Hub : Genes

MTMR9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1690	0.0610	3.4e-03	0.026	NA	0.013	NA	0.019	3.1e-03	NA	2.9e-02	NA	1.1e-02
2	GTEx	Colon Sigmoid	0.2410	0.0870	5.7e-04	0.175	NA	0.050	NA	0.136	8.7e-07	NA	7.6e-03	NA	1.6e-05
3	GTEx	Colon Transverse	0.2070	0.0820	1.8e-03	0.063	NA	0.007	NA	0.033	5.9e-04	NA	1.5e-01	NA	1.0e-02
4	GTEx	Heart Atrial Appendage	0.3700	0.1130	3.8e-03	-0.006	NA	0.002	NA	0.005	8.5e-01	NA	2.5e-01	NA	1.8e-01
5	GTEx	Lung	0.0739	0.0360	2.3e-03	0.006	NA	-0.002	NA	0.012	9.7e-02	NA	4.8e-01	NA	3.9e-02
6	ROSMAP	Brain Pre-frontal Cortex	0.0716	0.0237	6.6e-09	0.063	0.074	0.082	0.072	0.073	1.4e-08	8.3e-10	9.5e-11	1.3e-09	1.1e-09
7	YFS	Blood	0.0574	0.0155	5.5e-08	0.032	0.027	0.035	0.031	0.041	7.9e-11	2.6e-09	1.1e-11	1.8e-10	1.9e-13

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.5	0.9	2.0	0.3	0.6	0.4	-1.0	-1.0	-1.4	1.2
Bipolar Disorder or Schizophrenia	1.9	4.7	12.2	-1.8	2.2	1.3	0.3	-3.5	-3.3	0.8
Depressed Affect (Nagel 2018)	1.1	2.4	7.6	1.7	-0.9	-1.0	-2.8	0.6	1.4	1.5
Depression (Nagel 2018)	0.3	0.4	1.5	1.2	0.5	-0.1	0.3	-0.9	0.4	0.4
Intelligence (Savage-Jansen 2018)	0.7	2.1	4.6	2.1	0.1	0.2	1.8	1.9	1.7	0.1
Neuroticism (Nagel 2018)	1.8	4.2	9.3	2.1	-2.1	-2.1	-3.0	0.9	1.7	1.7
Schizophrenia (2018)	2.6	5.4	13.3	-2.5	2.4	1.3	0.9	-3.7	-3.1	0.1
Schizophrenia vs Biploar Disorder	1.8	2.4	4.9	-2.2	1.7	1.1	1.0	-2.2	-1.4	0.2
Worry (Nagel 2018)	0.8	1.7	4.8	1.5	-1.8	-2.2	-0.9	-0.5	-0.1	0.6
Alzheimer’s Disease (in mother)	1.0	1.2	1.9	-1.4	-1.0	-1.1	1.4	-0.1	-0.8	-1.2
Alzheimer’s Disease (in father)	0.4	0.5	0.9	0.9	-0.7	-0.8	-0.8	0.8	0.1	-0.1
Alzheimer’s Disease (including proxy)	0.6	0.9	2.6	0.3	-1.6	-1.6	0.3	0.7	-0.2	-0.5
Crohns Disease (2017)	0.7	1.5	5.2	-1.1	0.8	0.5	-0.5	-2.3	-1.6	0.6
Irritable Bowel Disease (IBD)	0.3	0.8	2.7	0.0	0.3	0.0	-1.3	-1.0	-0.3	1.6
Ulcerative Colitis (UC)	0.4	0.8	1.7	1.1	0.1	-0.1	-1.3	0.6	0.6	1.2
Major Depression (MDD)	0.3	0.4	1.0	1.0	-0.0	-0.2	0.2	0.8	0.7	0.8
Reaction Time	0.9	1.8	3.9	1.8	-1.0	-1.6	-0.6	-0.4	1.2	2.0
Verbal and Numeric Reasoning (VNR)	1.2	3.0	8.1	2.8	-0.1	0.1	2.2	2.0	2.0	0.5
Breast Cancer	1.7	4.0	9.0	0.2	2.9	3.0	0.2	-0.8	-2.9	-1.1
Ovarian Cancer	0.9	1.2	1.8	1.3	1.2	1.1	-0.9	1.3	1.0	0.1
Prostate Cancer	3.9	5.4	12.4	-0.7	3.5	3.4	-2.4	-1.2	-2.5	0.7
Age at First Birth	1.2	1.8	8.2	2.9	0.3	0.2	0.1	1.3	1.2	-1.0
Bipolar Disorder (2011)	1.0	1.0	2.9	0.4	0.8	0.6	-0.3	-1.4	-0.8	-1.7
Body Mass Index (BMI) (2010)	1.9	2.6	5.6	1.0	2.2	2.4	0.4	-1.1	-1.9	1.4
Coronary Artery Disease (CAD)	0.6	0.7	2.0	1.0	0.7	0.6	1.4	0.5	0.9	-0.1
Crohns Disease (2012)	1.0	1.6	5.7	0.5	1.2	0.9	1.2	-2.4	-1.1	0.1
Mean Putamen Volume	0.8	1.0	2.6	-1.6	-0.2	-0.6	-0.0	-1.3	-1.4	-0.3
Fasting Glucose	0.7	0.8	1.5	0.5	0.3	0.7	1.0	-1.2	-1.1	-1.1
HbA1C	0.9	1.0	1.8	0.5	1.3	1.2	0.9	-0.8	-0.7	-1.2
HDL Cholesterol	0.3	0.5	1.7	-1.3	-0.4	-0.4	-0.3	1.1	0.4	-0.0
LDL Cholesterol	0.2	0.2	0.7	-0.7	0.2	0.0	-0.8	-0.7	-0.2	-0.2
Lupus	5.5	8.4	16.1	-2.3	2.7	2.3	3.0	-3.7	-4.0	1.2
Neuroticism (2016)	20.8	30.0	49.1	4.5	-6.9	-6.3	-0.1	6.8	7.0	2.5
Primary Biliary Cirrhosis	1.0	1.5	5.0	0.7	1.4	0.9	-0.1	-2.2	-1.1	0.8
Rheumatoid Arthritis	0.8	1.1	2.8	-1.7	-0.4	-0.8	1.5	-0.8	0.7	0.9
Schizophrenia (2014)	2.9	6.5	20.9	-2.1	2.8	1.4	0.7	-4.6	-3.2	-0.3
