6	-1.1	0.9	0.3	-0.4	-0.4	-0.1
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.7	-0.1	0.1	0.2	0.8	0.1	0.8	0.1	-0.7	1.6	0.1	0.8	0.6	1.6	-0.7	0.6	0.5	0.4	1.4
Ever had hysterectomy (womb removed)	3.5	4.0	5.7	2.3	1.1	2.3	2.0	2.2	2.0	2.3	-2.4	2.0	1.7	1.9	2.0	1.9	-2.0	1.8	2.0	2.4	1.4
Systolic blood pressure, automated reading	8.5	24.7	31.5	5.2	3.8	5.3	5.3	5.2	4.3	5.5	-5.6	5.2	4.6	4.8	5.4	4.7	-5.6	4.9	4.6	5.1	3.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.2	-0.5	0.1	-0.5	-0.9	-0.5	-0.2	-0.8	0.7	-1.0	-0.7	-0.5	-0.9	-0.6	1.1	-0.6	-0.5	-0.6	-0.6
Angina	0.3	0.4	1.4	0.5	-0.0	0.6	0.6	0.5	-1.0	0.7	-1.0	0.3	1.2	0.7	0.4	0.3	-0.6	-0.5	0.5	0.6	-0.5
Medication for hormone replacement therapy	0.4	0.4	2.1	0.1	0.2	0.3	0.7	0.2	0.3	0.0	-0.9	1.5	0.6	0.5	0.0	1.3	-0.8	-0.2	0.7	0.4	0.3
Vitamin and mineral supplements	2.1	2.9	5.2	-1.8	-0.4	-1.9	-2.3	-1.9	-0.4	-2.0	2.2	-1.7	-1.9	-1.8	-1.9	-1.5	1.9	-1.4	-1.6	-1.9	-0.2
Supplements: Zinc	1.1	1.2	2.5	0.7	-0.5	0.8	1.3	0.8	1.4	1.0	-1.2	1.6	0.2	0.6	1.2	1.3	-1.4	1.3	0.8	1.0	1.3
Medication: Co-codamol	1.0	1.2	3.6	0.7	1.9	0.9	1.2	0.8	1.3	1.5	-0.9	0.5	1.1	0.9	0.9	0.3	-1.3	1.6	1.2	0.7	0.0
Medication: Metformin	1.9	2.6	5.8	1.7	1.3	1.9	1.9	1.7	-0.0	1.9	-2.0	1.2	2.4	1.5	1.2	1.1	-2.0	0.3	2.0	1.5	-1.3
Diabetes (father)	4.4	5.5	7.2	2.4	1.8	2.5	2.6	2.4	1.3	2.7	-2.6	2.3	2.5	2.4	2.4	2.4	-2.5	2.6	2.6	2.4	0.6
Diabetes (mother)	0.7	0.9	2.1	1.5	0.6	1.3	0.8	1.4	-0.1	1.1	-1.1	0.5	1.0	1.1	1.1	0.7	-0.6	0.4	0.7	1.1	-0.1
Severe depression (siblings)	0.2	0.2	0.7	0.6	0.1	0.5	0.5	0.5	0.2	0.3	-0.4	0.5	0.1	0.3	0.3	0.2	-0.4	0.9	0.7	0.5	-0.1
Pack years adult smoking proportion	1.2	1.8	4.0	1.3	0.8	1.4	1.4	1.3	0.6	1.3	-2.0	1.7	1.7	1.5	1.4	1.9	-1.3	0.5	0.9	1.2	0.9
Impedance of leg (right)	11.7	56.6	72.9	-7.9	-5.9	-8.2	-8.4	-8.1	-6.1	-8.5	8.5	-7.5	-7.4	-7.2	-7.8	-7.3	8.5	-7.4	-7.9	-7.9	-3.2
Leg fat-free mass (left)	3.9	20.4	30.5	4.8	3.5	5.0	5.3	4.9	4.2	4.7	-5.5	5.0	4.0	4.1	4.1	4.5	-5.4	3.6	4.9	4.6	0.9
Trunk fat percentage	0.9	3.8	5.6	2.0	1.0	2.1	2.4	2.1	1.2	2.0	-2.3	2.3	1.9	2.0	1.9	2.2	-2.3	1.5	2.1	2.1	0.6
Hand grip strength (right)	0.2	0.6	2.2	1.0	1.5	0.9	0.8	1.0	0.6	0.5	-0.6	0.5	0.6	0.7	0.3	0.5	-0.7	0.4	0.9	0.5	-1.1
Townsend deprivation index at recruitment	0.1	0.2	0.9	-0.2	-0.2	-0.3	-0.1	-0.2	-0.5	-0.2	0.4	-0.7	-0.3	-0.4	-0.4	-0.7	0.2	-0.5	-0.3	-0.4	-1.0
Current tobacco smoking	5.9	9.6	20.6	2.6	3.4	2.8	3.1	2.7	4.5	2.7	-3.2	4.1	2.3	2.2	2.5	3.5	-3.7	3.3	3.2	2.7	2.2
Average weekly fortified wine intake	4.4	5.1	10.6	-2.2	-2.6	-2.3	-2.1	-2.3	-3.3	-2.4	2.3	-2.1	-1.8	-1.7	-2.1	-2.1	2.5	-2.7	-2.1	-2.2	-1.5
Maternal smoking around birth	2.3	3.3	5.8	-2.1	-2.3	-2.1	-1.8	-2.1	-2.3	-2.0	1.7	-1.3	-1.2	-1.6	-1.6	-1.2	1.7	-2.4	-1.9	-2.0	-0.3
Fed-up feelings	17.7	32.2	43.3	-6.3	-4.5	-6.4	-6.0	-6.3	-5.1	-6.5	6.6	-5.6	-5.5	-5.4	-5.6	-5.0	6.2	-5.2	-6.0	-6.3	-2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	5.1	6.8	13.1	-2.4	-1.8	-2.4	-2.3	-2.4	-3.6	-2.9	2.5	-2.3	-1.7	-2.4	-2.9	-2.8	2.3	-3.5	-2.3	-2.8	-3.0
Relative age voice broke	0.3	0.5	1.8	-0.6	0.3	-0.5	-0.3	-0.6	0.2	-0.7	0.3	-0.2	-0.4	-1.0	-1.1	-0.9	-0.1	-1.4	-0.3	-0.7	-1.3
Taking other prescription medications	0.2	0.4	3.8	-0.4	-1.1	-0.2	-0.1	-0.3	-2.0	0.0	-0.1	-0.3	0.6	0.1	-0.2	-0.2	0.2	-0.8	-0.0	-0.0	-0.7
Age when periods started (menarche)	1.0	2.3	5.3	-1.9	-2.3	-1.7	-1.5	-1.9	-1.0	-2.0	0.8	-0.0	-1.9	-1.6	-1.9	-0.7	1.4	-1.7	-1.3	-1.2	0.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	1.4	0.9	0.0	1.0	1.0	0.9	0.4	0.9	-1.2	0.8	0.6	0.7	0.7	0.6	-1.0	0.5	0.9	0.9	0.0
Heel bone mineral density (BMD) T-score, automated (left)	27.9	63.3	85.0	8.5	6.3	8.8	8.9	8.6	5.6	8.4	-9.2	8.6	8.3	8.0	7.9	8.3	-8.9	6.4	8.6	8.5	2.4
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	4.9	1.3	1.5	1.4	2.2	1.4	1.0	1.7	-1.5	1.6	1.4	1.3	1.3	1.0	-2.1	1.9	1.7	1.2	-0.7
Qualifications: CSEs or equivalent	0.3	0.4	1.2	-0.5	0.2	-0.7	-0.6	-0.6	0.3	-0.9	1.1	-0.5	-0.9	-0.7	-0.5	-0.2	0.6	-0.2	-0.7	-0.9	0.1
Serious illness, injury or assault to yourself	2.6	3.1	4.7	-1.8	-1.1	-1.9	-2.0	-1.9	-1.6	-1.8	2.0	-2.0	-1.7	-1.6	-1.8	-1.7	2.2	-1.5	-2.1	-2.0	-0.8
High blood pressure	6.9	19.3	27.8	4.8	3.7	4.9	4.8	4.8	4.6	4.9	-5.2	4.6	3.8	3.7	4.3	3.7	-5.3	4.2	4.2	4.4	2.2
Hayfever, allergic rhinitis or eczema	0.8	1.7	4.1	0.8	-0.7	1.0	1.4	0.9	-1.3	0.9	-1.5	1.9	2.0	1.8	1.3	1.9	-1.0	-0.1	1.4	1.5	0.9
