TWAS hub - RHOT1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1080	0.0400	3.0e-04	-0.002	NA	0.011	NA	0.002	4.6e-01	NA	7.8e-02	NA	2.3e-01
2	GTEx	Artery Coronary	0.1690	0.0700	5.4e-03	0.015	NA	-0.008	NA	-0.003	1.0e-01	NA	8.6e-01	NA	4.2e-01
3	GTEx	Artery Tibial	0.1498	0.0435	5.8e-08	0.059	NA	0.103	NA	0.096	2.2e-05	NA	1.8e-08	NA	6.1e-08
4	GTEx	Cells EBV-transformed lymphocytes	0.1040	0.0480	8.2e-03	0.012	NA	0.008	NA	0.014	1.2e-01	NA	1.8e-01	NA	1.1e-01
5	GTEx	Colon Transverse	0.1160	0.0490	2.8e-03	0.004	NA	-0.001	NA	-0.002	2.1e-01	NA	3.6e-01	NA	4.1e-01
6	GTEx	Esophagus Mucosa	0.0740	0.0340	6.8e-03	-0.003	NA	-0.001	NA	0.005	6.8e-01	NA	3.7e-01	NA	1.5e-01
7	GTEx	Esophagus Muscularis	0.2740	0.0720	2.6e-09	0.166	NA	0.193	NA	0.163	2.6e-10	NA	6.9e-12	NA	3.7e-10
8	GTEx	Nerve Tibial	0.0741	0.0296	4.5e-04	0.006	NA	0.022	NA	0.016	1.0e-01	NA	1.0e-02	NA	2.4e-02
9	GTEx	Small Intestine Terminal Ileum	0.1930	0.0780	4.2e-03	0.010	NA	0.047	NA	0.034	1.9e-01	NA	3.4e-02	NA	6.0e-02
10	GTEx	Thyroid	0.1270	0.0450	4.1e-04	-0.004	NA	0.004	NA	-0.004	9.5e-01	NA	1.6e-01	NA	8.7e-01
11	METSIM	Adipose	0.0542	0.0190	4.6e-06	0.023	0.055	0.034	0.051	0.034	1.7e-04	1.0e-08	6.5e-06	3.7e-08	6.0e-06
12	YFS	Blood	0.0390	0.0110	5.7e-14	0.052	0.053	0.048	0.052	0.050	1.2e-16	7.9e-17	2.4e-15	1.2e-16	5.7e-16
13	TCGA	Kidney Renal Clear Cell Carcinoma	0.0348	0.0216	1.6e-04	0.042	0.032	0.038	NA	0.036	1.7e-05	1.3e-04	3.5e-05	NA	5.7e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	11	12	13
Wheeze or whistling in the chest in last year	9.3	16.5	25.3	4.1	4.7	3.4	4.0	4.9	4.2	4.2	4.7	3.7	3.7	3.9	5.0
Medication: Ventolin 100micrograms inhaler	7.2	9.2	14.9	2.4	3.4	2.2	3.1	3.8	3.2	3.2	3.9	3.1	3.1	3.1	3.1
Respiratory disease	7.0	15.5	29.2	3.0	4.1	3.0	3.4	4.6	3.9	5.4	4.3	4.7	4.0	3.5	4.5
Alcohol drinker status: Never	6.7	8.1	14.4	-3.8	-3.2	-2.5	-2.8	-3.2	-2.9	-3.1	-2.9	-2.7	-2.5	-2.4	-3.2
Average weekly beer plus cider intake	6.5	9.4	14.7	1.3	3.8	2.9	2.8	3.5	2.9	3.3	3.2	3.2	3.5	3.3	3.8
Forced expiratory volume in 1-second (FEV1), Best measure	6.0	19.1	28.8	-3.7	-5.2	-3.1	-5.3	-4.9	-5.4	-3.3	-4.8	-3.4	-5.0	-5.2	-4.3
Mouth/teeth dental problems: Bleeding gums	5.2	6.8	10.4	2.1	2.8	2.7	2.8	3.0	2.8	2.7	3.2	2.7	2.5	2.2	2.8
