Hub : Genes

MTMR9

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1690 0.0610 3.4e-03 0.026 NA 0.013 NA 0.019 3.1e-03 NA 2.9e-02 NA 1.1e-02
2 GTEx Colon Sigmoid 0.2410 0.0870 5.7e-04 0.175 NA 0.050 NA 0.136 8.7e-07 NA 7.6e-03 NA 1.6e-05
3 GTEx Colon Transverse 0.2070 0.0820 1.8e-03 0.063 NA 0.007 NA 0.033 5.9e-04 NA 1.5e-01 NA 1.0e-02
4 GTEx Heart Atrial Appendage 0.3700 0.1130 3.8e-03 -0.006 NA 0.002 NA 0.005 8.5e-01 NA 2.5e-01 NA 1.8e-01
5 GTEx Lung 0.0739 0.0360 2.3e-03 0.006 NA -0.002 NA 0.012 9.7e-02 NA 4.8e-01 NA 3.9e-02
6 ROSMAP Brain Pre-frontal Cortex 0.0716 0.0237 6.6e-09 0.063 0.074 0.082 0.072 0.073 1.4e-08 8.3e-10 9.5e-11 1.3e-09 1.1e-09
7 YFS Blood 0.0574 0.0155 5.5e-08 0.032 0.027 0.035 0.031 0.041 7.9e-11 2.6e-09 1.1e-11 1.8e-10 1.9e-13

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.5 0.9 2.0 0.3 0.6 0.4 -1.0 -1.0 -1.4 1.2
Bipolar Disorder or Schizophrenia 1.9 4.7 12.2 -1.8 2.2 1.3 0.3 -3.5 -3.3 0.8
Depressed Affect (Nagel 2018) 1.1 2.4 7.6 1.7 -0.9 -1.0 -2.8 0.6 1.4 1.5
Depression (Nagel 2018) 0.3 0.4 1.5 1.2 0.5 -0.1 0.3 -0.9 0.4 0.4
Intelligence (Savage-Jansen 2018) 0.7 2.1 4.6 2.1 0.1 0.2 1.8 1.9 1.7 0.1
Neuroticism (Nagel 2018) 1.8 4.2 9.3 2.1 -2.1 -2.1 -3.0 0.9 1.7 1.7
Schizophrenia (2018) 2.6 5.4 13.3 -2.5 2.4 1.3 0.9 -3.7 -3.1 0.1
Schizophrenia vs Biploar Disorder 1.8 2.4 4.9 -2.2 1.7 1.1 1.0 -2.2 -1.4 0.2
Worry (Nagel 2018) 0.8 1.7 4.8 1.5 -1.8 -2.2 -0.9 -0.5 -0.1 0.6
Alzheimer’s Disease (in mother) 1.0 1.2 1.9 -1.4 -1.0 -1.1 1.4 -0.1 -0.8 -1.2
Alzheimer’s Disease (in father) 0.4 0.5 0.9 0.9 -0.7 -0.8 -0.8 0.8 0.1 -0.1
Alzheimer’s Disease (including proxy) 0.6 0.9 2.6 0.3 -1.6 -1.6 0.3 0.7 -0.2 -0.5
Crohns Disease (2017) 0.7 1.5 5.2 -1.1 0.8 0.5 -0.5 -2.3 -1.6 0.6
Irritable Bowel Disease (IBD) 0.3 0.8 2.7 0.0 0.3 0.0 -1.3 -1.0 -0.3 1.6
Ulcerative Colitis (UC) 0.4 0.8 1.7 1.1 0.1 -0.1 -1.3 0.6 0.6 1.2
Major Depression (MDD) 0.3 0.4 1.0 1.0 -0.0 -0.2 0.2 0.8 0.7 0.8
Reaction Time 0.9 1.8 3.9 1.8 -1.0 -1.6 -0.6 -0.4 1.2 2.0
Verbal and Numeric Reasoning (VNR) 1.2 3.0 8.1 2.8 -0.1 0.1 2.2 2.0 2.0 0.5
Breast Cancer 1.7 4.0 9.0 0.2 2.9 3.0 0.2 -0.8 -2.9 -1.1
Ovarian Cancer 0.9 1.2 1.8 1.3 1.2 1.1 -0.9 1.3 1.0 0.1
Prostate Cancer 3.9 5.4 12.4 -0.7 3.5 3.4 -2.4 -1.2 -2.5 0.7
Age at First Birth 1.2 1.8 8.2 2.9 0.3 0.2 0.1 1.3 1.2 -1.0
Bipolar Disorder (2011) 1.0 1.0 2.9 0.4 0.8 0.6 -0.3 -1.4 -0.8 -1.7
Body Mass Index (BMI) (2010) 1.9 2.6 5.6 1.0 2.2 2.4 0.4 -1.1 -1.9 1.4
Coronary Artery Disease (CAD) 0.6 0.7 2.0 1.0 0.7 0.6 1.4 0.5 0.9 -0.1
Crohns Disease (2012) 1.0 1.6 5.7 0.5 1.2 0.9 1.2 -2.4 -1.1 0.1
Mean Putamen Volume 0.8 1.0 2.6 -1.6 -0.2 -0.6 -0.0 -1.3 -1.4 -0.3
Fasting Glucose 0.7 0.8 1.5 0.5 0.3 0.7 1.0 -1.2 -1.1 -1.1
HbA1C 0.9 1.0 1.8 0.5 1.3 1.2 0.9 -0.8 -0.7 -1.2
HDL Cholesterol 0.3 0.5 1.7 -1.3 -0.4 -0.4 -0.3 1.1 0.4 -0.0
LDL Cholesterol 0.2 0.2 0.7 -0.7 0.2 0.0 -0.8 -0.7 -0.2 -0.2
Lupus 5.5 8.4 16.1 -2.3 2.7 2.3 3.0 -3.7 -4.0 1.2
Neuroticism (2016) 20.8 30.0 49.1 4.5 -6.9 -6.3 -0.1 6.8 7.0 2.5
Primary Biliary Cirrhosis 1.0 1.5 5.0 0.7 1.4 0.9 -0.1 -2.2 -1.1 0.8
Rheumatoid Arthritis 0.8 1.1 2.8 -1.7 -0.4 -0.8 1.5 -0.8 0.7 0.9
Schizophrenia (2014) 2.9 6.5 20.9 -2.1 2.8 1.4 0.7 -4.6 -3.2 -0.3
