Best TWAS P=1.94e-16 · Best GWAS P=2.16e-17 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | VPS13C | 0.08 | 0.04 | lasso | 2 | 0.02 | 1.3e-02 | -6.6 | 6.7 | 3.0e-11 | -0.69 | 0.25 | 0.47 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | HERC1 | 0.13 | 0.02 | lasso | 4 | 0.02 | 3.5e-02 | 6.0 | 5.7 | 1.1e-08 | 0.01 | 0.18 | 0.50 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | VPS13C | 0.16 | 0.06 | enet | 15 | 0.05 | 9.2e-04 | 7.3 | 6.6 | 4.2e-11 | -0.63 | 0.44 | 0.32 | FALSE |
| 4 | GTEx | Artery Tibial | FBXL22 | 0.05 | 0.03 | lasso | 4 | 0.03 | 1.2e-03 | 6.0 | -5.7 | 1.4e-08 | 0.00 | 0.24 | 0.53 | FALSE |
| 5 | GTEx | Heart Left Ventricle | FBXL22 | 0.07 | 0.08 | lasso | 4 | 0.05 | 8.8e-04 | 5.8 | -5.9 | 4.1e-09 | 0.01 | 0.19 | 0.50 | FALSE |
| 6 | GTEx | Muscle Skeletal | FBXL22 | 0.08 | 0.09 | lasso | 3 | 0.09 | 3.2e-09 | 6.0 | -6.0 | 1.4e-09 | 0.00 | 0.33 | 0.67 | TRUE |
| 7 | GTEx | Skin Sun Exposed Lower leg | VPS13C | 0.09 | 0.09 | lasso | 2 | 0.08 | 1.8e-07 | 7.2 | 7.3 | 2.5e-13 | -0.79 | 0.45 | 0.55 | FALSE |
| 8 | GTEx | Spleen | VPS13C | 0.27 | 0.19 | lasso | 7 | 0.12 | 6.6e-04 | 7.2 | 7.4 | 1.4e-13 | -0.79 | 0.28 | 0.50 | FALSE |
| 9 | GTEx | Testis | RAB8B | 0.19 | 0.03 | lasso | 4 | 0.05 | 2.4e-03 | -4.0 | -5.2 | 2.2e-07 | 0.01 | 0.16 | 0.05 | TRUE |
| 10 | GTEx | Testis | USP3-AS1 | 0.31 | 0.27 | lasso | 4 | 0.30 | 1.3e-13 | 6.2 | -6.1 | 1.2e-09 | 0.01 | 0.24 | 0.76 | FALSE |
| 11 | GTEx | Whole Blood | VPS13C | 0.09 | 0.00 | enet | 35 | 0.00 | 1.9e-01 | -8.3 | 6.9 | 4.9e-12 | -0.60 | 0.06 | 0.83 | FALSE |
| 12 | METSIM | Adipose | HERC1 | 0.07 | 0.06 | lasso | 6 | 0.06 | 7.2e-10 | 6.0 | 6.4 | 1.7e-10 | -0.01 | 0.47 | 0.53 | FALSE |
| 13 | NTR | Blood | USP3 | 0.02 | 0.02 | enet | 4 | 0.02 | 5.4e-07 | 6.8 | 7.0 | 2.1e-12 | -0.01 | 0.15 | 0.85 | TRUE |
| 14 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C2CD4A | 0.03 | 0.01 | blup | 59 | 0.02 | 7.2e-03 | -8.0 | -6.5 | 8.0e-11 | 0.81 | 0.02 | 0.74 | FALSE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HERC1 | 0.03 | 0.01 | blup | 99 | 0.01 | 2.1e-02 | 2.7 | 5.4 | 5.9e-08 | 0.00 | 0.08 | 0.72 | FALSE |
| 16 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C2CD4A | 0.09 | 0.11 | lasso | 1 | 0.08 | 9.4e-04 | -8.2 | -8.2 | 1.9e-16 | 0.96 | 0.02 | 0.83 | TRUE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | VPS13C | 0.07 | 0.03 | enet | 15 | 0.03 | 5.3e-04 | -8.2 | 6.4 | 1.9e-10 | -0.74 | 0.02 | 0.91 | FALSE |