Best TWAS P=3.58e-10 · Best GWAS P=2.63e-11 conditioned to 0.0704
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | GS1-259H13.2 | 0.23 | 0.12 | lasso | 1 | 0.09 | 1.8e-05 | 5.8 | -5.8 | 7.7e-09 | -0.70 | 0.32 | 0.64 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Female) | ATP5J2 | 0.13 | 0.04 | enet | 10 | 0.10 | 5.5e-04 | -4.8 | -5.9 | 3.1e-09 | -0.46 | 0.05 | 0.34 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | CPSF4 | 0.08 | 0.03 | lasso | 4 | 0.03 | 1.8e-03 | 5.7 | 5.8 | 8.5e-09 | 0.72 | 0.20 | 0.52 | FALSE |
| 4 | GTEx | Esophagus Mucosa | GS1-259H13.2 | 0.07 | 0.07 | lasso | 3 | 0.05 | 1.7e-04 | 5.8 | -5.8 | 4.9e-09 | -0.73 | 0.17 | 0.76 | FALSE |
| 5 | GTEx | Lung | ZKSCAN5 | 0.09 | 0.05 | lasso | 2 | 0.03 | 2.7e-03 | 5.7 | -5.4 | 8.0e-08 | -0.70 | 0.25 | 0.44 | FALSE |
| 6 | GTEx | Lung | GS1-259H13.2 | 0.09 | 0.07 | lasso | 4 | 0.05 | 8.4e-05 | 5.8 | -5.8 | 6.1e-09 | -0.70 | 0.28 | 0.66 | FALSE |
| 7 | GTEx | Nerve Tibial | GS1-259H13.2 | 0.15 | 0.10 | lasso | 4 | 0.09 | 3.4e-07 | 5.8 | -5.8 | 7.7e-09 | -0.68 | 0.33 | 0.67 | FALSE |
| 8 | GTEx | Spleen | GIGYF1 | 0.22 | 0.00 | enet | 19 | 0.10 | 1.3e-03 | -3.3 | -5.5 | 2.9e-08 | -0.14 | 0.12 | 0.09 | TRUE |
| 9 | METSIM | Adipose | GS1-259H13.2 | 0.04 | 0.03 | lasso | 3 | 0.02 | 1.4e-03 | 5.9 | -5.8 | 4.8e-09 | -0.69 | 0.20 | 0.77 | TRUE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | ZKSCAN1 | 0.05 | 0.01 | blup | 265 | 0.03 | 6.1e-05 | -3.7 | -5.5 | 5.1e-08 | -0.46 | 0.18 | 0.43 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZKSCAN5 | 0.03 | 0.04 | lasso | 2 | 0.03 | 1.0e-04 | 6.3 | 6.2 | 4.0e-10 | 0.94 | 0.01 | 0.99 | FALSE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZKSCAN5 | 0.03 | 0.03 | enet | 8 | 0.03 | 5.4e-04 | 6.2 | 6.3 | 3.6e-10 | 0.77 | 0.01 | 0.83 | TRUE |