TWAS hub - COPRS

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1550	0.0560	1.2e-03	0.007	NA	0.044	NA	0.013	1.2e-01	NA	1.8e-03	NA	6.2e-02
2	GTEx	Artery Tibial	0.0759	0.0293	5.7e-04	0.027	NA	0.041	NA	0.034	3.1e-03	NA	3.7e-04	NA	1.1e-03
3	GTEx	Esophagus Mucosa	0.2280	0.0540	5.3e-09	0.213	NA	0.186	NA	0.183	2.7e-14	NA	1.7e-12	NA	2.7e-12
4	GTEx	Heart Left Ventricle	0.0793	0.0353	8.4e-03	0.062	NA	0.052	NA	0.065	3.1e-04	NA	9.3e-04	NA	2.4e-04
5	GTEx	Nerve Tibial	0.0770	0.0346	3.7e-03	0.052	NA	0.028	NA	0.031	1.5e-04	NA	4.0e-03	NA	2.8e-03
6	GTEx	Pancreas	0.1430	0.0640	3.5e-03	0.122	NA	0.033	NA	0.069	7.7e-06	NA	1.5e-02	NA	7.2e-04
7	GTEx	Skin Not Sun Exposed Suprapubic	0.2910	0.0700	3.5e-07	0.259	NA	0.212	NA	0.239	1.8e-14	NA	7.5e-12	NA	2.6e-13
8	GTEx	Skin Sun Exposed Lower leg	0.1800	0.0460	3.3e-07	0.152	NA	0.158	NA	0.149	1.4e-12	NA	4.8e-13	NA	2.5e-12
9	GTEx	Testis	0.3140	0.0700	1.1e-10	0.263	NA	0.285	NA	0.282	4.5e-12	NA	4.3e-13	NA	5.9e-13
10	GTEx	Thyroid	0.1670	0.0520	2.2e-04	-0.003	NA	0.005	NA	-0.003	7.8e-01	NA	1.2e-01	NA	5.9e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Forced expiratory volume in 1-second (FEV1), Best measure	6.8	21.6	31.5	-3.4	-4.2	-5.1	-5.3	-4.2	-5.2	-5.1	-5.0	5.6	-2.3
Forced expiratory volume in 1-second (FEV1)	5.7	19.3	27.4	-2.8	-4.2	-5.0	-4.9	-4.0	-4.9	-4.8	-4.7	5.2	-2.4
Wheeze or whistling in the chest in last year	5.5	9.7	18.2	1.6	2.6	2.8	4.3	3.8	2.9	2.9	3.0	-4.0	2.5
Alcohol drinker status: Never	5.4	6.5	9.3	-1.3	-1.9	-2.9	-3.0	-2.4	-2.8	-2.8	-2.7	3.1	-2.0
Sitting height	5.1	36.5	47.2	-4.0	-4.9	-6.9	-5.3	-6.0	-6.7	-6.6	-6.2	6.5	-6.5
Peak expiratory flow (PEF)	5.0	11.6	17.2	-1.0	-2.9	-3.9	-3.8	-3.0	-4.0	-4.0	-3.9	4.2	-1.7
Supplements: Zinc	4.6	5.0	7.3	-1.2	-2.7	-2.5	-2.2	-2.2	-2.5	-2.6	-2.4	2.4	-0.8
Medication: Paracetamol	4.5	7.4	10.5	1.1	2.4	2.7	3.2	3.2	2.9	2.8	2.4	-3.2	2.6
Height	4.2	80.4	108.2	-4.2	-6.5	-9.8	-8.5	-8.8	-10.4	-10.3	-8.8	10.2	-10.2
Time employed in main current job	4.2	4.9	13.4	-0.5	-2.3	-2.0	-3.7	-2.1	-2.0	-2.0	-2.2	2.9	-0.3
Mouth/teeth dental problems: Bleeding gums	4.2	5.4	7.3	2.0	2.5	2.5	2.7	2.3	2.2	2.2	2.1	-2.6	2.2
Osteoarthritis (self-reported)	4.2	5.4	8.6	1.2	2.6	2.2	2.9	2.8	1.9	1.8	2.1	-2.6	2.5
Ever taken oral contraceptive pill	4.1	4.5	6.0	1.1	1.8	2.0	2.2	1.9	2.4	2.4	2.4	-2.2	2.3
Angina (self-reported)	3.8	5.0	8.5	0.9	2.8	2.4	2.9	2.1	1.7	1.7	2.2	-2.4	2.3
Average weekly beer plus cider intake	3.8	5.6	12.5	0.8	2.2	2.4	3.5	1.9	2.5	2.5	2.4	-3.0	0.5
Lung FEV1/FVC ratio	3.7	19.0	26.1	-2.8	-4.4	-4.8	-5.0	-4.0	-4.4	-4.4	-5.1	4.9	-3.2
Medication: Ventolin 100micrograms inhaler	3.7	4.8	8.6	2.4	2.4	2.0	2.9	2.6	1.7	1.7	1.9	-2.6	-0.1
Angina	3.6	4.7	8.7	0.8	2.6	2.4	2.9	2.0	1.7	1.8	2.1	-2.5	2.3
Heart attack	3.6	4.6	6.7	0.4	2.3	2.6	2.2	1.9	1.9	2.0	2.5	-2.2	2.5
Medication: Seretide 50 evohaler	3.6	4.2	6.9	2.4	2.1	1.6	2.1	2.6	2.0	2.0	2.0	-2.2	0.2
Knee pain experienced in last month	3.6	5.6	8.1	2.0	2.0	2.6	2.8	2.8	2.4	2.4	2.3	-2.8	1.3
Forced vital capacity (FVC), Best measure	3.4	12.6	19.3	-2.5	-3.0	-4.0	-4.2	-3.2	-4.1	-4.0	-3.6	4.4	-1.9
Respiratory disease	3.3	7.4	10.2	2.5	3.0	2.6	3.2	3.2	2.7	2.7	2.7	-3.1	0.6
Forced vital capacity (FVC)	3.3	12.6	18.2	-2.3	-3.4	-4.1	-4.0	-3.4	-3.9	-3.8	-3.5	4.3	-2.2
Medication for pain relief, constipation, heartburn	3.3	5.7	12.9	-1.4	-1.6	-2.5	-2.2	-2.4	-2.3	-2.3	-2.5	2.4	-3.6
Medication for hormone replacement therapy	3.1	3.4	5.6	-0.8	-1.9	-2.0	-1.6	-2.0	-1.7	-1.8	-2.0	1.9	-2.4
Standing height	3.1	30.8	51.0	-2.9	-4.0	-5.9	-5.0	-5.3	-6.3	-6.2	-5.3	6.2	-7.1
Number of self-reported non-cancer illnesses	3.1	5.5	7.8	0.5	2.1	2.6	2.6	2.0	2.8	2.8	2.4	-2.8	1.9
Heart attack/myocardial infarction (self-reported)	3.1	4.0	6.6	0.2	2.0	2.4	2.1	1.6	1.9	1.9	2.6	-2.0	2.4
Exposure to tobacco smoke at home	2.8	3.1	5.7	1.0	2.4	1.7	2.0	2.2	1.4	1.4	1.6	-1.7	1.8