Multivitamins +/- minerals	0.2	0.2	1.0	0.3	-0.3	0.5	0.8	0.4	0.1	0.5	-1.0	0.8	0.4	0.1	0.3	0.4	-0.8	0.3	0.3	0.4	-0.0
Stomach or abdominal pain in last month	2.8	3.5	7.9	-1.8	-1.9	-2.0	-2.0	-1.9	-2.8	-1.9	2.3	-2.2	-1.3	-0.9	-1.1	-1.4	2.6	-1.4	-2.2	-1.8	-0.1
Supplements: Glucosamine	0.2	0.3	0.9	0.3	0.4	0.3	0.4	0.3	0.8	0.8	-0.2	-0.8	-0.1	-0.2	0.0	-1.0	-0.4	0.9	0.2	0.2	-0.8
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	1.7	0.3	0.8	0.3	-0.2	0.3	1.3	0.1	-0.2	0.1	-0.4	-0.2	-0.0	0.2	0.1	0.6	0.1	0.2	0.1
Medication: Atenolol	2.0	2.5	4.3	1.7	1.5	1.7	2.0	1.8	1.1	1.7	-1.8	1.5	1.5	1.4	1.4	1.4	-2.1	1.1	1.7	1.4	-0.5
Medication: Levothyroxine sodium	15.7	26.6	36.3	-5.4	-4.4	-5.5	-5.5	-5.5	-4.5	-5.8	5.3	-4.9	-4.8	-4.7	-5.1	-4.6	5.9	-6.0	-5.7	-5.5	-2.5
Sitting height	0.9	6.5	11.4	2.8	2.1	3.0	3.1	2.9	2.2	2.5	-3.4	3.0	2.4	2.0	1.7	1.9	-3.4	1.1	3.2	2.6	-0.7
Chronic bronchitis/emphysema (father)	0.1	0.1	0.4	-0.1	-0.0	-0.1	-0.3	-0.1	0.2	-0.3	-0.1	0.1	-0.4	0.1	-0.2	0.3	0.3	-0.6	-0.3	-0.2	0.2
High blood pressure (mother)	3.0	4.2	9.3	2.1	0.7	2.2	2.4	2.2	2.0	1.9	-2.8	3.1	1.5	1.6	1.7	2.3	-2.5	1.4	2.0	2.2	0.9
Body mass index (BMI)	10.2	43.4	54.8	6.9	4.8	7.1	7.4	7.0	4.7	7.2	-7.4	6.9	6.8	6.9	7.0	7.0	-7.3	5.9	6.8	6.9	2.9
Impedance of leg (left)	12.0	58.3	75.9	-8.1	-6.2	-8.4	-8.4	-8.2	-6.2	-8.6	8.7	-7.6	-7.7	-7.3	-7.7	-7.3	8.7	-7.1	-8.1	-8.1	-2.8
Leg predicted mass (left)	3.8	20.0	30.3	4.8	3.4	5.0	5.2	4.9	4.2	4.7	-5.5	5.0	3.9	4.1	4.0	4.5	-5.4	3.6	4.9	4.6	0.9
Trunk fat mass	1.8	7.7	11.2	3.0	1.7	3.1	3.3	3.0	2.0	2.9	-3.3	3.1	2.7	2.8	2.7	3.0	-3.2	2.1	3.0	2.9	0.7
Waist circumference	1.2	4.4	7.5	2.3	0.6	2.4	2.5	2.3	0.9	2.5	-2.7	2.2	2.4	2.1	2.1	2.1	-2.5	1.2	2.2	2.4	0.6
Number of incorrect matches in round	0.9	1.4	2.2	-1.5	-1.0	-1.5	-0.9	-1.4	-1.1	-1.1	1.4	-1.3	-1.5	-1.2	-1.0	-1.4	0.9	-0.3	-1.2	-1.4	-0.7
Past tobacco smoking	2.1	3.9	8.5	-2.0	-2.9	-2.1	-2.0	-2.0	-0.8	-2.1	1.8	-1.4	-2.7	-2.5	-1.7	-1.6	2.0	-1.4	-2.5	-2.0	0.6
Alcohol usually taken with meals	2.7	4.4	6.8	1.9	0.1	1.9	2.0	1.9	0.9	2.4	-2.1	2.0	2.1	2.4	2.5	2.4	-1.7	2.6	2.3	2.6	2.2
Nervous feelings	19.7	36.8	49.7	-7.0	-5.8	-7.1	-6.4	-6.9	-5.4	-6.4	7.0	-6.3	-6.2	-5.7	-5.5	-5.4	6.6	-4.6	-6.6	-6.5	-1.3
Frequency of tenseness / restlessness in last 2 weeks	2.8	4.3	6.1	-2.2	-2.2	-2.2	-2.0	-2.2	-2.3	-2.5	2.0	-1.7	-1.9	-1.9	-2.0	-1.8	2.3	-2.3	-2.3	-2.2	-0.7
Hearing difficulty/problems with background noise	1.2	2.0	3.0	-1.4	-1.5	-1.5	-1.4	-1.4	-0.9	-1.5	1.4	-1.3	-1.7	-1.7	-1.4	-1.4	1.2	-1.3	-1.5	-1.4	-0.6
Hair/balding pattern: Pattern 2	0.7	0.9	4.2	1.0	1.8	0.9	0.5	0.9	2.0	0.4	-0.6	0.9	0.2	0.2	0.6	0.9	-0.9	0.8	0.5	0.4	0.8
Had menopause	1.1	1.4	2.8	1.1	-0.0	1.2	1.1	1.1	0.2	1.2	-1.2	1.5	1.1	1.5	1.5	1.5	-1.0	0.9	0.9	1.2	1.7
Had other major operations	3.6	4.4	8.1	1.9	0.2	2.0	1.8	1.9	1.4	2.0	-2.5	2.8	2.0	2.2	2.1	2.8	-1.7	2.0	1.9	2.4	2.7
Forced vital capacity (FVC)	1.6	6.3	10.4	-2.4	-1.0	-2.5	-2.4	-2.4	-1.9	-3.2	2.7	-2.1	-2.7	-2.5	-3.1	-2.5	2.4	-2.8	-2.0	-2.8	-2.8
Heel bone mineral density (BMD) T-score, automated (right)	30.4	69.6	95.3	9.0	6.5	9.3	9.1	9.1	6.0	8.8	-9.8	8.9	8.6	8.5	8.3	8.5	-9.1	6.9	9.1	9.1	2.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	3.9	-0.3	-0.8	-0.3	-0.1	-0.3	-2.0	0.1	0.5	-0.8	0.7	0.6	0.3	-0.0	0.4	-0.1	-0.1	-0.2	-0.3
Qualifications: None of the above	0.1	0.2	0.7	-0.5	-0.5	-0.5	-0.6	-0.5	-0.6	-0.7	0.5	-0.3	-0.0	-0.1	-0.6	-0.0	0.7	-0.8	-0.3	-0.4	-0.1
Financial difficulties in last 2 years	0.2	0.3	0.9	0.2	0.7	0.2	0.5	0.2	0.9	0.2	-0.3	0.9	0.3	0.1	0.3	0.7	-0.8	1.0	0.5	0.3	0.7
Mouth/teeth dental problems	4.1	6.3	11.3	-2.3	-1.9	-2.6	-2.7	-2.4	-2.8	-2.4	3.2	-3.4	-2.3	-1.9	-2.0	-2.6	3.0	-2.1	-2.6	-2.6	-1.5
Heart attack	0.4	0.5	1.8	-0.4	-0.3	-0.4	-0.9	-0.5	0.1	0.0	0.4	-1.4	-0.5	-0.4	-0.1	-1.0	0.9	-0.0	-0.8	-0.2	1.2
Allergy	3.0	6.9	12.0	-2.6	-0.5	-2.7	-2.9	-2.6	0.1	-2.4	3.3	-3.5	-3.1	-3.3	-2.6	-3.2	2.6	-1.2	-3.0	-3.2	-1.2
Pain all over the body in last month	1.1	1.2	2.7	1.2	1.2	1.2	1.1	1.2	0.8	1.7	-1.0	0.3	1.2	1.1	1.3	0.4	-1.1	1.6	1.0	1.1	0.4
Diabetes (self-reported)	0.6	0.9	2.0	0.8	1.2	1.0	1.2	0.9	0.3	1.1	-1.2	0.6	1.1	0.5	0.5	0.2	-1.4	0.1	1.1	0.6	-1.4
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	6.7	-1.4	-1.8	-1.3	-1.1	-1.4	-2.6	-1.4	1.0	-1.0	-0.4	-1.0	-1.5	-1.2	1.3	-2.2	-1.1	-1.2	-1.4
