Best TWAS P=9.51e-09 · Best GWAS P=1.62e-08 conditioned to 0.000573
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NEIL2 | 0.17 | 0.04 | blup | 460 | 0.07 | 5.0e-09 | -3.3 | -5.7 | 9.5e-09 | -0.45 | 0.90 | 0.06 | TRUE |
| 2 | GTEx | Esophagus Muscularis | AF131215.9 | 0.14 | 0.17 | enet | 16 | 0.17 | 1.6e-10 | -4.5 | 5.2 | 2.0e-07 | 0.51 | 0.35 | 0.63 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | AF131215.9 | 0.19 | 0.17 | enet | 29 | 0.21 | 3.9e-17 | -4.4 | 5.5 | 4.9e-08 | 0.51 | 0.53 | 0.44 | FALSE |
| 4 | GTEx | Thyroid | AF131215.2 | 0.11 | 0.15 | enet | 17 | 0.18 | 1.2e-13 | -4.2 | 5.3 | 1.2e-07 | 0.53 | 0.46 | 0.51 | FALSE |
| 5 | GTEx | Thyroid | AF131215.9 | 0.11 | 0.08 | enet | 16 | 0.17 | 4.7e-13 | -4.5 | 5.2 | 1.9e-07 | 0.52 | 0.44 | 0.54 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | MTMR9 | 0.07 | 0.06 | enet | 16 | 0.08 | 9.5e-11 | -4.6 | -5.4 | 6.3e-08 | -0.52 | 0.57 | 0.42 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | XKR6 | 0.11 | 0.10 | enet | 23 | 0.13 | 1.2e-16 | -5.5 | 5.4 | 6.6e-08 | 0.63 | 0.02 | 0.97 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | AMAC1L2 | 0.03 | 0.03 | blup | 55 | 0.04 | 3.0e-05 | 4.8 | -5.1 | 2.9e-07 | -0.51 | 0.02 | 0.97 | FALSE |