Asthma (self-reported)	2.8	5.5	7.2	2.5	2.4	2.1	2.4	2.5	2.7	2.6	2.3	-2.7	0.1
Age at First Birth	2.7	3.9	8.1	-0.8	-0.9	-2.0	-2.0	-1.7	-2.3	-2.2	-1.9	2.3	-2.8
Comparative height size at age 10	2.7	14.9	27.1	-2.7	-3.4	-3.8	-3.3	-4.0	-3.9	-3.8	-4.2	3.8	-5.2
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	5.0	1.3	1.5	1.3	2.2	1.9	1.7	1.7	1.4	-2.2	1.5
Smoking Status	2.6	6.2	10.5	0.6	1.4	2.2	3.2	2.2	2.9	2.9	2.7	-3.2	2.4
Average weekly fortified wine intake	2.6	3.1	5.4	2.3	2.2	1.9	0.8	2.2	1.6	1.7	1.8	-1.6	0.6
Asthma	2.5	5.0	6.9	2.1	2.3	1.9	2.4	2.4	2.5	2.5	2.3	-2.6	-0.4
Age at first live birth	2.5	4.5	7.5	-1.3	-1.6	-1.9	-2.7	-2.2	-2.2	-2.1	-1.7	2.7	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	6.2	0.9	1.8	1.6	2.0	2.5	1.3	1.4	1.4	-1.8	1.7
Commuting to job workplace: Cycle	2.5	3.0	5.8	0.6	1.5	1.8	2.0	1.7	1.9	1.9	2.4	-1.9	0.9
Medication: Paracetamol	2.4	3.7	5.8	0.9	1.5	2.0	2.2	1.9	2.4	2.3	1.8	-2.4	1.2
Average weekly spirits intake	2.3	2.9	5.8	1.0	2.4	1.4	2.4	2.2	1.3	1.4	1.4	-2.0	-0.1
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	4.6	-0.7	-1.4	-1.3	-2.0	-1.9	-1.9	-1.9	-1.4	2.1	-1.5
Taking other prescription medications	2.2	3.3	4.6	2.0	2.1	1.7	1.9	2.1	1.4	1.4	1.7	-1.7	1.9
Qualifications: CSEs or equivalent	2.2	2.9	8.4	0.2	1.6	1.1	2.9	2.3	1.0	1.1	1.4	-2.3	1.4
Happiness	2.2	2.6	4.7	-0.1	1.0	2.0	1.5	1.8	1.8	1.8	2.2	-1.6	1.2
Length of working week for main job	2.2	2.4	5.4	1.4	2.0	1.3	1.9	2.3	0.8	1.0	1.1	-1.7	1.2
Glaucoma (self-reported)	2.2	2.5	3.8	1.9	1.3	1.9	1.9	1.5	1.6	1.5	1.5	-1.8	0.6
Alcohol drinker status: Previous	2.2	2.6	4.2	0.9	1.4	2.1	1.3	1.3	2.0	2.0	2.0	-1.8	0.5
Past tobacco smoking	2.1	3.8	6.0	-1.5	-2.0	-1.9	-1.7	-2.3	-1.6	-1.6	-2.2	1.9	-2.5
HbA1C	2.0	2.3	4.4	0.1	2.1	1.2	0.8	1.6	1.9	1.7	2.1	-1.4	0.8
Lupus	2.0	3.1	6.5	0.3	2.2	1.4	2.5	2.2	1.6	1.7	1.2	-2.2	1.0
Stomach or abdominal pain in last month	2.0	2.5	4.8	0.5	0.9	1.3	1.9	1.1	2.2	2.2	1.7	-2.0	0.9
Hair/balding pattern: Pattern 2	2.0	2.6	5.8	-1.4	-2.4	-1.7	-1.5	-1.5	-1.4	-1.5	-1.9	1.5	-0.5
Commuting to job workplace: Walk	2.0	2.2	3.8	-1.9	-1.3	-1.4	-1.4	-1.9	-1.4	-1.4	-1.2	1.6	-0.7
Supplements: Calcium	2.0	2.3	13.6	1.1	0.3	0.6	0.9	1.2	1.2	1.2	0.9	-1.2	3.7
Primary Biliary Cirrhosis	1.9	2.7	6.7	-2.1	-1.3	-1.9	-0.1	-1.6	-1.3	-1.4	-1.8	0.9	-2.6
Lung FVC	1.9	9.4	16.0	-2.3	-3.5	-3.3	-4.0	-3.0	-3.0	-2.9	-3.1	3.6	1.0
Financial difficulties in last 2 years	1.9	2.5	4.2	1.1	1.1	1.5	1.6	1.7	2.0	2.0	1.8	-1.9	0.2
Medication: Simvastatin	1.9	2.8	8.0	-2.8	-2.0	-1.4	-1.5	-1.6	-1.4	-1.4	-1.3	1.7	-0.7
Diastolic blood pressure, automated reading	1.9	5.9	8.1	2.7	2.8	2.7	2.0	2.8	1.9	2.0	2.3	-2.4	2.3
Alzheimer’s Disease (in father)	1.8	1.9	3.2	-0.8	-1.4	-1.8	-1.0	-1.4	-1.4	-1.4	-1.6	1.3	-1.6
Chronic bronchitis/emphysema (father)	1.8	2.1	3.1	1.3	1.3	1.7	1.2	1.8	1.4	1.4	1.3	-1.5	1.6
Mouth/teeth dental problems	1.8	2.8	4.4	-0.8	-2.1	-2.0	-1.6	-1.6	-1.3	-1.3	-1.7	1.5	-2.1
Falls in the last year	1.8	2.5	3.8	0.1	1.4	1.9	1.7	1.5	1.4	1.4	1.7	-1.7	1.9
Chest pain or discomfort	1.8	2.6	4.1	-0.3	1.2	1.6	1.9	1.6	1.9	1.9	1.8	-2.0	1.1
Ever had prostate specific antigen (PSA) test	1.8	2.0	3.1	-0.2	-1.3	-1.8	-1.0	-1.5	-1.7	-1.8	-1.7	1.5	-1.1
Emphysema/chronic bronchitis	1.7	1.9	3.7	0.0	1.0	1.6	1.9	1.2	1.3	1.3	1.4	-1.6	1.5
Age at last live birth	1.7	2.5	6.1	-0.9	-1.8	-1.3	-2.5	-1.5	-1.1	-1.1	-1.0	1.9	-1.9
Medication: Lisinopril	1.7	2.1	4.0	-2.0	-2.0	-0.9	-1.5	-1.9	-1.2	-1.2	-1.2	1.6	-0.2
Medication: Atenolol	1.6	2.0	3.1	0.5	1.6	1.5	1.8	1.5	0.9	1.0	1.2	-1.6	1.7
Medication for cholesterol	1.6	2.4	4.3	1.7	1.8	1.4	1.1	1.6	1.6	1.7	2.1	-1.5	-0.6
Smoking status: Current	1.6	2.5	5.6	-0.4	0.9	1.3	2.4	1.4	2.0	2.0	1.3	-2.2	0.8
Ever had hysterectomy (womb removed)	1.5	1.7	5.5	-1.9	-0.9	-1.5	-0.2	-1.5	-0.8	-0.8	-1.0	0.6	-2.4
Number of full sisters	1.5	1.8	3.0	0.1	1.2	1.5	1.4	1.7	1.3	1.3	0.9	-1.5	1.5