Medication: Ramipril	1.2	1.5	7.4	1.0	2.0	1.1	1.2	1.0	2.7	1.4	-1.3	0.9	0.4	0.1	0.7	0.1	-1.8	1.4	0.7	0.5	0.1
Medication: Simvastatin	1.1	1.5	3.6	1.4	0.8	1.6	1.3	1.4	0.6	1.3	-1.9	1.5	1.7	0.8	0.9	0.8	-1.6	0.0	1.2	1.4	-0.1
Fluid intelligence score	0.9	1.8	4.4	-1.2	-1.6	-1.1	-1.1	-1.2	-2.1	-1.1	0.9	-1.2	-0.6	-1.5	-1.6	-1.6	0.9	-1.8	-0.8	-0.9	-1.9
Illnesses of siblings	0.6	0.8	2.9	-0.7	-1.1	-0.8	-0.8	-0.7	-1.7	-0.9	0.9	-0.9	-0.4	-0.5	-0.8	-0.7	1.2	-1.1	-0.8	-0.8	-0.9
Neuroticism score	29.7	62.0	81.4	-8.6	-6.9	-8.8	-8.0	-8.6	-7.3	-8.6	9.0	-8.2	-8.0	-7.5	-7.5	-7.4	8.4	-6.6	-8.5	-8.6	-3.6
Weight	3.5	17.3	24.6	4.4	3.0	4.6	4.9	4.5	3.4	4.4	-5.0	4.6	4.0	4.1	4.0	4.4	-4.9	3.3	4.4	4.3	1.2
Impedance of arm (right)	13.5	63.1	81.5	-8.3	-6.3	-8.5	-8.8	-8.4	-5.7	-9.0	8.7	-7.7	-8.1	-8.3	-8.6	-8.1	8.6	-7.8	-8.2	-8.2	-3.6
Arm fat percentage (right)	3.6	14.0	18.7	4.1	2.6	4.1	4.3	4.1	2.5	4.0	-4.3	4.0	4.0	3.9	3.8	4.0	-4.2	2.9	3.9	3.9	1.2
Trunk fat-free mass	1.4	8.2	13.0	3.1	2.6	3.3	3.4	3.2	3.0	3.1	-3.6	3.0	2.4	2.5	2.3	2.5	-3.6	2.0	3.2	2.8	-0.2
Hip circumference	3.1	13.5	20.0	4.0	2.8	4.2	4.3	4.1	2.9	4.1	-4.3	3.7	3.8	3.4	3.5	3.3	-4.5	2.9	4.0	3.8	0.5
Time employed in main current job	1.5	1.7	3.9	-1.4	-1.9	-1.4	-1.3	-1.4	-1.7	-0.6	1.3	-2.0	-0.7	-1.4	-1.0	-1.8	1.1	-0.8	-1.1	-0.8	-0.2
Alcohol intake versus 10 years previously	1.4	2.0	4.5	-1.5	-0.4	-1.6	-1.2	-1.5	-1.1	-1.0	1.9	-2.1	-1.3	-1.3	-1.2	-1.8	1.3	-0.5	-1.5	-1.9	-1.3
Father’s age at death	7.1	9.5	15.4	-3.3	-3.2	-3.4	-3.6	-3.4	-2.5	-3.2	3.5	-3.4	-2.9	-2.8	-3.0	-2.7	3.9	-2.5	-3.2	-3.0	-0.7
Worrier / anxious feelings	30.7	58.0	80.5	-7.9	-6.8	-8.3	-7.8	-8.0	-8.5	-8.4	9.0	-8.1	-7.3	-6.4	-7.1	-7.1	8.7	-6.6	-7.9	-8.1	-3.7
Frequency of tiredness / lethargy in last 2 weeks	3.4	5.5	9.0	-2.7	-1.8	-2.7	-2.5	-2.7	-1.9	-3.0	2.5	-1.9	-2.4	-2.0	-2.5	-1.8	2.5	-2.7	-2.4	-2.5	-0.5
Falls in the last year	0.3	0.4	2.6	-0.3	-0.6	-0.2	0.5	-0.2	-0.7	0.2	-0.1	0.5	0.0	0.8	1.0	1.1	-0.2	0.9	-0.1	0.1	1.6
Hair/balding pattern: Pattern 3	0.2	0.4	2.3	-0.3	-1.5	-0.3	-0.8	-0.4	-0.6	0.0	0.1	-0.8	-0.4	-0.3	-0.3	-0.6	0.9	0.3	-0.2	0.3	0.6
Number of live births	0.2	0.2	2.0	0.1	-0.5	0.0	-0.2	0.0	-0.1	-0.3	-0.1	0.7	-0.2	0.4	0.3	1.0	0.2	0.2	0.0	0.3	1.4
Forced expiratory volume in 1-second (FEV1)	4.8	16.2	22.7	-3.9	-1.9	-4.1	-4.0	-4.0	-2.9	-4.7	4.3	-4.0	-4.1	-4.2	-4.8	-4.3	4.1	-4.2	-3.7	-4.5	-3.9
Pulse rate	2.7	4.6	7.3	-2.6	-1.6	-2.6	-2.1	-2.5	-1.0	-2.2	2.4	-2.0	-2.7	-2.4	-2.1	-2.4	2.0	-1.0	-2.3	-2.5	-0.2
Happiness	0.8	1.0	6.7	0.9	0.3	0.9	0.4	0.8	-1.3	0.5	-0.6	-0.3	1.4	0.5	-0.5	-0.9	-0.2	-1.3	1.0	0.6	-2.6
Noisy workplace	0.4	0.5	1.0	-0.6	-0.1	-0.7	-0.4	-0.6	-0.8	-0.9	1.0	-0.6	-0.8	-0.2	-0.6	-0.6	0.8	-0.4	-0.8	-1.0	-0.9
Qualifications: A levels/AS levels or equivalent	1.9	4.2	7.1	-2.2	-2.1	-2.0	-2.2	-2.2	-1.5	-2.0	1.5	-1.8	-1.6	-2.4	-2.7	-2.4	2.0	-2.7	-1.8	-1.8	-1.4
Serious illness, injury or assault of a close relative in last 2 years	6.9	8.0	12.9	-3.1	-2.4	-3.1	-3.6	-3.2	-1.4	-3.0	2.9	-2.9	-3.2	-2.8	-3.0	-2.4	3.4	-2.6	-3.0	-2.8	-0.1
Mouth/teeth dental problems: Dentures	7.2	12.1	17.5	3.8	2.8	3.9	4.2	3.9	1.1	3.6	-4.0	3.8	4.2	3.7	3.2	3.1	-4.2	2.1	4.1	3.7	-0.3
Asthma	3.8	7.5	11.9	3.0	1.3	3.2	3.0	3.1	1.0	2.7	-3.4	3.4	3.1	2.9	2.6	2.9	-3.0	1.4	3.0	3.1	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.7	-1.6	-1.3	-1.6	-1.1	-1.6	-0.9	-1.1	1.6	-1.1	-0.9	-0.9	-0.8	-0.5	1.3	-0.1	-1.0	-1.1	0.6
Medication: Cholesterol lowering	0.8	1.3	3.3	1.1	0.9	1.3	1.2	1.1	1.4	1.4	-1.8	1.3	1.3	0.6	0.7	0.7	-1.6	0.2	1.2	1.3	0.1
Depression (self-reported)	3.0	3.6	10.6	-1.9	-2.2	-1.8	-1.1	-1.8	-3.3	-2.1	1.7	-1.1	-1.0	-1.6	-1.9	-1.3	1.3	-2.4	-1.4	-1.9	-2.6
Medication: Lansoprazole	0.3	0.4	1.2	0.2	-1.0	0.3	0.7	0.3	-1.1	0.6	-0.6	0.4	0.9	0.7	0.7	0.7	-0.5	0.2	0.7	0.7	-0.2
Prospective memory result	0.2	0.3	1.1	-0.2	1.1	-0.0	0.6	-0.0	0.7	0.1	-0.1	0.6	0.1	0.5	0.5	0.9	-0.5	0.9	0.1	-0.3	0.1
Lung cancer (father)	0.3	0.3	1.2	-0.3	-0.3	-0.3	-0.9	-0.4	-0.4	-0.7	-0.1	0.1	-0.2	-0.0	-0.3	0.4	0.7	-1.1	-0.7	-0.3	1.0
Illnesses of mother	0.1	0.1	0.3	-0.1	0.2	-0.1	0.0	-0.1	0.5	0.3	0.1	-0.4	-0.3	-0.1	-0.1	-0.3	0.0	0.5	0.1	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	4.0	12.8	18.7	-3.4	-1.9	-3.5	-3.8	-3.5	-2.3	-4.2	3.6	-3.5	-3.7	-3.9	-4.3	-3.9	3.8	-4.0	-3.3	-3.8	-3.2
Pulse wave Arterial Stiffness index	0.8	0.9	3.3	0.4	0.9	0.5	0.8	0.4	1.8	1.3	-0.6	0.3	0.4	0.4	1.0	0.5	-1.1	1.8	0.5	0.5	1.5
