[Hub]/) : Traits : Medication: Levothyroxine sodium :

chr12:55,677,395-57,125,879

Best TWAS P=2.63e-10 · Best GWAS P=3.52e-10 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex RPS26 0.48 0.62 lasso 5 0.63 5.9e-99 5.5 5.6 1.9e-08 0.81 0.35 0.65 FALSE
2 GTEx Artery Tibial RPS26 0.07 0.02 enet 5 0.01 3.5e-02 5.5 5.5 3.4e-08 0.81 0.09 0.69 FALSE
3 GTEx Brain Cortex SUOX 0.16 0.11 lasso 4 0.10 1.1e-03 5.6 -5.6 2.8e-08 -0.84 0.04 0.60 FALSE
4 GTEx Breast Mammary Tissue (Female) RPS26 0.20 0.11 lasso 3 0.10 6.6e-04 5.6 5.7 1.6e-08 0.81 0.04 0.30 FALSE
5 GTEx Colon Sigmoid SUOX 0.23 0.18 lasso 4 0.15 7.9e-06 5.6 -5.4 6.8e-08 -0.82 0.08 0.91 FALSE
6 GTEx Esophagus Gastroesophageal Junction SUOX 0.20 0.16 lasso 5 0.19 2.7e-07 5.5 -5.6 1.7e-08 -0.82 0.12 0.87 FALSE
7 GTEx Esophagus Muscularis SUOX 0.24 0.19 enet 16 0.15 2.3e-09 5.6 -6.0 1.8e-09 -0.81 0.32 0.68 FALSE
8 GTEx Heart Atrial Appendage SUOX 0.09 0.10 enet 8 0.09 1.1e-04 5.5 -5.5 4.8e-08 -0.82 0.06 0.85 FALSE
9 GTEx Muscle Skeletal RAB5B 0.29 0.32 lasso 4 0.33 1.3e-33 6.2 -6.3 2.7e-10 -0.99 0.01 0.99 TRUE
10 GTEx Muscle Skeletal SUOX 0.11 0.04 lasso 7 0.04 4.4e-05 5.6 -5.2 1.9e-07 -0.82 0.19 0.76 FALSE
11 GTEx Muscle Skeletal AC034102.1 0.28 0.31 lasso 4 0.31 2.3e-31 6.3 -6.3 2.6e-10 -0.99 0.01 0.99 FALSE
12 GTEx Ovary SUOX 0.23 0.14 enet 12 0.21 8.4e-06 5.5 -6.1 1.3e-09 -0.75 0.11 0.33 FALSE
13 GTEx Prostate SUOX 0.22 0.04 enet 11 0.05 2.3e-02 5.5 -6.2 6.2e-10 -0.88 0.03 0.80 FALSE
14 GTEx Skin Not Sun Exposed Suprapubic SUOX 0.10 0.14 lasso 2 0.12 2.5e-07 5.6 -5.5 2.8e-08 -0.84 0.08 0.91 FALSE
15 GTEx Skin Sun Exposed Lower leg SUOX 0.23 0.30 lasso 3 0.29 1.9e-24 5.6 -5.7 1.2e-08 -0.86 0.31 0.69 FALSE
16 GTEx Stomach SUOX 0.15 0.17 enet 8 0.09 6.7e-05 5.6 -5.3 1.2e-07 -0.83 0.26 0.71 FALSE
17 GTEx Testis SUOX 0.27 0.18 lasso 14 0.18 1.4e-08 5.6 -5.7 1.2e-08 -0.84 0.12 0.88 FALSE
18 GTEx Thyroid SUOX 0.37 0.40 lasso 7 0.38 5.4e-31 5.6 -5.5 4.1e-08 -0.83 0.31 0.69 FALSE
19 GTEx Whole Blood RPS26 0.05 0.05 lasso 1 0.05 3.4e-05 5.5 5.5 2.9e-08 0.85 0.04 0.94 FALSE
20 METSIM Adipose IKZF4 0.04 0.04 enet 3 0.04 1.0e-06 5.4 5.5 5.1e-08 0.76 0.49 0.51 FALSE
21 METSIM Adipose RPS26 0.30 0.40 lasso 5 0.41 7.2e-66 5.3 5.5 4.1e-08 0.78 0.46 0.54 FALSE
22 YFS Blood SUOX 0.11 0.09 bslmm 269 0.09 3.4e-27 5.5 -5.7 1.0e-08 -0.81 0.32 0.68 FALSE
23 The Cancer Genome Atlas Bladder Urothelial Carcinoma RPS26 0.14 0.22 lasso 2 0.23 4.8e-19 5.3 5.4 5.9e-08 0.77 0.35 0.65 FALSE
24 The Cancer Genome Atlas Breast Invasive Carcinoma RPS26 0.30 0.44 enet 10 0.45 5.2e-104 5.5 5.7 1.2e-08 0.83 0.21 0.79 FALSE
