Hub : Genes

C17orf79

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0163	0.0095	1.7e-04	0.027	0.019	0.020	NA	0.024	2.7e-06	5.8e-05	5.0e-05	NA	8.7e-06
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0434	0.0240	5.0e-04	0.006	0.014	0.009	NA	0.003	6.2e-02	9.1e-03	3.0e-02	NA	1.2e-01
3	TCGA	Prostate Adenocarcinoma	0.0720	0.0368	7.4e-05	0.040	0.032	0.025	NA	0.034	4.9e-05	2.6e-04	9.9e-04	NA	1.5e-04
4	TCGA	Soft Tissue Sarcoma	0.0590	0.0430	3.2e-03	0.076	0.048	0.019	NA	0.063	2.8e-05	7.4e-04	2.6e-02	NA	1.2e-04
5	TCGA	Thyroid Carcinoma	0.1350	0.0540	8.0e-09	0.094	0.104	0.085	NA	0.094	1.9e-09	2.4e-10	1.2e-08	NA	1.9e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.1	0.2	0.7	0.1	0.2	0.4	-0.8	0.2
Bipolar Disorder or Schizophrenia	0.2	0.4	1.1	-1.1	-0.6	-0.1	0.3	-0.8
Depressed Affect (Nagel 2018)	0.1	0.3	0.9	0.5	-0.9	0.3	-0.1	0.5
Depression (Nagel 2018)	0.2	0.3	0.5	-0.5	-0.3	-0.7	0.4	-0.5
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.9	-1.0	-0.7	-0.3	0.5	-0.3
Neuroticism (Nagel 2018)	0.1	0.3	1.2	0.4	-1.1	-0.5	-0.2	-0.3
Schizophrenia (2018)	0.5	1.1	2.0	-1.4	-0.9	-0.5	1.0	-1.2
Schizophrenia vs Biploar Disorder	0.4	0.5	1.0	1.0	0.8	0.6	0.2	0.7
Worry (Nagel 2018)	0.2	0.4	1.0	0.4	-1.0	-0.6	-0.6	-0.5
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	0.1	0.0	0.7	-0.8	0.2
Alzheimer’s Disease (in father)	1.8	1.9	2.7	-1.3	-1.5	-1.6	1.3	-1.2
Alzheimer’s Disease (including proxy)	0.2	0.2	0.7	0.2	0.2	0.6	-0.9	0.3
Crohns Disease (2017)	0.1	0.2	0.8	0.2	0.9	-0.2	0.5	-0.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.7	0.2	0.9	-0.2	0.0	-0.3
Ulcerative Colitis (UC)	0.1	0.3	0.6	0.4	0.8	0.3	-0.7	-0.0
Major Depression (MDD)	0.0	0.1	0.1	0.1	-0.2	-0.3	-0.3	-0.1
Reaction Time	0.8	1.5	2.5	1.6	1.4	1.1	-0.9	1.1
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	0.1	0.3	0.7	-0.6	0.5
Breast Cancer	0.2	0.6	1.6	-0.5	-0.1	-0.9	0.3	-1.3
Ovarian Cancer	1.6	2.2	3.4	1.8	1.4	1.4	-1.4	1.3
Prostate Cancer	1.1	1.6	3.0	-1.7	-1.1	-0.9	1.1	-1.3
Age at First Birth	3.1	4.6	8.1	-1.8	-1.7	-2.4	1.7	-2.8
Bipolar Disorder (2011)	1.2	1.2	2.9	-1.7	-0.6	-0.8	1.1	-0.9
Body Mass Index (BMI) (2010)	1.1	1.5	2.2	1.5	1.3	1.2	-1.4	0.8
Coronary Artery Disease (CAD)	1.2	1.4	2.9	0.4	1.4	1.4	-1.7	0.2
Crohns Disease (2012)	0.2	0.3	0.6	0.2	0.8	0.5	0.3	0.7
Mean Putamen Volume	0.2	0.2	0.4	-0.5	0.0	-0.6	0.3	-0.5
Fasting Glucose	1.1	1.3	2.4	-0.7	-0.4	-1.4	1.6	-1.2
HbA1C	3.3	3.7	6.4	1.9	2.5	1.8	-1.8	1.4
HDL Cholesterol	0.2	0.3	0.9	-0.4	-0.5	-0.3	1.0	0.1
LDL Cholesterol	1.2	1.9	3.9	-2.0	-1.4	-1.0	0.9	-1.4
Lupus	2.0	3.1	4.4	2.1	1.5	1.7	-1.6	1.7
Neuroticism (2016)	1.1	1.7	3.5	-1.1	-1.9	-1.4	0.0	-1.3
Primary Biliary Cirrhosis	1.4	2.1	3.5	-1.9	-1.8	-1.1	0.8	-1.3
Rheumatoid Arthritis	1.5	2.0	3.1	1.3	1.4	1.8	-1.2	1.4
Schizophrenia (2014)	0.6	1.3	2.4	-1.2	-1.2	-1.0	0.7	-1.5
