Hub : Genes

RAB8B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.1996	0.0682	0.00130	-0.005	NA	0.003	NA	-0.001	9.9e-01	NA	2.1e-01	NA	3.8e-01
2	GTEx	Testis	0.1890	0.0720	0.00640	0.026	NA	0.022	NA	0.052	2.4e-02	NA	3.6e-02	NA	2.4e-03
3	TCGA	Breast Invasive Carcinoma	0.0283	0.0152	0.00083	0.014	0.015	0.010	NA	0.012	6.7e-04	4.2e-04	2.5e-03	NA	1.1e-03
4	TCGA	Skin Cutaneous Melanoma	0.1540	0.0740	0.00300	0.066	0.060	0.044	NA	0.013	7.8e-03	1.0e-02	2.5e-02	NA	1.4e-01
5	TCGA	Thyroid Carcinoma	0.3610	0.0720	0.00000	0.340	0.288	0.305	NA	0.319	4.1e-34	3.3e-28	4.1e-30	NA	1.2e-31

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.3	2.0	5.2	-1.3	2.3	1.8	0.5	-0.4
Bipolar Disorder or Schizophrenia	3.9	9.6	13.1	-0.2	3.6	3.2	3.4	-3.6
Depressed Affect (Nagel 2018)	0.3	0.6	2.2	-1.5	0.3	0.7	-0.4	0.2
Depression (Nagel 2018)	0.3	0.5	1.0	-0.3	0.7	0.3	0.7	-1.0
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.8	0.9	-0.1	0.1	0.1	0.0
Neuroticism (Nagel 2018)	0.5	1.1	3.1	-1.8	1.3	0.5	-0.5	0.4
Schizophrenia (2018)	4.7	9.8	18.4	0.5	2.7	2.7	4.0	-4.3
Schizophrenia vs Biploar Disorder	0.6	0.8	1.4	0.9	-0.5	-0.1	1.2	-1.2
Worry (Nagel 2018)	0.6	1.2	5.0	-0.1	2.2	0.8	-0.4	0.2
Alzheimer’s Disease (in mother)	0.4	0.5	1.1	-0.9	-0.7	-1.0	-0.3	-0.0
Alzheimer’s Disease (in father)	2.6	2.8	4.4	-1.5	-1.0	-1.9	-2.1	1.7
Alzheimer’s Disease (including proxy)	4.2	6.2	8.3	-1.8	-2.4	-2.9	-2.7	2.4
Crohns Disease (2017)	0.9	2.0	4.8	2.2	0.4	0.9	1.6	-1.2
Irritable Bowel Disease (IBD)	0.3	0.8	1.2	0.9	0.9	0.7	1.1	-0.7
Ulcerative Colitis (UC)	0.1	0.3	0.5	-0.6	0.2	-0.4	-0.5	0.7
Major Depression (MDD)	0.7	0.9	2.2	-0.3	-1.3	-1.5	-0.7	0.4
Reaction Time	1.2	2.3	3.9	1.2	1.5	0.8	2.0	-1.8
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.4	0.2	0.9	1.6	1.2	-0.5
Breast Cancer	0.5	1.2	2.7	0.0	-1.4	-1.6	0.8	-0.8
Ovarian Cancer	1.0	1.4	3.1	0.2	-0.7	-1.1	-1.3	1.8
Prostate Cancer	4.2	5.9	8.8	2.8	0.6	2.7	3.0	-2.2
Age at First Birth	1.3	1.9	3.8	0.2	1.9	1.9	1.3	-0.8
Bipolar Disorder (2011)	2.6	2.5	6.3	-0.7	2.5	1.4	1.0	-1.7
Body Mass Index (BMI) (2010)	1.0	1.4	2.6	1.1	0.8	0.5	1.5	-1.6
Coronary Artery Disease (CAD)	0.3	0.4	1.3	0.1	0.3	0.6	1.1	-0.3
Crohns Disease (2012)	1.9	3.1	4.5	2.1	1.1	1.5	1.9	-2.0
Mean Putamen Volume	0.8	1.0	1.5	-1.2	0.7	0.6	-1.2	1.0
Fasting Glucose	1.2	1.5	2.5	1.1	0.9	1.6	1.0	-1.3
HbA1C	0.5	0.6	2.0	-1.4	-0.7	-0.3	0.2	-0.5
HDL Cholesterol	4.2	7.0	13.0	-1.5	-2.0	-1.9	-3.6	3.5
LDL Cholesterol	0.1	0.2	0.3	0.5	0.0	0.4	0.6	-0.4
Lupus	2.4	3.6	7.0	1.1	-1.9	-1.1	-2.2	2.6
Neuroticism (2016)	0.2	0.2	1.1	-0.2	-0.1	0.2	-0.3	1.0
Primary Biliary Cirrhosis	0.6	0.9	1.8	0.8	0.3	0.1	1.3	-1.4
Rheumatoid Arthritis	1.5	2.1	3.2	-1.8	-1.1	-1.4	-1.6	1.3
Schizophrenia (2014)	3.9	8.5	12.3	-0.1	3.3	3.0	3.3	-3.5
Triglycerides	1.8	2.9	4.4	1.1	1.4	1.5	2.1	-2.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	-0.5	0.1	-0.0	0.5	-0.4