Back pain experienced in last month	1.5	2.3	4.1	0.2	1.3	1.4	1.8	1.6	1.4	1.5	1.4	-1.7	2.0
Medication: Blood pressure	1.4	2.4	6.5	-2.5	-2.2	-1.0	-1.6	-2.0	-1.0	-1.1	-0.7	1.5	0.1
Risk taking	1.4	2.0	4.9	-2.2	-1.1	-1.6	0.3	-1.1	-1.4	-1.4	-1.9	0.6	-1.3
Ovarian Cancer	1.3	1.7	3.1	0.6	0.8	1.6	1.2	1.8	1.4	1.5	1.2	-1.3	1.2
Rheumatoid Arthritis	1.3	1.7	3.2	0.7	1.1	1.3	1.3	1.3	1.8	1.8	1.2	-1.7	-0.4
Medication: Co-codamol	1.3	1.5	4.6	0.2	2.1	0.8	1.6	2.0	0.4	0.4	0.9	-1.3	0.6
Townsend deprivation index at recruitment	1.3	1.8	3.3	1.0	1.8	1.2	1.6	1.0	1.2	1.2	1.7	-1.4	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	2.4	1.1	0.3	1.5	0.9	1.1	1.5	1.5	1.5	-1.4	1.2
Family relationship satisfaction	1.3	1.6	4.6	-1.4	1.2	0.9	2.1	0.7	1.1	1.1	1.3	-1.5	0.9
Pain experienced in last month	1.3	2.2	4.2	-0.9	-1.1	-1.4	-2.0	-1.7	-1.2	-1.3	-1.3	1.8	-1.6
Body Mass Index (BMI) (2010)	1.2	1.7	4.2	1.0	2.1	1.2	1.8	1.6	0.9	0.9	1.1	-1.4	-0.4
LDL Cholesterol	1.2	1.9	3.5	-1.7	-1.2	-1.6	-0.8	-1.9	-1.1	-1.3	-1.7	1.2	-0.9
Age when periods started (menarche)	1.2	3.0	7.5	2.2	2.1	1.8	0.9	1.0	0.9	0.9	2.5	-0.7	2.7
Body mass index (BMI)	1.2	5.1	10.4	0.3	3.0	2.0	3.2	2.8	1.9	2.0	1.0	-3.0	-1.4
Allergy	1.2	2.9	4.2	-0.8	-1.8	-1.4	-1.7	-2.0	-2.1	-2.0	-1.8	2.0	0.2
Hayfever/allergic rhinitis (self-reported)	1.2	1.7	2.6	0.1	1.4	1.0	1.2	1.3	1.6	1.6	1.6	-1.5	0.3
Leg fat percentage (right)	1.2	4.5	8.4	0.7	2.6	2.0	2.8	2.4	2.2	2.2	1.4	-2.9	-0.1
Number of full brothers	1.2	1.6	4.1	0.1	-0.2	1.4	1.0	0.8	1.4	1.4	1.5	-1.2	2.0
Smoking status: Previous	1.2	1.8	3.7	1.5	1.4	1.3	0.8	1.7	0.9	0.9	1.6	-1.0	1.9
Age started oral contraceptive pill	1.2	1.5	1.9	-1.1	-1.2	-1.2	-1.2	-0.8	-1.3	-1.3	-1.2	1.3	-1.4
Heart disease (siblings)	1.2	1.5	6.5	-0.2	0.8	1.6	0.4	0.6	1.3	1.3	0.9	-0.8	2.5
Sensitivity / hurt feelings	1.1	1.9	4.0	-0.2	-1.1	-1.7	-0.8	-0.9	-2.0	-2.0	-1.8	1.4	0.5
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	4.1	0.9	0.8	1.0	2.0	1.1	1.1	1.1	1.0	-1.5	1.9
Impedance of arm (left)	1.1	5.2	11.7	-0.7	-3.2	-2.2	-3.4	-2.5	-1.7	-1.8	-1.5	3.0	0.6
Breastfed as a baby	1.1	1.4	2.5	-1.0	-1.6	-0.9	-1.2	-1.5	-1.1	-1.1	-1.1	1.4	-0.8
Pulse wave reflection index	1.1	1.4	5.1	-2.3	-1.0	-1.2	-0.5	-1.2	-0.9	-0.9	-1.5	0.7	0.6
Medication: Atorvastatin	1.1	1.4	4.4	0.5	1.5	1.2	1.1	1.0	0.7	0.6	1.2	-1.1	2.1
Leg fat percentage (left)	1.1	4.0	7.4	0.5	2.5	1.9	2.7	2.5	1.9	1.9	1.2	-2.7	0.1
Coronary Artery Disease (CAD)	1.0	1.2	2.0	0.3	1.3	1.0	1.4	0.4	1.4	1.4	1.1	-1.2	-0.3
Neuroticism (2016)	1.0	1.5	3.9	-0.4	0.1	-1.5	-0.1	-0.7	-2.0	-2.0	-1.7	1.0	-0.3
Vitamin and mineral supplements	1.0	1.4	2.4	-1.0	-1.3	-0.8	-1.3	-1.6	-1.4	-1.3	-1.1	1.4	-0.3
Maternal smoking around birth	1.0	1.4	3.8	-0.7	1.5	0.6	1.9	0.9	1.3	1.2	0.6	-1.6	0.4
Depression (self-reported)	1.0	1.2	2.2	0.8	0.7	1.1	0.9	1.0	1.1	1.1	1.5	-0.9	1.5
Blood clot in the leg (DVT)	1.0	1.3	3.5	-0.0	0.8	1.2	1.9	0.6	1.2	1.3	0.8	-1.6	-0.6
Exposure to tobacco smoke outside home	1.0	1.3	3.8	1.3	0.9	0.9	1.5	1.4	0.5	0.6	0.6	-1.1	2.0
Illnesses of siblings: Diabetes	1.0	1.2	2.5	-1.2	0.7	0.9	1.4	1.0	0.9	0.9	0.7	-1.2	1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	3.2	-1.8	-0.7	-1.6	-1.6	-1.3	-1.7	-1.6	-0.9	1.8	-1.1
Cholesterol lowering medication	1.0	1.5	3.2	-1.4	-1.0	-1.2	-0.5	-1.1	-1.5	-1.5	-1.8	1.1	0.5
Impedance of whole body	1.0	5.3	11.9	-1.0	-3.2	-2.1	-3.4	-2.9	-1.6	-1.6	-1.4	2.9	0.9
Reaction Time	0.9	1.8	3.2	1.7	1.5	1.8	0.8	1.4	1.3	1.3	1.6	-1.1	0.3
Prostate Cancer	0.9	1.2	3.1	-1.2	-1.1	-0.6	-0.9	-1.8	-0.9	-1.0	-1.3	1.1	0.7
BMI	0.9	5.1	11.5	-0.4	3.0	2.3	3.4	2.7	1.8	1.9	1.4	-2.9	-0.9
Current tobacco smoking	0.9	1.4	3.4	-0.9	0.4	0.8	1.9	0.9	1.5	1.5	0.8	-1.7	0.5
Arm fat percentage (right)	0.9	3.6	6.3	0.6	2.4	1.8	2.5	2.5	1.8	1.8	0.9	-2.5	-1.0
Arm fat-free mass (right)	0.9	4.6	27.9	-1.8	0.6	-1.4	0.4	-0.8	-2.0	-1.9	-1.9	0.7	-5.3
Arm predicted mass (right)	0.9	4.8	28.4	-1.6	0.4	-1.5	0.2	-0.9	-2.1	-2.0	-1.9	0.9	-5.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	3.5	-1.1	-1.2	-1.4	-1.9	-1.1	-1.3	-1.3	-1.6	1.6	0.5