Triglycerides	0.3	0.5	0.8	-0.1	0.4	-0.8	-0.9	-0.8
Type 2 Diabetes (T2D) (2012)	1.2	1.4	5.2	0.2	1.0	0.8	-2.3	0.0
Ulcerative Colitis	1.1	1.6	2.8	1.2	1.4	1.2	-1.7	0.7
Blood Eosinophil Count	0.1	0.8	1.6	0.5	0.8	0.9	-1.0	1.2
Blood Platelet Count	0.3	3.5	5.3	-1.8	-0.9	-2.3	1.9	-2.0
Blood Red Count	0.1	1.4	5.6	-0.5	0.7	0.9	-2.4	-0.3
Blood White Count	0.3	2.0	3.5	1.5	0.7	1.6	-1.1	1.9
Heel T-Score	1.0	7.8	9.9	-2.6	-2.8	-2.7	3.1	-2.7
BMI	1.0	5.9	9.7	2.2	1.9	2.6	-3.1	2.2
Height	4.6	88.1	106.1	-8.9	-9.9	-10.3	7.8	-9.7
Waist Hip Ratio (WHR)	0.5	2.3	3.9	1.1	1.1	1.7	-2.0	1.4
Systolic Blood Pressure	0.0	0.1	0.5	-0.0	-0.7	-0.0	0.1	0.2
Smoking Status	2.7	6.5	8.8	2.1	1.9	3.0	-2.7	2.9
Allergy or Eczema	0.3	0.9	1.9	0.9	1.4	0.5	-0.5	1.1
Cardiovascular Disease	0.2	0.8	1.2	0.8	0.1	1.1	-1.0	1.1
Hypothyroidism (self reported)	0.3	0.6	0.9	-0.8	-0.6	-0.7	0.9	-0.8
Respiratory disease	3.5	7.9	10.2	3.2	2.5	2.6	-2.9	2.8
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.2	-0.2	0.5	-0.4	0.1	0.1
Lung FEV1/FVC ratio	3.7	18.9	20.2	-4.1	-4.5	-4.3	4.3	-4.5
Lung FVC	1.8	9.0	13.4	-2.8	-2.4	-3.4	3.7	-2.5
Neuroticism	0.2	0.5	1.5	-0.2	-1.2	-0.6	-0.2	-0.7
Chronotype (morning person)	0.1	0.2	0.5	0.1	-0.5	0.4	-0.7	0.4
Hair Pigment	0.0	1.3	2.4	-1.6	-0.3	-0.8	-1.1	-1.4
Tanning	0.0	0.5	1.1	0.2	0.3	-1.1	0.6	-0.9
Hand grip strength (left)	0.0	0.1	0.2	0.5	-0.2	0.0	-0.2	0.2
Number of treatments/medications taken	0.4	0.6	1.1	0.7	0.4	0.7	-1.0	1.0
Average weekly spirits intake	3.4	4.2	9.5	1.9	1.3	2.0	-3.1	1.6
Sensitivity / hurt feelings	1.5	2.6	4.5	-1.0	-2.1	-1.6	1.7	-1.3
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.2	0.1	-0.0	-0.1	-0.4	0.2
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.4	0.4	0.2	-0.5	0.3
Relative age of first facial hair	0.1	0.2	0.8	-0.1	-0.0	0.2	0.9	0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.4	-0.6	0.2	0.2	-0.1	0.2
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	-0.1	-0.4	0.2	0.7	0.6
Ever had hysterectomy (womb removed)	0.9	1.0	2.8	-1.7	-0.8	-0.7	0.8	-0.7
Systolic blood pressure, automated reading	0.3	0.8	1.6	0.9	0.0	1.1	-0.4	1.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.7	-0.8	-0.0	-0.0	0.7	-0.1
Angina	3.4	4.4	5.5	1.9	2.0	2.3	-2.3	2.1
Medication for hormone replacement therapy	3.7	4.2	5.5	-2.0	-1.5	-2.1	2.4	-2.2
Vitamin and mineral supplements	1.3	1.8	2.2	-1.5	-1.4	-1.4	1.5	-0.8
Supplements: Zinc	4.6	5.0	5.9	-2.4	-2.3	-2.2	2.4	-1.8
Medication: Co-codamol	1.9	2.2	3.3	1.7	1.1	1.1	-1.8	1.5
Medication: Metformin	0.1	0.1	0.2	0.0	0.4	0.3	-0.1	0.5
Diabetes (father)	0.5	0.6	1.1	-0.4	-1.1	-0.8	0.8	-0.6
Diabetes (mother)	0.3	0.3	1.5	-0.1	0.2	0.2	-1.2	0.1
Severe depression (siblings)	0.1	0.2	0.4	-0.2	0.4	0.1	0.6	0.4
Pack years adult smoking proportion	0.4	0.6	2.1	-0.1	-0.4	0.7	-1.5	-0.2
Impedance of leg (right)	0.3	1.3	2.9	-1.7	-0.1	-0.9	1.0	-1.3