Triglycerides 3.4 5.6 14.1 3.4 -1.7 -1.2 0.8 2.6 3.8 1.5
Type 2 Diabetes (T2D) (2012) 2.4 2.8 7.0 0.6 2.6 2.5 -0.8 -1.1 -2.0 0.3
Ulcerative Colitis 1.4 2.1 3.8 1.6 -0.9 -1.0 -1.3 1.2 1.8 2.0
Blood Eosinophil Count 0.2 1.6 4.5 1.3 1.9 2.1 0.7 0.4 0.2 -0.5
Blood Platelet Count 0.2 1.8 4.5 -0.5 -1.6 -1.8 -2.1 -0.2 0.8 1.2
Blood Red Count 0.2 1.8 4.9 0.7 1.5 1.5 -2.2 -0.3 0.8 1.3
Blood White Count 0.2 1.3 3.4 1.9 1.0 1.0 -1.4 0.4 -1.3 -0.2
Heel T-Score 0.1 0.5 1.8 0.3 -0.3 -0.7 0.8 -1.3 0.2 0.8
BMI 0.4 2.2 9.8 3.1 -0.7 0.4 0.7 1.1 1.2 1.2
Height 0.1 1.3 4.0 -0.1 1.5 2.0 -1.3 0.4 -0.9 -0.6
Waist Hip Ratio (WHR) 0.4 2.0 5.1 -0.4 -1.4 -1.4 2.0 0.6 0.5 2.3
Systolic Blood Pressure 0.8 4.1 8.1 0.7 -2.8 -2.3 -2.6 1.7 1.2 2.0
Smoking Status 0.1 0.3 1.6 1.3 0.5 0.4 -0.2 0.5 0.3 -0.1
Allergy or Eczema 0.5 1.2 3.2 0.9 -1.4 -1.3 -0.3 0.5 0.9 1.8
Cardiovascular Disease 0.1 0.5 1.2 0.7 -0.3 0.2 -1.0 1.1 -0.1 0.6
Hypothyroidism (self reported) 0.4 1.0 4.2 -2.0 0.6 0.2 0.6 1.1 0.1 -0.8
Respiratory disease 0.1 0.3 0.9 0.6 0.3 0.1 0.1 0.1 0.9 -0.9
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.4 1.1 0.1 0.2 -0.0 -0.7 -1.5 1.5
Lung FEV1/FVC ratio 0.3 1.3 4.1 1.2 -1.1 -0.8 0.4 -1.1 -2.0 0.1
Lung FVC 0.3 1.7 2.9 -0.2 1.7 1.2 1.4 -1.5 -1.0 1.5
Neuroticism 0.9 2.3 5.3 2.0 -1.1 -1.5 -1.7 -0.2 0.1 2.3
Chronotype (morning person) 0.3 0.8 1.3 -1.0 -1.1 -0.3 1.2 1.0 -0.7 0.5
Hair Pigment 0.0 0.3 1.1 0.0 -1.1 -0.9 -0.4 0.2 -0.0 0.2
Tanning 0.0 0.6 1.6 -1.3 0.8 0.8 0.2 0.6 -0.7 -0.2
Hand grip strength (left) 1.0 2.7 6.7 0.4 2.6 2.3 -0.6 -0.2 -1.6 -1.8
Number of treatments/medications taken 0.2 0.3 1.1 -0.3 -0.3 0.0 0.8 -0.3 -1.0 0.4
Average weekly spirits intake 0.9 1.1 1.7 1.2 -0.7 -0.7 -1.3 1.3 1.3 0.4
Sensitivity / hurt feelings 8.4 14.4 28.9 4.5 -3.7 -3.4 -0.7 4.9 5.4 1.7
Frequency of depressed mood in last 2 weeks 2.7 3.8 10.0 3.2 -1.7 -1.7 0.4 1.6 2.8 0.9
Hearing difficulty/problems: Yes 0.7 1.1 5.2 2.3 -1.0 -0.4 -0.9 0.3 0.3 0.3
Relative age of first facial hair 0.3 0.6 3.1 0.8 0.1 -0.1 0.7 -0.4 -0.4 1.7
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 1.8 -0.0 -0.5 -0.3 1.1 1.3 1.1 0.7
Ever used hormone-replacement therapy (HRT) 0.6 0.8 3.4 0.4 0.4 0.4 -1.9 -0.5 -0.9 -0.5
Ever had hysterectomy (womb removed) 2.6 3.0 10.6 -0.7 1.4 0.8 -0.5 -3.3 -2.6 0.1
Systolic blood pressure, automated reading 3.5 10.1 21.5 -3.9 2.3 1.9 -2.0 -4.6 -4.6 0.2
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.1 0.8 -1.2 -1.5 -0.2 0.1 0.3 1.4
Angina 0.6 0.8 1.8 0.6 0.6 0.8 1.2 -0.8 -1.4 0.5
Medication for hormone replacement therapy 0.2 0.2 0.6 0.2 0.8 0.8 -0.6 -0.1 -0.2 0.1
Vitamin and mineral supplements 1.2 1.7 3.4 0.1 -1.8 -1.1 -0.4 1.4 1.4 1.7
Supplements: Zinc 1.2 1.3 4.0 -1.1 2.0 1.7 -0.7 -0.4 -0.3 -0.3
Medication: Co-codamol 0.3 0.4 1.3 -0.1 -0.5 -0.1 0.6 -0.5 -0.7 1.1
Medication: Metformin 1.7 2.4 6.4 -1.3 1.4 1.2 0.7 -1.7 -2.5 1.6
Diabetes (father) 2.4 3.0 4.9 -1.6 2.1 2.2 -1.1 -1.8 -2.0 -0.4
Diabetes (mother) 0.3 0.4 1.1 -0.2 0.3 0.1 -0.7 -1.0 -0.9 -0.3
Severe depression (siblings) 0.6 0.7 2.4 -1.5 -0.5 -0.5 0.6 -1.2 -0.4 0.4
Pack years adult smoking proportion 1.4 2.1 4.3 -1.4 1.4 1.3 -0.4 -2.1 -2.0 -0.5
Impedance of leg (right) 6.5 31.2 57.1 5.2 -7.1 -6.7 -0.1 6.2 7.6 0.6