Ulcerative Colitis	0.3	0.4	1.0	-0.6	1.0	0.5	0.4	-0.2
Blood Eosinophil Count	0.8	6.2	11.8	0.2	2.4	2.7	3.4	-2.5
Blood Platelet Count	2.8	32.9	45.6	-5.7	-4.3	-5.6	-6.8	6.0
Blood Red Count	0.4	3.4	7.4	-0.6	-2.7	-2.5	0.6	-1.7
Blood White Count	0.5	3.7	11.8	-0.9	0.1	-0.2	2.4	-3.4
Heel T-Score	0.9	7.3	15.1	3.9	2.3	1.6	2.4	-2.8
BMI	0.3	1.6	6.2	-2.5	-0.4	-0.2	0.9	-0.8
Height	0.2	3.5	9.1	-1.4	-3.0	-2.3	-1.0	0.5
Waist Hip Ratio (WHR)	1.6	7.0	8.5	-2.4	-2.7	-2.9	-2.6	2.6
Systolic Blood Pressure	1.5	7.5	12.0	3.5	1.3	2.5	3.1	-2.9
Smoking Status	0.8	2.0	5.8	-1.2	-1.1	-2.4	-1.2	0.1
Allergy or Eczema	0.5	1.2	1.5	-0.7	-1.2	-1.2	-1.1	1.1
Cardiovascular Disease	0.2	0.5	1.6	1.3	0.5	-0.1	0.5	-0.7
Hypothyroidism (self reported)	3.1	7.0	18.1	0.5	2.0	1.4	3.3	-4.2
Respiratory disease	0.5	1.1	2.7	-1.6	0.5	0.8	-0.6	1.4
Type 2 Diabetes (T2D) (2018)	1.6	3.1	9.7	-0.8	-3.1	-2.1	-0.5	0.3
Lung FEV1/FVC ratio	0.6	3.1	9.1	0.1	0.8	-0.5	2.3	-3.0
Lung FVC	0.9	4.8	9.2	1.9	3.0	1.1	2.1	-2.4
Neuroticism	0.3	0.7	1.4	-1.0	1.2	0.7	-0.3	0.5
Chronotype (morning person)	0.1	0.3	0.9	-0.3	0.1	-0.2	-1.0	0.7
Hair Pigment	0.0	1.3	3.5	1.3	-1.1	-1.9	-0.2	-0.3
Tanning	0.1	1.3	2.4	-0.6	-0.9	-1.0	-1.4	1.6
Hand grip strength (left)	0.2	0.6	1.5	0.7	-0.7	-1.2	0.3	-0.8
Number of treatments/medications taken	0.2	0.3	0.7	0.5	0.4	0.8	-0.3	0.8
Average weekly spirits intake	2.8	3.5	7.1	-1.7	-2.7	-1.5	-1.4	1.7
Sensitivity / hurt feelings	0.7	1.2	3.5	-1.9	0.1	-0.6	-1.2	0.7
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.7	-1.0	0.4	-0.0	1.0	-1.3
Hearing difficulty/problems: Yes	2.6	4.0	7.5	-0.6	-1.7	-1.6	-2.7	2.5
Relative age of first facial hair	1.8	3.7	10.2	-1.0	-2.2	-3.2	-1.4	0.7
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	4.0	0.8	0.9	2.0	0.1	1.0
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.3	-0.4	-0.1	0.4	-0.3
Ever had hysterectomy (womb removed)	0.4	0.5	1.5	-0.5	-1.2	-0.7	-0.1	0.1
Systolic blood pressure, automated reading	2.7	7.7	12.6	2.1	2.1	3.5	3.1	-2.8
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.5	-0.5	-1.2	-0.1	1.0	-0.8
Angina	0.5	0.7	1.4	1.2	-0.2	0.3	-0.8	1.1
Medication for hormone replacement therapy	0.6	0.7	2.2	-1.5	-1.0	-0.3	0.3	0.1
Vitamin and mineral supplements	1.9	2.6	5.8	-1.1	1.3	0.7	1.9	-2.4
Supplements: Zinc	0.8	0.9	1.8	-1.0	0.9	-0.2	-0.8	1.3
Medication: Co-codamol	0.7	0.8	1.4	-1.2	0.0	0.9	1.0	-0.9
Medication: Metformin	2.8	4.0	10.1	-1.5	-3.2	-2.3	-1.2	0.9
Diabetes (father)	1.8	2.2	3.9	-1.7	-2.0	-1.9	-0.6	0.4
Diabetes (mother)	0.1	0.2	0.5	0.4	-0.4	0.2	0.7	-0.1
Severe depression (siblings)	1.1	1.3	2.7	-1.6	0.6	-0.1	-1.6	0.9
Pack years adult smoking proportion	0.9	1.4	4.4	0.3	0.8	2.1	1.3	-0.6
Impedance of leg (right)	1.0	4.7	12.0	-0.3	-3.5	-2.1	-2.2	1.4
Leg fat-free mass (left)	0.2	1.0	2.6	-1.6	0.0	0.0	1.2	-0.9