Leg fat-free mass (left)	0.3	1.4	4.3	-0.7	-2.1	-1.0	0.1	-1.2
Trunk fat percentage	0.1	0.3	0.6	0.2	-0.6	0.2	-0.8	-0.5
Hand grip strength (right)	0.1	0.2	0.4	0.3	-0.6	-0.3	-0.3	-0.4
Townsend deprivation index at recruitment	1.0	1.3	3.0	0.9	1.7	1.1	-1.0	0.8
Current tobacco smoking	0.9	1.5	2.6	0.7	0.4	1.6	-1.4	1.6
Average weekly fortified wine intake	2.9	3.4	5.2	2.3	1.3	2.0	-1.5	2.0
Maternal smoking around birth	1.4	2.0	5.5	0.6	1.0	1.6	-2.3	0.8
Fed-up feelings	0.5	1.0	1.7	1.0	0.1	1.3	-0.9	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.2	-0.2	-0.5	-0.3	-0.1
Relative age voice broke	0.2	0.3	0.4	0.6	-0.2	0.6	-0.5	0.6
Taking other prescription medications	2.3	3.5	5.0	2.2	2.2	1.4	-1.8	1.6
Age when periods started (menarche)	0.6	1.5	4.2	1.2	2.1	0.6	-1.0	0.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	-0.1	0.1	0.8	-0.7	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.4	-0.0	-1.2	-0.6	0.5	-0.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	-0.8	-0.6	-0.1	0.0	-0.3
Qualifications: CSEs or equivalent	2.5	3.3	4.8	1.9	0.1	2.2	-1.8	2.1
Serious illness, injury or assault to yourself	0.5	0.6	1.7	0.6	0.7	0.7	-1.3	0.4
High blood pressure	0.1	0.3	0.7	-0.4	-0.9	-0.1	0.8	0.4
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.0	0.9	1.4	0.8	-1.3	1.0
Multivitamins +/- minerals	0.1	0.1	0.3	0.4	0.2	0.2	-0.6	-0.2
Stomach or abdominal pain in last month	2.3	2.8	4.5	1.0	2.0	1.9	-2.1	0.9
Supplements: Glucosamine	0.5	0.7	1.7	-0.6	-0.7	-0.8	1.3	-0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	-0.1	-0.3	-0.2	-0.2	-0.3
Medication: Atenolol	1.7	2.1	3.3	1.3	0.6	1.7	-1.8	1.6
Medication: Levothyroxine sodium	0.4	0.6	0.8	-0.8	-0.6	-0.9	0.6	-0.9
Sitting height	5.4	38.4	45.3	-6.0	-6.4	-6.7	5.1	-6.6
Chronic bronchitis/emphysema (father)	2.0	2.4	4.2	1.7	1.0	1.7	-0.9	2.1
High blood pressure (mother)	0.6	0.9	1.7	0.4	-0.4	1.3	-0.9	1.3
Body mass index (BMI)	1.3	5.5	9.1	2.2	1.4	2.8	-3.0	2.0
Impedance of leg (left)	0.3	1.5	2.4	-1.6	-0.4	-1.2	1.2	-1.4
Leg predicted mass (left)	0.3	1.5	4.5	-0.7	-2.1	-1.0	0.1	-1.2
Trunk fat mass	0.1	0.4	1.2	-0.1	-1.1	-0.1	-0.6	-0.8
Waist circumference	0.3	1.0	3.7	0.5	-0.3	1.0	-1.9	0.3
Number of incorrect matches in round	0.4	0.6	1.0	-1.0	0.4	-0.7	0.6	-0.9
Past tobacco smoking	2.1	3.9	5.2	-2.3	-1.7	-1.9	1.8	-2.0
Alcohol usually taken with meals	0.3	0.5	0.9	0.6	0.7	0.3	0.9	0.8
Nervous feelings	0.5	1.0	1.8	-0.4	-1.2	-1.2	-0.2	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.2	1.1	1.0	0.8	-1.1	1.0
Hearing difficulty/problems with background noise	0.3	0.5	0.9	-1.0	-0.4	-0.7	0.5	-0.7
Hair/balding pattern: Pattern 2	1.9	2.4	4.3	-1.5	-2.1	-1.4	1.1	-1.4
Had menopause	0.3	0.4	1.2	-0.7	-0.4	-0.3	1.1	-0.1
Had other major operations	0.4	0.5	0.5	0.7	0.7	0.7	0.6	0.7