Triglycerides	3.4	5.6	14.1	3.4	-1.7	-1.2	0.8	2.6	3.8	1.5
Type 2 Diabetes (T2D) (2012)	2.4	2.8	7.0	0.6	2.6	2.5	-0.8	-1.1	-2.0	0.3
Ulcerative Colitis	1.4	2.1	3.8	1.6	-0.9	-1.0	-1.3	1.2	1.8	2.0
Blood Eosinophil Count	0.2	1.6	4.5	1.3	1.9	2.1	0.7	0.4	0.2	-0.5
Blood Platelet Count	0.2	1.8	4.5	-0.5	-1.6	-1.8	-2.1	-0.2	0.8	1.2
Blood Red Count	0.2	1.8	4.9	0.7	1.5	1.5	-2.2	-0.3	0.8	1.3
Blood White Count	0.2	1.3	3.4	1.9	1.0	1.0	-1.4	0.4	-1.3	-0.2
Heel T-Score	0.1	0.5	1.8	0.3	-0.3	-0.7	0.8	-1.3	0.2	0.8
BMI	0.4	2.2	9.8	3.1	-0.7	0.4	0.7	1.1	1.2	1.2
Height	0.1	1.3	4.0	-0.1	1.5	2.0	-1.3	0.4	-0.9	-0.6
Waist Hip Ratio (WHR)	0.4	2.0	5.1	-0.4	-1.4	-1.4	2.0	0.6	0.5	2.3
Systolic Blood Pressure	0.8	4.1	8.1	0.7	-2.8	-2.3	-2.6	1.7	1.2	2.0
Smoking Status	0.1	0.3	1.6	1.3	0.5	0.4	-0.2	0.5	0.3	-0.1
Allergy or Eczema	0.5	1.2	3.2	0.9	-1.4	-1.3	-0.3	0.5	0.9	1.8
Cardiovascular Disease	0.1	0.5	1.2	0.7	-0.3	0.2	-1.0	1.1	-0.1	0.6
Hypothyroidism (self reported)	0.4	1.0	4.2	-2.0	0.6	0.2	0.6	1.1	0.1	-0.8
Respiratory disease	0.1	0.3	0.9	0.6	0.3	0.1	0.1	0.1	0.9	-0.9
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.4	1.1	0.1	0.2	-0.0	-0.7	-1.5	1.5
Lung FEV1/FVC ratio	0.3	1.3	4.1	1.2	-1.1	-0.8	0.4	-1.1	-2.0	0.1
Lung FVC	0.3	1.7	2.9	-0.2	1.7	1.2	1.4	-1.5	-1.0	1.5
Neuroticism	0.9	2.3	5.3	2.0	-1.1	-1.5	-1.7	-0.2	0.1	2.3
Chronotype (morning person)	0.3	0.8	1.3	-1.0	-1.1	-0.3	1.2	1.0	-0.7	0.5
Hair Pigment	0.0	0.3	1.1	0.0	-1.1	-0.9	-0.4	0.2	-0.0	0.2
Tanning	0.0	0.6	1.6	-1.3	0.8	0.8	0.2	0.6	-0.7	-0.2
Hand grip strength (left)	1.0	2.7	6.7	0.4	2.6	2.3	-0.6	-0.2	-1.6	-1.8
Number of treatments/medications taken	0.2	0.3	1.1	-0.3	-0.3	0.0	0.8	-0.3	-1.0	0.4
Average weekly spirits intake	0.9	1.1	1.7	1.2	-0.7	-0.7	-1.3	1.3	1.3	0.4
Sensitivity / hurt feelings	8.4	14.4	28.9	4.5	-3.7	-3.4	-0.7	4.9	5.4	1.7
Frequency of depressed mood in last 2 weeks	2.7	3.8	10.0	3.2	-1.7	-1.7	0.4	1.6	2.8	0.9
Hearing difficulty/problems: Yes	0.7	1.1	5.2	2.3	-1.0	-0.4	-0.9	0.3	0.3	0.3
Relative age of first facial hair	0.3	0.6	3.1	0.8	0.1	-0.1	0.7	-0.4	-0.4	1.7
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.8	-0.0	-0.5	-0.3	1.1	1.3	1.1	0.7
Ever used hormone-replacement therapy (HRT)	0.6	0.8	3.4	0.4	0.4	0.4	-1.9	-0.5	-0.9	-0.5
Ever had hysterectomy (womb removed)	2.6	3.0	10.6	-0.7	1.4	0.8	-0.5	-3.3	-2.6	0.1
Systolic blood pressure, automated reading	3.5	10.1	21.5	-3.9	2.3	1.9	-2.0	-4.6	-4.6	0.2
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.1	0.8	-1.2	-1.5	-0.2	0.1	0.3	1.4
Angina	0.6	0.8	1.8	0.6	0.6	0.8	1.2	-0.8	-1.4	0.5
Medication for hormone replacement therapy	0.2	0.2	0.6	0.2	0.8	0.8	-0.6	-0.1	-0.2	0.1
Vitamin and mineral supplements	1.2	1.7	3.4	0.1	-1.8	-1.1	-0.4	1.4	1.4	1.7
Supplements: Zinc	1.2	1.3	4.0	-1.1	2.0	1.7	-0.7	-0.4	-0.3	-0.3
Medication: Co-codamol	0.3	0.4	1.3	-0.1	-0.5	-0.1	0.6	-0.5	-0.7	1.1
Medication: Metformin	1.7	2.4	6.4	-1.3	1.4	1.2	0.7	-1.7	-2.5	1.6
Diabetes (father)	2.4	3.0	4.9	-1.6	2.1	2.2	-1.1	-1.8	-2.0	-0.4
Diabetes (mother)	0.3	0.4	1.1	-0.2	0.3	0.1	-0.7	-1.0	-0.9	-0.3
Severe depression (siblings)	0.6	0.7	2.4	-1.5	-0.5	-0.5	0.6	-1.2	-0.4	0.4
Pack years adult smoking proportion	1.4	2.1	4.3	-1.4	1.4	1.3	-0.4	-2.1	-2.0	-0.5
Impedance of leg (right)	6.5	31.2	57.1	5.2	-7.1	-6.7	-0.1	6.2	7.6	0.6