High cholesterol (Self-reported)	0.9	1.7	4.6	-2.2	-0.9	-1.6	-0.4	-1.0	-1.5	-1.5	-1.3	0.9	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	3.4	-0.4	0.8	1.1	1.9	0.5	1.2	1.2	0.7	-1.6	-0.7
Fasting Glucose	0.8	1.0	2.4	-0.6	-1.2	-0.6	-0.6	-0.6	-1.0	-1.1	-1.3	1.1	-1.5
Ulcerative Colitis	0.8	1.2	2.8	0.5	1.7	1.0	1.4	1.3	0.9	0.8	1.1	-1.2	-0.7
Heel T-Score	0.8	6.5	8.8	2.5	-1.0	-2.5	-2.9	-2.5	-3.0	-2.9	-2.4	3.0	-2.3
Fed-up feelings	0.8	1.5	4.9	1.1	1.1	0.7	2.2	1.4	0.9	0.9	0.6	-1.6	1.1
Trunk fat-free mass	0.8	4.6	29.4	-1.5	0.2	-1.5	0.2	-1.1	-1.9	-1.8	-1.7	0.9	-5.4
Hip circumference	0.8	3.5	25.9	-1.6	1.2	-0.7	0.8	0.0	-0.9	-0.9	-1.4	-0.1	-5.1
Qualifications: A levels/AS levels or equivalent	0.8	1.7	5.2	0.7	1.2	0.6	0.6	1.2	1.4	1.4	1.6	-1.2	-2.3
Trunk predicted mass	0.8	4.6	29.9	-1.6	0.3	-1.5	0.2	-1.1	-1.9	-1.8	-1.6	0.8	-5.5
Birth weight	0.8	1.7	4.2	0.6	1.2	1.3	2.1	1.6	1.2	1.2	0.8	-1.8	0.2
Medication: Aspirin	0.8	1.0	2.0	0.1	1.2	1.1	0.8	1.1	1.0	0.9	1.4	-0.9	0.9
Whole body fat-free mass	0.8	4.8	30.6	-1.3	0.6	-1.5	0.4	-0.7	-2.0	-1.9	-1.9	0.8	-5.5
Leg fat-free mass (right)	0.8	4.0	23.5	-0.8	0.8	-1.4	0.4	-0.1	-2.2	-2.0	-2.0	0.8	-4.8
Loneliness, isolation	0.8	1.1	2.5	1.1	1.6	0.6	1.5	1.3	0.4	0.5	0.6	-1.0	0.7
Long-standing illness, disability or infirmity	0.8	1.2	3.2	-0.7	0.4	0.8	1.8	0.5	1.2	1.2	1.5	-1.4	0.7
Whole body water mass	0.8	4.6	30.2	-1.3	0.6	-1.4	0.4	-0.7	-2.0	-1.9	-1.8	0.7	-5.5
Mother’s age at death	0.8	1.0	2.7	-0.4	-0.5	-0.8	-1.7	-1.1	-1.1	-1.1	-0.3	1.4	-0.7
Eye problems/disorders: Glaucoma	0.8	0.9	3.2	1.8	0.3	1.1	0.7	0.7	1.1	1.1	0.8	-0.9	0.3
Arm predicted mass (left)	0.8	3.9	26.1	-1.3	0.7	-1.2	0.6	-0.5	-1.7	-1.6	-1.7	0.4	-5.1
Schizophrenia (2014)	0.7	1.6	3.7	0.8	-0.8	-1.6	-0.8	-1.3	-1.1	-1.1	-1.5	1.2	-1.9
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	4.2	-2.0	-1.2	-0.5	-0.1	-0.9	0.4	0.4	-0.0	0.1	-0.6
Leg fat-free mass (left)	0.7	3.8	24.3	-0.9	0.9	-1.3	0.6	-0.1	-1.9	-1.7	-1.9	0.5	-4.9
Supplements: Glucosamine	0.7	0.9	1.3	-0.6	-0.8	-0.8	-0.9	-0.7	-1.0	-1.0	-1.1	1.0	-1.1
Leg predicted mass (left)	0.7	3.9	25.2	-0.9	0.8	-1.3	0.6	-0.2	-1.9	-1.8	-1.9	0.6	-5.0
Pain all over the body in last month	0.7	0.7	1.6	-1.0	-0.7	-0.7	-0.4	-0.8	-1.2	-1.1	-1.3	0.8	-0.0
Illnesses of siblings	0.7	1.0	6.8	0.8	-0.6	-0.8	-0.8	-0.4	-0.2	-0.3	-0.2	0.5	-2.6
Impedance of arm (right)	0.7	3.3	7.4	-0.3	-2.7	-1.7	-2.7	-2.0	-1.4	-1.4	-1.1	2.4	0.8
Worrier / anxious feelings	0.7	1.4	3.4	0.7	0.2	-1.3	-0.7	0.6	-1.8	-1.9	-1.1	1.1	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.8	-0.7	0.2	0.7	1.3	0.7	1.1	1.0	0.4	-1.1	1.1
High blood pressure (siblings)	0.7	1.1	3.1	-0.2	0.8	1.0	1.6	0.8	0.6	0.6	0.6	-1.1	1.8
Health satisfaction	0.7	0.9	3.9	-0.1	0.9	0.6	2.0	1.1	0.6	0.6	0.8	-1.3	-0.4
Qualifications: College or University degree	0.7	2.1	9.2	1.7	1.0	0.6	0.5	-0.1	1.3	1.3	1.8	-0.6	-3.0
Leg fat mass (right)	0.7	2.7	5.7	0.3	2.4	1.2	2.3	2.0	1.2	1.2	0.5	-2.0	-1.9
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.5	-1.5	-1.6	-0.6	-0.4	-0.5	-0.3	-0.3	-0.4	0.4	1.6
Arm fat percentage (left)	0.7	2.7	5.1	0.3	2.2	1.5	2.1	2.3	1.4	1.4	0.6	-2.1	-1.2
Leg predicted mass (right)	0.7	3.9	23.0	-0.7	0.9	-1.4	0.5	-0.1	-2.1	-2.0	-1.9	0.7	-4.8
Medication: Bendroflumethiazide	0.7	1.1	5.5	-1.3	-1.2	0.1	-0.3	-0.9	-0.4	-0.4	-0.8	0.5	2.4
Basal metabolic rate	0.7	3.9	27.2	-1.0	0.9	-1.2	0.7	-0.3	-1.7	-1.6	-1.7	0.4	-5.2
Number of operations (self-reported)	0.7	1.1	3.1	-1.2	-1.8	-1.0	-0.4	-1.3	-0.6	-0.6	-0.8	0.5	-1.3
Myopia	0.7	1.0	3.3	1.2	1.8	0.6	1.3	1.2	0.4	0.4	0.4	-0.8	-1.0
Schizophrenia (2018)	0.6	1.2	2.6	1.3	-1.2	-1.0	-0.3	-1.6	-0.6	-0.6	-1.3	0.8	-1.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.5	-0.8	1.6	0.6	1.4	0.6	-0.2	-0.1	0.2	-0.8	-0.7
Diabetes (father)	0.6	0.7	3.6	-0.7	-0.7	-0.8	0.1	-0.2	-0.8	-0.8	-0.8	0.3	-1.9
