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chr1:171,053,153-173,278,365

Best TWAS P=8.43e-26 · Best GWAS P=8.32e-50 conditioned to 2.36e-26

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	PIGC	0.11	0.01	enet	11	0.00	2.8e-01	5.0	5.2	2.2e-07	0.08	0.06	0.03	FALSE
2	GTEx	Artery Tibial	PIGC	0.11	0.00	enet	21	0.01	8.4e-02	-2.0	10.5	8.4e-26	0.27	0.06	0.07	TRUE
3	GTEx	Breast Mammary Tissue (Female)	SUCO	0.33	0.00	lasso	9	0.01	1.8e-01	4.3	-5.7	1.4e-08	-0.01	0.08	0.05	FALSE
4	GTEx	Cells Transformed fibroblasts	PIGC	0.12	0.00	enet	29	0.04	2.7e-04	12.5	-6.6	3.4e-11	-0.40	0.07	0.19	TRUE
5	GTEx	Muscle Skeletal	SUCO	0.09	0.07	lasso	7	0.07	1.0e-07	-5.4	-5.3	1.2e-07	-0.06	0.99	0.00	TRUE
6	GTEx	Nerve Tibial	PIGC	0.10	0.02	enet	10	0.02	1.3e-02	-5.4	8.2	2.8e-16	0.21	0.16	0.04	FALSE
7	GTEx	Pancreas	SUCO	0.17	0.00	enet	15	0.07	5.6e-04	8.1	-5.5	3.9e-08	0.04	0.12	0.06	FALSE
8	GTEx	Skin Sun Exposed Lower leg	PIGC	0.08	0.02	lasso	5	0.02	8.8e-03	7.6	7.2	7.0e-13	-0.04	0.52	0.02	FALSE
9	GTEx	Spleen	PIGC	0.29	0.04	lasso	6	0.07	6.6e-03	4.5	7.5	6.9e-14	0.23	0.06	0.13	FALSE
10	GTEx	Testis	METTL13	0.29	0.05	lasso	10	0.09	9.9e-05	-5.0	9.6	5.7e-22	0.18	0.26	0.03	TRUE
11	GTEx	Whole Blood	PIGC	0.19	0.10	enet	23	0.12	3.2e-11	6.9	6.4	1.3e-10	0.19	1.00	0.00	FALSE
12	The Cancer Genome Atlas	Colon Adenocarcinoma	C1orf105	0.10	0.01	blup	100	0.04	1.8e-03	6.9	8.1	8.2e-16	0.23	0.02	0.78	TRUE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PIGC	0.10	0.01	blup	94	0.05	1.0e-06	-5.4	7.2	4.1e-13	-0.03	0.09	0.30	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	PIGC	0.09	0.00	blup	94	0.04	2.9e-05	-1.6	6.8	9.8e-12	0.05	0.05	0.37	FALSE
15	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PIGC	0.16	0.06	blup	94	0.07	6.9e-04	4.4	-5.7	1.2e-08	0.12	0.07	0.64	TRUE
16	The Cancer Genome Atlas	Thyroid Carcinoma	PIGC	0.09	0.02	blup	94	0.05	5.2e-06	-1.9	7.2	8.1e-13	0.07	0.12	0.42	FALSE