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Medication: Levothyroxine sodium
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chr19:4,118,871-5,529,588
Best TWAS P=7.23e-10 · Best GWAS P=3.24e-16 conditioned to 2.16e-06
4.2M
4.4M
4.6M
4.8M
5M
5.2M
5.4M
5.6M
0
5
10
15
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
ROSMAP
Brain Pre-frontal Cortex
TICAM1
0.07
0.02
lasso
5
0.04
1.2e-05
7.1
6.2
7.2e-10
0.81
0.01
0.99
TRUE
2
The Cancer Genome Atlas
Pancreatic Adenocarcinoma
FEM1A
0.10
0.10
lasso
3
0.08
4.6e-04
-5.7
-5.5
4.5e-08
-0.66
0.03
0.46
TRUE
3
The Cancer Genome Atlas
Thyroid Carcinoma
TICAM1
0.07
0.04
blup
54
0.06
1.6e-06
6.9
5.4
8.5e-08
0.78
0.01
0.99
FALSE