Forced vital capacity (FVC)	3.5	13.3	18.9	-3.0	-3.5	-4.3	3.6	-3.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.7	-0.6	-1.3	-0.9	0.9	-0.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.0	0.4	-0.5	-0.2	-1.0	-0.2
Qualifications: None of the above	0.1	0.2	0.6	0.4	-0.5	0.1	-0.8	-0.1
Financial difficulties in last 2 years	2.3	3.1	4.4	1.7	1.7	2.1	-1.4	1.9
Mouth/teeth dental problems	2.0	3.1	4.7	-1.8	-2.2	-1.5	1.5	-1.8
Heart attack	3.7	4.7	6.5	1.9	2.5	2.1	-2.3	1.9
Allergy	1.7	3.9	5.0	-1.8	-1.6	-2.0	2.2	-2.2
Pain all over the body in last month	0.9	0.9	1.8	-0.8	-1.2	-0.9	1.4	-0.1
Diabetes (self-reported)	0.1	0.2	0.2	-0.5	0.4	0.3	-0.5	0.3
Hayfever/allergic rhinitis (self-reported)	2.0	2.6	3.8	1.2	1.6	1.7	-1.6	1.9
Medication: Ramipril	0.3	0.4	0.8	-0.9	-0.9	0.1	0.4	0.2
Medication: Simvastatin	1.3	1.9	2.4	-1.5	-0.9	-1.5	1.5	-1.2
Fluid intelligence score	0.1	0.3	0.8	-0.4	-0.2	0.6	-0.9	0.2
Illnesses of siblings	0.3	0.5	1.7	-0.4	-1.3	-0.3	-0.1	-0.7
Neuroticism score	0.2	0.4	2.0	0.2	-1.4	-0.2	-0.3	-0.3
Weight	0.1	0.6	1.7	-0.2	-1.3	-0.1	-0.9	-0.7
Impedance of arm (right)	0.8	3.7	5.4	-1.6	-1.1	-2.3	2.1	-2.2
Arm fat percentage (right)	1.0	3.9	5.8	2.0	1.4	2.3	-2.4	1.6
Trunk fat-free mass	0.4	2.1	5.2	-1.5	-2.3	-1.2	0.5	-1.2
Hip circumference	0.2	0.7	1.9	-0.5	-1.4	-0.2	-0.7	-0.8
Time employed in main current job	4.6	5.3	9.6	-1.8	-1.4	-2.6	3.1	-2.2
Alcohol intake versus 10 years previously	0.2	0.3	0.9	-0.9	0.5	-0.3	0.3	-0.2
Father’s age at death	0.7	0.9	1.8	-1.0	0.2	-1.1	1.4	-0.6
Worrier / anxious feelings	0.5	0.9	1.7	0.4	-1.3	-1.1	0.1	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.0	0.2	-0.5	0.4	0.8	1.0
Falls in the last year	2.1	2.9	5.0	1.3	1.4	1.7	-2.2	1.7
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	0.8	1.1	0.7	-0.6	0.7
Number of live births	0.0	0.0	0.0	0.2	-0.1	0.2	0.1	0.1
Forced expiratory volume in 1-second (FEV1)	6.0	20.3	27.6	-3.8	-4.4	-5.2	4.3	-4.6
Pulse rate	0.6	1.0	1.4	1.1	1.1	0.9	-1.2	0.6
Happiness	2.6	3.1	4.1	2.0	1.9	1.7	-1.0	2.0
Noisy workplace	0.8	0.9	2.2	1.5	0.9	0.6	0.1	1.2
Qualifications: A levels/AS levels or equivalent	0.6	1.2	1.8	1.3	0.7	1.2	-0.9	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.2	0.7	0.5	1.0	-1.5	0.8
Mouth/teeth dental problems: Dentures	0.3	0.5	0.9	0.8	1.0	0.5	-0.6	0.6
Asthma	2.7	5.2	6.0	2.4	2.1	2.3	-2.5	2.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.5	0.6	0.6	0.7	-0.4	0.7
Medication: Cholesterol lowering	0.1	0.1	0.2	0.3	0.1	0.5	-0.3	0.3
Depression (self-reported)	1.2	1.5	2.1	1.3	1.4	0.7	-1.4	1.1
Medication: Lansoprazole	0.0	0.0	0.2	0.1	-0.0	-0.2	0.0	-0.4
Prospective memory result	0.3	0.4	0.8	0.6	0.7	0.4	0.5	0.9
Lung cancer (father)	0.3	0.4	0.9	-0.5	-0.5	-0.6	0.5	-0.9
Illnesses of mother	0.2	0.3	0.5	0.7	0.7	0.3	-0.2	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	7.0	22.3	31.7	-4.0	-4.3	-5.6	4.6	-4.9
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.4	-0.3	0.7	-0.3	0.5