Leg fat-free mass (left)	2.3	12.4	23.5	-2.9	4.6	4.9	-1.1	-3.7	-4.3	-0.0
Trunk fat percentage	0.4	1.5	4.8	-0.6	0.8	1.0	0.4	-2.2	-1.7	0.4
Hand grip strength (right)	0.5	1.4	3.4	0.7	1.9	1.6	-0.5	-0.4	-1.2	-1.3
Townsend deprivation index at recruitment	0.3	0.4	1.8	0.6	-0.1	0.0	1.3	0.6	0.6	0.5
Current tobacco smoking	4.2	6.8	16.3	-1.4	3.4	3.2	-0.1	-2.7	-4.0	-0.1
Average weekly fortified wine intake	4.8	5.7	10.5	0.4	-3.1	-3.2	1.8	1.4	3.2	2.0
Maternal smoking around birth	0.5	0.7	1.2	1.0	-0.6	-0.9	-1.1	0.6	0.5	-0.8
Fed-up feelings	6.4	11.6	19.2	4.4	-3.7	-3.4	-2.0	3.9	4.1	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.8	1.9	-0.4	-0.8	0.9	0.4	1.3	1.0
Relative age voice broke	0.2	0.3	1.2	0.5	0.3	0.0	-0.2	-0.5	-0.4	1.1
Taking other prescription medications	0.3	0.5	1.0	0.3	0.5	0.8	-0.6	1.0	0.6	1.0
Age when periods started (menarche)	0.9	2.1	6.0	2.2	-0.2	0.6	0.8	2.4	1.6	-0.3
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.3	1.3	1.5	1.5	0.8	-0.5	-1.0	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	13.0	29.4	62.4	-4.8	6.6	5.7	-0.9	-6.4	-7.9	-1.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.6	-0.9	0.6	0.4	-0.4	-1.3	-1.6	-0.1
Qualifications: CSEs or equivalent	0.1	0.1	0.3	0.3	0.2	0.5	0.2	0.2	0.6	0.5
Serious illness, injury or assault to yourself	1.2	1.5	3.9	2.0	-0.6	-0.2	1.4	1.8	1.0	-0.1
High blood pressure	4.8	13.4	29.5	-4.7	4.0	3.5	-0.3	-3.8	-5.4	-0.5
Hayfever, allergic rhinitis or eczema	0.2	0.3	1.3	0.5	0.1	-0.1	0.2	-1.1	-0.5	0.7
Multivitamins +/- minerals	0.6	0.7	1.9	-0.3	0.9	0.1	0.0	-1.2	-0.9	-1.4
Stomach or abdominal pain in last month	3.2	4.0	8.3	1.4	-2.9	-2.8	0.3	1.1	2.8	0.3
Supplements: Glucosamine	1.3	1.7	7.5	-0.6	0.2	0.1	1.3	-1.4	-0.6	-2.7
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	-0.2	0.1	0.2	-0.5	-0.1	-0.0	0.4
Medication: Atenolol	1.6	2.0	5.4	-0.9	1.4	1.4	0.5	-1.9	-2.3	0.2
Medication: Levothyroxine sodium	4.5	7.7	18.1	3.3	-1.9	-1.6	0.8	4.2	4.1	1.1
Sitting height	0.8	5.7	11.8	-3.4	1.8	1.1	-3.1	-2.9	-2.3	0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.4	0.4	0.5	0.7	0.0	0.3	-0.0	-0.1
High blood pressure (mother)	0.5	0.7	1.4	-0.0	1.0	0.9	-0.4	-1.2	-0.7	0.9
Body mass index (BMI)	4.2	18.0	39.2	-3.3	4.8	4.8	0.1	-5.5	-6.3	-0.1
Impedance of leg (left)	6.5	31.4	55.8	5.1	-7.2	-6.9	0.4	6.2	7.5	0.8
Leg predicted mass (left)	2.3	12.4	23.7	-2.9	4.6	4.9	-1.0	-3.7	-4.3	-0.1
Trunk fat mass	0.8	3.4	7.9	-1.0	1.9	2.1	-0.0	-2.8	-2.6	0.3
Waist circumference	0.4	1.4	3.4	0.2	0.9	1.1	0.4	-1.8	-1.5	1.4
Number of incorrect matches in round	2.3	3.8	8.1	1.8	-2.8	-2.7	-2.1	0.3	1.6	0.6
Past tobacco smoking	1.1	1.9	4.0	1.1	-1.8	-1.7	-2.0	1.1	1.0	0.3
Alcohol usually taken with meals	1.7	2.7	6.9	-1.4	2.6	2.3	0.7	-1.2	-1.7	0.1
Nervous feelings	15.0	28.0	46.4	5.4	-6.6	-6.0	-0.8	5.9	6.8	2.1
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.7	1.3	-1.4	-1.3	0.3	1.1	1.7	0.3
Hearing difficulty/problems with background noise	1.4	2.3	4.2	1.9	-1.7	-1.1	-0.8	0.9	1.5	2.1
Hair/balding pattern: Pattern 2	1.8	2.2	4.0	-0.9	2.0	1.9	1.3	-1.0	-0.8	-1.9
Had menopause	0.8	1.1	2.3	-0.8	1.1	0.5	-0.1	-1.5	-1.3	1.2
Had other major operations	2.3	2.8	6.7	-2.6	1.8	1.6	0.4	-0.8	-2.4	0.1
Forced vital capacity (FVC)	0.6	2.3	6.2	1.8	0.4	0.0	-0.5	2.4	2.5	0.5
