[Hub]/) : Traits : Medication: Levothyroxine sodium : ← →

chr17:44,788,310-46,474,610

Best TWAS P=4.99e-10 · Best GWAS P=2.36e-10 conditioned to 0.000455

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Breast Mammary Tissue (Male) EFCAB13 0.11 0.09 lasso 1 -0.01 5.0e-01 -5.4 -5.4 7.4e-08 -0.71 0.05 0.14 FALSE
2 GTEx Heart Atrial Appendage TBKBP1 0.09 0.02 lasso 5 0.01 8.8e-02 4.5 5.6 2.5e-08 0.50 0.09 0.72 FALSE
3 GTEx Testis EFCAB13 0.25 0.26 enet 18 0.25 2.4e-11 4.3 -5.1 2.9e-07 -0.40 0.96 0.04 FALSE
4 GTEx Uterus EFCAB13 0.41 0.03 lasso 9 0.28 1.7e-06 5.1 -6.2 6.9e-10 -0.23 0.04 0.46 TRUE
5 METSIM Adipose NPEPPS 0.04 0.02 lasso 6 0.03 1.4e-05 5.2 6.2 5.0e-10 0.70 0.05 0.95 TRUE
6 METSIM Adipose TBKBP1 0.08 0.10 lasso 4 0.10 2.1e-14 4.2 5.2 2.6e-07 0.85 0.46 0.54 FALSE
7 The Cancer Genome Atlas Breast Invasive Carcinoma TBKBP1 0.02 0.03 lasso 2 0.03 3.0e-06 -5.4 5.3 1.5e-07 0.71 0.40 0.57 FALSE
8 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma TBKBP1 0.12 0.09 blup 46 0.08 8.4e-05 4.2 5.3 9.6e-08 0.84 0.08 0.78 FALSE
9 The Cancer Genome Atlas Colon Adenocarcinoma TBKBP1 0.09 0.06 blup 46 0.09 7.8e-06 4.2 5.2 2.0e-07 0.80 0.13 0.83 FALSE
10 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TBKBP1 0.07 0.06 lasso 8 0.07 5.1e-08 -5.4 5.2 2.1e-07 0.79 0.50 0.50 FALSE
11 The Cancer Genome Atlas Liver Hepatocellular Carcinoma C17orf57 0.28 0.16 lasso 6 0.15 1.4e-07 -4.0 -5.2 2.1e-07 -0.56 0.47 0.46 FALSE
12 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma TBKBP1 0.11 0.04 blup 45 0.03 5.3e-02 -5.4 5.3 1.2e-07 0.79 0.02 0.69 FALSE