Trunk fat percentage	0.8	3.0	6.1	-2.1	-0.7	0.9	2.5	-1.9
Hand grip strength (right)	0.2	0.7	2.1	0.3	-0.1	-0.5	0.9	-1.5
Townsend deprivation index at recruitment	0.8	1.1	2.6	-0.5	-0.9	-0.1	-1.4	1.6
Current tobacco smoking	0.6	1.0	1.7	-1.3	-0.8	-1.1	-0.9	0.7
Average weekly fortified wine intake	0.2	0.3	0.6	0.8	0.3	0.5	0.3	-0.5
Maternal smoking around birth	4.9	7.1	13.3	-3.6	-3.0	-1.4	-2.2	2.5
Fed-up feelings	0.7	1.3	3.5	-1.7	-1.9	-0.3	-0.2	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	1.7	-0.5	0.6	1.3	1.2	-1.1
Relative age voice broke	1.5	2.2	4.8	-1.6	-1.5	-2.2	-0.9	0.7
Taking other prescription medications	0.5	0.7	1.8	-0.5	1.3	1.2	0.3	0.4
Age when periods started (menarche)	0.3	0.6	1.0	-0.8	-0.5	-1.0	-0.6	0.9
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.5	0.7	-0.4	-0.1	0.2	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	5.2	2.0	2.3	1.8	1.3	-1.7
Tinnitus: Yes, but not now, but have in the past	2.2	2.4	3.6	1.4	1.3	1.3	1.7	-1.9
Qualifications: CSEs or equivalent	0.8	1.0	4.1	-2.0	-0.6	-0.7	-0.4	0.4
Serious illness, injury or assault to yourself	1.9	2.3	3.5	0.9	1.2	1.9	1.7	-1.7
High blood pressure	0.0	0.1	0.3	0.6	-0.2	-0.3	0.2	-0.1
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.1	0.2	0.4	-0.2	0.2	0.0
Multivitamins +/- minerals	3.2	4.0	7.0	0.2	-2.6	-1.0	-2.3	2.6
Stomach or abdominal pain in last month	1.7	2.1	4.2	2.1	1.7	1.3	1.0	-0.7
Supplements: Glucosamine	2.4	3.1	7.8	0.6	-0.2	-0.9	-2.5	2.8
Diverticular disease/diverticulitis (self-reported)	3.2	3.8	7.3	2.5	2.7	2.0	1.0	-0.9
Medication: Atenolol	0.5	0.6	1.5	1.2	0.5	0.0	-0.8	0.9
Medication: Levothyroxine sodium	1.7	2.8	5.6	1.8	1.4	0.8	1.6	-2.4
Sitting height	1.5	10.4	26.8	-2.4	-5.2	-4.2	-1.1	0.7
Chronic bronchitis/emphysema (father)	1.4	1.7	2.4	0.5	1.4	1.4	-1.3	1.6
High blood pressure (mother)	0.2	0.3	1.0	1.0	0.3	-0.6	-0.5	-0.0
Body mass index (BMI)	0.5	2.1	4.7	-1.3	0.4	0.9	2.2	-1.8
Impedance of leg (left)	0.6	3.1	10.0	-0.3	-3.2	-1.7	-1.4	0.8
Leg predicted mass (left)	0.2	1.0	2.4	-1.6	0.1	0.1	1.2	-0.9
Trunk fat mass	0.6	2.6	5.3	-2.3	-1.0	0.1	2.0	-1.6
Waist circumference	0.6	2.1	3.8	-1.8	-0.6	0.4	1.9	-1.7
Number of incorrect matches in round	1.3	2.1	4.4	-0.1	-1.2	-1.1	-1.9	2.1
Past tobacco smoking	0.6	1.0	3.1	0.3	0.9	1.8	1.1	-0.2
Alcohol usually taken with meals	0.1	0.1	0.3	0.5	0.4	0.1	-0.1	0.5
Nervous feelings	1.1	2.0	3.4	0.7	1.5	1.0	1.9	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.4	-1.5	-0.5	0.1	-0.1	0.1
Hearing difficulty/problems with background noise	0.2	0.3	1.1	-0.2	-0.4	-1.0	0.1	-0.3
Hair/balding pattern: Pattern 2	1.1	1.4	2.7	-0.9	-1.6	-1.5	-1.0	0.7
Had menopause	1.0	1.3	3.2	1.8	0.5	1.6	0.0	0.6
Had other major operations	1.3	1.6	5.9	2.4	0.6	0.4	-0.3	1.2
Forced vital capacity (FVC)	0.4	1.5	4.0	0.0	-1.4	-2.0	-0.9	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.6	1.0	1.6	1.0	0.6	-0.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.9	-1.4	-0.6	-0.3	-1.0	0.5