Angina (self-reported)	5.0	6.6	17.6	3.3	2.5	4.2	2.7	3.0	2.8	1.5	2.4	2.7	1.7	1.9	2.3
Forced expiratory volume in 1-second (FEV1)	4.8	16.1	26.7	-3.3	-4.7	-2.6	-5.2	-4.5	-5.2	-2.3	-4.6	-3.0	-4.6	-5.0	-3.7
Angina	4.7	6.1	15.8	3.2	2.5	4.0	2.6	3.0	2.6	1.4	2.4	2.6	1.6	1.9	2.1
Asthma	4.7	9.2	14.4	2.5	3.0	2.1	3.2	3.8	3.3	3.6	3.6	3.4	3.5	2.5	2.9
Time employed in main current job	4.6	5.3	7.8	-2.5	-2.7	-1.8	-2.8	-2.4	-2.3	-2.1	-2.8	-2.7	-1.8	-2.1	-2.4
Asthma (self-reported)	4.6	9.2	13.9	2.5	3.0	2.3	3.1	3.7	3.3	3.7	3.6	3.3	3.5	2.6	2.9
Length of working week for main job	4.4	4.9	7.4	2.0	2.5	2.3	2.1	2.3	2.6	2.1	2.6	1.6	2.0	2.7	2.5
Peak expiratory flow (PEF)	4.1	9.5	16.5	-2.7	-3.7	-1.7	-4.1	-3.4	-3.8	-1.3	-3.4	-2.1	-3.4	-4.0	-3.5
Lung FEV1/FVC ratio	3.9	20.0	31.0	-4.7	-5.0	-3.3	-5.5	-5.3	-5.6	-3.8	-4.4	-3.9	-4.0	-4.6	-5.1
Medication: Seretide 50 evohaler	3.8	4.4	7.5	0.9	2.6	1.5	1.9	2.7	2.6	2.0	2.7	1.8	2.0	2.5	2.2
Qualifications: CSEs or equivalent	3.7	4.9	8.3	2.6	2.7	2.3	2.5	2.1	1.9	2.9	1.8	1.5	2.2	2.5	2.3
Medication: Paracetamol	3.7	6.2	10.0	1.7	3.1	1.8	3.2	3.1	3.0	1.6	2.9	1.9	2.7	2.7	2.6
Knee pain experienced in last month	3.7	5.8	9.4	2.6	2.6	3.1	2.4	2.4	2.6	2.5	2.3	1.9	2.6	2.4	2.7
Body mass index (BMI)	3.6	15.5	22.1	4.3	3.9	3.1	4.4	4.7	4.0	4.4	4.0	4.7	3.8	3.6	4.0
Height	3.5	66.7	104.0	-6.6	-8.1	-8.3	-10.2	-9.5	-10.1	-6.2	-7.8	-9.8	-9.6	-7.7	-6.8
Sitting height	3.5	24.9	42.5	-2.4	-4.5	-5.3	-6.5	-5.9	-6.2	-3.4	-5.0	-6.5	-6.3	-4.9	-3.3
Number of self-reported non-cancer illnesses	3.5	6.2	11.0	2.4	2.5	2.8	2.5	2.9	2.6	3.3	2.4	2.7	2.4	1.9	2.4
Lupus	3.4	5.1	7.7	1.4	2.3	2.4	2.2	2.8	2.4	2.3	2.0	2.8	2.7	2.0	2.6
Leg fat percentage (left)	3.4	12.4	21.7	3.1	3.3	2.6	4.1	4.0	3.6	4.3	3.2	4.7	4.0	3.2	3.4
Smoking Status	3.3	7.9	11.9	2.2	3.3	2.3	2.9	3.4	2.8	3.1	2.8	3.1	3.5	1.7	3.4
Leg fat percentage (right)	3.3	12.1	20.2	3.3	3.3	2.6	4.2	4.0	3.7	3.9	3.2	4.5	3.9	3.1	3.2
Forced vital capacity (FVC), Best measure	3.2	11.8	18.3	-2.7	-3.9	-2.6	-4.3	-3.9	-4.1	-2.9	-3.9	-3.0	-4.1	-3.9	-3.0
Commuting to job workplace: Walk	3.2	3.5	6.6	-2.4	-2.0	-2.3	-1.3	-1.8	-2.0	-1.8	-1.7	-1.6	-1.4	-1.9	-2.6
