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chr11:60,549,966-62,346,131

Best TWAS P=4.72e-09 · Best GWAS P=1.7e-08 conditioned to 0.721

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Muscle Skeletal	FADS2	0.08	0.04	lasso	2	0.03	5.9e-04	-5.6	-5.9	4.7e-09	0.94	0.01	0.99	TRUE
8	ROSMAP	Brain Pre-frontal Cortex	TMEM258	0.14	0.16	lasso	4	0.15	4.7e-19	-5.2	-5.4	5.6e-08	0.92	0.03	0.96	FALSE
9	ROSMAP	Brain Pre-frontal Cortex	FADS1	0.08	0.08	enet	10	0.09	1.5e-11	-5.3	5.4	5.9e-08	-0.95	0.02	0.98	FALSE
3	GTEx	Artery Tibial	TMEM258	0.08	0.05	lasso	5	0.02	1.1e-02	-5.4	-5.3	1.1e-07	0.97	0.02	0.98	FALSE
4	GTEx	Brain Cerebellum	FADS3	0.26	0.18	lasso	4	0.14	5.7e-05	-4.9	5.2	2.0e-07	-0.91	0.03	0.84	FALSE
11	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf10	0.02	0.02	blup	44	0.02	1.8e-03	-4.8	-5.2	2.0e-07	0.95	0.02	0.70	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FADS1	0.14	0.16	lasso	2	0.16	7.2e-19	-5.2	5.2	2.2e-07	-0.96	0.02	0.97	FALSE
5	GTEx	Heart Left Ventricle	FADS2	0.17	0.12	enet	3	0.13	1.5e-07	-5.0	-5.2	2.2e-07	0.72	0.10	0.89	FALSE
10	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FADS2	0.26	0.29	enet	15	0.29	2.9e-33	-4.2	-5.2	2.2e-07	0.72	0.79	0.19	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FEN1	0.07	0.06	lasso	4	0.06	1.1e-07	-5.2	-5.2	2.4e-07	0.96	0.02	0.98	FALSE
7	GTEx	Uterus	PPP1R32	0.66	-0.01	lasso	13	0.14	8.8e-04	1.2	-5.2	2.4e-07	0.58	0.02	0.50	FALSE