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chr12:55,677,395-57,125,879

Best TWAS P=2.63e-10 · Best GWAS P=3.52e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	GTEx	Muscle Skeletal	RAB5B	0.29	0.32	lasso	4	0.33	1.3e-33	6.2	-6.3	2.7e-10	-0.99	0.01	0.99	TRUE
11	GTEx	Muscle Skeletal	AC034102.1	0.28	0.31	lasso	4	0.31	2.3e-31	6.3	-6.3	2.6e-10	-0.99	0.01	0.99	FALSE
42	The Cancer Genome Atlas	Skin Cutaneous Melanoma	RPS26	0.28	0.15	lasso	2	0.17	3.0e-05	6.3	6.2	5.0e-10	0.97	0.01	0.97	FALSE
13	GTEx	Prostate	SUOX	0.22	0.04	enet	11	0.05	2.3e-02	5.5	-6.2	6.2e-10	-0.88	0.03	0.80	FALSE
36	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RPS26	0.30	0.20	lasso	4	0.24	3.9e-16	5.5	6.1	9.5e-10	0.90	0.03	0.97	FALSE
12	GTEx	Ovary	SUOX	0.23	0.14	enet	12	0.21	8.4e-06	5.5	-6.1	1.3e-09	-0.75	0.11	0.33	FALSE
7	GTEx	Esophagus Muscularis	SUOX	0.24	0.19	enet	16	0.15	2.3e-09	5.6	-6.0	1.8e-09	-0.81	0.32	0.68	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	RAB5B	0.03	0.02	enet	7	0.02	4.3e-03	6.2	5.8	5.5e-09	0.83	0.00	0.83	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RPS26	0.22	0.31	lasso	3	0.31	1.6e-35	5.5	5.8	6.7e-09	0.83	0.21	0.79	FALSE
26	The Cancer Genome Atlas	Colon Adenocarcinoma	RPS26	0.43	0.48	lasso	4	0.47	1.8e-30	5.5	5.8	7.4e-09	0.83	0.20	0.80	FALSE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RPS26	0.27	0.38	enet	8	0.40	5.0e-24	5.5	5.8	7.5e-09	0.84	0.22	0.78	FALSE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	RPS26	0.26	0.45	enet	9	0.47	3.6e-61	5.5	5.8	7.7e-09	0.84	0.25	0.75	FALSE
44	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RPS26	0.46	0.64	lasso	4	0.65	8.5e-30	5.5	5.7	9.4e-09	0.82	0.23	0.77	FALSE
22	YFS	Blood	SUOX	0.11	0.09	bslmm	269	0.09	3.4e-27	5.5	-5.7	1.0e-08	-0.81	0.32	0.68	FALSE
25	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RPS26	0.23	0.40	lasso	2	0.39	1.5e-20	5.5	5.7	1.1e-08	0.82	0.16	0.84	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPS26	0.33	0.52	enet	9	0.54	5.6e-66	5.5	5.7	1.1e-08	0.83	0.22	0.78	FALSE
15	GTEx	Skin Sun Exposed Lower leg	SUOX	0.23	0.30	lasso	3	0.29	1.9e-24	5.6	-5.7	1.2e-08	-0.86	0.31	0.69	FALSE
17	GTEx	Testis	SUOX	0.27	0.18	lasso	14	0.18	1.4e-08	5.6	-5.7	1.2e-08	-0.84	0.12	0.88	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPS26	0.30	0.44	enet	10	0.45	5.2e-104	5.5	5.7	1.2e-08	0.83	0.21	0.79	FALSE
27	The Cancer Genome Atlas	Esophageal Carcinoma	RPS26	0.19	0.13	lasso	5	0.11	2.4e-04	5.5	5.7	1.2e-08	0.82	0.01	0.96	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPS26	0.31	0.53	enet	8	0.55	1.7e-74	5.5	5.7	1.2e-08	0.82	0.26	0.74	FALSE