Impedance of arm (left)	11.2	51.9	65.8	-7.4	-5.8	-7.6	-7.9	-7.5	-5.8	-8.1	7.8	-7.0	-7.0	-7.5	-7.9	-7.5	7.8	-7.4	-7.2	-7.3	-3.8
Arm fat mass (right)	5.2	21.4	28.7	5.0	3.5	5.1	5.3	5.1	3.6	4.9	-5.4	5.0	4.6	4.7	4.6	4.9	-5.3	3.6	4.8	4.8	1.5
Trunk predicted mass	1.4	8.3	13.1	3.1	2.6	3.3	3.4	3.2	3.0	3.1	-3.6	3.0	2.4	2.6	2.4	2.5	-3.6	2.0	3.2	2.8	-0.2
Standing height	2.3	22.4	34.0	-4.8	-3.5	-4.8	-4.8	-4.9	-2.4	-5.5	4.5	-4.1	-5.5	-5.4	-5.8	-5.0	4.4	-5.3	-4.4	-5.1	-3.5
Length of working week for main job	1.7	1.9	3.7	1.1	1.3	1.2	1.5	1.2	0.6	1.6	-1.3	1.2	1.7	1.5	1.3	1.4	-1.5	1.9	1.9	1.5	0.5
Exposure to tobacco smoke at home	0.6	0.7	3.4	1.2	1.2	1.1	0.4	1.1	1.8	0.2	-1.0	1.2	0.4	0.1	0.0	0.5	-0.6	0.1	0.7	0.8	0.1
Breastfed as a baby	0.6	0.7	1.1	-1.1	-0.5	-1.0	-0.9	-1.0	-0.2	-0.8	0.9	-0.9	-1.0	-0.9	-0.9	-1.0	0.7	-0.8	-0.8	-0.8	-0.1
Tense / ‘highly strung’	16.0	26.4	38.2	-5.8	-3.9	-6.0	-5.5	-5.8	-3.3	-5.5	6.2	-5.5	-5.6	-5.3	-4.5	-4.7	5.5	-3.7	-6.1	-5.9	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	5.1	-2.2	-2.3	-2.1	-1.5	-2.1	-2.1	-2.0	1.7	-1.2	-1.5	-1.7	-1.7	-1.3	1.6	-1.9	-1.8	-1.9	-0.9
Hair/balding pattern: Pattern 4	0.0	0.1	0.3	-0.4	-0.2	-0.3	0.1	-0.3	0.5	-0.2	-0.0	0.4	-0.4	-0.5	-0.3	0.1	-0.2	-0.2	-0.2	-0.3	0.0
Birth weight of first child	0.5	0.9	3.7	-0.8	-0.9	-0.8	-0.3	-0.8	-1.9	-0.8	1.0	-0.9	-0.3	-0.6	-0.8	-0.7	0.5	-1.0	-0.5	-0.9	-1.9
Peak expiratory flow (PEF)	8.2	19.0	25.7	-4.5	-2.4	-4.6	-4.4	-4.6	-2.6	-4.9	4.7	-4.3	-4.5	-4.9	-5.1	-4.8	4.1	-4.5	-4.2	-4.9	-3.5
Pulse wave reflection index	3.0	3.7	6.2	2.2	2.5	2.0	1.7	2.1	2.1	2.3	-1.4	1.0	1.8	2.1	2.3	1.5	-1.7	2.3	1.6	1.8	1.5
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.6	-1.0	-1.0	-0.9	-0.8	-1.0	-1.3	-0.6	0.8	-1.1	-0.3	-0.6	-0.6	-0.8	0.9	-0.8	-1.0	-1.0	-0.2
Loud music exposure frequency	0.2	0.2	1.0	0.3	0.3	0.3	0.4	0.3	-0.9	0.4	0.1	-0.1	1.0	0.8	0.5	0.3	-0.1	-0.3	0.4	0.1	-0.3
Qualifications: O levels/GCSEs or equivalent	2.0	3.1	6.3	-2.1	-2.5	-2.1	-1.4	-2.0	-2.5	-1.3	1.8	-2.0	-1.6	-1.6	-1.4	-1.9	1.5	-1.0	-1.6	-1.7	-1.1
Mouth/teeth dental problems: Bleeding gums	5.1	6.6	12.7	2.6	2.0	2.6	2.6	2.6	3.6	2.3	-3.1	3.3	1.8	1.7	2.1	2.6	-2.8	2.7	2.4	2.6	1.8
Blood clot in the leg (DVT)	2.2	2.9	5.1	2.1	1.9	2.1	1.5	2.0	2.3	1.7	-2.1	1.6	1.3	1.5	1.5	1.2	-1.6	1.3	1.6	1.8	0.8
Medication: Paracetamol	1.7	2.8	6.0	-2.0	-2.4	-2.0	-1.5	-1.9	-2.5	-1.7	1.8	-1.5	-1.3	-1.4	-1.4	-1.4	1.8	-1.0	-1.6	-1.5	-0.6
Headache pain in last month	4.0	6.9	9.8	-3.1	-1.9	-3.1	-2.6	-3.1	-2.5	-2.9	3.1	-2.6	-2.3	-2.5	-2.6	-2.6	2.7	-2.1	-2.7	-3.0	-1.1
Medication for cholesterol, blood pressure or diabetes	2.9	4.7	8.1	-2.2	-1.8	-2.4	-2.1	-2.2	-2.7	-2.4	2.8	-2.4	-1.9	-1.6	-1.8	-1.9	2.6	-1.7	-2.3	-2.4	-1.2
Glaucoma (self-reported)	0.9	1.0	1.7	1.3	1.2	1.3	1.2	1.3	0.3	1.2	-1.0	0.6	1.1	1.1	1.0	0.4	-1.2	0.8	1.1	1.0	-0.3
Gout (self-reported)	0.1	0.2	0.5	0.6	0.4	0.7	0.1	0.6	0.2	0.4	-0.7	0.1	0.4	0.3	0.1	0.1	-0.2	-0.1	0.3	0.4	-0.5
Hypothyroidism/myxoedema (self-reported)	20.1	39.2	56.4	-6.6	-5.5	-6.6	-6.8	-6.7	-5.4	-7.0	6.4	-6.0	-5.6	-5.8	-6.4	-5.7	7.1	-7.5	-6.8	-6.5	-2.6
Medication: Amlodipine	2.2	3.1	7.4	1.3	1.8	1.4	1.4	1.4	2.7	1.5	-1.8	2.2	0.9	1.3	1.7	2.1	-1.8	2.1	1.6	1.7	2.2
Medication: Ventolin 100micrograms inhaler	1.5	1.9	5.0	1.3	-0.1	1.4	1.7	1.3	-1.4	1.4	-1.7	1.3	2.2	1.4	0.9	0.9	-1.6	-0.5	1.6	1.3	-1.3
Birth weight	1.2	2.7	4.5	2.1	1.8	2.1	1.7	2.1	1.5	1.8	-2.0	1.3	1.7	1.6	1.4	1.2	-1.6	1.1	1.7	1.7	0.1
Chronic bronchitis/emphysema (mother)	0.5	0.5	2.5	-0.9	-1.4	-0.9	-0.4	-0.8	-1.6	-0.5	0.8	-0.4	0.2	-0.0	0.0	0.0	0.6	-0.5	-0.5	-0.5	0.6
High blood pressure (siblings)	1.5	2.2	3.3	1.3	1.8	1.3	1.6	1.4	1.6	1.3	-1.2	1.6	1.2	1.5	1.7	1.7	-1.6	1.8	1.3	1.2	1.4
Forced vital capacity (FVC), Best measure	1.1	4.1	7.3	-1.7	-0.8	-1.8	-2.1	-1.8	-1.4	-2.7	2.0	-1.6	-2.1	-2.1	-2.6	-2.0	2.2	-2.6	-1.7	-2.1	-2.2
Body fat percentage	2.0	7.8	10.6	3.0	1.6	3.0	3.3	3.0	1.7	3.0	-3.3	3.1	2.9	3.0	2.9	3.1	-3.1	2.1	2.9	3.0	1.0
Leg fat percentage (right)	3.4	12.4	16.2	3.8	2.4	3.8	4.0	3.8	2.1	3.9	-3.9	3.5	3.8	4.0	3.9	3.8	-3.8	2.9	3.5	3.7	1.5
Arm fat-free mass (right)	3.5	17.9	25.0	4.5	3.5	4.7	4.9	4.6	3.8	4.6	-5.0	4.5	3.8	4.1	4.0	4.1	-5.0	3.5	4.6	4.3	1.0
Exposure to tobacco smoke outside home	0.8	1.1	3.1	-1.2	-1.1	-1.2	-1.1	-1.2	0.5	-1.1	0.7	-0.5	-1.6	-1.8	-1.3	-0.9	0.6	-0.4	-1.1	-0.9	0.2