Glaucoma (self-reported)	3.1	3.6	5.8	1.6	1.8	2.0	2.0	2.3	1.8	2.1	1.9	1.8	2.4	1.8	2.2
Age at first live birth	3.1	5.4	10.8	-1.7	-2.9	-1.4	-3.0	-2.3	-2.6	-2.4	-1.6	-1.9	-3.2	-1.9	-3.3
Forced vital capacity (FVC)	3.0	11.7	19.6	-2.6	-3.8	-2.6	-4.4	-3.9	-4.3	-2.2	-3.9	-2.8	-4.1	-4.2	-2.8
Impedance of arm (left)	3.0	14.1	22.6	-4.8	-3.7	-3.8	-4.0	-4.3	-3.6	-4.4	-3.7	-4.7	-3.1	-3.0	-3.6
Ever had stillbirth, spontaneous miscarriage or termination	2.9	3.1	7.1	2.2	1.6	1.2	2.7	2.1	1.9	1.7	1.4	2.1	2.0	1.2	1.1
Osteoarthritis (self-reported)	2.9	3.8	7.8	0.7	2.2	2.2	2.4	1.7	2.2	1.5	2.4	1.3	2.8	2.2	1.8
Medication: Lisinopril	2.9	3.8	8.6	-0.7	-2.5	-1.2	-1.6	-1.7	-2.2	-1.4	-2.5	-1.5	-2.3	-2.9	-2.4
Impedance of whole body	2.9	14.6	26.4	-5.1	-3.9	-3.3	-4.1	-4.5	-3.8	-4.2	-4.1	-4.2	-2.9	-3.3	-3.8
Age at last live birth	2.8	4.1	8.4	-1.0	-2.9	-1.4	-2.4	-2.0	-2.4	-2.1	-1.1	-1.8	-2.5	-1.6	-2.9
Smoking status: Current	2.8	4.5	7.3	1.9	2.6	2.0	2.0	2.1	2.0	2.4	2.1	2.2	2.7	1.2	2.7
Supplements: Zinc	2.7	2.9	5.5	-0.8	-1.5	-1.3	-2.3	-2.4	-2.3	-1.0	-1.8	-1.9	-1.8	-1.9	-1.6
Heart attack	2.7	3.4	8.5	2.4	1.4	2.9	2.2	2.2	2.1	1.0	1.7	2.3	1.0	1.7	0.9
Health satisfaction	2.7	3.5	8.2	2.6	2.3	1.8	1.4	1.7	1.6	2.7	1.5	0.9	1.1	1.7	2.9
BMI	2.6	15.1	22.8	4.3	4.0	3.5	4.2	4.6	3.9	4.2	4.1	4.8	3.1	3.7	3.8
Arm fat percentage (right)	2.6	10.4	14.4	3.4	3.2	2.3	3.6	3.8	3.5	3.5	3.4	3.5	3.3	3.1	3.4
Loneliness, isolation	2.6	3.6	7.7	2.0	1.6	2.2	1.9	2.1	1.7	2.8	2.1	2.2	1.3	1.2	2.0
Medication: Gliclazide	2.6	2.9	10.5	1.7	1.2	1.1	1.4	1.4	1.1	3.2	1.1	2.7	1.7	1.5	1.6
Medication: Atorvastatin	2.6	3.2	7.1	2.0	1.3	2.7	1.5	1.9	1.6	2.4	1.3	2.6	1.4	1.1	1.8
Chest pain or discomfort	2.5	3.6	8.5	2.9	1.9	1.6	2.0	2.3	1.9	1.8	1.6	2.5	1.6	1.0	1.9
Alcohol drinker status: Previous	2.5	2.8	6.5	1.4	1.4	1.5	2.3	1.8	2.1	1.0	2.1	1.4	2.6	1.4	1.2
Ulcerative Colitis	2.4	3.5	6.9	2.5	2.1	2.5	0.8	2.1	1.8	2.3	1.8	1.3	1.1	1.5	2.6
Stomach or abdominal pain in last month	2.4	3.0	5.8	1.6	2.4	1.5	1.6	1.5	1.9	1.1	2.2	0.5	2.0	1.8	2.4
Standing height	2.4	23.7	41.0	-3.5	-4.6	-5.0	-6.4	-5.7	-6.2	-3.5	-4.4	-6.4	-5.8	-4.5	-3.6
Financial difficulties in last 2 years	2.3	3.1	4.7	1.1	1.9	1.0	1.7	1.8	1.6	2.0	2.1	2.2	2.0	2.2	1.9