Heel bone mineral density (BMD) T-score, automated (right)	13.3	30.6	61.6	-5.2	6.1	5.1	-0.7	-7.6	-7.8	-1.9
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	3.1	1.1	-1.8	-1.7	-0.5	0.2	0.8	1.4
Qualifications: None of the above	0.3	0.6	1.5	-0.8	-1.2	-0.8	1.1	0.4	-0.6	-0.2
Financial difficulties in last 2 years	0.8	1.1	2.4	-1.2	1.5	1.6	-0.3	0.0	-0.8	-1.1
Mouth/teeth dental problems	1.5	2.3	5.2	2.3	-0.4	-0.0	-1.7	1.9	1.3	-1.5
Heart attack	0.2	0.2	1.0	0.1	0.2	0.2	1.0	0.6	0.1	0.0
Allergy	0.8	1.8	4.0	0.3	-1.7	-1.7	0.7	2.0	1.5	0.1
Pain all over the body in last month	0.7	0.7	2.6	-0.8	-0.1	-0.2	0.1	-1.6	-1.3	-0.3
Diabetes (self-reported)	1.4	2.2	3.7	0.4	1.6	1.4	1.0	-1.9	-1.9	1.4
Hayfever/allergic rhinitis (self-reported)	2.3	3.1	6.4	2.5	-1.8	-1.6	0.1	1.4	1.7	2.0
Medication: Ramipril	1.2	1.5	3.7	-1.0	1.9	1.7	0.0	-0.4	-1.6	-0.7
Medication: Simvastatin	0.3	0.4	1.3	1.0	0.1	0.1	-0.0	-0.3	-0.8	1.1
Fluid intelligence score	1.3	2.8	6.9	2.0	-0.2	-0.0	1.1	2.5	2.6	0.9
Illnesses of siblings	0.5	0.6	2.4	0.7	-0.3	-0.2	-0.8	1.5	0.9	-0.2
Neuroticism score	17.7	36.9	61.5	7.5	-7.0	-6.6	-0.5	6.3	7.8	2.9
Weight	1.7	8.2	15.2	-2.0	3.5	3.6	-1.0	-3.6	-3.9	0.1
Impedance of arm (right)	5.2	24.3	46.3	4.1	-6.0	-5.7	1.7	5.9	6.8	-0.2
Arm fat percentage (right)	1.6	6.3	15.2	-1.9	2.5	2.6	0.9	-3.3	-3.9	-0.1
Trunk fat-free mass	1.0	5.9	11.6	-1.5	3.2	3.4	-2.0	-2.2	-2.9	-0.2
Hip circumference	2.0	8.8	16.2	-1.6	3.5	3.6	-1.1	-4.0	-4.0	0.2
Time employed in main current job	3.0	3.4	9.1	1.2	-3.0	-2.9	0.4	1.3	1.7	-0.0
Alcohol intake versus 10 years previously	0.2	0.3	1.0	0.5	0.4	1.0	0.9	-0.3	0.1	-0.1
Father’s age at death	4.1	5.5	13.2	1.6	-3.5	-3.6	-1.3	1.2	2.6	0.5
Worrier / anxious feelings	19.9	37.5	66.4	6.5	-8.2	-7.5	-0.5	5.8	7.6	2.2
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	4.0	1.8	0.3	0.5	-0.1	1.7	2.0	1.0
Falls in the last year	0.2	0.3	0.8	0.3	0.9	0.7	-0.3	-0.3	-0.7	0.3
Hair/balding pattern: Pattern 3	1.9	2.8	5.8	1.4	-2.4	-2.4	-0.9	1.6	1.0	1.5
Number of live births	0.3	0.5	2.0	-0.2	0.3	0.2	-0.7	1.4	0.8	-0.3
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	11.0	3.3	-1.0	-0.9	-0.2	3.1	3.1	1.0
Pulse rate	1.6	2.6	6.2	1.7	-2.5	-2.0	0.7	1.3	1.5	0.9
Happiness	0.1	0.2	0.4	0.4	-0.6	-0.5	0.2	0.4	0.6	-0.0
Noisy workplace	0.8	1.0	3.4	0.7	-1.8	-1.2	-0.1	1.0	0.6	0.2
Qualifications: A levels/AS levels or equivalent	2.5	5.6	8.7	2.3	-1.7	-2.0	2.4	2.7	2.9	2.2
Serious illness, injury or assault of a close relative in last 2 years	3.0	3.5	9.3	1.8	-1.6	-1.2	-0.1	2.7	3.1	-0.7
Mouth/teeth dental problems: Dentures	2.4	4.1	9.7	-3.1	1.3	1.4	0.1	-2.6	-2.6	1.1
Asthma	1.9	3.7	5.6	-1.6	2.3	2.0	-0.1	-2.4	-1.7	-2.3
Medication: Ibuprofen (e.g. Nurofen)	2.6	3.3	5.9	2.1	-1.8	-1.4	1.0	1.2	2.3	2.4
Medication: Cholesterol lowering	0.4	0.6	1.8	0.1	0.5	1.0	1.0	-0.1	0.1	1.3
Depression (self-reported)	2.3	2.8	6.3	0.5	-2.4	-2.5	-1.0	0.8	1.5	1.8
Medication: Lansoprazole	0.3	0.4	1.2	0.3	-0.0	-0.1	1.1	-0.5	-0.9	-0.5
Prospective memory result	0.5	0.6	1.8	0.6	-0.5	-0.6	0.8	-1.3	-0.6	-0.7
Lung cancer (father)	0.2	0.2	1.2	-1.1	-0.3	-0.1	-0.2	-0.0	-0.1	0.3
Illnesses of mother	0.6	0.8	1.4	-0.3	0.9	1.2	1.2	-0.9	-1.1	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.0	10.5	3.2	-1.1	-1.0	-0.5	2.7	3.1	2.2