Leg fat-free mass (left) 2.3 12.4 23.5 -2.9 4.6 4.9 -1.1 -3.7 -4.3 -0.0
Trunk fat percentage 0.4 1.5 4.8 -0.6 0.8 1.0 0.4 -2.2 -1.7 0.4
Hand grip strength (right) 0.5 1.4 3.4 0.7 1.9 1.6 -0.5 -0.4 -1.2 -1.3
Townsend deprivation index at recruitment 0.3 0.4 1.8 0.6 -0.1 0.0 1.3 0.6 0.6 0.5
Current tobacco smoking 4.2 6.8 16.3 -1.4 3.4 3.2 -0.1 -2.7 -4.0 -0.1
Average weekly fortified wine intake 4.8 5.7 10.5 0.4 -3.1 -3.2 1.8 1.4 3.2 2.0
Maternal smoking around birth 0.5 0.7 1.2 1.0 -0.6 -0.9 -1.1 0.6 0.5 -0.8
Fed-up feelings 6.4 11.6 19.2 4.4 -3.7 -3.4 -2.0 3.9 4.1 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 3.8 1.9 -0.4 -0.8 0.9 0.4 1.3 1.0
Relative age voice broke 0.2 0.3 1.2 0.5 0.3 0.0 -0.2 -0.5 -0.4 1.1
Taking other prescription medications 0.3 0.5 1.0 0.3 0.5 0.8 -0.6 1.0 0.6 1.0
Age when periods started (menarche) 0.9 2.1 6.0 2.2 -0.2 0.6 0.8 2.4 1.6 -0.3
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 2.3 1.3 1.5 1.5 0.8 -0.5 -1.0 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 13.0 29.4 62.4 -4.8 6.6 5.7 -0.9 -6.4 -7.9 -1.4
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 2.6 -0.9 0.6 0.4 -0.4 -1.3 -1.6 -0.1
Qualifications: CSEs or equivalent 0.1 0.1 0.3 0.3 0.2 0.5 0.2 0.2 0.6 0.5
Serious illness, injury or assault to yourself 1.2 1.5 3.9 2.0 -0.6 -0.2 1.4 1.8 1.0 -0.1
High blood pressure 4.8 13.4 29.5 -4.7 4.0 3.5 -0.3 -3.8 -5.4 -0.5
Hayfever, allergic rhinitis or eczema 0.2 0.3 1.3 0.5 0.1 -0.1 0.2 -1.1 -0.5 0.7
Multivitamins +/- minerals 0.6 0.7 1.9 -0.3 0.9 0.1 0.0 -1.2 -0.9 -1.4
Stomach or abdominal pain in last month 3.2 4.0 8.3 1.4 -2.9 -2.8 0.3 1.1 2.8 0.3
Supplements: Glucosamine 1.3 1.7 7.5 -0.6 0.2 0.1 1.3 -1.4 -0.6 -2.7
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.3 -0.2 0.1 0.2 -0.5 -0.1 -0.0 0.4
Medication: Atenolol 1.6 2.0 5.4 -0.9 1.4 1.4 0.5 -1.9 -2.3 0.2
Medication: Levothyroxine sodium 4.5 7.7 18.1 3.3 -1.9 -1.6 0.8 4.2 4.1 1.1
Sitting height 0.8 5.7 11.8 -3.4 1.8 1.1 -3.1 -2.9 -2.3 0.2
Chronic bronchitis/emphysema (father) 0.1 0.1 0.4 0.4 0.5 0.7 0.0 0.3 -0.0 -0.1
High blood pressure (mother) 0.5 0.7 1.4 -0.0 1.0 0.9 -0.4 -1.2 -0.7 0.9
Body mass index (BMI) 4.2 18.0 39.2 -3.3 4.8 4.8 0.1 -5.5 -6.3 -0.1
Impedance of leg (left) 6.5 31.4 55.8 5.1 -7.2 -6.9 0.4 6.2 7.5 0.8
Leg predicted mass (left) 2.3 12.4 23.7 -2.9 4.6 4.9 -1.0 -3.7 -4.3 -0.1
Trunk fat mass 0.8 3.4 7.9 -1.0 1.9 2.1 -0.0 -2.8 -2.6 0.3
Waist circumference 0.4 1.4 3.4 0.2 0.9 1.1 0.4 -1.8 -1.5 1.4
Number of incorrect matches in round 2.3 3.8 8.1 1.8 -2.8 -2.7 -2.1 0.3 1.6 0.6
Past tobacco smoking 1.1 1.9 4.0 1.1 -1.8 -1.7 -2.0 1.1 1.0 0.3
Alcohol usually taken with meals 1.7 2.7 6.9 -1.4 2.6 2.3 0.7 -1.2 -1.7 0.1
Nervous feelings 15.0 28.0 46.4 5.4 -6.6 -6.0 -0.8 5.9 6.8 2.1
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 2.7 1.3 -1.4 -1.3 0.3 1.1 1.7 0.3
Hearing difficulty/problems with background noise 1.4 2.3 4.2 1.9 -1.7 -1.1 -0.8 0.9 1.5 2.1
Hair/balding pattern: Pattern 2 1.8 2.2 4.0 -0.9 2.0 1.9 1.3 -1.0 -0.8 -1.9
Had menopause 0.8 1.1 2.3 -0.8 1.1 0.5 -0.1 -1.5 -1.3 1.2
Had other major operations 2.3 2.8 6.7 -2.6 1.8 1.6 0.4 -0.8 -2.4 0.1
Forced vital capacity (FVC) 0.6 2.3 6.2 1.8 0.4 0.0 -0.5 2.4 2.5 0.5