Qualifications: None of the above	0.1	0.3	0.9	-0.7	0.3	-0.2	-0.9	0.1
Financial difficulties in last 2 years	1.1	1.5	6.2	-2.5	-0.5	-0.9	-0.5	0.1
Mouth/teeth dental problems	1.8	2.7	5.1	0.9	1.7	1.1	2.3	-1.9
Heart attack	0.3	0.4	0.8	0.7	-0.9	0.6	0.5	-0.2
Allergy	0.0	0.1	0.2	0.0	-0.3	-0.5	-0.2	-0.3
Pain all over the body in last month	0.3	0.3	0.5	-0.6	-0.4	0.7	0.5	-0.4
Diabetes (self-reported)	1.2	1.8	5.5	-1.1	-2.4	-1.5	0.1	-0.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.6	-1.3	-1.2	0.2	0.3	0.4
Medication: Ramipril	0.3	0.4	1.4	-0.5	-0.5	0.1	1.2	-0.2
Medication: Simvastatin	0.3	0.5	0.9	0.7	-0.9	-0.6	0.6	-0.4
Fluid intelligence score	0.1	0.3	0.9	-0.0	0.6	0.9	0.3	-0.2
Illnesses of siblings	0.6	0.8	2.2	-1.5	0.4	0.4	-0.9	0.8
Neuroticism score	0.6	1.2	5.1	-2.3	0.6	0.6	0.0	0.3
Weight	0.4	2.0	4.1	-2.0	-0.8	-0.2	1.7	-1.5
Impedance of arm (right)	0.1	0.6	1.6	-0.3	-1.3	0.2	-0.6	0.9
Arm fat percentage (right)	0.7	2.6	5.4	-2.0	-0.1	0.8	2.3	-1.8
Trunk fat-free mass	0.3	1.5	3.3	-1.6	-1.2	-1.8	-0.4	0.2
Hip circumference	0.9	3.8	8.0	-0.9	0.6	2.0	2.8	-2.4
Time employed in main current job	0.8	1.0	1.7	-0.8	0.8	1.0	1.3	-1.0
Alcohol intake versus 10 years previously	0.8	1.2	2.1	1.1	-1.0	0.1	-1.3	1.4
Father’s age at death	0.1	0.2	0.4	0.3	-0.4	0.6	0.0	0.6
Worrier / anxious feelings	0.5	1.0	4.3	-0.3	2.1	0.7	0.5	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	4.5	0.4	0.3	0.8	2.1	-1.9
Falls in the last year	0.5	0.7	1.2	-1.1	0.7	0.2	0.9	-0.9
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	-0.4	0.5	-0.1	-0.0	-0.2
Number of live births	0.6	0.9	2.3	-1.5	-0.5	-0.8	-0.0	-1.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.8	0.1	-0.9	-1.7	-0.2	0.0
Pulse rate	1.0	1.8	4.4	-1.2	-0.5	0.2	-1.7	2.1
Happiness	3.2	3.9	6.1	0.2	2.2	1.6	2.4	-2.5
Noisy workplace	1.5	1.8	3.2	-0.3	-1.7	-0.7	-1.5	1.8
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.8	-1.8	-0.4	-0.6	-1.2	2.0
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	3.0	-0.5	1.5	1.7	1.0	-1.4
Mouth/teeth dental problems: Dentures	10.8	18.2	39.0	-1.5	-3.4	-3.8	-6.2	4.9
Asthma	0.5	1.0	2.0	-1.4	0.5	1.4	0.1	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.5	-0.5	-0.1	0.0	-0.4	0.7
Medication: Cholesterol lowering	1.1	1.7	3.6	0.7	-1.9	-1.1	-1.2	1.3
Depression (self-reported)	0.8	0.9	3.0	-1.0	-0.3	-1.7	-0.8	0.3
Medication: Lansoprazole	0.6	0.7	1.7	-0.5	-1.0	-1.3	-0.7	0.3
Prospective memory result	0.4	0.5	0.9	0.9	0.3	0.6	-0.9	0.5
Lung cancer (father)	1.4	1.6	3.6	1.4	-1.9	-1.4	-0.7	0.4
Illnesses of mother	0.1	0.1	0.4	-0.4	-0.2	0.6	0.4	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	1.9	-0.8	-0.3	-1.4	0.8	-0.8
Pulse wave Arterial Stiffness index	0.7	0.8	1.5	-1.0	0.3	1.2	0.8	-0.9