25 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma RPS26 0.23 0.40 lasso 2 0.39 1.5e-20 5.5 5.7 1.1e-08 0.82 0.16 0.84 FALSE
26 The Cancer Genome Atlas Colon Adenocarcinoma RPS26 0.43 0.48 lasso 4 0.47 1.8e-30 5.5 5.8 7.4e-09 0.83 0.20 0.80 FALSE
27 The Cancer Genome Atlas Esophageal Carcinoma RPS26 0.19 0.13 lasso 5 0.11 2.4e-04 5.5 5.7 1.2e-08 0.82 0.01 0.96 FALSE
28 The Cancer Genome Atlas Glioblastoma Multiforme RPS26 0.41 0.38 enet 9 0.39 7.9e-13 5.3 5.5 2.8e-08 0.79 0.24 0.76 FALSE
29 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma RPS26 0.17 0.29 lasso 4 0.29 6.2e-33 5.3 5.5 3.7e-08 0.78 0.34 0.66 FALSE
30 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma RPS26 0.27 0.38 enet 8 0.40 5.0e-24 5.5 5.8 7.5e-09 0.84 0.22 0.78 FALSE
31 The Cancer Genome Atlas Brain Lower Grade Glioma RPS26 0.31 0.53 enet 8 0.55 1.7e-74 5.5 5.7 1.2e-08 0.82 0.26 0.74 FALSE
32 The Cancer Genome Atlas Liver Hepatocellular Carcinoma RPS26 0.18 0.31 lasso 2 0.29 3.9e-14 5.5 5.5 3.6e-08 0.78 0.23 0.77 FALSE
33 The Cancer Genome Atlas Lung Adenocarcinoma RAB5B 0.03 0.02 enet 7 0.02 4.3e-03 6.2 5.8 5.5e-09 0.83 0.00 0.83 FALSE
34 The Cancer Genome Atlas Lung Adenocarcinoma RPS26 0.26 0.45 enet 9 0.47 3.6e-61 5.5 5.8 7.7e-09 0.84 0.25 0.75 FALSE
35 The Cancer Genome Atlas Lung Squamous Cell Carcinoma RPS26 0.22 0.31 lasso 3 0.31 1.6e-35 5.5 5.8 6.7e-09 0.83 0.21 0.79 FALSE
36 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma RPS26 0.30 0.20 lasso 4 0.24 3.9e-16 5.5 6.1 9.5e-10 0.90 0.03 0.97 FALSE
37 The Cancer Genome Atlas Pancreatic Adenocarcinoma RPS26 0.36 0.44 lasso 7 0.42 2.4e-19 5.3 5.5 4.8e-08 0.79 0.30 0.70 FALSE
38 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma RPS26 0.47 0.43 lasso 2 0.44 3.2e-19 5.5 5.6 1.9e-08 0.84 0.20 0.79 FALSE
39 The Cancer Genome Atlas Prostate Adenocarcinoma RPS26 0.33 0.52 enet 9 0.54 5.6e-66 5.5 5.7 1.1e-08 0.83 0.22 0.78 FALSE
40 The Cancer Genome Atlas Rectum Adenocarcinoma RPS26 0.24 0.18 lasso 2 0.20 1.9e-05 5.5 5.6 2.0e-08 0.82 0.05 0.61 FALSE
41 The Cancer Genome Atlas Soft Tissue Sarcoma RPS26 0.23 0.31 lasso 3 0.30 2.4e-18 5.5 5.6 1.9e-08 0.80 0.20 0.80 FALSE
42 The Cancer Genome Atlas Skin Cutaneous Melanoma RPS26 0.28 0.15 lasso 2 0.17 3.0e-05 6.3 6.2 5.0e-10 0.97 0.01 0.97 FALSE
43 The Cancer Genome Atlas Stomach Adenocarcinoma RPS26 0.19 0.32 lasso 5 0.34 2.0e-25 5.3 5.6 2.6e-08 0.79 0.33 0.67 FALSE
44 The Cancer Genome Atlas Testicular Germ Cell Tumors RPS26 0.46 0.64 lasso 4 0.65 8.5e-30 5.5 5.7 9.4e-09 0.82 0.23 0.77 FALSE
45 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma RPS26 0.17 0.19 lasso 4 0.18 1.3e-05 5.5 5.7 1.4e-08 0.84 0.02 0.96 FALSE