Pulse wave Arterial Stiffness index	0.9	1.1	3.0	-1.0	0.9	1.1	0.5	-0.2	-1.7	-1.1
Impedance of arm (left)	4.5	21.0	46.4	3.7	-5.3	-5.3	1.8	5.3	6.8	0.1
Arm fat mass (right)	2.3	9.6	20.2	-2.3	3.5	3.6	0.1	-4.0	-4.5	0.2
Trunk predicted mass	1.0	5.9	12.0	-1.5	3.3	3.5	-2.0	-2.2	-2.8	-0.2
Standing height	0.8	8.1	20.2	2.5	-2.5	-1.9	-2.6	3.6	4.5	0.6
Length of working week for main job	2.3	2.6	3.9	-1.5	1.8	1.9	1.6	-1.2	-2.0	-0.9
Exposure to tobacco smoke at home	0.3	0.3	0.8	-0.1	0.6	0.5	0.5	-0.9	-0.5	-0.7
Breastfed as a baby	1.5	1.8	3.6	1.0	-1.3	-1.3	0.1	1.8	1.9	1.4
Tense / ‘highly strung’	9.4	15.5	27.0	4.6	-5.2	-5.1	0.1	2.8	5.1	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	3.7	5.7	9.9	1.9	-3.1	-3.0	-1.0	1.9	3.1	1.8
Hair/balding pattern: Pattern 4	0.2	0.4	1.4	-0.4	0.2	0.7	0.0	0.9	1.2	0.5
Birth weight of first child	1.4	2.6	5.3	1.8	-2.3	-1.7	2.3	0.3	-0.1	-1.3
Peak expiratory flow (PEF)	2.8	6.4	16.6	3.5	-1.6	-1.2	-0.5	3.5	4.1	0.4
Pulse wave reflection index	2.4	2.9	6.1	-1.2	2.5	2.1	-0.4	-1.2	-2.2	-1.5
Ever highly irritable/argumentative for 2 days	1.2	1.4	4.8	2.2	-0.9	-0.5	1.2	0.7	1.5	-0.2
Loud music exposure frequency	0.7	0.8	2.4	-1.0	0.6	1.0	-1.5	0.4	0.5	0.5
Qualifications: O levels/GCSEs or equivalent	2.2	3.6	7.6	1.8	-1.9	-1.7	1.5	2.3	2.8	0.3
Mouth/teeth dental problems: Bleeding gums	2.2	2.8	7.7	-2.1	1.4	0.7	-0.5	-2.8	-2.2	0.4
Blood clot in the leg (DVT)	2.5	3.2	8.0	-0.6	2.6	2.8	-0.8	-1.8	-1.9	0.0
Medication: Paracetamol	2.0	3.2	5.7	2.4	-1.4	-1.0	1.6	2.2	2.0	1.6
Headache pain in last month	2.9	4.9	12.4	3.5	-0.9	-0.9	0.6	2.5	3.2	2.0
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	3.4	1.4	-1.5	-1.8	-1.6	1.5	1.7	-0.8
Glaucoma (self-reported)	1.6	1.9	4.3	0.1	1.9	1.8	-2.1	-0.4	-0.8	-1.0
Gout (self-reported)	0.8	1.1	4.3	0.3	0.5	1.0	-2.1	1.0	0.7	-0.7
Hypothyroidism/myxoedema (self-reported)	6.1	11.8	25.8	3.1	-3.5	-3.2	0.7	4.9	5.1	0.3
Medication: Amlodipine	1.4	1.9	5.2	-2.0	-0.1	0.0	-0.3	-1.1	-2.3	1.8
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.6	0.1	1.3	1.2	-0.3	-0.9	-0.8	-0.6
Birth weight	0.3	0.6	2.2	0.6	0.5	0.9	-1.5	0.6	0.2	0.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.2	0.6	-0.2	-0.1	0.1	1.5	1.0	-0.8
High blood pressure (siblings)	0.3	0.5	1.1	-1.0	-0.1	-0.1	0.4	-1.1	-0.7	0.8
Forced vital capacity (FVC), Best measure	0.4	1.6	4.0	1.6	0.3	-0.1	-0.4	1.4	1.7	2.0
Body fat percentage	0.7	2.6	7.1	-1.0	1.3	1.4	0.6	-2.7	-2.4	0.6
Leg fat percentage (right)	1.0	3.6	9.0	-1.3	1.5	1.7	0.6	-3.0	-2.9	0.3
Arm fat-free mass (right)	1.9	9.8	17.9	-2.2	4.1	4.2	-2.1	-3.3	-3.7	0.6
Exposure to tobacco smoke outside home	0.6	0.8	2.4	-1.0	-0.7	-0.4	-0.3	1.5	0.9	0.8
Comparative body size at age 10	6.5	18.0	37.5	-3.8	4.9	5.0	1.3	-4.7	-6.1	-1.0
Number of full brothers	0.8	1.0	1.9	-0.3	1.2	1.4	0.5	-1.2	-1.4	0.0
Worry too long after embarrassment	13.1	22.0	37.0	4.7	-6.1	-5.9	-0.1	4.6	5.5	2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	4.7	0.7	-2.2	-1.9	-0.1	-0.0	0.9	0.9
Wheeze or whistling in the chest in last year	1.9	3.4	4.8	-1.9	2.1	2.1	0.9	-1.7	-2.2	-1.5
Number of children fathered	1.8	2.0	4.3	-2.1	1.2	1.3	-0.2	-0.9	-1.6	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.6	0.8	-1.3	-1.2	-0.3	0.7	0.4	-0.1
Age at first live birth	1.7	2.9	5.6	1.9	-2.2	-2.1	0.1	1.4	2.4	0.2