High blood pressure (mother)	0.6	0.8	2.5	-0.8	0.8	0.5	1.6	0.7	0.7	0.7	0.3	-1.3	-0.7
Nervous feelings	0.6	1.1	2.9	0.5	-0.0	-1.2	-0.6	-0.2	-1.7	-1.7	-1.2	1.1	-0.4
Medication: Ramipril	0.6	0.8	4.4	-2.1	-1.0	-0.1	0.7	-0.8	-0.0	-0.1	-0.6	-0.2	-0.8
Father’s age at death	0.6	0.9	2.3	0.6	-0.9	-0.4	-1.5	-1.4	-0.5	-0.5	-0.0	1.2	-1.1
Pulse rate	0.6	1.1	2.2	1.2	1.3	0.2	0.2	1.1	1.1	1.1	1.1	-0.7	-1.5
Noisy workplace	0.6	0.7	2.7	0.3	0.2	0.6	0.6	1.5	0.6	0.6	0.2	-0.7	1.6
Arm fat mass (right)	0.6	2.4	6.7	-0.1	2.1	1.0	2.0	1.8	0.8	0.8	0.0	-1.7	-2.6
Overall health rating	0.6	1.4	2.7	-0.5	0.8	0.9	1.6	1.2	1.4	1.4	1.1	-1.6	-0.4
Qualifications: nursing, teaching	0.6	0.9	6.4	-0.7	-0.4	-0.1	0.1	-1.1	0.6	0.6	0.5	0.0	-2.5
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.0	0.1	1.4	1.1	1.2	1.1	0.7	0.7	1.4	-1.0	0.4
Medication: Gliclazide	0.6	0.7	2.3	0.4	0.6	0.8	1.0	1.1	0.3	0.4	0.5	-0.9	1.5
Arm fat mass (left)	0.6	2.5	7.3	-0.0	2.2	1.0	2.0	1.9	0.7	0.8	-0.0	-1.7	-2.7
Miserableness	0.6	1.0	3.5	1.0	0.6	0.1	1.9	1.1	0.1	0.0	0.1	-0.9	1.8
Financial situation satisfaction	0.6	0.8	3.8	0.1	0.7	1.0	0.4	0.9	0.6	0.6	0.9	-0.6	1.9
Ever smoked	0.6	1.0	2.3	0.8	0.9	0.7	0.9	1.1	0.9	0.9	1.5	-1.0	1.1
Arm fat-free mass (left)	0.6	3.2	23.8	-1.1	1.1	-0.8	0.9	-0.0	-1.2	-1.1	-1.2	-0.0	-4.9
Leg fat mass (left)	0.6	2.5	5.5	0.2	2.4	1.1	2.2	2.0	1.0	1.0	0.4	-1.9	-1.9
Waist Hip Ratio (WHR)	0.5	2.0	4.7	0.3	0.8	1.2	1.7	1.4	1.5	1.5	1.0	-1.7	2.2
Relative age of first facial hair	0.5	1.0	8.6	0.7	0.1	0.8	0.3	-0.1	0.2	0.1	0.5	-0.2	2.9
Impedance of leg (left)	0.5	2.2	4.9	-0.5	-2.2	-0.9	-2.2	-2.0	-0.3	-0.4	-0.2	1.6	2.1
Hearing difficulty/problems with background noise	0.5	0.8	3.4	-0.8	-0.6	-0.7	-0.6	-0.9	-0.6	-0.6	-0.6	0.7	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.2	0.6	0.1	-1.2	-0.9	-0.4	-1.5	-1.4	-1.1	1.0	-1.1
Weight	0.5	2.7	19.6	-0.8	1.3	-0.6	1.0	0.4	-0.9	-0.9	-1.4	-0.2	-4.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	3.1	0.6	0.3	0.4	0.4	0.5	0.7	0.7	0.8	-0.6	1.8
Illnesses of mother	0.5	0.6	2.3	1.5	0.3	0.7	0.1	0.4	0.8	0.8	1.0	-0.4	-0.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.9	-0.6	-0.2	-1.2	-1.1	-0.8	-0.4	-0.5	-0.6	1.0	-1.7
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.6	1.6	1.4	0.4	0.9	1.1	0.5	0.5	-0.1	-0.9	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.7	0.9	-0.6	1.3	0.1	-0.1	1.2	1.2	0.3	-0.6	-0.0
Pulse wave peak to peak time	0.5	0.5	1.8	1.3	0.1	-0.1	-1.1	-0.2	-0.7	-0.7	0.5	0.9	-0.3
Medication: Omeprazole	0.5	0.6	3.1	-0.4	-0.1	0.9	0.5	0.7	0.5	0.6	0.4	-0.5	1.8
Leg pain on walking	0.5	0.6	2.3	-1.5	-1.1	-0.8	0.1	-0.3	-0.5	-0.4	-1.0	0.3	-0.1
Supplements: Vitamin C	0.5	0.6	3.1	1.8	1.2	0.2	0.3	0.6	0.3	0.3	0.4	-0.5	-0.3
Wears glasses or contact lenses	0.5	0.6	1.8	-0.0	0.6	-0.8	-0.4	-0.2	-1.3	-1.3	-0.4	0.8	-0.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	3.1	1.8	0.8	0.9	0.3	0.6	0.4	0.5	0.2	-0.5	-0.6
Vascular/heart problems diagnosed by doctor	0.5	1.4	7.8	0.9	-0.3	-1.5	-0.8	-0.7	-0.7	-0.7	-0.3	0.9	-2.8
Basal cell carcinoma (self-reported)	0.5	0.6	2.7	1.0	1.6	0.6	0.6	0.9	-0.4	-0.5	0.0	-0.0	-0.2
Schizophrenia vs Biploar Disorder	0.4	0.6	2.0	1.4	0.7	0.2	0.5	0.9	0.7	0.7	0.8	-0.6	-0.1
Major Depression (MDD)	0.4	0.5	1.2	-1.1	0.9	-0.1	0.4	0.2	-1.1	-1.1	0.1	0.3	-0.3
Cardiovascular Disease	0.4	1.4	5.2	-1.8	0.6	1.0	1.2	0.9	0.6	0.5	0.4	-1.0	2.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	4.3	-2.1	-0.2	-0.6	0.4	-0.5	0.0	0.0	0.2	-0.2	-0.2
Systolic blood pressure, automated reading	0.4	1.1	3.7	0.7	0.1	1.7	0.6	0.9	0.8	0.8	0.7	-1.0	1.9
Medication: Metformin	0.4	0.5	4.2	-2.1	-0.3	0.4	-0.0	-0.0	0.4	0.4	0.4	-0.2	-0.2
Impedance of leg (right)	0.4	1.9	4.8	-0.5	-2.2	-0.8	-2.0	-2.1	0.1	0.0	0.1	1.3	1.7
Relative age voice broke	0.4	0.6	3.7	0.7	0.7	0.5	0.6	0.9	0.1	0.0	0.1	-0.5	1.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	2.0	0.5	0.2	0.2	1.4	0.1	0.7	0.7	-0.1	-1.0	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.7	1.6	0.7	-0.7	-0.4	0.2	-1.2	-1.2	-0.7	0.6	-1.0