Impedance of arm (left)	1.2	5.6	7.7	-2.1	-1.3	-2.8	2.6	-2.7
Arm fat mass (right)	0.4	1.6	3.3	1.3	0.4	1.5	-1.8	0.9
Trunk predicted mass	0.3	2.0	4.7	-1.5	-2.2	-1.2	0.5	-1.2
Standing height	3.3	32.6	39.6	-5.4	-6.1	-6.3	4.7	-5.9
Length of working week for main job	2.3	2.6	4.6	2.0	0.7	1.5	-2.1	1.1
Exposure to tobacco smoke at home	2.7	3.0	5.2	2.3	1.7	1.4	-1.7	1.4
Breastfed as a baby	1.6	1.9	2.4	-1.5	-0.9	-1.4	1.5	-1.5
Tense / ‘highly strung’	0.2	0.3	0.5	0.4	-0.7	0.0	-0.7	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.9	1.0	0.7	-0.0	-0.8	0.4
Hair/balding pattern: Pattern 4	0.1	0.3	0.9	-0.3	0.4	-0.5	0.3	-0.9
Birth weight of first child	0.1	0.1	0.3	-0.3	-0.2	0.3	0.1	0.5
Peak expiratory flow (PEF)	5.3	12.2	17.9	-2.9	-3.2	-4.2	2.5	-4.2
Pulse wave reflection index	0.7	0.9	2.1	-1.5	-1.0	-0.5	0.6	-0.6
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	0.5	0.9	-0.2	-0.8	-0.5
Loud music exposure frequency	0.4	0.5	2.0	-0.0	0.4	0.6	-1.4	0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.7	-0.7	0.2	-0.8	-0.1	-1.3
Mouth/teeth dental problems: Bleeding gums	3.8	5.0	5.6	2.4	2.2	2.2	-2.1	2.3
Blood clot in the leg (DVT)	0.8	1.1	2.4	0.3	0.4	1.5	-1.6	0.8
Medication: Paracetamol	5.6	9.2	12.3	3.1	2.7	3.1	-2.7	3.5
Headache pain in last month	0.2	0.3	1.0	1.0	-0.2	0.1	-0.6	0.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.8	0.9	0.4	0.6	-0.7	0.8
Glaucoma (self-reported)	1.3	1.5	2.6	1.5	0.9	1.6	-0.3	1.4
Gout (self-reported)	0.3	0.4	1.2	-0.8	-0.3	-0.2	0.1	-1.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	-0.5	-0.6	-0.7	0.9	-0.5
Medication: Amlodipine	0.1	0.1	0.2	-0.4	-0.1	0.1	-0.5	-0.1
Medication: Ventolin 100micrograms inhaler	3.8	4.9	7.2	2.4	1.2	2.3	-2.7	2.2
Birth weight	0.8	1.7	3.0	1.5	0.5	1.6	-0.6	1.7
Chronic bronchitis/emphysema (mother)	0.0	0.1	0.2	-0.4	0.2	0.1	-0.3	0.1
High blood pressure (siblings)	0.4	0.6	1.3	0.8	1.1	0.7	-0.2	0.9
Forced vital capacity (FVC), Best measure	3.5	13.0	20.2	-2.9	-3.2	-4.5	3.5	-3.7
Body fat percentage	0.3	1.1	2.9	0.9	0.2	1.2	-1.7	0.4
Leg fat percentage (right)	1.5	5.3	9.2	1.9	1.6	2.8	-3.0	1.9
Arm fat-free mass (right)	0.4	1.9	5.0	-1.3	-2.2	-1.1	0.3	-1.2
Exposure to tobacco smoke outside home	0.5	0.6	1.7	1.3	0.3	0.8	-0.6	0.7
Comparative body size at age 10	0.2	0.5	1.0	0.7	-0.7	0.6	-0.1	1.0
Number of full brothers	1.0	1.2	1.8	0.8	1.4	1.1	-0.6	1.3
Worry too long after embarrassment	0.4	0.7	1.3	-0.0	-1.2	-0.9	0.7	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.0	-0.1	-0.2	-1.0	0.4	-0.5
Wheeze or whistling in the chest in last year	6.3	11.2	14.1	3.6	1.8	3.6	-3.8	3.6
Number of children fathered	0.3	0.3	1.3	0.2	-0.4	0.4	0.2	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.6	0.3	0.5	0.6	0.8	0.8
Age at first live birth	2.7	4.7	8.4	-1.9	-0.9	-2.9	1.8	-2.8
Pulse wave peak to peak time	0.4	0.5	1.3	0.0	-0.2	-1.1	0.6	-0.9