Comparative body size at age 10	10.6	29.2	42.3	5.8	5.0	5.9	6.0	5.9	4.8	6.5	-5.9	4.7	5.3	4.9	5.7	4.6	-6.3	5.6	5.5	5.5	1.7
Number of full brothers	3.3	4.2	7.3	2.6	1.6	2.6	2.3	2.5	1.3	2.3	-2.7	1.8	2.2	1.8	1.5	1.1	-2.2	1.3	2.4	2.4	-0.7
Worry too long after embarrassment	14.9	24.9	34.9	-5.2	-3.5	-5.4	-5.2	-5.2	-4.6	-5.2	5.9	-5.9	-4.7	-4.9	-4.9	-5.5	5.2	-4.0	-5.2	-5.4	-2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.9	-1.1	-0.5	-1.0	-0.4	-1.0	-0.6	-0.8	1.0	-1.1	-0.8	-1.1	-1.0	-1.3	0.3	-0.9	-0.8	-1.3	-1.4
Wheeze or whistling in the chest in last year	3.8	6.8	10.4	2.7	2.4	2.9	2.9	2.8	1.7	2.8	-3.2	2.8	3.1	2.5	2.3	2.3	-3.1	2.0	2.9	2.7	0.3
Number of children fathered	1.7	1.9	3.0	1.3	0.4	1.4	1.3	1.3	0.4	1.5	-1.5	1.5	1.7	1.5	1.6	1.6	-1.4	1.1	1.5	1.7	1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	4.8	-1.4	-0.8	-1.5	-1.1	-1.4	-1.4	-0.7	1.7	-2.2	-1.0	-1.0	-0.7	-1.6	1.3	-0.1	-1.5	-1.5	-0.6
Age at first live birth	2.4	4.3	8.0	-2.2	-1.7	-2.3	-2.0	-2.2	-2.3	-1.8	2.5	-2.8	-1.6	-1.8	-1.7	-2.6	2.4	-1.5	-2.2	-2.1	-1.2
Pulse wave peak to peak time	1.4	1.6	5.2	-0.7	-1.2	-0.8	-1.2	-0.8	-2.0	-1.7	0.9	-0.6	-0.8	-0.8	-1.5	-0.9	1.4	-2.3	-0.7	-0.8	-1.9
Health satisfaction	3.5	4.6	7.2	2.5	2.1	2.5	2.5	2.5	1.9	2.1	-2.7	2.5	1.9	2.0	1.7	1.8	-2.5	1.5	2.3	2.0	-0.1
Shortness of breath walking on level ground	0.7	0.8	1.6	1.1	0.6	1.0	1.1	1.1	0.7	1.1	-1.0	0.5	0.7	1.1	1.2	0.5	-0.8	1.2	0.7	0.9	0.6
Qualifications: College or University degree	0.2	0.6	4.5	0.2	-0.1	0.3	0.2	0.2	-1.2	0.1	-0.5	-0.2	0.8	-0.1	-0.7	-0.8	-0.2	-1.4	0.6	0.2	-2.1
Eye problems/disorders: None of the above	0.7	0.8	1.6	-0.8	-1.1	-0.9	-1.1	-0.9	-1.3	-0.9	1.0	-0.8	-0.6	-0.6	-0.6	-0.4	1.1	-1.2	-1.0	-0.7	-0.1
Mouth/teeth dental problems: Loose teeth	3.3	3.9	6.1	2.4	1.7	2.4	2.1	2.4	1.0	2.1	-2.5	2.1	2.2	1.9	1.9	1.8	-2.1	1.1	1.8	2.1	0.5
Emphysema/chronic bronchitis	5.7	6.4	8.1	2.6	2.4	2.6	2.7	2.7	1.7	2.7	-2.3	2.4	2.7	2.7	2.9	2.5	-2.8	2.8	2.7	2.6	1.3
Medication for pain relief, constipation, heartburn	0.5	0.9	3.2	1.3	1.8	1.3	0.8	1.3	0.9	0.4	-1.1	1.0	0.7	0.6	0.2	0.3	-0.9	-0.4	0.9	0.6	-0.9
Neck or shoulder pain in last month	0.6	0.8	1.4	-1.2	-0.9	-1.2	-0.8	-1.1	-0.8	-0.9	1.1	-0.9	-0.9	-0.2	-0.3	-0.1	1.1	-0.6	-1.1	-1.1	0.5
Medication: Blood pressure	4.8	8.5	11.5	3.0	2.1	3.1	2.8	3.0	3.3	3.2	-3.4	3.1	2.3	2.5	3.0	2.8	-3.2	3.0	2.7	3.1	2.5
Angina (self-reported)	0.4	0.6	2.1	0.7	0.1	0.8	0.7	0.7	-0.9	1.0	-1.1	0.3	1.4	0.8	0.6	0.3	-0.8	-0.3	0.8	0.8	-0.5
Migraine (self-reported)	0.3	0.4	1.3	-0.6	0.1	-0.5	-0.3	-0.5	-0.6	-0.7	0.4	-0.2	-0.4	-0.7	-0.8	-0.5	0.2	-0.8	-0.5	-0.9	-1.1
Medication: Ibuprofen	1.2	1.4	2.5	-1.6	-1.4	-1.6	-1.3	-1.6	-1.1	-1.3	1.5	-1.0	-1.0	-1.1	-1.0	-0.6	1.4	-0.5	-1.2	-1.2	0.5
Medication: Allopurinol	0.8	1.1	2.0	1.2	-0.1	1.2	0.9	1.2	-0.2	1.3	-1.4	0.8	1.3	1.4	1.2	1.1	-0.7	0.7	0.9	1.3	0.8
Medication: Omeprazole	0.1	0.2	0.6	-0.4	0.2	-0.2	0.4	-0.3	-0.4	0.5	0.0	-0.4	0.5	-0.3	0.0	-0.3	-0.7	0.8	0.4	-0.0	-0.6
Medication: Seretide 50 evohaler	1.3	1.5	3.0	1.3	0.2	1.3	1.1	1.3	-0.2	1.7	-1.4	0.8	1.7	1.3	1.5	1.0	-1.0	1.3	1.2	1.5	0.6
Mean time to correctly identify matches	0.2	0.4	2.6	-0.3	-0.6	-0.4	-0.0	-0.3	-0.6	0.4	0.6	-0.6	-0.1	0.1	0.7	-0.2	0.1	1.4	-0.3	0.1	1.6
Heart disease (mother)	0.2	0.2	1.1	-0.3	-0.8	-0.3	-0.3	-0.3	-1.0	-0.2	0.5	-0.3	0.2	-0.1	0.2	-0.1	0.3	-0.1	-0.3	-0.1	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.8	5.7	7.4	-2.6	-2.4	-2.6	-2.7	-2.6	-1.7	-2.5	2.6	-2.4	-2.5	-2.5	-2.5	-2.5	2.7	-1.9	-2.4	-2.3	-0.5
Whole body fat mass	3.1	12.9	18.7	3.9	2.4	4.0	4.3	4.0	2.6	3.9	-4.3	3.9	3.5	3.7	3.5	3.7	-4.2	2.8	3.8	3.8	0.9
Leg fat mass (right)	5.3	20.7	28.4	4.9	3.2	5.0	5.2	5.0	3.3	4.9	-5.3	4.8	4.6	4.8	4.6	4.7	-5.1	3.6	4.7	4.7	1.5
Arm predicted mass (right)	3.9	19.8	27.5	4.7	3.4	4.9	5.2	4.8	3.8	4.9	-5.2	4.6	4.1	4.4	4.3	4.4	-5.2	3.9	4.8	4.5	1.2
Pulse rate, automated reading	0.1	0.4	3.0	-0.5	-0.7	-0.4	-0.1	-0.4	0.1	0.1	0.1	0.2	-0.4	0.1	0.5	0.4	0.1	1.2	-0.4	-0.1	1.7
Alcohol intake frequency.	0.1	0.2	0.6	-0.3	-0.3	-0.3	0.0	-0.3	-0.6	0.2	0.4	-0.5	0.6	-0.4	-0.3	-0.7	-0.3	-0.0	0.3	-0.1	-0.7
Comparative height size at age 10	0.1	0.4	3.0	0.4	1.0	0.4	0.5	0.5	1.7	0.1	-0.5	0.5	-0.4	-0.3	-0.2	-0.1	-0.8	0.1	0.5	0.1	-0.7
Number of full sisters	2.2	2.7	6.2	1.3	1.2	1.6	1.7	1.4	2.5	1.9	-2.1	1.9	1.6	0.7	1.2	1.3	-2.3	1.5	1.8	1.7	0.7
