Best TWAS P=4.93e-09 · Best GWAS P=2.46e-08 conditioned to 0.0746
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Atrial Appendage | MED19 | 0.11 | 0.14 | lasso | 1 | 0.14 | 6.0e-07 | -5.3 | 5.3 | 1.4e-07 | 0.53 | 0.07 | 0.93 | FALSE |
| 2 | GTEx | Pancreas | MED19 | 0.10 | 0.08 | lasso | 3 | 0.02 | 5.0e-02 | -5.2 | 5.2 | 2.0e-07 | 0.49 | 0.08 | 0.46 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | ZDHHC5 | 0.05 | 0.03 | lasso | 8 | 0.02 | 6.2e-03 | -5.0 | -5.8 | 4.9e-09 | -0.75 | 0.08 | 0.90 | TRUE |
| 4 | GTEx | Testis | MED19 | 0.16 | 0.15 | enet | 12 | 0.15 | 3.0e-07 | 5.4 | -5.4 | 6.5e-08 | -0.80 | 0.04 | 0.96 | FALSE |
| 5 | YFS | Blood | ZDHHC5 | 0.06 | 0.07 | enet | 20 | 0.07 | 1.2e-22 | -5.3 | -5.4 | 7.5e-08 | -0.46 | 0.10 | 0.89 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMX2 | 0.01 | 0.01 | enet | 7 | 0.01 | 3.3e-03 | 5.0 | -5.4 | 8.4e-08 | -0.79 | 0.01 | 0.88 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | YPEL4 | 0.02 | 0.03 | lasso | 3 | 0.02 | 5.4e-06 | 5.4 | -5.2 | 2.4e-07 | -0.75 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | YPEL4 | 0.04 | 0.05 | blup | 33 | 0.04 | 2.6e-05 | 4.4 | -5.2 | 1.7e-07 | -0.70 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MED19 | 0.03 | 0.02 | lasso | 1 | 0.01 | 1.8e-02 | -5.3 | 5.3 | 1.4e-07 | 0.53 | 0.01 | 0.64 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMX2 | 0.03 | 0.02 | blup | 29 | 0.02 | 3.7e-03 | 5.0 | -5.7 | 1.5e-08 | -0.77 | 0.02 | 0.88 | FALSE |