Best TWAS P=8.98e-20 · Best GWAS P=1.69e-17 conditioned to 0.197
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NOV | 0.06 | 0.02 | enet | 8 | 0.05 | 1.5e-06 | -7.1 | -7.4 | 1.1e-13 | 0.76 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Adrenal Gland | DEPTOR | 0.16 | -0.01 | enet | 24 | 0.00 | 3.7e-01 | -4.6 | 7.3 | 2.9e-13 | -0.09 | 0.10 | 0.05 | TRUE |
| 3 | GTEx | Artery Aorta | NOV | 0.12 | 0.05 | enet | 18 | 0.04 | 3.7e-03 | -5.9 | -7.2 | 4.7e-13 | 0.68 | 0.08 | 0.66 | FALSE |
| 4 | GTEx | Artery Tibial | NOV | 0.09 | 0.00 | enet | 33 | 0.00 | 2.7e-01 | -8.1 | -5.5 | 3.7e-08 | 0.50 | 0.02 | 0.94 | FALSE |
| 5 | GTEx | Brain Cerebellar Hemisphere | NOV | 0.37 | 0.10 | enet | 17 | 0.20 | 9.9e-06 | 5.9 | -5.6 | 2.2e-08 | 0.17 | 0.78 | 0.01 | FALSE |
| 6 | GTEx | Brain Cerebellar Hemisphere | DEPTOR | 0.32 | 0.15 | lasso | 8 | 0.29 | 3.4e-08 | 5.7 | -5.7 | 1.2e-08 | 0.12 | 0.61 | 0.02 | FALSE |
| 7 | GTEx | Brain Cerebellum | DEPTOR | 0.24 | 0.22 | lasso | 3 | 0.17 | 7.9e-06 | 5.7 | -5.7 | 1.1e-08 | 0.08 | 0.42 | 0.05 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | NOV | 0.10 | 0.04 | enet | 30 | 0.03 | 3.7e-03 | -8.5 | -9.1 | 9.0e-20 | 0.77 | 0.01 | 0.99 | TRUE |
| 9 | GTEx | Colon Sigmoid | NOV | 0.15 | 0.16 | lasso | 4 | 0.15 | 6.6e-06 | -8.1 | -8.1 | 4.8e-16 | 0.87 | 0.02 | 0.97 | FALSE |
| 10 | GTEx | Colon Sigmoid | DEPTOR | 0.28 | 0.22 | lasso | 4 | 0.23 | 1.7e-08 | 4.9 | 5.2 | 2.2e-07 | -0.08 | 0.92 | 0.00 | FALSE |
| 11 | GTEx | Esophagus Muscularis | NOV | 0.11 | 0.03 | enet | 19 | 0.05 | 3.9e-04 | -8.1 | -5.5 | 3.3e-08 | 0.71 | 0.03 | 0.94 | FALSE |
| 12 | GTEx | Lung | NOV | 0.06 | 0.02 | enet | 23 | 0.03 | 2.5e-03 | -3.9 | -7.6 | 3.2e-14 | 0.67 | 0.17 | 0.52 | FALSE |
| 13 | GTEx | Lung | DEPTOR | 0.16 | 0.12 | enet | 28 | 0.15 | 1.3e-11 | 5.7 | 6.1 | 1.2e-09 | -0.12 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Nerve Tibial | TAF2 | 0.14 | 0.04 | enet | 10 | 0.07 | 1.5e-05 | 3.4 | -6.3 | 3.4e-10 | 0.25 | 0.86 | 0.07 | FALSE |
| 15 | GTEx | Skin Sun Exposed Lower leg | NOV | 0.11 | 0.03 | lasso | 7 | 0.04 | 1.4e-04 | -7.3 | -7.0 | 2.0e-12 | 0.83 | 0.06 | 0.94 | FALSE |
| 16 | NTR | Blood | NOV | 0.02 | 0.01 | bslmm | 481 | 0.01 | 1.7e-04 | -8.4 | -9.1 | 1.1e-19 | 0.68 | 0.02 | 0.98 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | NOV | 0.10 | 0.02 | bslmm | 475 | 0.07 | 5.7e-09 | -7.3 | 5.6 | 2.2e-08 | -0.61 | 0.24 | 0.76 | FALSE |
| 18 | ROSMAP | Brain Pre-frontal Cortex | TNFRSF11B | 0.06 | 0.04 | bslmm | 499 | 0.04 | 2.5e-06 | 5.8 | -5.6 | 1.8e-08 | 0.15 | 0.91 | 0.00 | FALSE |
| 19 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NOV | 0.03 | 0.00 | blup | 42 | 0.01 | 5.3e-02 | -7.3 | -7.9 | 3.2e-15 | 0.85 | 0.03 | 0.70 | FALSE |
| 20 | The Cancer Genome Atlas | Colon Adenocarcinoma | NOV | 0.31 | 0.10 | blup | 42 | 0.10 | 1.2e-06 | -8.0 | -5.7 | 1.4e-08 | 0.69 | 0.03 | 0.96 | FALSE |
| 21 | The Cancer Genome Atlas | Lung Adenocarcinoma | COLEC10 | 0.03 | 0.00 | blup | 72 | 0.01 | 2.3e-02 | 5.2 | 5.7 | 1.2e-08 | -0.16 | 0.02 | 0.28 | FALSE |
| 22 | The Cancer Genome Atlas | Lung Adenocarcinoma | TNFRSF11B | 0.05 | 0.05 | lasso | 3 | 0.04 | 1.4e-05 | 5.9 | 6.3 | 3.7e-10 | -0.14 | 0.01 | 0.99 | FALSE |
| 23 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | COLEC10 | 0.03 | 0.01 | blup | 72 | 0.02 | 1.9e-03 | 5.6 | 7.2 | 6.7e-13 | -0.22 | 0.02 | 0.31 | TRUE |
| 24 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NOV | 0.11 | 0.02 | enet | 15 | 0.05 | 2.9e-03 | -8.0 | -7.6 | 2.7e-14 | 0.74 | 0.02 | 0.54 | TRUE |
| 25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NOV | 0.04 | 0.05 | blup | 42 | 0.05 | 8.7e-06 | -8.4 | -7.1 | 1.2e-12 | 0.85 | 0.01 | 0.99 | FALSE |
| 26 | The Cancer Genome Atlas | Thyroid Carcinoma | TNFRSF11B | 0.06 | 0.05 | lasso | 5 | 0.04 | 2.2e-04 | -4.9 | 5.5 | 4.5e-08 | -0.10 | 0.01 | 0.97 | FALSE |