Serious illness, injury or assault to yourself	0.4	0.5	1.1	-0.1	1.1	0.6	1.1	0.7	0.6	0.6	0.6	-0.8	-0.3
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.4	0.5	1.1	0.5	-0.2	0.9	1.2	1.2	1.0	-0.6	-1.1
Medication: Levothyroxine sodium	0.4	0.7	1.7	-1.2	-0.7	-1.0	-0.2	-0.6	-0.9	-0.9	-1.3	0.7	-0.5
Trunk fat mass	0.4	1.5	10.0	-0.9	0.9	-0.5	0.5	0.5	-0.7	-0.7	-1.3	-0.1	-3.2
Waist circumference	0.4	1.6	6.3	-0.8	1.6	0.3	1.8	1.2	0.2	0.3	-0.6	-1.2	-2.5
Alcohol usually taken with meals	0.4	0.6	3.0	1.7	-0.1	0.8	-0.2	0.2	0.7	0.7	0.4	-0.2	-0.8
Had other major operations	0.4	0.5	0.9	0.3	-0.2	0.3	0.8	0.6	0.9	0.9	0.9	-0.9	0.6
Hair/balding pattern: Pattern 3	0.4	0.6	1.9	0.5	0.6	0.8	0.4	0.8	0.8	0.8	1.4	-0.6	-0.5
Loud music exposure frequency	0.4	0.4	1.3	-0.3	1.1	0.4	1.1	0.2	0.3	0.3	0.4	-0.7	0.7
Medication: Amlodipine	0.4	0.5	3.7	-1.9	-0.8	0.2	-0.1	-0.5	0.0	0.0	-0.0	0.1	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.3	-0.7	-0.5	-0.8	-0.1	-0.2	-1.0	-1.0	-0.4	0.7	1.1
Shortness of breath walking on level ground	0.4	0.5	2.4	-1.5	-0.4	-0.6	0.8	-0.6	-0.3	-0.3	-0.7	-0.1	-0.1
Medication: Allopurinol	0.4	0.6	1.1	0.2	-0.2	-0.8	-0.5	-0.7	-1.0	-0.9	-1.1	0.8	-0.8
Whole body fat mass	0.4	1.6	7.3	-0.4	1.7	0.4	1.4	1.2	0.2	0.2	-0.5	-1.0	-2.7
Had major operations	0.4	0.5	3.1	-1.8	-0.6	-0.2	0.3	-0.4	-0.0	0.0	0.1	-0.1	-1.2
Hypertension (Self-reported)	0.4	1.0	4.1	-2.0	-0.9	0.2	-0.2	-0.6	-0.3	-0.3	-0.8	0.2	1.9
Diabetes diagnosed by doctor	0.4	0.6	5.6	-2.4	-0.4	0.2	-0.3	-0.6	-0.2	-0.2	0.1	0.3	-0.1
Eye problems/disorders: Cataract	0.4	0.4	1.0	-0.1	1.0	0.4	-0.7	1.0	0.4	0.3	0.9	-0.0	0.6
Illnesses of father: None of the above (group 1)	0.4	0.4	1.6	1.3	0.0	0.2	-0.3	0.1	0.7	0.7	1.2	-0.2	0.4
Guilty feelings	0.4	0.6	4.4	0.9	-0.3	-0.1	0.5	0.3	-0.1	-0.2	-0.3	-0.2	2.1
Commuting to job workplace: Public transport	0.4	0.5	1.2	0.1	1.1	0.6	1.1	0.9	0.2	0.2	0.7	-0.6	0.8
Medication: Blood pressure	0.4	0.8	4.7	-1.3	0.0	0.8	0.8	0.1	0.2	0.2	-0.5	-0.5	2.2
Bipolar Disorder or Schizophrenia	0.3	0.6	2.3	0.8	-0.7	-0.8	0.1	-1.2	-0.2	-0.3	-0.9	0.4	-1.5
Depressed Affect (Nagel 2018)	0.3	0.7	4.3	0.2	0.4	0.1	2.1	0.9	-0.1	-0.2	-0.3	-0.9	0.8
Intelligence (Savage-Jansen 2018)	0.3	0.8	6.1	0.1	0.2	-0.3	0.4	-0.8	-0.0	-0.0	-0.8	-0.1	-2.5
Worry (Nagel 2018)	0.3	0.7	2.0	1.4	0.5	-0.9	0.1	0.6	-1.2	-1.2	-0.5	0.4	0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.1	0.4	1.0	0.6	1.1	0.2	0.9	0.9	0.3	-1.0	-1.5
Breast Cancer	0.3	0.6	1.6	0.3	-0.6	-0.5	-1.2	-0.5	-0.9	-0.9	-0.2	1.0	1.1
Mean Putamen Volume	0.3	0.3	0.8	0.2	0.2	-0.3	0.4	-0.5	-0.8	-0.9	-0.7	0.3	-0.9
Triglycerides	0.3	0.5	2.4	-1.5	0.2	-0.4	-0.3	-0.2	-0.9	-0.6	-0.4	0.7	1.0
Blood Platelet Count	0.3	3.4	7.2	-0.9	-1.8	-2.2	-1.7	-1.9	-1.7	-1.8	-1.4	2.0	2.7
Systolic Blood Pressure	0.3	1.7	13.9	-0.5	-1.3	0.7	-0.4	-0.2	0.3	0.3	0.5	0.0	3.7
Hypothyroidism (self reported)	0.3	0.6	2.0	-1.1	-0.6	-0.5	-0.1	-0.7	-0.8	-0.8	-1.4	0.6	0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.5	4.1	-2.0	-0.3	-0.1	-0.5	-0.2	-0.2	-0.2	0.3	0.4	-0.1
Hand grip strength (left)	0.3	0.7	5.6	2.4	0.7	0.3	0.7	0.3	0.1	0.2	0.6	-0.3	-0.3
Number of treatments/medications taken	0.3	0.5	3.5	-0.3	0.4	0.4	0.5	0.8	0.3	0.2	0.2	-0.5	1.9
Diabetes (mother)	0.3	0.4	2.6	-1.6	0.6	-0.1	0.4	0.1	-0.2	-0.1	0.3	-0.2	1.0
High blood pressure	0.3	0.8	3.0	-1.7	-0.8	0.2	-0.2	-0.3	-0.3	-0.3	-0.8	0.1	1.7
Qualifications: None of the above	0.3	0.7	5.2	1.1	0.3	0.5	-0.0	0.6	-0.3	-0.3	0.0	-0.1	2.3
Diabetes (self-reported)	0.3	0.5	3.7	-1.9	-0.4	0.5	-0.0	-0.5	0.4	0.4	0.4	-0.1	0.3
Fluid intelligence score	0.3	0.6	2.7	0.5	0.8	0.2	1.1	-0.2	0.6	0.5	0.0	-0.8	-1.6
Mouth/teeth dental problems: Dentures	0.3	0.4	1.1	0.5	0.9	1.0	0.6	0.7	0.4	0.4	0.5	-0.5	0.8
Prospective memory result	0.3	0.4	0.9	0.3	0.3	0.9	0.5	0.5	0.7	0.7	0.2	-0.5	1.0