Heel bone mineral density (BMD) T-score, automated (right) 13.3 30.6 61.6 -5.2 6.1 5.1 -0.7 -7.6 -7.8 -1.9
Ever unenthusiastic/disinterested for a whole week 1.2 1.4 3.1 1.1 -1.8 -1.7 -0.5 0.2 0.8 1.4
Qualifications: None of the above 0.3 0.6 1.5 -0.8 -1.2 -0.8 1.1 0.4 -0.6 -0.2
Financial difficulties in last 2 years 0.8 1.1 2.4 -1.2 1.5 1.6 -0.3 0.0 -0.8 -1.1
Mouth/teeth dental problems 1.5 2.3 5.2 2.3 -0.4 -0.0 -1.7 1.9 1.3 -1.5
Heart attack 0.2 0.2 1.0 0.1 0.2 0.2 1.0 0.6 0.1 0.0
Allergy 0.8 1.8 4.0 0.3 -1.7 -1.7 0.7 2.0 1.5 0.1
Pain all over the body in last month 0.7 0.7 2.6 -0.8 -0.1 -0.2 0.1 -1.6 -1.3 -0.3
Diabetes (self-reported) 1.4 2.2 3.7 0.4 1.6 1.4 1.0 -1.9 -1.9 1.4
Hayfever/allergic rhinitis (self-reported) 2.3 3.1 6.4 2.5 -1.8 -1.6 0.1 1.4 1.7 2.0
Medication: Ramipril 1.2 1.5 3.7 -1.0 1.9 1.7 0.0 -0.4 -1.6 -0.7
Medication: Simvastatin 0.3 0.4 1.3 1.0 0.1 0.1 -0.0 -0.3 -0.8 1.1
Fluid intelligence score 1.3 2.8 6.9 2.0 -0.2 -0.0 1.1 2.5 2.6 0.9
Illnesses of siblings 0.5 0.6 2.4 0.7 -0.3 -0.2 -0.8 1.5 0.9 -0.2
Neuroticism score 17.7 36.9 61.5 7.5 -7.0 -6.6 -0.5 6.3 7.8 2.9
Weight 1.7 8.2 15.2 -2.0 3.5 3.6 -1.0 -3.6 -3.9 0.1
Impedance of arm (right) 5.2 24.3 46.3 4.1 -6.0 -5.7 1.7 5.9 6.8 -0.2
Arm fat percentage (right) 1.6 6.3 15.2 -1.9 2.5 2.6 0.9 -3.3 -3.9 -0.1
Trunk fat-free mass 1.0 5.9 11.6 -1.5 3.2 3.4 -2.0 -2.2 -2.9 -0.2
Hip circumference 2.0 8.8 16.2 -1.6 3.5 3.6 -1.1 -4.0 -4.0 0.2
Time employed in main current job 3.0 3.4 9.1 1.2 -3.0 -2.9 0.4 1.3 1.7 -0.0
Alcohol intake versus 10 years previously 0.2 0.3 1.0 0.5 0.4 1.0 0.9 -0.3 0.1 -0.1
Father’s age at death 4.1 5.5 13.2 1.6 -3.5 -3.6 -1.3 1.2 2.6 0.5
Worrier / anxious feelings 19.9 37.5 66.4 6.5 -8.2 -7.5 -0.5 5.8 7.6 2.2
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 4.0 1.8 0.3 0.5 -0.1 1.7 2.0 1.0
Falls in the last year 0.2 0.3 0.8 0.3 0.9 0.7 -0.3 -0.3 -0.7 0.3
Hair/balding pattern: Pattern 3 1.9 2.8 5.8 1.4 -2.4 -2.4 -0.9 1.6 1.0 1.5
Number of live births 0.3 0.5 2.0 -0.2 0.3 0.2 -0.7 1.4 0.8 -0.3
Forced expiratory volume in 1-second (FEV1) 1.4 4.8 11.0 3.3 -1.0 -0.9 -0.2 3.1 3.1 1.0
Pulse rate 1.6 2.6 6.2 1.7 -2.5 -2.0 0.7 1.3 1.5 0.9
Happiness 0.1 0.2 0.4 0.4 -0.6 -0.5 0.2 0.4 0.6 -0.0
Noisy workplace 0.8 1.0 3.4 0.7 -1.8 -1.2 -0.1 1.0 0.6 0.2
Qualifications: A levels/AS levels or equivalent 2.5 5.6 8.7 2.3 -1.7 -2.0 2.4 2.7 2.9 2.2
Serious illness, injury or assault of a close relative in last 2 years 3.0 3.5 9.3 1.8 -1.6 -1.2 -0.1 2.7 3.1 -0.7
Mouth/teeth dental problems: Dentures 2.4 4.1 9.7 -3.1 1.3 1.4 0.1 -2.6 -2.6 1.1
Asthma 1.9 3.7 5.6 -1.6 2.3 2.0 -0.1 -2.4 -1.7 -2.3
Medication: Ibuprofen (e.g. Nurofen) 2.6 3.3 5.9 2.1 -1.8 -1.4 1.0 1.2 2.3 2.4
Medication: Cholesterol lowering 0.4 0.6 1.8 0.1 0.5 1.0 1.0 -0.1 0.1 1.3
Depression (self-reported) 2.3 2.8 6.3 0.5 -2.4 -2.5 -1.0 0.8 1.5 1.8
Medication: Lansoprazole 0.3 0.4 1.2 0.3 -0.0 -0.1 1.1 -0.5 -0.9 -0.5
Prospective memory result 0.5 0.6 1.8 0.6 -0.5 -0.6 0.8 -1.3 -0.6 -0.7
Lung cancer (father) 0.2 0.2 1.2 -1.1 -0.3 -0.1 -0.2 -0.0 -0.1 0.3
Illnesses of mother 0.6 0.8 1.4 -0.3 0.9 1.2 1.2 -0.9 -1.1 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.6 5.0 10.5 3.2 -1.1 -1.0 -0.5 2.7 3.1 2.2
Pulse wave Arterial Stiffness index 0.9 1.1 3.0 -1.0 0.9 1.1 0.5 -0.2 -1.7 -1.1