Health satisfaction	0.7	0.9	1.1	0.9	0.8	1.0	-1.0	0.8
Shortness of breath walking on level ground	0.3	0.3	0.7	-0.8	-0.4	-0.3	-0.4	-0.7
Qualifications: College or University degree	0.2	0.6	2.3	0.3	1.5	0.4	-0.7	0.1
Eye problems/disorders: None of the above	0.2	0.2	0.4	0.4	0.5	0.5	-0.7	0.0
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.4	0.4	-0.3	0.1	-0.4	0.6
Emphysema/chronic bronchitis	1.5	1.7	2.9	1.2	0.9	1.4	-1.3	1.7
Medication for pain relief, constipation, heartburn	3.2	5.4	6.6	-2.4	-2.0	-2.5	2.0	-2.6
Neck or shoulder pain in last month	0.3	0.4	1.2	-0.4	-0.9	-0.0	1.1	0.3
Medication: Blood pressure	1.1	2.0	3.4	-1.8	-1.0	-1.3	1.5	-1.3
Angina (self-reported)	3.6	4.7	5.8	2.0	2.2	2.2	-2.4	2.0
Migraine (self-reported)	0.2	0.2	0.6	0.2	-0.6	-0.5	0.8	-0.1
Medication: Ibuprofen	0.0	0.0	0.1	0.2	0.2	0.3	-0.1	0.2
Medication: Allopurinol	0.6	0.9	1.9	-0.8	-0.9	-0.8	0.6	-1.4
Medication: Omeprazole	0.5	0.6	1.1	0.7	0.6	0.5	-1.0	0.7
Medication: Seretide 50 evohaler	4.7	5.4	9.0	2.6	1.6	2.3	-3.0	1.8
Mean time to correctly identify matches	0.1	0.1	0.5	-0.2	0.1	-0.4	0.7	-0.2
Heart disease (mother)	0.1	0.1	0.4	0.3	-0.1	0.3	0.0	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.3	1.1	0.8	1.4	-0.5	1.8
Whole body fat mass	0.2	0.7	2.2	0.6	-0.2	0.8	-1.5	0.1
Leg fat mass (right)	0.6	2.5	5.5	1.4	0.7	1.9	-2.3	1.0
Arm predicted mass (right)	0.5	2.3	6.0	-1.4	-2.5	-1.2	0.3	-1.4
Pulse rate, automated reading	0.1	0.3	0.6	0.7	0.8	0.3	-0.2	0.4
Alcohol intake frequency.	0.0	0.1	0.3	-0.1	-0.3	0.0	-0.6	-0.3
Comparative height size at age 10	2.9	15.9	23.0	-4.1	-4.8	-3.8	3.6	-3.5
Number of full sisters	2.1	2.5	3.2	1.6	1.6	1.5	-1.8	1.4
Suffer from ‘nerves’	0.1	0.2	0.4	-0.2	-0.6	-0.3	-0.3	-0.6
Overall health rating	0.9	1.8	2.6	1.0	1.0	1.6	-1.6	1.5
Chest pain or discomfort	2.2	3.1	4.1	1.6	1.6	2.0	-1.7	1.9
Had major operations	0.2	0.2	0.4	-0.6	0.1	0.2	0.6	0.4
Age at last live birth	1.5	2.1	3.3	-1.2	-0.8	-1.7	1.5	-1.8
Family relationship satisfaction	0.9	1.1	2.0	0.6	1.4	1.1	-0.8	1.1
Leg pain on walking	0.2	0.3	0.8	-0.4	-0.9	-0.4	0.4	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.5	-0.4	-0.7	-0.2	0.7	0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.6	-0.3	0.1	-0.2	0.8	-0.2
Illness, injury, bereavement, stress in last 2 years	2.9	3.5	5.3	-1.7	-1.4	-2.3	1.9	-2.0
Medication: Aspirin	1.0	1.3	2.2	1.2	1.5	0.9	-1.0	1.0
Supplements: Vitamin C	0.3	0.3	0.8	0.5	0.2	0.8	-0.9	0.1
Knee pain experienced in last month	3.8	5.9	7.6	2.7	2.0	2.7	-2.2	2.3
Hypertension (Self-reported)	0.2	0.5	1.1	-0.7	-0.8	-0.1	1.0	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.2	3.7	5.7	2.4	1.4	1.8	-2.3	1.6
Illnesses of father: Heart disease	0.1	0.1	0.2	0.0	-0.4	-0.3	0.4	-0.2
Illnesses of siblings: Diabetes	1.0	1.3	2.7	0.8	1.0	1.0	-1.0	1.7