Pulse wave peak to peak time	1.2	1.5	4.5	1.1	-1.0	-1.1	-0.5	0.6	2.1	1.2
Health satisfaction	1.5	1.9	4.0	0.6	1.6	2.0	0.7	-1.9	-1.4	-0.4
Shortness of breath walking on level ground	0.5	0.6	2.2	1.5	0.2	0.3	0.7	0.5	0.5	1.1
Qualifications: College or University degree	0.1	0.2	0.7	0.1	0.2	-0.4	0.1	0.4	0.5	0.8
Eye problems/disorders: None of the above	0.7	0.8	3.4	1.0	-0.3	0.3	0.4	1.8	0.7	0.6
Mouth/teeth dental problems: Loose teeth	1.7	2.1	5.8	-0.5	1.2	1.4	2.1	-0.6	-2.4	-0.3
Emphysema/chronic bronchitis	5.4	6.1	12.5	-1.4	3.5	3.5	2.3	-1.4	-2.9	-0.5
Medication for pain relief, constipation, heartburn	2.2	3.7	7.8	-2.1	1.9	1.8	-1.7	-0.9	-1.7	-2.8
Neck or shoulder pain in last month	1.1	1.6	3.9	1.7	0.5	0.8	0.1	1.5	0.9	2.0
Medication: Blood pressure	3.2	5.7	10.7	-2.8	1.9	2.0	2.5	-2.6	-3.3	1.0
Angina (self-reported)	0.6	0.8	2.4	0.6	0.6	0.7	1.0	-0.9	-1.5	0.4
Migraine (self-reported)	0.9	1.1	4.1	0.4	-1.6	-2.0	0.0	-0.5	0.0	0.5
Medication: Ibuprofen	2.0	2.4	6.6	1.8	-1.6	-1.1	0.8	0.9	1.5	2.6
Medication: Allopurinol	1.2	1.6	3.7	0.3	1.8	1.9	-1.2	0.2	-0.5	-1.6
Medication: Omeprazole	0.2	0.3	1.3	-0.1	0.4	0.4	-1.1	0.0	0.1	-0.5
Medication: Seretide 50 evohaler	1.2	1.4	3.2	-1.4	1.8	1.8	1.1	-0.3	-0.5	0.1
Mean time to correctly identify matches	0.8	1.6	4.6	1.1	-0.9	-1.4	-0.7	-1.3	0.3	2.1
Heart disease (mother)	1.6	2.0	3.4	-0.9	-1.5	-1.6	-0.4	1.3	1.8	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.9	3.5	9.8	0.7	-2.2	-1.8	0.9	2.2	3.1	-0.2
Whole body fat mass	1.2	5.1	10.6	-1.3	2.5	2.7	0.1	-3.1	-3.3	0.5
Leg fat mass (right)	2.0	7.8	16.4	-1.9	3.0	3.3	-0.1	-3.8	-4.1	0.3
Arm predicted mass (right)	2.0	10.2	18.8	-2.3	4.2	4.3	-2.0	-3.4	-3.8	0.8
Pulse rate, automated reading	0.2	0.6	3.0	0.0	0.3	0.6	-0.5	0.5	-0.8	-1.7
Alcohol intake frequency.	0.2	0.5	1.2	0.5	-0.3	-0.1	-1.1	0.4	1.0	0.8
Comparative height size at age 10	0.4	2.5	8.0	-0.8	2.0	2.1	-2.8	-0.6	-0.0	0.0
Number of full sisters	1.7	2.1	5.0	-1.7	0.9	1.0	-1.0	-1.9	-2.2	0.4
Suffer from ‘nerves’	7.3	11.5	25.5	5.0	-3.3	-3.0	-0.9	3.7	4.3	1.7
Overall health rating	3.1	6.6	13.1	-0.7	3.5	3.6	2.3	-2.2	-3.2	0.2
Chest pain or discomfort	0.4	0.5	1.2	-0.0	-0.5	-0.2	0.8	1.0	1.1	0.9
Had major operations	0.5	0.6	1.5	-1.2	-0.0	0.1	0.7	-0.8	-0.2	-1.2
Age at last live birth	2.7	4.0	12.0	1.8	-1.9	-1.9	1.6	1.6	3.5	0.5
Family relationship satisfaction	1.1	1.4	2.8	0.1	-1.5	-1.3	0.2	1.4	1.7	0.9
Leg pain on walking	0.9	1.1	2.6	-1.1	0.7	0.9	-0.7	-1.6	-1.5	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.3	-0.3	0.2	0.2	-1.1	-0.2	0.7	0.7
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.5	1.2	0.1	0.3	-0.9	-0.6	-0.2	0.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.5	-0.7	0.6	0.3	0.0	-1.2	-0.7	0.0
Medication: Aspirin	0.8	1.0	2.1	-0.9	0.9	0.5	0.3	-1.4	-1.4	1.1
Supplements: Vitamin C	2.6	3.0	8.8	-1.0	3.0	2.1	0.3	-1.0	-1.7	-1.7
Knee pain experienced in last month	1.1	1.7	3.7	-1.4	1.9	1.8	0.2	-1.4	-1.1	-0.2
Hypertension (Self-reported)	5.1	14.0	32.6	-4.7	3.9	3.4	-0.4	-4.1	-5.7	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	-0.0	-0.3	-0.7	-0.6	-0.2	-0.6	-0.1
Illnesses of father: Heart disease	0.1	0.1	0.3	-0.1	-0.1	-0.3	0.6	0.4	-0.4	-0.3
Illnesses of siblings: Diabetes	1.8	2.3	6.5	0.2	1.4	1.3	-0.0	-2.2	-2.5	-1.0