Impedance of arm (left) 4.5 21.0 46.4 3.7 -5.3 -5.3 1.8 5.3 6.8 0.1
Arm fat mass (right) 2.3 9.6 20.2 -2.3 3.5 3.6 0.1 -4.0 -4.5 0.2
Trunk predicted mass 1.0 5.9 12.0 -1.5 3.3 3.5 -2.0 -2.2 -2.8 -0.2
Standing height 0.8 8.1 20.2 2.5 -2.5 -1.9 -2.6 3.6 4.5 0.6
Length of working week for main job 2.3 2.6 3.9 -1.5 1.8 1.9 1.6 -1.2 -2.0 -0.9
Exposure to tobacco smoke at home 0.3 0.3 0.8 -0.1 0.6 0.5 0.5 -0.9 -0.5 -0.7
Breastfed as a baby 1.5 1.8 3.6 1.0 -1.3 -1.3 0.1 1.8 1.9 1.4
Tense / ‘highly strung’ 9.4 15.5 27.0 4.6 -5.2 -5.1 0.1 2.8 5.1 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 3.7 5.7 9.9 1.9 -3.1 -3.0 -1.0 1.9 3.1 1.8
Hair/balding pattern: Pattern 4 0.2 0.4 1.4 -0.4 0.2 0.7 0.0 0.9 1.2 0.5
Birth weight of first child 1.4 2.6 5.3 1.8 -2.3 -1.7 2.3 0.3 -0.1 -1.3
Peak expiratory flow (PEF) 2.8 6.4 16.6 3.5 -1.6 -1.2 -0.5 3.5 4.1 0.4
Pulse wave reflection index 2.4 2.9 6.1 -1.2 2.5 2.1 -0.4 -1.2 -2.2 -1.5
Ever highly irritable/argumentative for 2 days 1.2 1.4 4.8 2.2 -0.9 -0.5 1.2 0.7 1.5 -0.2
Loud music exposure frequency 0.7 0.8 2.4 -1.0 0.6 1.0 -1.5 0.4 0.5 0.5
Qualifications: O levels/GCSEs or equivalent 2.2 3.6 7.6 1.8 -1.9 -1.7 1.5 2.3 2.8 0.3
Mouth/teeth dental problems: Bleeding gums 2.2 2.8 7.7 -2.1 1.4 0.7 -0.5 -2.8 -2.2 0.4
Blood clot in the leg (DVT) 2.5 3.2 8.0 -0.6 2.6 2.8 -0.8 -1.8 -1.9 0.0
Medication: Paracetamol 2.0 3.2 5.7 2.4 -1.4 -1.0 1.6 2.2 2.0 1.6
Headache pain in last month 2.9 4.9 12.4 3.5 -0.9 -0.9 0.6 2.5 3.2 2.0
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 3.4 1.4 -1.5 -1.8 -1.6 1.5 1.7 -0.8
Glaucoma (self-reported) 1.6 1.9 4.3 0.1 1.9 1.8 -2.1 -0.4 -0.8 -1.0
Gout (self-reported) 0.8 1.1 4.3 0.3 0.5 1.0 -2.1 1.0 0.7 -0.7
Hypothyroidism/myxoedema (self-reported) 6.1 11.8 25.8 3.1 -3.5 -3.2 0.7 4.9 5.1 0.3
Medication: Amlodipine 1.4 1.9 5.2 -2.0 -0.1 0.0 -0.3 -1.1 -2.3 1.8
Medication: Ventolin 100micrograms inhaler 0.6 0.7 1.6 0.1 1.3 1.2 -0.3 -0.9 -0.8 -0.6
Birth weight 0.3 0.6 2.2 0.6 0.5 0.9 -1.5 0.6 0.2 0.1
Chronic bronchitis/emphysema (mother) 0.5 0.6 2.2 0.6 -0.2 -0.1 0.1 1.5 1.0 -0.8
High blood pressure (siblings) 0.3 0.5 1.1 -1.0 -0.1 -0.1 0.4 -1.1 -0.7 0.8
Forced vital capacity (FVC), Best measure 0.4 1.6 4.0 1.6 0.3 -0.1 -0.4 1.4 1.7 2.0
Body fat percentage 0.7 2.6 7.1 -1.0 1.3 1.4 0.6 -2.7 -2.4 0.6
Leg fat percentage (right) 1.0 3.6 9.0 -1.3 1.5 1.7 0.6 -3.0 -2.9 0.3
Arm fat-free mass (right) 1.9 9.8 17.9 -2.2 4.1 4.2 -2.1 -3.3 -3.7 0.6
Exposure to tobacco smoke outside home 0.6 0.8 2.4 -1.0 -0.7 -0.4 -0.3 1.5 0.9 0.8
Comparative body size at age 10 6.5 18.0 37.5 -3.8 4.9 5.0 1.3 -4.7 -6.1 -1.0
Number of full brothers 0.8 1.0 1.9 -0.3 1.2 1.4 0.5 -1.2 -1.4 0.0
Worry too long after embarrassment 13.1 22.0 37.0 4.7 -6.1 -5.9 -0.1 4.6 5.5 2.8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 4.7 0.7 -2.2 -1.9 -0.1 -0.0 0.9 0.9
Wheeze or whistling in the chest in last year 1.9 3.4 4.8 -1.9 2.1 2.1 0.9 -1.7 -2.2 -1.5
Number of children fathered 1.8 2.0 4.3 -2.1 1.2 1.3 -0.2 -0.9 -1.6 -1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.6 0.8 -1.3 -1.2 -0.3 0.7 0.4 -0.1
Age at first live birth 1.7 2.9 5.6 1.9 -2.2 -2.1 0.1 1.4 2.4 0.2