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	6.8	-0.8	-1.4	-1.5	-2.1	-2.0	-1.6	-2.6	-1.5	-2.4	-1.6	-1.6	-1.1
Medication: Paracetamol	2.3	3.5	6.3	1.1	2.0	1.3	2.5	2.5	2.2	0.9	2.3	1.7	2.4	1.9	1.8
Heart attack/myocardial infarction (self-reported)	2.3	2.9	6.8	2.3	1.2	2.6	2.1	2.0	1.9	0.8	1.6	2.4	0.8	1.5	0.8
Leg fat mass (right)	2.2	8.7	13.2	3.1	2.9	2.4	3.2	3.5	2.9	3.6	2.9	3.6	2.8	2.8	3.1
Family relationship satisfaction	2.2	2.7	6.8	2.2	1.7	1.4	1.6	1.8	1.5	2.6	1.2	1.5	1.6	0.8	2.0
Deep venous thrombosis (DVT) (self-reported)	2.2	2.8	5.3	1.9	2.1	1.1	2.0	2.3	1.7	2.0	1.4	1.7	1.2	1.1	1.7
Leg fat mass (left)	2.2	8.8	14.3	2.9	2.9	2.2	3.1	3.4	2.8	3.8	2.9	3.7	2.9	2.8	3.1
Medication: Simvastatin	2.1	3.1	6.0	-1.3	-1.9	-1.6	-1.7	-1.5	-2.1	-1.2	-2.3	-0.7	-2.5	-2.4	-1.8
Impedance of arm (right)	2.1	9.7	18.0	-3.9	-2.9	-3.0	-3.5	-3.7	-3.0	-3.6	-3.0	-4.2	-2.4	-2.4	-2.8
Arm fat percentage (left)	2.1	8.2	11.6	3.0	2.8	2.0	3.3	3.4	3.1	3.0	3.0	3.1	2.9	2.8	3.0
Lung FVC	2.0	10.0	20.1	-1.1	-3.8	-2.8	-3.1	-3.5	-3.5	-2.4	-4.2	-2.1	-3.9	-4.5	-3.1
Medication for hormone replacement therapy	2.0	2.2	4.7	-1.0	-1.4	-0.6	-1.5	-1.1	-1.5	-1.8	-2.0	-1.5	-2.0	-2.2	-1.5
Current tobacco smoking	2.0	3.2	5.2	1.6	2.2	1.7	1.5	1.8	1.6	2.2	1.8	2.1	2.3	0.7	2.2
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	6.4	2.0	2.2	1.7	1.5	1.9	1.6	1.9	1.6	1.3	1.9	1.5	2.5
Blood clot in the leg (DVT)	2.0	2.6	4.5	2.0	2.1	1.2	1.9	2.1	1.7	2.0	1.4	1.5	1.1	1.0	1.8
Medication: Blood pressure	2.0	3.6	9.3	-1.5	-2.1	-0.8	-1.9	-1.8	-2.3	-1.5	-2.2	-1.5	-2.2	-3.1	-1.8
Arm fat mass (left)	2.0	8.3	12.0	3.4	2.9	2.1	3.0	3.5	2.8	3.4	3.1	3.1	2.6	2.7	3.1
Age at First Birth	1.9	2.7	6.4	-2.5	-1.7	-2.0	-2.0	-2.0	-1.6	-2.1	-1.2	-1.3	-1.2	-0.6	-1.2
Medication: Atenolol	1.9	2.3	6.5	2.5	0.9	1.8	2.1	1.9	1.4	1.0	1.6	2.0	1.0	0.7	1.0
High blood pressure (mother)	1.9	2.6	6.3	1.6	1.7	1.7	1.8	2.4	1.2	1.1	2.1	2.5	0.8	0.6	1.4
Ever unenthusiastic/disinterested for a whole week	1.9	2.4	13.2	1.9	1.2	1.1	1.0	1.4	0.9	3.6	0.9	1.8	0.6	0.2	1.8
Arm fat mass (right)	1.9	8.0	11.9	3.4	2.8	2.1	2.9	3.4	2.7	3.5	3.0	3.1	2.5	2.6	3.1
Average weekly spirits intake	1.8	2.3	5.0	0.7	1.5	0.3	2.2	1.7	2.0	0.9	1.6	2.2	1.0	2.1	1.1