Impedance of arm (left)	0.0	0.2	0.6	-0.3	-0.8	0.3	-0.0	0.4
Arm fat mass (right)	0.5	2.2	4.1	-2.0	-0.6	0.1	2.0	-1.6
Trunk predicted mass	0.2	1.4	3.1	-1.5	-1.1	-1.8	-0.4	0.1
Standing height	0.4	3.5	7.1	-2.0	-2.7	-2.4	-0.7	0.5
Length of working week for main job	0.8	0.9	1.7	-1.1	-1.2	-1.3	-0.4	0.0
Exposure to tobacco smoke at home	0.9	1.1	2.8	-0.4	-0.5	-0.2	-1.7	1.4
Breastfed as a baby	3.1	3.8	6.3	2.5	1.6	1.8	2.1	-1.5
Tense / ‘highly strung’	0.7	1.1	2.2	-1.2	1.5	1.2	0.5	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.6	-0.5	0.2	0.3	-1.2	1.3
Hair/balding pattern: Pattern 4	1.7	4.0	5.3	2.3	2.0	2.3	1.9	-1.4
Birth weight of first child	0.5	0.9	2.0	-1.4	0.6	0.9	-0.8	0.9
Peak expiratory flow (PEF)	0.1	0.1	0.3	0.0	0.1	-0.5	0.3	-0.6
Pulse wave reflection index	1.4	1.7	3.1	1.0	0.9	1.0	1.8	-1.7
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.3	0.6	0.5	0.5	-0.6	0.5
Loud music exposure frequency	0.7	0.8	2.1	-0.2	-0.7	-1.4	0.6	-1.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.1	-1.0	-1.1	-1.8	-0.8	0.7
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	4.8	0.9	-0.3	1.5	2.2	-1.8
Blood clot in the leg (DVT)	0.5	0.6	2.1	-0.6	0.2	1.5	-0.2	0.6
Medication: Paracetamol	1.3	2.1	5.9	0.7	1.6	2.4	0.6	-1.1
Headache pain in last month	0.2	0.4	1.4	-0.6	0.1	0.0	0.2	-1.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.1	-0.7	0.7	0.5	0.9	-1.1
Glaucoma (self-reported)	1.5	1.7	4.6	-0.5	-0.7	-0.7	-1.7	2.1
Gout (self-reported)	1.3	1.8	3.3	-0.5	0.5	1.8	1.6	-1.6
Hypothyroidism/myxoedema (self-reported)	3.1	6.1	11.3	1.5	2.6	1.8	2.7	-3.4
Medication: Amlodipine	1.3	1.9	3.8	1.1	0.8	1.0	1.9	-1.7
Medication: Ventolin 100micrograms inhaler	2.0	2.5	5.4	-1.8	-0.4	-0.5	-1.9	2.3
Birth weight	0.1	0.1	0.4	-0.0	0.2	0.3	0.7	-0.1
Chronic bronchitis/emphysema (mother)	1.1	1.3	5.3	-2.3	-0.1	0.3	-0.3	1.0
High blood pressure (siblings)	0.0	0.1	0.2	0.3	0.2	-0.4	-0.2	0.1
Forced vital capacity (FVC), Best measure	0.1	0.3	0.7	-0.3	0.0	-0.8	0.6	-0.5
Body fat percentage	0.7	2.7	5.5	-1.9	-0.7	0.7	2.3	-1.9
Leg fat percentage (right)	0.4	1.3	2.4	-1.5	-1.4	-0.2	1.0	-1.0
Arm fat-free mass (right)	0.2	1.1	2.7	-1.6	-0.6	-0.8	0.7	-1.1
Exposure to tobacco smoke outside home	1.4	1.9	6.1	-2.5	-1.0	-1.5	-0.5	0.2
Comparative body size at age 10	0.5	1.3	2.4	1.4	1.3	1.5	0.0	0.6
Number of full brothers	0.3	0.4	1.2	1.1	-0.2	0.3	0.7	-0.4
Worry too long after embarrassment	1.2	2.0	3.0	-1.7	1.5	1.0	1.6	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.5	-1.0	0.6	0.2	-1.2	1.1
Wheeze or whistling in the chest in last year	0.5	0.9	2.4	-1.6	-0.3	0.3	-0.3	1.3
Number of children fathered	1.9	2.2	6.9	0.6	-0.8	-0.6	-1.7	2.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.0	1.0	-0.0	-0.2	0.3	-0.3
Age at first live birth	0.3	0.6	1.4	-0.4	1.0	-0.3	-0.5	1.2
Pulse wave peak to peak time	0.7	0.9	1.6	1.0	-0.3	-1.3	-0.9	0.9