Pulse wave peak to peak time 1.2 1.5 4.5 1.1 -1.0 -1.1 -0.5 0.6 2.1 1.2
Health satisfaction 1.5 1.9 4.0 0.6 1.6 2.0 0.7 -1.9 -1.4 -0.4
Shortness of breath walking on level ground 0.5 0.6 2.2 1.5 0.2 0.3 0.7 0.5 0.5 1.1
Qualifications: College or University degree 0.1 0.2 0.7 0.1 0.2 -0.4 0.1 0.4 0.5 0.8
Eye problems/disorders: None of the above 0.7 0.8 3.4 1.0 -0.3 0.3 0.4 1.8 0.7 0.6
Mouth/teeth dental problems: Loose teeth 1.7 2.1 5.8 -0.5 1.2 1.4 2.1 -0.6 -2.4 -0.3
Emphysema/chronic bronchitis 5.4 6.1 12.5 -1.4 3.5 3.5 2.3 -1.4 -2.9 -0.5
Medication for pain relief, constipation, heartburn 2.2 3.7 7.8 -2.1 1.9 1.8 -1.7 -0.9 -1.7 -2.8
Neck or shoulder pain in last month 1.1 1.6 3.9 1.7 0.5 0.8 0.1 1.5 0.9 2.0
Medication: Blood pressure 3.2 5.7 10.7 -2.8 1.9 2.0 2.5 -2.6 -3.3 1.0
Angina (self-reported) 0.6 0.8 2.4 0.6 0.6 0.7 1.0 -0.9 -1.5 0.4
Migraine (self-reported) 0.9 1.1 4.1 0.4 -1.6 -2.0 0.0 -0.5 0.0 0.5
Medication: Ibuprofen 2.0 2.4 6.6 1.8 -1.6 -1.1 0.8 0.9 1.5 2.6
Medication: Allopurinol 1.2 1.6 3.7 0.3 1.8 1.9 -1.2 0.2 -0.5 -1.6
Medication: Omeprazole 0.2 0.3 1.3 -0.1 0.4 0.4 -1.1 0.0 0.1 -0.5
Medication: Seretide 50 evohaler 1.2 1.4 3.2 -1.4 1.8 1.8 1.1 -0.3 -0.5 0.1
Mean time to correctly identify matches 0.8 1.6 4.6 1.1 -0.9 -1.4 -0.7 -1.3 0.3 2.1
Heart disease (mother) 1.6 2.0 3.4 -0.9 -1.5 -1.6 -0.4 1.3 1.8 -1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.9 3.5 9.8 0.7 -2.2 -1.8 0.9 2.2 3.1 -0.2
Whole body fat mass 1.2 5.1 10.6 -1.3 2.5 2.7 0.1 -3.1 -3.3 0.5
Leg fat mass (right) 2.0 7.8 16.4 -1.9 3.0 3.3 -0.1 -3.8 -4.1 0.3
Arm predicted mass (right) 2.0 10.2 18.8 -2.3 4.2 4.3 -2.0 -3.4 -3.8 0.8
Pulse rate, automated reading 0.2 0.6 3.0 0.0 0.3 0.6 -0.5 0.5 -0.8 -1.7
Alcohol intake frequency. 0.2 0.5 1.2 0.5 -0.3 -0.1 -1.1 0.4 1.0 0.8
Comparative height size at age 10 0.4 2.5 8.0 -0.8 2.0 2.1 -2.8 -0.6 -0.0 0.0
Number of full sisters 1.7 2.1 5.0 -1.7 0.9 1.0 -1.0 -1.9 -2.2 0.4
Suffer from ‘nerves’ 7.3 11.5 25.5 5.0 -3.3 -3.0 -0.9 3.7 4.3 1.7
Overall health rating 3.1 6.6 13.1 -0.7 3.5 3.6 2.3 -2.2 -3.2 0.2
Chest pain or discomfort 0.4 0.5 1.2 -0.0 -0.5 -0.2 0.8 1.0 1.1 0.9
Had major operations 0.5 0.6 1.5 -1.2 -0.0 0.1 0.7 -0.8 -0.2 -1.2
Age at last live birth 2.7 4.0 12.0 1.8 -1.9 -1.9 1.6 1.6 3.5 0.5
Family relationship satisfaction 1.1 1.4 2.8 0.1 -1.5 -1.3 0.2 1.4 1.7 0.9
Leg pain on walking 0.9 1.1 2.6 -1.1 0.7 0.9 -0.7 -1.6 -1.5 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.3 -0.3 0.2 0.2 -1.1 -0.2 0.7 0.7
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.5 1.2 0.1 0.3 -0.9 -0.6 -0.2 0.0
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.5 -0.7 0.6 0.3 0.0 -1.2 -0.7 0.0
Medication: Aspirin 0.8 1.0 2.1 -0.9 0.9 0.5 0.3 -1.4 -1.4 1.1
Supplements: Vitamin C 2.6 3.0 8.8 -1.0 3.0 2.1 0.3 -1.0 -1.7 -1.7
Knee pain experienced in last month 1.1 1.7 3.7 -1.4 1.9 1.8 0.2 -1.4 -1.1 -0.2
Hypertension (Self-reported) 5.1 14.0 32.6 -4.7 3.9 3.4 -0.4 -4.1 -5.7 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.5 -0.0 -0.3 -0.7 -0.6 -0.2 -0.6 -0.1
Illnesses of father: Heart disease 0.1 0.1 0.3 -0.1 -0.1 -0.3 0.6 0.4 -0.4 -0.3
Illnesses of siblings: Diabetes 1.8 2.3 6.5 0.2 1.4 1.3 -0.0 -2.2 -2.5 -1.0