Smoking status: Previous	0.5	0.8	4.8	-0.6	0.3	0.2	2.2	-0.2	0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	5.3	2.3	-0.6	-0.6	-1.8	1.4	1.1	-0.6
Whole body fat-free mass	1.6	9.1	17.7	-2.1	4.0	4.2	-1.7	-3.0	-3.7	-0.0
Leg fat-free mass (right)	2.4	13.0	23.4	-3.1	4.7	4.8	-0.9	-3.8	-4.4	-0.2
Arm fat percentage (left)	1.8	7.3	15.5	-2.1	2.9	2.9	0.9	-3.7	-3.9	0.1
Average weekly red wine intake	0.8	1.2	3.2	-1.8	0.6	-0.2	-0.4	-1.6	-1.1	-0.7
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.1	-0.6	0.9	0.7	-0.1	0.4	-0.4	-1.1
Mood swings	7.3	13.3	30.7	5.5	-3.1	-2.8	-1.2	4.0	4.4	2.7
Loneliness, isolation	1.2	1.6	3.0	1.2	-1.2	-1.4	-0.3	1.4	1.7	1.1
Long-standing illness, disability or infirmity	1.3	1.9	5.2	0.9	1.8	2.3	2.0	-0.0	0.5	-0.3
Ever had bowel cancer screening	1.0	1.2	2.7	0.4	-1.6	-1.7	-1.2	0.6	0.9	0.6
Diabetes diagnosed by doctor	1.3	2.1	6.2	-0.4	1.1	0.9	0.6	-2.1	-2.5	1.2
Ever had stillbirth, spontaneous miscarriage or termination	3.5	3.7	8.1	-1.5	2.1	1.6	1.1	-2.8	-2.5	-1.1
Friendships satisfaction	0.1	0.1	0.3	0.3	0.5	0.5	0.3	0.1	-0.1	-0.5
Qualifications: nursing, teaching	0.6	1.0	1.7	0.3	-1.0	-1.3	1.1	-1.1	0.9	0.9
Commuting to job workplace: Walk	1.0	1.1	2.5	-1.6	-0.2	0.0	1.3	0.6	0.3	1.6
Eye problems/disorders: Cataract	0.7	0.8	2.2	-1.2	-0.5	-0.9	0.9	-1.5	-0.3	-0.5
Mouth/teeth dental problems: Mouth ulcers	2.6	4.2	8.0	2.8	-1.2	-1.4	1.7	2.7	2.8	0.7
Medication for cholesterol	2.1	3.2	6.6	1.2	-2.0	-1.6	2.6	1.2	2.5	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.6	0.1	1.2	1.2	-0.8	-0.1	0.0	0.3
Back pain experienced in last month	1.3	1.9	4.9	-0.1	1.8	2.2	1.7	1.1	-0.4	0.9
Mineral and other dietary supplements	4.0	5.4	9.9	2.0	-2.1	-1.8	0.9	3.1	3.1	2.5
Breast cancer (self-reported)	0.3	0.3	0.7	-0.5	0.8	0.8	0.7	-0.3	0.1	0.5
Asthma (self-reported)	1.9	3.8	6.5	-1.7	2.4	2.0	-0.1	-2.5	-1.9	-2.1
Osteoporosis (self-reported)	3.0	3.7	7.7	2.4	-1.7	-1.1	-1.7	2.3	2.8	-0.5
Osteoarthritis (self-reported)	0.6	0.8	2.2	-1.0	0.5	1.0	1.5	-0.7	-0.1	0.5
Medication: Aspirin	0.6	0.8	1.7	-0.8	0.7	0.3	0.6	-1.2	-1.3	1.1
Medication: Gliclazide	0.9	1.0	3.1	0.1	-0.2	-0.4	1.8	-0.7	-1.4	1.3
Illnesses of father: None of the above (group 1)	1.9	2.4	5.0	0.3	-2.2	-2.1	-0.3	1.0	2.1	1.2
Smoking status: Current	4.4	7.1	16.8	-1.5	3.4	3.1	-0.5	-3.0	-4.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	6.4	1.5	-1.5	-1.5	0.1	2.2	2.5	0.5
Whole body water mass	1.6	9.2	17.5	-2.1	4.0	4.2	-1.8	-3.1	-3.7	0.0
Leg predicted mass (right)	2.4	12.9	23.5	-3.1	4.7	4.8	-0.9	-3.8	-4.5	-0.2
Arm fat mass (left)	2.3	9.5	19.0	-2.4	3.6	3.6	-0.1	-4.0	-4.4	0.3
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	-0.2	0.3	0.4	-0.0	-0.1	0.5	0.4
Average weekly champagne plus white wine intake	0.9	1.3	3.9	-2.0	0.1	-0.7	-0.1	-1.6	-1.2	-0.6
Miserableness	8.9	15.3	29.6	5.0	-3.9	-3.8	-1.7	4.0	5.4	2.0
Guilty feelings	7.3	11.0	21.5	3.4	-3.7	-3.6	0.3	4.1	4.6	1.1
Wears glasses or contact lenses	1.0	1.1	2.8	1.3	-1.3	-1.7	-0.2	0.5	1.1	-0.3
Ever taken oral contraceptive pill	1.3	1.4	4.7	2.2	-0.9	-0.6	1.0	1.2	0.6	-1.2
Hearing aid user	1.4	1.6	4.6	1.4	0.1	0.6	2.1	1.1	1.0	1.4
Mother’s age at death	2.7	3.3	10.7	0.5	-3.2	-3.3	-0.2	0.9	1.0	0.8
Financial situation satisfaction	0.4	0.6	2.2	-0.3	-0.1	0.3	-0.6	-0.6	-0.9	1.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.5	1.0	-0.1	-0.4	0.3	1.4	1.6	-0.3