Health satisfaction	1.0	1.3	3.2	-0.0	1.2	1.8	1.0	-0.8
Shortness of breath walking on level ground	1.2	1.4	2.5	0.2	1.4	1.6	1.1	-1.1
Qualifications: College or University degree	0.1	0.2	0.3	0.1	0.5	0.3	0.5	0.4
Eye problems/disorders: None of the above	2.3	2.7	5.9	-2.4	-1.8	-2.0	-0.7	-0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.9	-0.5	-0.4	-0.9	-0.1	0.3
Emphysema/chronic bronchitis	0.4	0.5	1.1	-1.0	0.3	0.6	-0.5	0.8
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	-0.3	-0.0	-0.7	0.5	-0.4
Neck or shoulder pain in last month	0.8	1.2	3.4	-0.6	1.3	1.9	0.4	-0.6
Medication: Blood pressure	0.0	0.1	0.1	0.3	-0.3	0.3	-0.2	0.2
Angina (self-reported)	0.5	0.7	1.5	0.9	-0.3	0.3	-0.9	1.2
Migraine (self-reported)	0.8	1.0	1.3	0.2	-1.1	-1.1	-1.1	1.2
Medication: Ibuprofen	0.1	0.1	0.1	-0.4	0.3	0.3	-0.1	0.3
Medication: Allopurinol	1.2	1.6	6.8	-2.6	0.5	0.8	0.3	-0.3
Medication: Omeprazole	0.8	0.9	1.9	-0.7	0.7	0.2	1.3	-1.4
Medication: Seretide 50 evohaler	3.2	3.7	8.2	-2.0	-1.0	-0.8	-2.2	2.9
Mean time to correctly identify matches	2.8	5.2	7.7	1.8	2.1	2.1	2.8	-2.5
Heart disease (mother)	0.1	0.1	0.2	0.5	-0.0	0.5	-0.2	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.4	0.4	-0.1	0.6	0.1	0.0
Whole body fat mass	0.6	2.5	4.3	-2.0	-1.0	0.2	2.1	-1.8
Leg fat mass (right)	0.4	1.7	3.9	-2.0	-1.4	-0.1	1.3	-1.1
Arm predicted mass (right)	0.2	1.1	2.6	-1.6	-0.8	-1.2	0.5	-0.6
Pulse rate, automated reading	2.8	9.2	19.0	-1.6	-2.3	-2.0	-3.9	4.4
Alcohol intake frequency.	0.5	1.2	1.8	1.4	1.3	1.1	0.5	-0.9
Comparative height size at age 10	0.2	1.3	1.9	-0.9	-1.4	-0.8	-1.1	1.4
Number of full sisters	0.2	0.3	0.6	0.8	-0.3	-0.0	-0.7	0.4
Suffer from ‘nerves’	0.3	0.5	0.8	-0.9	0.8	0.7	0.5	-0.6
Overall health rating	3.0	6.5	10.0	0.2	1.8	3.1	3.1	-3.2
Chest pain or discomfort	0.2	0.3	1.4	-0.2	-0.2	1.2	-0.1	-0.1
Had major operations	0.5	0.6	2.5	-1.6	0.0	0.2	-0.2	0.5
Age at last live birth	0.1	0.1	0.2	0.0	0.4	0.2	0.4	-0.1
Family relationship satisfaction	2.1	2.6	6.1	0.8	1.2	2.5	1.7	-1.4
Leg pain on walking	2.3	2.9	4.7	0.1	1.2	2.0	2.2	-2.1
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.0	4.8	-1.5	-2.2	-1.9	-1.6	1.3
Commuting to job workplace: Car/motor vehicle	1.0	1.1	3.0	-0.9	0.0	-0.4	1.2	-1.7
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	4.9	2.2	-0.5	-0.4	-0.0	0.8
Medication: Aspirin	0.5	0.6	2.0	1.4	-0.9	-0.1	-0.3	0.5
Supplements: Vitamin C	1.9	2.3	5.7	2.4	0.2	-0.1	-1.8	1.6
Knee pain experienced in last month	0.4	0.7	2.8	-1.7	0.5	0.2	0.2	-0.5
Hypertension (Self-reported)	0.0	0.1	0.4	0.6	0.3	0.3	0.3	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	6.1	-2.5	-0.2	-0.5	-0.0	-0.5
Illnesses of father: Heart disease	1.4	1.9	3.8	1.8	0.6	0.0	2.0	-1.5
Illnesses of siblings: Diabetes	0.7	0.9	3.3	-0.3	-1.8	-0.6	0.6	-0.6
Smoking status: Previous	0.3	0.5	1.2	-0.3	-0.6	-1.1	-0.9	0.4