Suffer from ‘nerves’	15.4	24.2	32.6	-5.5	-4.5	-5.6	-5.0	-5.5	-4.3	-5.3	5.7	-5.1	-5.3	-4.9	-4.7	-4.9	5.0	-3.4	-5.2	-5.3	-1.6
Overall health rating	3.1	6.7	9.8	2.9	2.4	3.0	2.5	2.9	2.4	2.4	-3.1	3.0	2.7	2.6	2.2	2.6	-2.6	1.7	2.8	2.8	1.1
Chest pain or discomfort	0.4	0.6	1.3	-0.8	-1.2	-0.7	-0.5	-0.7	-0.6	-0.5	0.4	-0.8	-0.7	-1.1	-0.9	-1.1	0.3	-0.8	-0.8	-0.9	-1.0
Had major operations	0.3	0.3	0.6	-0.8	-0.7	-0.7	-0.7	-0.8	-0.7	-0.5	0.5	-0.4	-0.2	-0.4	-0.5	-0.4	0.5	-0.6	-0.5	-0.5	0.4
Age at last live birth	5.0	7.2	11.8	-2.9	-2.4	-2.9	-2.9	-2.9	-2.5	-2.3	3.1	-3.4	-2.3	-2.6	-2.4	-3.1	3.0	-2.1	-2.9	-2.6	-0.9
Family relationship satisfaction	0.3	0.3	2.0	0.1	0.1	-0.0	-0.2	0.0	-0.9	-0.8	0.3	-0.1	-0.0	0.1	-0.5	-0.2	0.5	-1.3	-0.1	-0.4	-1.4
Leg pain on walking	2.5	3.1	5.0	2.0	1.6	1.9	1.8	2.0	2.2	1.6	-1.8	1.9	1.2	1.7	1.7	1.5	-1.6	2.0	1.7	1.8	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.1	-0.7	0.1	-0.7	-0.3	-0.7	0.8	-0.8	0.4	0.8	-0.8	-0.2	-0.3	0.7	0.2	0.0	-0.3	-0.5	1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.9	0.2	0.3	0.4	0.5	0.3	1.4	0.8	-1.0	0.8	0.4	0.3	0.5	1.0	-0.5	1.1	0.5	0.8	0.9
Illness, injury, bereavement, stress in last 2 years	3.1	3.8	5.6	2.1	1.7	2.2	2.3	2.2	1.5	2.1	-2.1	2.0	1.9	1.9	2.1	1.8	-2.4	1.5	2.0	2.0	0.7
Medication: Aspirin	3.1	4.1	7.7	1.9	1.4	2.1	2.2	2.0	2.1	2.8	-2.2	1.4	1.8	1.8	2.2	1.6	-2.4	2.6	2.1	2.2	0.8
Supplements: Vitamin C	3.6	4.2	5.9	2.3	1.0	2.3	2.3	2.3	1.9	2.3	-2.4	2.2	1.9	2.0	2.2	2.0	-2.1	1.9	1.8	2.2	1.4
Knee pain experienced in last month	1.3	2.1	5.1	1.2	0.2	1.4	2.3	1.4	-0.3	1.9	-2.0	1.4	1.7	1.3	1.3	1.0	-2.1	1.1	1.6	1.4	-0.7
Hypertension (Self-reported)	7.4	20.6	27.5	5.0	4.0	5.1	4.8	5.0	4.7	5.0	-5.2	4.7	4.1	4.0	4.5	4.0	-5.2	4.2	4.3	4.6	2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.5	-0.4	0.7	-0.3	0.2	-0.3	0.3	0.0	0.5	-0.2	0.4	0.1	0.1	0.1	-0.4	-0.0	0.1	-0.3	-0.2
Illnesses of father: Heart disease	0.1	0.1	0.4	-0.4	-0.6	-0.3	0.6	-0.2	-0.6	0.1	0.0	0.5	0.2	0.3	0.5	0.4	-0.5	0.1	0.0	-0.0	0.4
Illnesses of siblings: Diabetes	1.7	2.1	3.7	1.5	0.6	1.6	1.5	1.5	0.3	1.8	-1.9	1.4	1.8	1.2	1.3	1.3	-1.8	0.9	1.9	1.8	-0.2
Smoking status: Previous	0.7	1.1	2.9	1.1	1.7	1.1	0.8	1.0	-0.6	1.0	-0.6	-0.0	1.7	1.5	0.8	0.4	-0.7	0.2	1.3	1.0	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	2.7	5.6	14.5	-1.8	-1.6	-1.7	-2.2	-1.8	-1.3	-2.9	1.5	-1.5	-2.2	-2.9	-3.6	-2.7	2.0	-3.8	-1.7	-2.1	-3.3
Whole body fat-free mass	2.4	13.9	21.3	4.0	3.1	4.2	4.4	4.1	3.7	4.0	-4.6	4.0	3.2	3.4	3.2	3.5	-4.6	2.8	4.1	3.7	0.3
Leg fat-free mass (right)	3.7	19.7	29.5	4.7	3.3	4.9	5.2	4.8	4.2	4.7	-5.4	5.0	3.8	4.0	4.0	4.4	-5.4	3.7	4.8	4.5	1.1
Arm fat percentage (left)	4.4	17.6	23.9	4.6	2.8	4.7	4.8	4.6	2.6	4.5	-4.9	4.4	4.5	4.4	4.3	4.4	-4.7	3.2	4.4	4.5	1.3
Average weekly red wine intake	2.4	3.6	5.7	1.7	0.8	1.8	2.1	1.8	1.0	1.9	-2.0	2.4	2.1	1.8	1.8	2.1	-2.1	1.9	2.4	2.2	1.1
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.2	0.7	0.7	0.6	0.0	0.6	-0.1	-0.5	-0.4	0.8	0.4	0.7	-0.1	0.7	0.2	-1.1	0.3	0.3	-0.4
Mood swings	9.9	18.0	23.9	-4.9	-3.9	-4.8	-3.8	-4.8	-4.3	-4.7	4.6	-3.9	-4.0	-3.9	-4.2	-3.7	4.2	-4.2	-4.4	-4.8	-2.7
Loneliness, isolation	3.2	4.5	6.9	-2.2	-1.0	-2.3	-2.0	-2.1	-1.3	-2.5	2.3	-2.0	-2.6	-2.4	-2.3	-2.3	1.9	-1.6	-2.3	-2.6	-1.5
Long-standing illness, disability or infirmity	0.1	0.2	0.8	0.1	-0.6	0.1	0.1	0.1	0.1	0.6	-0.4	-0.1	0.2	0.6	0.6	0.4	0.1	0.8	0.2	0.6	0.9
Ever had bowel cancer screening	1.1	1.3	2.6	-1.2	-1.5	-1.3	-1.2	-1.2	-0.0	-0.6	1.3	-1.6	-1.6	-1.1	-0.7	-1.3	1.2	0.3	-1.2	-0.8	0.7
Diabetes diagnosed by doctor	0.8	1.3	2.9	1.2	1.1	1.3	1.5	1.3	0.3	1.5	-1.6	0.8	1.3	0.9	0.9	0.5	-1.7	0.4	1.3	1.0	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	5.1	5.4	7.8	2.2	1.4	2.2	2.4	2.2	2.1	2.6	-2.3	2.4	2.2	2.1	2.8	2.3	-2.5	2.7	2.1	2.4	2.5
Friendships satisfaction	0.3	0.4	1.1	1.1	0.9	0.9	0.5	1.0	0.2	0.6	-0.2	0.1	0.7	0.5	0.4	-0.1	-0.5	0.6	0.8	0.5	-0.6
Qualifications: nursing, teaching	0.2	0.4	2.1	-0.0	-0.1	0.1	-0.0	-0.0	-1.0	0.5	-0.2	-0.8	0.6	-0.1	-0.3	-1.1	0.1	-0.8	0.1	0.1	-1.4
Commuting to job workplace: Walk	0.3	0.3	0.9	0.8	0.1	0.6	0.4	0.8	0.0	0.2	0.0	0.5	0.3	0.9	0.9	0.7	-0.1	0.5	0.4	0.6	0.9
Eye problems/disorders: Cataract	0.3	0.4	1.0	0.6	0.7	0.6	0.7	0.6	1.0	0.4	-0.8	0.7	0.2	-0.1	-0.0	-0.1	-1.0	0.2	0.7	0.4	-0.6
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	6.0	-2.3	-2.5	-2.1	-1.6	-2.2	-1.0	-1.5	1.6	-1.3	-1.9	-1.6	-1.4	-1.1	1.9	-0.6	-2.0	-1.6	0.8