Smoking status: Previous 0.5 0.8 4.8 -0.6 0.3 0.2 2.2 -0.2 0.4 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 5.3 2.3 -0.6 -0.6 -1.8 1.4 1.1 -0.6
Whole body fat-free mass 1.6 9.1 17.7 -2.1 4.0 4.2 -1.7 -3.0 -3.7 -0.0
Leg fat-free mass (right) 2.4 13.0 23.4 -3.1 4.7 4.8 -0.9 -3.8 -4.4 -0.2
Arm fat percentage (left) 1.8 7.3 15.5 -2.1 2.9 2.9 0.9 -3.7 -3.9 0.1
Average weekly red wine intake 0.8 1.2 3.2 -1.8 0.6 -0.2 -0.4 -1.6 -1.1 -0.7
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.1 -0.6 0.9 0.7 -0.1 0.4 -0.4 -1.1
Mood swings 7.3 13.3 30.7 5.5 -3.1 -2.8 -1.2 4.0 4.4 2.7
Loneliness, isolation 1.2 1.6 3.0 1.2 -1.2 -1.4 -0.3 1.4 1.7 1.1
Long-standing illness, disability or infirmity 1.3 1.9 5.2 0.9 1.8 2.3 2.0 -0.0 0.5 -0.3
Ever had bowel cancer screening 1.0 1.2 2.7 0.4 -1.6 -1.7 -1.2 0.6 0.9 0.6
Diabetes diagnosed by doctor 1.3 2.1 6.2 -0.4 1.1 0.9 0.6 -2.1 -2.5 1.2
Ever had stillbirth, spontaneous miscarriage or termination 3.5 3.7 8.1 -1.5 2.1 1.6 1.1 -2.8 -2.5 -1.1
Friendships satisfaction 0.1 0.1 0.3 0.3 0.5 0.5 0.3 0.1 -0.1 -0.5
Qualifications: nursing, teaching 0.6 1.0 1.7 0.3 -1.0 -1.3 1.1 -1.1 0.9 0.9
Commuting to job workplace: Walk 1.0 1.1 2.5 -1.6 -0.2 0.0 1.3 0.6 0.3 1.6
Eye problems/disorders: Cataract 0.7 0.8 2.2 -1.2 -0.5 -0.9 0.9 -1.5 -0.3 -0.5
Mouth/teeth dental problems: Mouth ulcers 2.6 4.2 8.0 2.8 -1.2 -1.4 1.7 2.7 2.8 0.7
Medication for cholesterol 2.1 3.2 6.6 1.2 -2.0 -1.6 2.6 1.2 2.5 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.5 1.6 0.1 1.2 1.2 -0.8 -0.1 0.0 0.3
Back pain experienced in last month 1.3 1.9 4.9 -0.1 1.8 2.2 1.7 1.1 -0.4 0.9
Mineral and other dietary supplements 4.0 5.4 9.9 2.0 -2.1 -1.8 0.9 3.1 3.1 2.5
Breast cancer (self-reported) 0.3 0.3 0.7 -0.5 0.8 0.8 0.7 -0.3 0.1 0.5
Asthma (self-reported) 1.9 3.8 6.5 -1.7 2.4 2.0 -0.1 -2.5 -1.9 -2.1
Osteoporosis (self-reported) 3.0 3.7 7.7 2.4 -1.7 -1.1 -1.7 2.3 2.8 -0.5
Osteoarthritis (self-reported) 0.6 0.8 2.2 -1.0 0.5 1.0 1.5 -0.7 -0.1 0.5
Medication: Aspirin 0.6 0.8 1.7 -0.8 0.7 0.3 0.6 -1.2 -1.3 1.1
Medication: Gliclazide 0.9 1.0 3.1 0.1 -0.2 -0.4 1.8 -0.7 -1.4 1.3
Illnesses of father: None of the above (group 1) 1.9 2.4 5.0 0.3 -2.2 -2.1 -0.3 1.0 2.1 1.2
Smoking status: Current 4.4 7.1 16.8 -1.5 3.4 3.1 -0.5 -3.0 -4.1 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.6 6.4 1.5 -1.5 -1.5 0.1 2.2 2.5 0.5
Whole body water mass 1.6 9.2 17.5 -2.1 4.0 4.2 -1.8 -3.1 -3.7 0.0
Leg predicted mass (right) 2.4 12.9 23.5 -3.1 4.7 4.8 -0.9 -3.8 -4.5 -0.2
Arm fat mass (left) 2.3 9.5 19.0 -2.4 3.6 3.6 -0.1 -4.0 -4.4 0.3
Number of self-reported non-cancer illnesses 0.1 0.1 0.2 -0.2 0.3 0.4 -0.0 -0.1 0.5 0.4
Average weekly champagne plus white wine intake 0.9 1.3 3.9 -2.0 0.1 -0.7 -0.1 -1.6 -1.2 -0.6
Miserableness 8.9 15.3 29.6 5.0 -3.9 -3.8 -1.7 4.0 5.4 2.0
Guilty feelings 7.3 11.0 21.5 3.4 -3.7 -3.6 0.3 4.1 4.6 1.1
Wears glasses or contact lenses 1.0 1.1 2.8 1.3 -1.3 -1.7 -0.2 0.5 1.1 -0.3
Ever taken oral contraceptive pill 1.3 1.4 4.7 2.2 -0.9 -0.6 1.0 1.2 0.6 -1.2
Hearing aid user 1.4 1.6 4.6 1.4 0.1 0.6 2.1 1.1 1.0 1.4
Mother’s age at death 2.7 3.3 10.7 0.5 -3.2 -3.3 -0.2 0.9 1.0 0.8
Financial situation satisfaction 0.4 0.6 2.2 -0.3 -0.1 0.3 -0.6 -0.6 -0.9 1.5
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.5 1.0 -0.1 -0.4 0.3 1.4 1.6 -0.3