Pulse wave Arterial Stiffness index	0.3	0.4	2.0	-1.4	-0.3	-0.3	0.9	-0.2	0.1	0.2	-0.9	-0.5	-0.1
Tense / ‘highly strung’	0.3	0.6	3.6	-0.4	0.1	-0.6	0.8	0.6	-0.5	-0.5	0.0	-0.3	1.9
Hair/balding pattern: Pattern 4	0.3	0.7	5.3	-0.3	0.4	-0.5	-0.2	-0.3	-0.4	-0.4	-0.7	0.4	-2.3
Ever highly irritable/argumentative for 2 days	0.3	0.4	3.4	-0.2	0.4	0.1	0.5	0.4	-0.1	-0.0	0.1	-0.1	1.8
Gout (self-reported)	0.3	0.4	2.6	-0.1	-0.2	-0.3	-0.7	-0.9	-0.3	-0.3	-0.2	0.5	-1.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.7	-0.7	-0.4	-0.5	0.4	-0.3	-0.7	-0.8	-1.3	0.3	1.2
Body fat percentage	0.3	1.1	2.4	-0.2	1.6	0.7	1.4	1.5	0.7	0.7	-0.2	-1.3	-1.2
Worry too long after embarrassment	0.3	0.5	1.4	0.1	-0.7	-1.2	-0.4	0.1	-0.9	-1.0	-0.9	0.7	-0.3
Number of children fathered	0.3	0.4	1.5	-0.9	-0.7	0.3	-0.2	0.2	0.4	0.3	-0.9	-0.2	1.2
Eye problems/disorders: None of the above	0.3	0.4	0.9	0.8	0.2	0.8	0.3	0.5	0.6	0.6	0.3	-0.5	1.0
Neck or shoulder pain in last month	0.3	0.4	1.7	-0.2	-1.2	-0.6	0.6	-0.2	-0.0	-0.0	-0.0	-0.3	1.3
Migraine (self-reported)	0.3	0.4	1.0	0.7	-0.3	-0.7	-0.7	0.1	-0.5	-0.6	-0.2	0.5	-1.0
Heart disease (mother)	0.3	0.3	2.0	-0.9	-0.2	0.2	0.4	0.5	-0.2	-0.1	-0.3	-0.3	1.4
Suffer from ‘nerves’	0.3	0.5	1.2	1.1	0.5	-0.6	0.3	-0.1	-0.8	-0.8	-0.9	0.2	-0.8
Illnesses of father: Heart disease	0.3	0.4	1.3	-1.1	0.2	-0.1	0.6	0.1	-0.7	-0.7	-0.8	0.2	-0.3
Mood swings	0.3	0.6	2.3	-1.5	-0.7	-0.9	0.3	-0.3	-0.5	-0.6	-0.9	0.1	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.1	1.1	-0.7	0.5	-0.5	-0.5	0.5	0.5	0.3	0.2	0.9
Mineral and other dietary supplements	0.3	0.4	0.6	-0.6	-0.5	-0.5	0.1	-0.7	-0.8	-0.7	-0.8	0.4	-0.5
Breast cancer (self-reported)	0.3	0.3	1.0	-0.4	1.0	0.2	-0.6	0.3	0.6	0.7	0.8	-0.3	-0.2
Hearing aid user	0.3	0.4	2.4	-0.9	0.3	-0.5	-0.3	-0.2	-0.2	-0.3	-0.1	0.4	-1.5
Irritability	0.3	0.6	1.9	-1.1	-0.5	-0.2	1.0	0.6	0.4	0.4	-0.1	-0.9	1.4
Depression (Nagel 2018)	0.2	0.2	0.5	-0.4	-0.6	-0.7	0.2	-0.5	-0.5	-0.5	-0.5	0.4	-0.2
Neuroticism (Nagel 2018)	0.2	0.5	1.4	0.6	0.3	-0.7	1.2	0.7	-0.9	-0.9	-0.5	-0.1	0.7
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	0.3	0.2	0.3	0.5	0.3	0.7	0.7	0.3	-0.6	0.0
Alzheimer’s Disease (including proxy)	0.2	0.3	1.4	0.2	0.1	0.0	-0.1	0.2	0.8	0.7	0.2	-0.4	-1.2
Ulcerative Colitis (UC)	0.2	0.3	1.5	0.1	1.2	0.8	0.6	0.4	0.2	0.2	0.7	-0.4	0.1
Blood White Count	0.2	1.7	3.1	0.3	1.2	1.2	1.8	1.6	1.3	1.4	1.4	-1.8	0.3
Allergy or Eczema	0.2	0.6	1.5	1.1	0.4	0.3	-0.4	0.8	1.2	1.2	0.9	-0.4	-0.5
Neuroticism	0.2	0.4	0.9	0.3	-0.1	-0.9	0.5	0.1	-0.9	-0.9	-0.9	0.3	0.4
Chronotype (morning person)	0.2	0.5	2.9	1.1	0.7	0.6	0.4	0.2	0.2	0.1	-0.1	-0.5	1.7
Severe depression (siblings)	0.2	0.3	0.7	-0.9	-0.7	0.5	0.3	-0.3	0.3	0.3	0.5	-0.2	-0.8
Pack years adult smoking proportion	0.2	0.4	1.2	-0.1	1.0	-0.3	1.1	0.2	0.2	0.1	0.1	-0.8	-0.8
Trunk fat percentage	0.2	0.7	3.9	-0.7	0.8	-0.2	0.5	0.7	-0.3	-0.2	-1.1	-0.3	-2.0
Hand grip strength (right)	0.2	0.7	3.7	1.9	1.1	-0.2	0.6	0.4	-0.7	-0.6	-0.0	0.1	-0.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.7	-0.7	-0.3	-0.2	-0.7	-0.2	-0.2	-0.5	0.3	0.3
Number of incorrect matches in round	0.2	0.4	1.4	-1.0	-0.4	-0.3	-0.4	-1.2	-0.2	-0.2	-0.5	0.6	-0.0
Had menopause	0.2	0.3	1.4	-0.4	-0.9	-0.1	0.3	-0.6	-0.1	-0.1	-1.2	-0.1	-0.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	0.2	0.4	-0.5	0.4	0.7	-0.5	-0.5	0.2	-0.1	0.6
Neuroticism score	0.2	0.5	1.1	0.6	0.2	-0.7	0.7	0.5	-0.8	-0.9	-0.8	-0.0	1.1
Alcohol intake versus 10 years previously	0.2	0.3	0.9	-0.9	-0.6	0.3	-0.2	-0.9	0.3	0.2	0.4	0.1	-0.6
Number of live births	0.2	0.2	1.8	-0.7	-0.1	-0.0	-0.1	0.2	-0.2	-0.2	-0.2	0.0	1.3
Medication: Cholesterol lowering	0.2	0.3	1.5	-1.2	0.1	0.3	0.4	0.3	0.1	0.1	0.8	-0.3	0.6
Lung cancer (father)	0.2	0.2	0.5	-0.1	-0.2	-0.6	-0.4	-0.6	-0.4	-0.5	-0.7	0.6	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.8	0.8	-0.4	0.6	0.9	0.0	0.0	0.4	-0.3	0.7
