Best TWAS P=3.45e-15 · Best GWAS P=3.61e-16 conditioned to 0.0566
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | LSP1 | 0.21 | 0.04 | enet | 28 | 0.06 | 3.4e-05 | 7.8 | 6.2 | 5.0e-10 | 0.68 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Skin Not Sun Exposed Suprapubic | TNNT3 | 0.33 | 0.16 | lasso | 7 | 0.17 | 2.0e-09 | 6.5 | 7.0 | 1.9e-12 | 0.87 | 0.03 | 0.97 | TRUE |
| 3 | YFS | Blood | TNNT3 | 0.02 | 0.02 | lasso | 3 | 0.01 | 1.9e-05 | 6.5 | -5.7 | 8.9e-09 | -0.79 | 0.05 | 0.94 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LSP1 | 0.12 | 0.08 | lasso | 5 | 0.10 | 5.0e-11 | -7.7 | -7.9 | 3.5e-15 | -0.61 | 0.03 | 0.97 | TRUE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LSP1 | 0.06 | 0.04 | enet | 6 | 0.04 | 3.1e-05 | 5.8 | 5.4 | 6.3e-08 | 0.12 | 0.63 | 0.07 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LSP1 | 0.07 | 0.03 | lasso | 4 | 0.03 | 2.4e-04 | 5.9 | -7.4 | 1.1e-13 | -0.35 | 0.08 | 0.35 | FALSE |
| 7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TNNI2 | 0.11 | 0.09 | lasso | 2 | 0.08 | 4.1e-06 | 5.9 | -5.9 | 4.7e-09 | -0.17 | 0.59 | 0.08 | TRUE |