Commuting to job workplace: Public transport 1.4 1.7 4.2 0.4 -1.1 -1.4 1.9 0.5 2.0 0.8
Eye problems/disorders: Glaucoma 3.7 4.3 9.1 0.7 3.0 2.8 -0.7 -1.6 -1.8 -2.5
Medication: Blood pressure 5.3 10.1 25.1 -3.1 3.7 2.9 -1.9 -3.1 -5.0 -0.5
Pain type(s) experienced in last month: Hip pain 1.2 1.5 4.6 0.6 1.8 2.1 1.1 0.4 -0.3 0.8
Supplements: Fish oil (including cod liver oil) 2.6 3.5 8.8 -1.4 1.5 1.1 -0.0 -2.9 -3.0 -1.3
High cholesterol (Self-reported) 0.3 0.5 1.6 0.0 1.0 1.3 -0.7 0.1 -0.5 0.7
Medication: Bendroflumethiazide 7.3 11.0 29.3 -2.7 4.0 3.5 0.8 -3.4 -5.4 -0.5
Medication: Paracetamol 2.3 3.6 6.8 2.6 -1.5 -0.9 2.0 2.1 1.6 2.1
Medication: Lisinopril 1.8 2.4 5.7 -2.4 0.7 0.6 1.5 -1.1 -2.2 1.4
Medication: Atorvastatin 0.3 0.3 1.5 -1.2 0.2 0.5 -0.5 -0.2 -0.3 0.1
Illnesses of father: High blood pressure 2.1 2.6 5.5 -1.4 2.3 2.3 0.8 -1.4 -1.5 0.7
Alcohol drinker status: Never 0.5 0.6 1.6 0.3 -0.9 -0.9 -0.9 0.4 1.2 -0.3
Ever smoked 0.7 1.2 3.1 0.6 1.5 1.7 1.8 -0.0 -0.2 0.3
Basal metabolic rate 1.7 9.5 18.0 -2.2 4.0 4.2 -1.5 -3.2 -3.8 -0.1
Leg fat percentage (left) 1.2 4.4 10.5 -1.8 1.7 1.8 0.8 -3.2 -3.2 0.4
Arm fat-free mass (left) 1.6 8.2 14.6 -1.6 3.7 3.8 -2.1 -3.2 -3.5 0.4
Number of operations (self-reported) 2.4 3.6 6.4 -2.4 1.6 1.6 2.5 -1.5 -2.4 0.2
Average weekly beer plus cider intake 6.8 9.8 20.7 3.4 -3.1 -2.5 -0.7 4.5 4.6 -0.6
Irritability 14.0 23.7 45.7 5.7 -5.7 -4.9 -0.3 5.3 6.8 1.9
Risk taking 5.3 7.8 15.4 -3.9 2.9 2.2 -1.1 -3.2 -3.5 -1.4
Ever had prostate specific antigen (PSA) test 0.6 0.6 1.3 -0.9 1.1 1.2 0.8 -0.4 0.1 -0.7
Fractured/broken bones in last 5 years 1.8 2.3 5.5 0.6 -1.6 -0.8 -2.3 2.4 0.2 -1.3
Age started oral contraceptive pill 1.6 2.0 5.0 2.2 -1.4 -1.1 -0.5 1.8 1.6 0.4
Diastolic blood pressure, automated reading 5.1 15.8 40.3 -3.5 4.2 3.9 -0.7 -4.9 -6.3 -0.5
Ever depressed for a whole week 3.3 4.0 8.6 1.4 -2.7 -2.9 -1.3 1.4 2.5 0.6
Unable to work because of sickness or disability 1.5 1.9 5.0 -1.0 1.7 2.0 0.3 -0.4 -2.2 0.6
Commuting to job workplace: Cycle 0.3 0.4 1.0 1.0 0.5 0.2 0.8 -0.6 -0.7 0.3
Myopia 0.7 1.0 2.8 1.7 0.1 0.1 -1.2 1.0 1.3 0.4
Vascular/heart problems diagnosed by doctor 3.5 9.5 20.4 4.2 -3.3 -2.9 -0.2 3.0 4.5 -0.1
Cholesterol lowering medication 0.2 0.3 0.9 0.7 0.1 0.1 -0.9 -0.3 -0.8 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.5 0.0 0.4 0.1 -1.2 -0.4 0.1 -0.8
Pain experienced in last month 0.4 0.7 2.1 -0.5 -0.9 -1.0 -0.3 -0.1 -0.8 -1.4
Supplements: Calcium 0.4 0.4 1.5 0.4 -0.7 -0.6 -1.2 0.4 0.6 0.1
Basal cell carcinoma (self-reported) 0.9 1.1 2.8 -1.7 -0.3 -0.6 -0.6 -1.2 -0.0 -1.6
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.6 -0.1 0.1 0.1 0.8 0.6 0.1 0.2
Deep venous thrombosis (DVT) (self-reported) 3.0 3.9 9.1 -0.6 2.8 3.0 -0.8 -2.0 -2.2 -0.1
Heart disease (siblings) 0.5 0.6 2.6 -1.6 -0.2 -0.3 0.0 0.2 1.1 -0.0
Alcohol drinker status: Previous 0.7 0.8 3.1 0.8 0.3 0.0 -1.1 -0.7 -0.1 -1.8
Pack years of smoking 0.6 0.9 2.0 -1.2 0.8 0.7 -0.4 -1.4 -1.2 -0.0
Impedance of whole body 5.8 29.7 59.5 4.8 -6.6 -6.5 1.1 6.2 7.7 0.4
Leg fat mass (left) 2.1 8.3 17.9 -2.2 3.1 3.3 0.1 -3.9 -4.2 0.4
Arm predicted mass (left) 1.7 8.8 15.2 -2.1 3.7 3.9 -2.2 -3.1 -3.6 0.3