Smoking status: Previous	1.1	1.7	2.6	1.6	1.4	1.1	-1.2	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	2.8	-1.3	-1.0	-1.7	0.4	-1.6
Whole body fat-free mass	0.4	2.1	5.6	-1.3	-2.4	-1.2	0.3	-1.3
Leg fat-free mass (right)	0.3	1.8	5.2	-0.7	-2.3	-1.2	0.2	-1.3
Arm fat percentage (left)	0.7	2.8	4.4	1.8	1.1	1.9	-2.1	1.2
Average weekly red wine intake	0.0	0.1	0.2	0.0	0.3	-0.1	0.1	-0.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.3	0.4	-0.1	-0.2	-0.1
Mood swings	0.2	0.4	1.5	-0.6	-1.2	-0.3	0.3	-0.1
Loneliness, isolation	0.4	0.6	1.2	1.1	0.6	0.5	-1.0	0.6
Long-standing illness, disability or infirmity	0.6	0.9	1.3	0.5	0.9	1.1	-1.1	1.1
Ever had bowel cancer screening	0.1	0.2	0.5	-0.3	-0.2	-0.3	0.7	0.2
Diabetes diagnosed by doctor	0.1	0.1	0.4	-0.6	0.4	-0.3	0.0	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	3.0	3.2	5.1	1.6	1.0	2.2	-1.9	1.9
Friendships satisfaction	0.1	0.1	0.4	-0.1	0.0	-0.5	0.6	0.1
Qualifications: nursing, teaching	0.3	0.5	1.0	-0.9	1.0	-0.3	0.6	-0.5
Commuting to job workplace: Walk	2.1	2.3	3.8	-1.9	-1.6	-1.4	1.4	-1.2
Eye problems/disorders: Cataract	0.8	0.9	1.5	1.2	1.2	0.4	-0.3	1.2
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.0	1.2	1.1	1.1	-0.9	1.4
Medication for cholesterol	1.6	2.5	3.0	1.7	1.5	1.7	-1.7	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	-0.4	0.6	0.1	0.5	0.0
Back pain experienced in last month	1.8	2.7	4.0	1.5	1.5	1.7	-1.4	2.0
Mineral and other dietary supplements	0.5	0.7	1.2	-0.8	-1.1	-0.7	0.3	-1.1
Breast cancer (self-reported)	0.5	0.6	1.0	0.4	1.0	0.7	-1.0	0.5
Asthma (self-reported)	2.9	5.9	7.0	2.5	2.3	2.4	-2.6	2.2
Osteoporosis (self-reported)	0.1	0.1	0.3	-0.0	0.5	0.2	-0.5	0.2
Osteoarthritis (self-reported)	4.6	6.0	9.6	2.8	1.8	2.5	-1.8	3.1
Medication: Aspirin	0.1	0.2	0.5	0.5	0.7	0.1	-0.2	0.4
Medication: Gliclazide	0.4	0.5	0.9	0.9	-0.4	0.7	-0.1	1.0
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	0.2	0.6	0.3	-0.5	0.2
Smoking status: Current	1.7	2.7	4.1	1.2	0.9	2.0	-1.7	2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.1	-1.0	-1.0	-1.4	1.4	-0.9
Whole body water mass	0.3	1.9	5.5	-1.2	-2.4	-1.1	0.3	-1.2
Leg predicted mass (right)	0.3	1.6	5.0	-0.6	-2.2	-1.2	0.2	-1.2
Arm fat mass (left)	0.4	1.6	3.0	1.3	0.4	1.5	-1.7	1.0
Number of self-reported non-cancer illnesses	3.7	6.5	8.4	1.9	2.7	2.9	-2.5	2.6
Average weekly champagne plus white wine intake	0.0	0.0	0.1	-0.2	-0.2	0.2	0.0	0.2
Miserableness	0.2	0.3	0.6	0.8	-0.6	0.4	-0.5	0.2
Guilty feelings	0.0	0.1	0.2	0.2	-0.5	0.1	-0.1	0.1
Wears glasses or contact lenses	0.5	0.6	1.4	-0.5	-0.3	-1.1	-0.2	-1.2
Ever taken oral contraceptive pill	4.0	4.4	5.8	1.9	2.4	2.2	-2.2	1.8
Hearing aid user	0.1	0.1	0.4	-0.2	0.1	-0.2	-0.4	-0.6
Mother’s age at death	1.0	1.3	2.4	-0.9	-0.5	-1.2	1.5	-1.3
Financial situation satisfaction	0.6	0.7	1.0	1.0	0.9	0.7	-0.6	1.0
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.4	0.6	0.1	0.4	-0.2	0.4