Medication for cholesterol	1.1	1.6	4.6	-0.8	-0.3	-1.0	-1.7	-1.0	-0.9	-0.9	1.6	-2.1	-0.6	-1.3	-1.1	-2.0	1.5	-1.2	-1.2	-1.1	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.7	-0.0	-0.5	0.0	-0.0	-0.0	-0.3	0.1	-0.2	0.2	0.3	0.4	0.4	0.5	0.0	-0.4	-0.0	0.3	0.8
Back pain experienced in last month	0.1	0.1	0.9	-0.4	0.1	-0.2	0.5	-0.2	-0.2	0.1	-0.2	0.2	0.3	-0.3	-0.4	-0.4	-0.6	0.2	0.4	-0.2	-1.0
Mineral and other dietary supplements	5.5	7.4	11.9	-3.4	-2.1	-3.3	-3.0	-3.4	-2.5	-3.4	3.0	-1.8	-2.4	-2.4	-2.8	-1.7	2.9	-3.1	-2.6	-2.9	-0.7
Breast cancer (self-reported)	0.2	0.2	0.8	-0.0	-0.1	0.1	0.6	0.1	0.1	0.9	-0.3	0.0	0.5	0.2	0.6	0.1	-0.8	0.9	0.1	0.1	0.4
Asthma (self-reported)	4.2	8.4	13.1	3.2	1.5	3.3	3.2	3.2	1.2	2.9	-3.6	3.5	3.3	3.0	2.7	3.0	-3.2	1.5	3.2	3.3	0.8
Osteoporosis (self-reported)	6.6	8.2	10.8	-3.3	-3.1	-3.3	-3.0	-3.3	-2.7	-2.8	3.1	-3.0	-2.7	-2.9	-3.0	-3.1	3.2	-2.1	-2.6	-2.7	-1.1
Osteoarthritis (self-reported)	1.3	1.6	2.9	1.6	1.3	1.7	1.2	1.6	1.0	1.1	-1.7	1.4	1.5	1.6	0.8	1.0	-1.0	0.3	1.4	1.4	-0.1
Medication: Aspirin	2.1	2.8	5.6	1.7	1.1	1.7	1.8	1.7	1.8	2.4	-1.8	1.0	1.4	1.4	1.8	1.1	-2.0	2.3	1.7	1.8	0.5
Medication: Gliclazide	0.6	0.6	1.1	0.8	0.8	0.9	0.8	0.8	0.9	0.9	-1.1	0.8	0.8	0.7	0.7	0.7	-0.9	0.4	0.9	0.8	0.2
Illnesses of father: None of the above (group 1)	0.5	0.6	1.6	-0.6	0.2	-0.6	-1.1	-0.7	-0.0	-1.0	0.7	-0.8	-0.7	-1.0	-1.3	-1.0	0.8	-0.9	-0.5	-0.7	-0.8
Smoking status: Current	5.6	8.9	21.3	2.4	3.4	2.7	2.9	2.5	4.6	2.5	-3.2	4.0	2.1	2.0	2.2	3.3	-3.7	3.1	3.1	2.6	2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.4	7.2	10.3	-2.6	-1.5	-2.7	-2.4	-2.6	-2.4	-2.8	2.9	-3.1	-2.5	-2.7	-2.9	-3.2	2.5	-2.7	-2.4	-2.9	-2.8
Whole body water mass	2.6	14.6	21.9	4.1	3.3	4.3	4.5	4.2	3.9	4.1	-4.7	4.1	3.2	3.4	3.4	3.6	-4.7	3.0	4.2	3.8	0.5
Leg predicted mass (right)	3.7	19.7	29.5	4.7	3.3	4.9	5.2	4.8	4.2	4.7	-5.4	5.0	3.8	4.0	4.0	4.5	-5.4	3.7	4.8	4.5	1.1
Arm fat mass (left)	5.5	22.5	30.3	5.2	3.5	5.3	5.4	5.2	3.6	5.1	-5.5	5.1	4.8	4.9	4.7	5.0	-5.3	3.7	5.0	4.9	1.6
Number of self-reported non-cancer illnesses	0.0	0.1	0.3	-0.0	-0.5	0.1	0.1	-0.0	-0.0	0.4	-0.4	-0.0	0.2	0.1	0.1	-0.2	-0.1	0.1	0.0	0.3	0.5
Average weekly champagne plus white wine intake	0.6	0.8	2.3	1.1	-0.2	1.1	1.2	1.1	0.2	0.7	-1.5	1.4	0.5	0.7	0.6	0.6	-1.0	0.3	0.9	1.0	-0.4
Miserableness	15.2	26.4	32.5	-5.6	-5.2	-5.7	-5.0	-5.6	-5.5	-5.5	5.6	-5.1	-4.8	-4.7	-5.0	-4.6	5.5	-4.6	-5.3	-5.4	-3.0
Guilty feelings	11.9	17.9	25.4	-4.7	-3.0	-4.8	-4.3	-4.7	-2.5	-4.8	5.0	-4.2	-4.8	-4.7	-4.2	-4.1	4.1	-3.2	-4.7	-4.9	-1.8
Wears glasses or contact lenses	0.2	0.2	1.5	-0.1	0.2	0.0	-0.1	-0.1	0.6	0.6	-0.0	-0.8	0.1	-0.7	-0.3	-1.2	-0.3	0.5	0.0	-0.0	-0.6
Ever taken oral contraceptive pill	0.2	0.2	0.6	-0.8	-0.4	-0.7	-0.1	-0.7	-0.5	-0.5	0.4	0.2	-0.2	-0.0	-0.1	0.4	0.1	-0.4	-0.3	-0.4	0.7
Hearing aid user	0.1	0.1	0.4	-0.4	-0.7	-0.2	0.3	-0.3	-0.2	0.1	-0.4	0.4	0.2	0.1	0.1	0.5	-0.4	-0.1	0.2	0.1	0.2
Mother’s age at death	2.4	3.0	8.3	-1.5	-1.5	-1.6	-1.5	-1.5	-2.9	-1.9	1.8	-1.7	-0.8	-1.0	-1.7	-1.6	1.9	-2.3	-1.3	-1.6	-2.1
Financial situation satisfaction	0.7	0.8	1.8	0.9	1.3	1.0	1.2	0.9	0.8	0.8	-1.2	1.1	0.8	0.7	0.6	0.3	-1.3	0.5	1.0	0.6	-0.2
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.3	-1.4	-1.2	-1.2	-0.6	-1.3	-1.5	-0.5	1.2	-1.5	-0.6	-1.0	-0.9	-1.4	0.6	-0.1	-0.5	-0.9	-1.2
Commuting to job workplace: Public transport	4.1	4.9	7.2	-2.4	-2.1	-2.4	-2.3	-2.4	-1.9	-2.7	2.5	-1.9	-2.2	-2.3	-2.5	-2.2	2.1	-2.4	-2.0	-2.2	-1.1
Eye problems/disorders: Glaucoma	1.2	1.4	2.3	1.4	1.4	1.4	1.5	1.5	0.5	1.2	-1.1	1.0	1.1	1.3	1.2	0.7	-1.4	1.3	1.3	1.1	-0.0
Medication: Blood pressure	4.9	9.4	14.2	3.1	2.2	3.3	3.4	3.2	3.0	3.2	-3.8	3.6	2.5	2.7	3.0	3.3	-3.6	2.7	2.8	3.0	1.9
Pain type(s) experienced in last month: Hip pain	1.8	2.2	3.6	1.6	1.2	1.7	1.8	1.6	0.9	1.4	-1.9	1.8	1.7	1.5	1.0	1.2	-1.7	0.8	1.8	1.5	-0.7
Supplements: Fish oil (including cod liver oil)	8.1	10.6	15.4	3.9	3.4	3.8	3.6	3.9	2.8	3.5	-3.3	2.9	3.0	3.1	3.4	2.7	-3.5	3.5	3.1	3.2	0.9
High cholesterol (Self-reported)	0.7	1.2	2.9	0.9	1.7	1.1	1.3	1.0	1.7	1.4	-1.3	0.9	1.1	0.5	0.8	0.4	-1.7	0.8	1.0	0.9	0.1
Medication: Bendroflumethiazide	8.8	13.3	20.8	3.6	3.1	3.9	4.2	3.7	3.3	4.2	-4.2	3.8	3.6	3.2	3.5	3.3	-4.6	3.5	3.8	3.7	1.5
Medication: Paracetamol	1.4	2.1	5.2	-1.7	-2.0	-1.7	-1.4	-1.7	-2.3	-1.6	1.6	-1.2	-1.1	-1.0	-1.1	-0.9	1.7	-1.0	-1.5	-1.3	-0.2