Birth weight of first child	0.2	0.3	1.8	-0.1	-0.4	-0.1	-0.7	-0.3	0.6	0.5	0.6	0.0	-1.3
Headache pain in last month	0.2	0.3	1.3	0.1	0.9	-0.6	0.3	1.1	-0.4	-0.4	0.1	-0.2	-0.3
Comparative body size at age 10	0.2	0.7	5.1	0.0	0.7	0.4	0.2	0.8	0.1	0.1	-0.4	-0.4	-2.3
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.0	-1.0	0.5	0.3	0.1	0.6	-0.4	-0.3	-0.7	-0.1	0.7
Medication: Ibuprofen	0.2	0.2	1.2	0.6	-0.0	0.1	-0.0	0.1	0.3	0.3	0.4	-0.2	1.1
Ever had bowel cancer screening	0.2	0.2	0.6	-0.2	-0.6	-0.1	-0.4	-0.2	-0.3	-0.4	-0.7	0.3	0.6
Friendships satisfaction	0.2	0.3	1.5	-1.2	-0.5	-0.2	0.3	-0.0	-0.4	-0.5	-0.1	0.2	0.4
Medication: Aspirin	0.2	0.2	0.5	-0.7	0.7	0.3	0.2	0.4	0.1	0.1	0.6	-0.2	0.7
Average weekly champagne plus white wine intake	0.2	0.3	1.4	-1.2	0.7	-0.2	0.7	0.0	-0.2	-0.2	-0.6	-0.3	-0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.5	0.4	0.6	0.4	-0.6	0.7	0.2	0.2	0.6	-0.0	-0.5
Fractured/broken bones in last 5 years	0.2	0.3	1.5	-1.2	-0.7	-0.3	-0.2	-0.7	-0.3	-0.4	-0.4	0.3	0.0
Unable to work because of sickness or disability	0.2	0.3	1.1	-0.9	-0.1	-0.1	-0.1	-0.1	0.5	0.5	0.3	-0.0	1.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	1.0	-0.7	-0.3	0.3	0.3	0.1	0.1	0.2	-0.0	-0.1	1.0
Bipolar Disorder (2018)	0.1	0.1	0.3	-0.4	0.4	-0.1	0.5	0.2	0.3	0.3	0.1	-0.3	-0.6
Crohns Disease (2017)	0.1	0.2	0.6	0.3	-0.3	0.2	-0.6	0.1	0.2	0.2	0.8	0.3	0.5
Crohns Disease (2012)	0.1	0.2	0.6	-0.5	-0.1	0.5	-0.0	0.2	0.5	0.5	0.8	-0.2	0.1
HDL Cholesterol	0.1	0.2	1.2	0.5	-0.6	-0.4	0.1	-0.2	-0.3	-0.3	-0.1	0.1	1.1
Blood Eosinophil Count	0.1	0.5	1.0	-0.4	0.4	0.5	1.0	0.7	0.8	0.7	0.1	-0.9	0.9
Blood Red Count	0.1	0.7	1.4	-1.1	0.9	-0.4	1.0	-0.0	0.3	0.3	1.1	-0.9	1.2
Tanning	0.1	0.9	3.2	1.0	-0.6	-0.4	-1.8	-0.2	-0.9	-0.9	-0.3	1.4	-0.5
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.9	0.0	-0.1	-0.2	0.9	0.3	-0.1	-0.1	0.2	-0.3	0.4
Hearing difficulty/problems: Yes	0.1	0.2	1.2	-0.6	0.5	0.3	0.4	0.4	0.1	0.1	0.0	-0.2	-1.1
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.7	0.7	-0.5	0.2	-0.0	-0.1	0.3	0.3	-0.2	-0.2	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.0	0.1	-0.5	0.3	-0.0	-0.4	-0.3	-0.2	0.1	0.3
Multivitamins +/- minerals	0.1	0.1	0.4	-0.0	0.4	-0.1	0.4	0.6	0.0	0.0	-0.1	-0.3	-0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	0.6	0.2	-0.1	-0.2	-0.0	-0.5	-0.5	-0.1	0.2	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	-0.2	-0.5	0.3	0.5	0.3	0.4	0.4	-0.2	-0.6	0.3
Medication: Lansoprazole	0.1	0.1	0.4	0.4	0.4	-0.6	-0.3	0.2	-0.2	-0.2	-0.3	0.2	-0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	-0.3	-0.1	-0.0	0.3	-0.3	0.1	0.1	-0.5	-0.2	0.4
Mean time to correctly identify matches	0.1	0.2	0.9	0.6	0.2	0.6	-0.3	-0.3	-0.1	-0.2	0.3	0.2	-1.0
Pulse rate, automated reading	0.1	0.2	0.5	-0.3	0.2	0.0	-0.2	0.7	0.7	0.7	0.5	-0.2	-0.3
Alcohol intake frequency.	0.1	0.3	2.8	0.4	0.6	0.1	-0.1	-0.0	-0.2	-0.2	0.2	0.1	-1.7
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.4	0.5	-0.5	-0.0	-0.6	-0.3	-0.1	-0.0	-0.6	0.3	-0.2
Average weekly red wine intake	0.1	0.2	1.8	1.3	0.2	-0.1	0.1	0.0	0.0	0.0	-0.0	-0.1	0.1
Osteoporosis (self-reported)	0.1	0.1	0.4	0.5	0.4	-0.4	-0.4	-0.1	0.2	0.1	0.2	0.1	0.6
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.7	0.3	-0.9	-0.1	-0.5	0.5	-0.0	0.0	0.0	0.1	0.4
Illnesses of father: High blood pressure	0.1	0.2	0.8	0.4	0.6	0.0	0.9	0.2	0.1	0.1	-0.4	-0.4	0.1
Ever depressed for a whole week	0.1	0.2	0.5	-0.2	0.2	-0.5	0.2	0.4	-0.7	-0.7	-0.1	0.3	0.6
Pack years of smoking	0.1	0.1	0.5	-0.4	0.4	-0.5	0.5	-0.1	-0.1	-0.2	-0.1	-0.3	-0.7
Irritable Bowel Disease (IBD)	0.0	0.1	0.4	0.4	0.4	0.3	-0.3	0.1	0.0	0.0	0.7	0.2	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.0	3.0	-1.7	-0.7	-0.9	-0.7	-1.5	-0.5	-0.5	-1.0	0.7	0.9
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	-0.1	0.1	-0.2	-0.3	-0.3	0.0	0.1	0.0	0.1	0.3

Hub : Genes

COPRS

Models

Trait associations