Commuting to job workplace: Public transport	1.4	1.7	4.2	0.4	-1.1	-1.4	1.9	0.5	2.0	0.8
Eye problems/disorders: Glaucoma	3.7	4.3	9.1	0.7	3.0	2.8	-0.7	-1.6	-1.8	-2.5
Medication: Blood pressure	5.3	10.1	25.1	-3.1	3.7	2.9	-1.9	-3.1	-5.0	-0.5
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.6	0.6	1.8	2.1	1.1	0.4	-0.3	0.8
Supplements: Fish oil (including cod liver oil)	2.6	3.5	8.8	-1.4	1.5	1.1	-0.0	-2.9	-3.0	-1.3
High cholesterol (Self-reported)	0.3	0.5	1.6	0.0	1.0	1.3	-0.7	0.1	-0.5	0.7
Medication: Bendroflumethiazide	7.3	11.0	29.3	-2.7	4.0	3.5	0.8	-3.4	-5.4	-0.5
Medication: Paracetamol	2.3	3.6	6.8	2.6	-1.5	-0.9	2.0	2.1	1.6	2.1
Medication: Lisinopril	1.8	2.4	5.7	-2.4	0.7	0.6	1.5	-1.1	-2.2	1.4
Medication: Atorvastatin	0.3	0.3	1.5	-1.2	0.2	0.5	-0.5	-0.2	-0.3	0.1
Illnesses of father: High blood pressure	2.1	2.6	5.5	-1.4	2.3	2.3	0.8	-1.4	-1.5	0.7
Alcohol drinker status: Never	0.5	0.6	1.6	0.3	-0.9	-0.9	-0.9	0.4	1.2	-0.3
Ever smoked	0.7	1.2	3.1	0.6	1.5	1.7	1.8	-0.0	-0.2	0.3
Basal metabolic rate	1.7	9.5	18.0	-2.2	4.0	4.2	-1.5	-3.2	-3.8	-0.1
Leg fat percentage (left)	1.2	4.4	10.5	-1.8	1.7	1.8	0.8	-3.2	-3.2	0.4
Arm fat-free mass (left)	1.6	8.2	14.6	-1.6	3.7	3.8	-2.1	-3.2	-3.5	0.4
Number of operations (self-reported)	2.4	3.6	6.4	-2.4	1.6	1.6	2.5	-1.5	-2.4	0.2
Average weekly beer plus cider intake	6.8	9.8	20.7	3.4	-3.1	-2.5	-0.7	4.5	4.6	-0.6
Irritability	14.0	23.7	45.7	5.7	-5.7	-4.9	-0.3	5.3	6.8	1.9
Risk taking	5.3	7.8	15.4	-3.9	2.9	2.2	-1.1	-3.2	-3.5	-1.4
Ever had prostate specific antigen (PSA) test	0.6	0.6	1.3	-0.9	1.1	1.2	0.8	-0.4	0.1	-0.7
Fractured/broken bones in last 5 years	1.8	2.3	5.5	0.6	-1.6	-0.8	-2.3	2.4	0.2	-1.3
Age started oral contraceptive pill	1.6	2.0	5.0	2.2	-1.4	-1.1	-0.5	1.8	1.6	0.4
Diastolic blood pressure, automated reading	5.1	15.8	40.3	-3.5	4.2	3.9	-0.7	-4.9	-6.3	-0.5
Ever depressed for a whole week	3.3	4.0	8.6	1.4	-2.7	-2.9	-1.3	1.4	2.5	0.6
Unable to work because of sickness or disability	1.5	1.9	5.0	-1.0	1.7	2.0	0.3	-0.4	-2.2	0.6
Commuting to job workplace: Cycle	0.3	0.4	1.0	1.0	0.5	0.2	0.8	-0.6	-0.7	0.3
Myopia	0.7	1.0	2.8	1.7	0.1	0.1	-1.2	1.0	1.3	0.4
Vascular/heart problems diagnosed by doctor	3.5	9.5	20.4	4.2	-3.3	-2.9	-0.2	3.0	4.5	-0.1
Cholesterol lowering medication	0.2	0.3	0.9	0.7	0.1	0.1	-0.9	-0.3	-0.8	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.5	0.0	0.4	0.1	-1.2	-0.4	0.1	-0.8
Pain experienced in last month	0.4	0.7	2.1	-0.5	-0.9	-1.0	-0.3	-0.1	-0.8	-1.4
Supplements: Calcium	0.4	0.4	1.5	0.4	-0.7	-0.6	-1.2	0.4	0.6	0.1
Basal cell carcinoma (self-reported)	0.9	1.1	2.8	-1.7	-0.3	-0.6	-0.6	-1.2	-0.0	-1.6
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.6	-0.1	0.1	0.1	0.8	0.6	0.1	0.2
Deep venous thrombosis (DVT) (self-reported)	3.0	3.9	9.1	-0.6	2.8	3.0	-0.8	-2.0	-2.2	-0.1
Heart disease (siblings)	0.5	0.6	2.6	-1.6	-0.2	-0.3	0.0	0.2	1.1	-0.0
Alcohol drinker status: Previous	0.7	0.8	3.1	0.8	0.3	0.0	-1.1	-0.7	-0.1	-1.8
Pack years of smoking	0.6	0.9	2.0	-1.2	0.8	0.7	-0.4	-1.4	-1.2	-0.0
Impedance of whole body	5.8	29.7	59.5	4.8	-6.6	-6.5	1.1	6.2	7.7	0.4
Leg fat mass (left)	2.1	8.3	17.9	-2.2	3.1	3.3	0.1	-3.9	-4.2	0.4
Arm predicted mass (left)	1.7	8.8	15.2	-2.1	3.7	3.9	-2.2	-3.1	-3.6	0.3