Medication: Lisinopril	1.6	2.1	3.7	1.4	1.0	1.5	1.5	1.4	0.4	1.7	-1.9	1.5	1.8	1.7	1.5	1.6	-1.4	1.2	1.4	1.6	0.8
Medication: Atorvastatin	0.1	0.1	1.2	-0.2	0.8	-0.1	-0.0	-0.2	1.1	-0.2	-0.2	0.4	-0.4	-0.2	-0.2	0.2	-0.3	-0.1	0.0	-0.2	0.0
Illnesses of father: High blood pressure	1.1	1.4	3.1	1.0	-0.3	1.1	1.8	1.1	-0.6	1.6	-1.2	0.8	1.3	1.0	1.4	0.8	-1.5	1.5	1.2	1.2	-0.6
Alcohol drinker status: Never	1.3	1.6	3.1	-1.2	-1.6	-1.2	-1.4	-1.3	-1.6	-1.1	1.1	-1.3	-0.7	-1.1	-1.4	-1.5	1.4	-1.7	-0.9	-0.9	-0.7
Ever smoked	0.8	1.3	3.6	0.9	1.9	1.0	1.3	1.0	0.2	1.0	-0.7	1.0	1.7	1.6	1.1	1.3	-1.3	0.9	1.5	0.9	-0.5
Basal metabolic rate	2.8	15.5	23.2	4.2	3.2	4.4	4.7	4.3	3.8	4.2	-4.8	4.3	3.4	3.6	3.5	3.8	-4.8	3.1	4.3	3.9	0.6
Leg fat percentage (left)	3.8	13.6	17.9	3.9	2.4	3.9	4.2	3.9	2.3	4.1	-4.0	3.7	3.9	4.2	4.2	4.0	-3.9	3.3	3.6	3.8	2.0
Arm fat-free mass (left)	3.0	15.1	20.7	4.1	3.4	4.2	4.5	4.2	3.8	4.2	-4.5	4.0	3.4	3.7	3.7	3.9	-4.6	3.4	4.1	3.8	1.1
Number of operations (self-reported)	4.1	6.0	9.0	2.5	0.7	2.6	2.5	2.5	1.4	2.7	-2.7	2.7	2.7	2.7	2.8	3.0	-2.3	2.1	2.3	2.8	2.3
Average weekly beer plus cider intake	10.4	15.0	21.9	-4.7	-3.1	-4.6	-4.3	-4.6	-2.0	-4.7	4.2	-3.0	-4.2	-3.9	-3.7	-2.7	4.1	-3.9	-4.6	-4.3	0.5
Irritability	25.7	43.5	53.4	-7.2	-4.6	-7.2	-6.8	-7.2	-5.3	-7.3	7.3	-6.6	-6.5	-6.7	-7.0	-6.7	6.9	-6.2	-6.8	-7.2	-4.0
Risk taking	3.9	5.7	8.3	2.3	1.5	2.4	2.9	2.4	1.6	2.8	-2.5	2.3	2.1	2.4	2.8	2.5	-2.8	2.8	2.3	2.4	1.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.3	0.7	0.3	0.7	1.3	0.8	0.2	0.7	-0.8	1.1	0.8	1.0	0.6	1.0	-1.0	1.0	1.5	1.0	-0.8
Fractured/broken bones in last 5 years	0.6	0.8	3.9	-0.7	-1.0	-0.8	-0.7	-0.7	0.8	0.0	0.8	-0.6	-1.0	-0.7	0.1	-0.3	0.6	1.8	-0.3	-0.0	2.0
Age started oral contraceptive pill	1.3	1.6	2.9	-1.4	-0.9	-1.4	-1.4	-1.4	-0.7	-1.3	1.5	-1.5	-1.6	-1.0	-1.0	-1.3	1.5	-1.0	-1.7	-1.4	0.3
Diastolic blood pressure, automated reading	10.2	31.7	42.2	6.1	3.4	6.2	6.2	6.2	3.8	6.1	-6.5	6.2	5.4	5.6	6.1	5.6	-6.2	5.5	5.5	6.0	3.3
Ever depressed for a whole week	1.8	2.2	6.3	-1.7	-2.4	-1.6	-1.3	-1.6	-2.5	-1.1	1.6	-1.7	-0.8	-0.8	-0.9	-0.9	1.6	-1.1	-1.3	-1.3	-0.8
Unable to work because of sickness or disability	2.5	3.3	5.8	1.8	1.1	1.9	2.0	1.9	0.4	1.8	-2.1	2.1	2.4	1.9	1.6	1.7	-2.0	1.5	2.4	2.2	0.4
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.1	-0.2	-0.0	0.2	0.1	-0.6	0.0	0.3	-0.4	-0.5	-0.1	0.2	-0.4	-0.0	0.6	-0.1	-0.2	-0.5
Myopia	1.2	1.8	3.2	-1.5	-0.9	-1.4	-1.4	-1.5	-1.0	-1.4	1.2	-1.2	-1.1	-1.8	-1.6	-1.5	1.1	-1.5	-1.2	-1.3	-0.9
Vascular/heart problems diagnosed by doctor	5.7	15.4	23.0	-4.2	-3.0	-4.4	-4.3	-4.2	-3.9	-4.3	4.8	-4.3	-3.4	-3.4	-3.9	-3.5	4.7	-3.6	-3.8	-4.1	-2.3
Cholesterol lowering medication	0.3	0.4	1.4	-0.6	-0.9	-0.7	-0.3	-0.6	-1.2	-0.7	0.6	-0.3	-0.6	-0.2	-0.3	-0.0	0.6	-0.7	-0.7	-0.6	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.5	-1.2	-0.3	-1.1	-0.4	-1.1	-0.6	-0.3	0.7	-1.0	-0.5	-0.8	-0.6	-0.8	0.2	0.2	-0.5	-0.8	-0.3
Pain experienced in last month	0.1	0.2	0.5	0.7	0.2	0.6	0.2	0.6	0.3	0.5	-0.4	0.3	0.3	0.6	0.7	0.6	-0.2	0.3	0.4	0.7	0.5
Supplements: Calcium	0.2	0.2	1.2	-0.4	-1.1	-0.4	-0.2	-0.4	0.2	0.0	-0.1	-0.2	-0.3	-0.5	0.0	-0.3	0.2	-0.6	-0.8	-0.3	0.8
Basal cell carcinoma (self-reported)	0.4	0.4	0.7	0.8	0.6	0.8	0.7	0.8	0.4	0.5	-0.8	0.9	0.8	0.7	0.5	0.6	-0.7	-0.1	0.6	0.6	-0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	2.1	-0.4	-0.4	-0.4	-0.9	-0.4	0.2	0.1	0.4	-1.3	-0.4	-0.3	0.1	-0.9	0.9	0.3	-0.8	-0.1	1.4
Deep venous thrombosis (DVT) (self-reported)	2.8	3.6	6.6	2.3	2.2	2.3	1.7	2.2	2.6	2.1	-2.3	1.7	1.5	1.6	1.7	1.2	-1.9	1.6	1.8	2.0	0.8
Heart disease (siblings)	0.2	0.3	2.1	-0.8	-1.4	-0.6	-0.1	-0.7	0.2	-0.1	-0.2	0.4	-0.4	-0.7	-0.5	-0.0	-0.2	-0.1	0.1	0.1	0.4
Alcohol drinker status: Previous	0.2	0.2	0.9	0.2	0.4	0.3	0.7	0.3	0.2	0.6	-0.3	0.5	0.8	0.2	0.5	0.4	-1.0	0.5	0.6	0.3	-0.0
Pack years of smoking	0.7	1.1	2.5	0.9	0.8	1.1	1.0	0.9	0.6	1.0	-1.6	1.2	1.4	1.1	1.0	1.5	-1.0	0.3	0.6	0.8	0.8
Impedance of whole body	12.8	64.9	82.7	-8.5	-6.6	-8.7	-8.9	-8.6	-6.6	-9.1	9.0	-7.9	-7.9	-8.0	-8.5	-8.0	8.9	-7.8	-8.3	-8.4	-3.6
Leg fat mass (left)	5.4	20.9	28.1	4.9	3.2	5.0	5.3	5.0	3.4	4.9	-5.3	4.9	4.5	4.8	4.7	4.9	-5.1	3.8	4.7	4.8	1.7
Arm predicted mass (left)	3.3	16.7	22.4	4.3	3.4	4.4	4.7	4.4	4.0	4.4	-4.7	4.3	3.5	4.0	4.0	4.2	-4.7	3.6	4.3	4.0	1.4