Pack years adult smoking proportion	1.8	2.8	5.6	1.8	1.9	1.4	1.3	1.6	1.4	2.4	1.8	2.0	1.5	1.2	2.0
Breastfed as a baby	1.8	2.2	5.4	-1.6	-1.3	-2.2	-1.6	-1.3	-1.6	-2.3	-1.2	-1.2	-1.1	-1.2	-1.4
Fasting Glucose	1.7	2.0	4.2	-0.8	-1.0	-0.5	-2.1	-1.7	-1.7	-1.7	-0.9	-1.3	-1.8	-1.5	-1.7
HbA1C	1.7	1.9	5.1	1.3	1.2	1.2	2.3	1.4	1.9	0.9	1.5	1.6	1.2	1.4	-0.1
Maternal smoking around birth	1.7	2.5	5.7	0.9	1.8	1.5	2.0	2.1	1.7	1.4	1.6	2.4	1.5	1.1	1.3
Exposure to tobacco smoke at home	1.7	1.9	4.1	0.5	1.4	2.0	1.4	1.4	1.8	0.2	1.2	1.0	1.7	1.4	1.8
Overall health rating	1.7	3.5	8.4	2.9	1.8	2.0	2.3	2.4	1.9	1.6	1.8	2.0	1.6	1.0	1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	5.8	-1.6	-1.9	-1.6	-1.9	-1.9	-2.0	-2.1	-1.8	-2.1	-2.4	-1.5	-2.3
Myopia	1.7	2.4	7.6	2.8	1.4	2.4	1.1	1.7	1.7	1.1	1.2	1.4	0.8	1.2	1.6
Medication for pain relief, constipation, heartburn	1.6	2.8	4.9	-2.1	-1.7	-1.3	-2.2	-2.0	-2.0	-1.2	-2.0	-1.3	-1.4	-1.8	-1.5
Long-standing illness, disability or infirmity	1.6	2.4	5.2	1.2	1.8	1.6	1.5	1.4	1.4	2.0	1.2	2.0	1.9	0.8	2.3
Illnesses of father: High blood pressure	1.6	1.9	7.8	1.0	0.8	2.0	0.6	1.4	0.5	2.8	1.1	2.2	0.7	0.4	1.4
Age started oral contraceptive pill	1.6	2.0	3.7	0.2	-1.5	-1.3	-1.6	-1.6	-1.5	-1.6	-1.7	-1.2	-1.9	-1.1	-1.9
Commuting to job workplace: Cycle	1.6	1.9	3.3	1.7	1.4	1.1	1.6	1.2	1.5	1.8	1.8	0.9	0.8	1.2	1.8
Impedance of leg (right)	1.5	7.3	16.7	-4.1	-2.8	-2.0	-2.6	-3.2	-2.5	-3.3	-3.2	-2.3	-1.5	-2.5	-3.1
Taking other prescription medications	1.5	2.3	3.7	1.8	1.3	1.9	1.8	1.7	1.9	1.2	1.8	1.8	0.7	1.3	1.1
Impedance of leg (left)	1.5	7.5	19.0	-4.4	-2.9	-1.9	-2.9	-3.2	-2.8	-2.8	-3.3	-2.1	-1.5	-2.5	-2.9
Waist circumference	1.5	5.6	9.4	2.7	2.4	1.5	2.6	3.0	2.2	2.9	2.1	3.1	2.2	2.1	2.5
Hair/balding pattern: Pattern 2	1.5	1.9	5.0	-0.9	-0.8	-1.7	-2.2	-1.8	-1.5	-0.8	-2.1	-0.7	-1.3	-1.5	-0.2
Comparative height size at age 10	1.5	8.0	15.3	-2.6	-2.6	-3.5	-3.6	-3.2	-3.9	-1.9	-2.3	-3.6	-2.8	-2.7	-1.7
Pain experienced in last month	1.5	2.5	4.2	-1.6	-2.0	-1.8	-1.8	-1.6	-1.6	-1.6	-1.4	-1.3	-1.4	-1.2	-2.1
Medication: Co-codamol	1.4	1.6	4.1	1.2	1.0	1.1	2.0	1.5	1.6	0.7	1.6	1.5	1.2	1.2	0.1
Fed-up feelings	1.4	2.5	4.5	0.4	1.6	1.9	2.1	1.7	1.2	1.9	1.7	1.2	2.0	1.4	1.8
