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chr11:60,549,966-62,346,131

Best TWAS P=4.72e-09 · Best GWAS P=1.7e-08 conditioned to 0.721

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FADS1 0.14 0.16 lasso 2 0.16 7.2e-19 -5.2 5.2 2.2e-07 -0.96 0.02 0.97 FALSE
2 CommonMind Brain Pre-frontal Cortex FEN1 0.07 0.06 lasso 4 0.06 1.1e-07 -5.2 -5.2 2.4e-07 0.96 0.02 0.98 FALSE
3 GTEx Artery Tibial TMEM258 0.08 0.05 lasso 5 0.02 1.1e-02 -5.4 -5.3 1.1e-07 0.97 0.02 0.98 FALSE
4 GTEx Brain Cerebellum FADS3 0.26 0.18 lasso 4 0.14 5.7e-05 -4.9 5.2 2.0e-07 -0.91 0.03 0.84 FALSE
5 GTEx Heart Left Ventricle FADS2 0.17 0.12 enet 3 0.13 1.5e-07 -5.0 -5.2 2.2e-07 0.72 0.10 0.89 FALSE
6 GTEx Muscle Skeletal FADS2 0.08 0.04 lasso 2 0.03 5.9e-04 -5.6 -5.9 4.7e-09 0.94 0.01 0.99 TRUE
7 GTEx Uterus PPP1R32 0.66 -0.01 lasso 13 0.14 8.8e-04 1.2 -5.2 2.4e-07 0.58 0.02 0.50 FALSE
8 ROSMAP Brain Pre-frontal Cortex TMEM258 0.14 0.16 lasso 4 0.15 4.7e-19 -5.2 -5.4 5.6e-08 0.92 0.03 0.96 FALSE
9 ROSMAP Brain Pre-frontal Cortex FADS1 0.08 0.08 enet 10 0.09 1.5e-11 -5.3 5.4 5.9e-08 -0.95 0.02 0.98 FALSE
10 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FADS2 0.26 0.29 enet 15 0.29 2.9e-33 -4.2 -5.2 2.2e-07 0.72 0.79 0.19 FALSE
11 The Cancer Genome Atlas Thyroid Carcinoma C11orf10 0.02 0.02 blup 44 0.02 1.8e-03 -4.8 -5.2 2.0e-07 0.95 0.02 0.70 FALSE