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	10.5	-1.6	-3.2	-2.3	-1.6	1.1
Whole body fat-free mass	0.1	0.7	2.1	-1.5	-0.5	-0.8	0.5	-0.5
Leg fat-free mass (right)	0.2	1.2	2.5	-1.4	0.3	0.3	1.6	-1.1
Arm fat percentage (left)	0.8	3.4	7.1	-2.0	0.3	1.1	2.7	-2.1
Average weekly red wine intake	0.3	0.5	1.2	0.8	-1.1	-0.6	0.3	-0.2
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.7	0.2	0.8	0.6	1.3	-0.7
Mood swings	0.7	1.2	3.9	-2.0	0.8	1.1	-0.1	0.1
Loneliness, isolation	1.2	1.6	5.6	-2.4	0.2	1.2	0.8	-0.6
Long-standing illness, disability or infirmity	0.5	0.8	2.2	0.2	1.1	1.5	-0.2	0.7
Ever had bowel cancer screening	3.7	4.3	9.9	3.1	2.4	2.0	1.1	-0.9
Diabetes diagnosed by doctor	1.3	2.1	5.7	-0.4	-2.4	-1.2	1.0	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.4	-0.2	-1.7	-1.9	-0.3	0.3
Friendships satisfaction	1.6	1.9	4.4	0.8	2.1	1.8	0.8	-0.8
Qualifications: nursing, teaching	0.1	0.1	0.4	0.2	-0.7	-0.1	0.1	0.3
Commuting to job workplace: Walk	0.3	0.3	1.2	1.1	-0.1	-0.2	-0.4	0.6
Eye problems/disorders: Cataract	7.9	9.1	18.1	4.2	3.2	2.8	2.5	-2.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.0	-0.5	0.5	0.4	1.0	-0.9
Medication for cholesterol	0.6	0.9	2.6	-0.0	-0.3	0.2	-1.6	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.4	5.2	10.9	-0.6	-1.2	-2.0	-3.3	3.0
Back pain experienced in last month	0.7	1.1	3.9	-0.3	-2.0	-0.9	-0.5	0.4
Mineral and other dietary supplements	3.1	4.2	9.5	-0.3	1.3	1.5	2.7	-3.1
Breast cancer (self-reported)	2.9	3.5	8.6	2.0	2.9	1.4	1.3	-1.1
Asthma (self-reported)	0.6	1.2	2.7	-1.5	0.6	1.6	0.3	0.8
Osteoporosis (self-reported)	0.7	0.8	3.2	0.4	0.3	1.8	0.9	0.0
Osteoarthritis (self-reported)	1.3	1.7	4.7	0.8	-1.0	-0.2	-1.5	2.2
Medication: Aspirin	0.9	1.2	3.6	1.9	-1.0	-0.1	-0.7	1.0
Medication: Gliclazide	2.0	2.3	5.7	-1.3	-2.4	-2.0	-0.4	-0.0
Illnesses of father: None of the above (group 1)	0.1	0.1	0.5	-0.1	0.1	-0.2	-0.7	0.3
Smoking status: Current	0.6	1.0	1.7	-1.2	-0.9	-1.3	-0.9	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.2	1.5	0.6	-0.3	0.3	-0.7
Whole body water mass	0.1	0.7	2.1	-1.4	-0.4	-0.8	0.7	-0.6
Leg predicted mass (right)	0.2	1.2	2.5	-1.4	0.3	0.3	1.6	-1.1
Arm fat mass (left)	0.6	2.5	5.0	-1.9	-0.5	0.2	2.2	-1.9
Number of self-reported non-cancer illnesses	0.1	0.3	0.6	-0.2	0.7	0.2	-0.3	0.8
Average weekly champagne plus white wine intake	0.6	0.8	3.0	-0.5	-1.7	-0.6	0.6	-0.1
Miserableness	1.5	2.6	3.9	-2.0	-1.5	-1.4	-1.8	1.1
Guilty feelings	0.8	1.1	3.4	-1.9	0.3	-0.1	0.9	-1.1
Wears glasses or contact lenses	0.4	0.4	1.0	0.8	0.1	0.7	-0.3	1.0
Ever taken oral contraceptive pill	0.3	0.3	1.6	-0.0	-1.3	-0.1	0.3	0.2
Hearing aid user	1.2	1.4	3.0	-0.2	-1.3	-0.2	-1.7	1.5
Mother’s age at death	0.4	0.5	1.3	0.4	-0.7	-1.2	-0.3	0.5
Financial situation satisfaction	2.0	2.4	3.7	1.8	0.7	1.3	1.7	-1.9