45	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	RPS26	0.17	0.19	lasso	4	0.18	1.3e-05	5.5	5.7	1.4e-08	0.84	0.02	0.96	FALSE
4	GTEx	Breast Mammary Tissue (Female)	RPS26	0.20	0.11	lasso	3	0.10	6.6e-04	5.6	5.7	1.6e-08	0.81	0.04	0.30	FALSE
6	GTEx	Esophagus Gastroesophageal Junction	SUOX	0.20	0.16	lasso	5	0.19	2.7e-07	5.5	-5.6	1.7e-08	-0.82	0.12	0.87	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RPS26	0.48	0.62	lasso	5	0.63	5.9e-99	5.5	5.6	1.9e-08	0.81	0.35	0.65	FALSE
38	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RPS26	0.47	0.43	lasso	2	0.44	3.2e-19	5.5	5.6	1.9e-08	0.84	0.20	0.79	FALSE
41	The Cancer Genome Atlas	Soft Tissue Sarcoma	RPS26	0.23	0.31	lasso	3	0.30	2.4e-18	5.5	5.6	1.9e-08	0.80	0.20	0.80	FALSE
40	The Cancer Genome Atlas	Rectum Adenocarcinoma	RPS26	0.24	0.18	lasso	2	0.20	1.9e-05	5.5	5.6	2.0e-08	0.82	0.05	0.61	FALSE
43	The Cancer Genome Atlas	Stomach Adenocarcinoma	RPS26	0.19	0.32	lasso	5	0.34	2.0e-25	5.3	5.6	2.6e-08	0.79	0.33	0.67	FALSE
3	GTEx	Brain Cortex	SUOX	0.16	0.11	lasso	4	0.10	1.1e-03	5.6	-5.6	2.8e-08	-0.84	0.04	0.60	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	SUOX	0.10	0.14	lasso	2	0.12	2.5e-07	5.6	-5.5	2.8e-08	-0.84	0.08	0.91	FALSE
28	The Cancer Genome Atlas	Glioblastoma Multiforme	RPS26	0.41	0.38	enet	9	0.39	7.9e-13	5.3	5.5	2.8e-08	0.79	0.24	0.76	FALSE
19	GTEx	Whole Blood	RPS26	0.05	0.05	lasso	1	0.05	3.4e-05	5.5	5.5	2.9e-08	0.85	0.04	0.94	FALSE
2	GTEx	Artery Tibial	RPS26	0.07	0.02	enet	5	0.01	3.5e-02	5.5	5.5	3.4e-08	0.81	0.09	0.69	FALSE
32	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RPS26	0.18	0.31	lasso	2	0.29	3.9e-14	5.5	5.5	3.6e-08	0.78	0.23	0.77	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RPS26	0.17	0.29	lasso	4	0.29	6.2e-33	5.3	5.5	3.7e-08	0.78	0.34	0.66	FALSE
18	GTEx	Thyroid	SUOX	0.37	0.40	lasso	7	0.38	5.4e-31	5.6	-5.5	4.1e-08	-0.83	0.31	0.69	FALSE
21	METSIM	Adipose	RPS26	0.30	0.40	lasso	5	0.41	7.2e-66	5.3	5.5	4.1e-08	0.78	0.46	0.54	FALSE
8	GTEx	Heart Atrial Appendage	SUOX	0.09	0.10	enet	8	0.09	1.1e-04	5.5	-5.5	4.8e-08	-0.82	0.06	0.85	FALSE
37	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RPS26	0.36	0.44	lasso	7	0.42	2.4e-19	5.3	5.5	4.8e-08	0.79	0.30	0.70	FALSE
20	METSIM	Adipose	IKZF4	0.04	0.04	enet	3	0.04	1.0e-06	5.4	5.5	5.1e-08	0.76	0.49	0.51	FALSE
23	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RPS26	0.14	0.22	lasso	2	0.23	4.8e-19	5.3	5.4	5.9e-08	0.77	0.35	0.65	FALSE
5	GTEx	Colon Sigmoid	SUOX	0.23	0.18	lasso	4	0.15	7.9e-06	5.6	-5.4	6.8e-08	-0.82	0.08	0.91	FALSE
16	GTEx	Stomach	SUOX	0.15	0.17	enet	8	0.09	6.7e-05	5.6	-5.3	1.2e-07	-0.83	0.26	0.71	FALSE
10	GTEx	Muscle Skeletal	SUOX	0.11	0.04	lasso	7	0.04	4.4e-05	5.6	-5.2	1.9e-07	-0.82	0.19	0.76	FALSE