Commuting to job workplace: Public transport	0.5	0.7	1.8	0.8	0.4	0.5	-1.3	0.6
Eye problems/disorders: Glaucoma	0.4	0.4	0.9	0.7	0.4	0.9	0.3	0.7
Medication: Blood pressure	0.1	0.1	0.5	-0.1	-0.0	0.4	-0.2	0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	0.6	-0.3	-0.0	0.7	0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	0.7	0.7	0.4	-0.5	0.5
High cholesterol (Self-reported)	0.7	1.2	2.2	-1.2	-1.5	-0.9	0.9	-0.8
Medication: Bendroflumethiazide	0.2	0.3	0.7	-0.8	-0.4	-0.6	0.6	-0.4
Medication: Paracetamol	2.9	4.5	6.4	1.9	1.9	2.4	-1.7	2.5
Medication: Lisinopril	2.0	2.6	5.5	-1.7	-1.0	-1.6	2.3	-0.9
Medication: Atorvastatin	0.9	1.1	1.3	0.9	1.1	1.1	-1.1	1.0
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.0	-0.4	0.3	-0.1	-0.2
Alcohol drinker status: Never	5.7	6.8	9.6	-2.6	-2.4	-2.8	2.1	-3.1
Ever smoked	0.7	1.2	2.1	1.0	0.7	1.1	-1.4	1.1
Basal metabolic rate	0.2	1.3	4.1	-0.9	-2.0	-0.8	-0.0	-1.1
Leg fat percentage (left)	1.3	4.8	8.6	1.9	1.4	2.5	-2.9	1.9
Arm fat-free mass (left)	0.1	0.7	2.7	-0.6	-1.6	-0.4	-0.3	-0.5
Number of operations (self-reported)	0.7	1.1	2.3	-1.4	-0.5	-0.6	1.5	-0.7
Average weekly beer plus cider intake	3.4	5.0	7.5	1.7	1.8	2.7	-2.6	2.1
Irritability	0.2	0.3	1.1	0.4	-0.4	0.6	-0.0	1.0
Risk taking	1.2	1.7	4.3	-1.6	-2.1	-0.9	0.7	-0.9
Ever had prostate specific antigen (PSA) test	2.5	2.8	3.4	-1.7	-1.9	-1.7	1.5	-1.5
Fractured/broken bones in last 5 years	0.2	0.2	0.6	-0.8	-0.4	-0.4	-0.0	-0.2
Age started oral contraceptive pill	1.4	1.8	4.4	-0.9	-1.2	-1.4	2.1	-0.6
Diastolic blood pressure, automated reading	1.7	5.2	7.4	2.7	1.4	2.4	-2.1	2.5
Ever depressed for a whole week	0.1	0.1	0.2	0.2	-0.2	-0.4	-0.4	0.1
Unable to work because of sickness or disability	0.1	0.2	0.5	-0.1	0.7	0.1	-0.4	-0.2
Commuting to job workplace: Cycle	2.8	3.4	4.3	1.8	2.1	1.6	-1.9	1.7
Myopia	0.4	0.6	1.1	1.0	0.8	0.5	-1.1	0.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.1	-0.7	-0.5	-1.1	0.4	-1.4
Cholesterol lowering medication	0.8	1.2	1.7	-1.3	-0.8	-1.3	0.9	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.0	0.2	-0.0	-0.6	-0.2
Pain experienced in last month	1.3	2.1	3.6	-1.6	-1.1	-1.6	0.9	-1.9
Supplements: Calcium	1.4	1.5	3.8	1.2	0.8	1.3	-0.2	1.9
Basal cell carcinoma (self-reported)	0.4	0.5	0.9	1.0	0.8	-0.3	-0.6	-0.5
Heart attack/myocardial infarction (self-reported)	3.0	3.9	6.5	1.6	2.5	1.8	-2.1	1.7
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	2.3	0.2	0.4	1.4	-1.5	0.9
Heart disease (siblings)	1.3	1.6	4.8	0.7	2.2	1.0	-0.6	1.3
Alcohol drinker status: Previous	2.4	2.8	4.3	1.4	2.1	1.7	-1.6	1.4
Pack years of smoking	0.2	0.3	0.9	-0.4	-0.6	0.3	-0.9	-0.4
Impedance of whole body	1.1	5.5	7.3	-2.4	-1.3	-2.7	2.4	-2.7
Leg fat mass (left)	0.6	2.2	5.0	1.4	0.6	1.7	-2.2	1.0
Arm predicted mass (left)	0.3	1.4	4.1	-1.0	-2.0	-0.8	0.0	-1.0