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.1	-0.0	-0.5	-0.3	0.5
Commuting to job workplace: Public transport	2.2	2.6	4.6	1.6	1.3	2.1	1.8	-1.1
Eye problems/disorders: Glaucoma	2.0	2.4	7.0	0.1	-0.8	-0.7	-1.9	2.6
Medication: Blood pressure	0.3	0.5	1.2	1.1	0.8	0.2	0.8	-0.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.3	0.4	-0.5	1.2	0.4	-0.4
Supplements: Fish oil (including cod liver oil)	1.7	2.3	3.8	1.0	-0.9	-1.5	-1.9	1.9
High cholesterol (Self-reported)	1.5	2.6	4.9	1.6	0.1	1.4	2.2	-1.9
Medication: Bendroflumethiazide	0.5	0.8	3.5	1.9	-0.7	-0.2	0.1	0.1
Medication: Paracetamol	1.4	2.2	6.5	1.0	1.4	2.5	0.7	-1.0
Medication: Lisinopril	0.2	0.3	0.6	-0.7	-0.8	-0.0	0.3	-0.3
Medication: Atorvastatin	2.8	3.5	6.2	1.8	0.7	1.3	2.5	-2.4
Illnesses of father: High blood pressure	0.8	1.0	2.7	-0.9	-1.6	-1.1	0.1	-0.3
Alcohol drinker status: Never	0.7	0.8	2.4	1.5	0.7	1.0	-0.0	0.5
Ever smoked	0.5	1.0	3.4	-0.4	-0.6	-1.8	-0.9	0.1
Basal metabolic rate	0.2	1.0	3.0	-1.7	-0.8	-0.8	0.8	-0.7
Leg fat percentage (left)	0.4	1.5	2.5	-1.6	-1.1	0.0	1.4	-1.3
Arm fat-free mass (left)	0.2	1.1	2.2	-1.1	-1.1	-1.5	0.6	-0.7
Number of operations (self-reported)	0.1	0.2	0.8	-0.1	-0.0	-0.2	-0.3	0.9
Average weekly beer plus cider intake	0.2	0.3	0.7	-0.5	-0.4	-0.6	-0.8	0.2
Irritability	0.6	1.0	3.3	-1.8	-0.2	0.0	-0.8	1.2
Risk taking	3.5	5.1	8.7	-2.5	-2.9	-2.6	-1.5	1.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.8	1.7	0.6	-0.1	-0.6	0.8
Fractured/broken bones in last 5 years	0.6	0.8	2.0	-0.9	-0.8	-1.4	-0.5	-0.0
Age started oral contraceptive pill	1.6	2.0	4.2	2.1	1.8	1.5	0.1	0.3
Diastolic blood pressure, automated reading	0.2	0.6	2.2	-0.6	0.2	1.5	0.4	-0.4
Ever depressed for a whole week	0.1	0.2	0.4	0.1	0.3	0.6	-0.2	0.6
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.3	-0.5	-0.2	0.2	0.0
Commuting to job workplace: Cycle	1.2	1.4	2.4	-0.9	-1.0	-1.3	-1.6	1.1
Myopia	0.3	0.4	0.6	-0.8	0.5	0.2	-0.8	0.7
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	-0.6	0.3	0.5	0.1	-0.2
Cholesterol lowering medication	3.1	4.6	10.3	1.1	0.5	1.3	3.2	-3.1
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.5	0.1	0.8	0.1	1.4	-1.6
Pain experienced in last month	1.1	1.9	4.2	0.6	-0.6	-1.7	-1.3	2.0
Supplements: Calcium	0.3	0.3	0.8	-0.4	-0.6	-0.0	-0.6	0.9
Basal cell carcinoma (self-reported)	0.3	0.3	0.7	0.7	0.8	0.5	-0.4	0.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	0.8	-0.8	0.7	0.4	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.5	-0.6	0.3	1.2	-0.3	0.6
Heart disease (siblings)	0.9	1.1	1.7	1.1	0.6	1.3	1.2	-0.8
Alcohol drinker status: Previous	0.8	0.9	1.7	-1.3	-0.6	-0.8	-1.1	0.7
Pack years of smoking	1.0	1.5	4.8	0.3	0.9	2.2	1.3	-0.6
Impedance of whole body	0.2	1.2	4.5	-0.3	-2.1	-0.7	-0.7	0.7
Leg fat mass (left)	0.5	1.9	4.1	-2.0	-1.3	-0.0	1.5	-1.3
Arm predicted mass (left)	0.2	1.1	2.1	-1.4	-1.2	-1.3	0.4	-0.5