Supplements: Glucosamine	1.4	1.8	4.0	-0.7	-1.5	-1.0	-1.4	-1.9	-1.4	-1.7	-1.2	-2.0	-1.3	-0.9	-1.4
Allergy	1.4	3.2	7.0	-1.6	-1.8	-0.4	-2.6	-2.3	-2.1	-2.4	-2.1	-2.0	-1.2	-1.4	-1.2
Birth weight	1.4	3.0	5.3	1.9	2.3	1.6	1.6	1.3	1.7	1.7	1.9	0.3	2.1	2.2	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	3.0	1.0	1.4	1.1	1.7	1.5	1.6	1.3	1.5	1.3	1.1	1.0	1.0
Hearing aid user	1.4	1.6	3.8	-1.0	-1.3	-1.4	-0.8	-1.5	-0.9	-1.1	-1.5	-1.9	-2.0	-0.9	-1.1
Father’s age at death	1.3	1.8	3.5	-0.5	-1.3	-1.8	-1.4	-1.3	-1.1	-1.8	-0.8	-1.8	-1.2	-1.3	-1.9
Falls in the last year	1.3	1.7	3.9	0.8	1.3	1.2	2.0	1.7	1.5	1.0	1.0	1.2	1.9	1.6	0.6
Loud music exposure frequency	1.3	1.4	3.5	1.0	1.3	1.4	0.6	1.6	1.0	1.9	1.2	0.7	0.6	0.9	1.7
Body fat percentage	1.3	5.3	8.2	2.0	2.2	1.4	2.6	2.8	2.3	2.9	2.2	2.7	2.7	2.3	2.4
Exposure to tobacco smoke outside home	1.3	1.8	5.0	0.4	1.5	1.1	1.0	1.3	1.2	1.5	1.6	1.1	1.4	1.4	2.2
Ever taken oral contraceptive pill	1.3	1.4	3.2	0.8	1.1	1.6	1.6	1.6	1.7	-0.1	1.8	1.1	0.6	1.0	0.5
Ovarian Cancer	1.2	1.5	4.4	0.4	1.1	2.1	0.8	1.3	1.3	1.3	0.8	1.1	1.2	1.4	1.7
Body Mass Index (BMI) (2010)	1.2	1.6	3.6	1.9	1.5	1.1	1.0	1.0	1.4	1.0	1.2	1.2	1.2	1.8	1.1
LDL Cholesterol	1.2	1.9	4.5	-0.1	-1.7	-1.5	-0.9	-1.5	-1.4	-1.4	-1.2	-1.4	-1.8	-2.1	-1.2
Lung cancer (father)	1.2	1.4	4.0	-2.0	-1.2	-1.4	-0.2	-1.0	-0.6	-1.9	-1.1	-1.1	-0.8	-0.7	-1.7
Whole body fat mass	1.2	5.1	9.1	2.5	2.2	1.5	2.3	2.7	2.1	3.0	2.3	2.4	2.2	2.2	2.5
Diastolic blood pressure, automated reading	1.2	3.8	7.4	1.7	1.5	2.5	2.7	2.2	2.5	0.9	2.2	1.4	2.4	1.9	1.3
Townsend deprivation index at recruitment	1.1	1.6	4.2	1.1	1.4	1.2	2.1	1.6	1.8	0.7	1.2	0.7	1.3	0.9	0.8
Average weekly fortified wine intake	1.1	1.2	2.7	1.3	0.9	0.9	1.4	0.9	1.6	0.2	1.3	0.9	1.3	1.6	0.7
Qualifications: A levels/AS levels or equivalent	1.1	2.4	6.7	1.9	1.3	0.7	0.6	1.0	1.1	2.5	1.8	2.6	1.0	1.7	1.7
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.8	1.1	1.3	0.7	1.5	1.3	1.5	1.0	1.7	1.2	1.9	1.9	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.7	0.8	0.6	0.2	1.7	1.5	1.1	0.5	1.5	1.9	1.5	0.8	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.2	-1.8	-1.4	0.0	-1.0	-1.7	-1.0	-0.8	-1.5	-0.7	-0.3	-1.4	-1.3
Rheumatoid Arthritis	1.0	1.4	2.3	1.3	1.3	1.0	1.3	1.1	1.4	0.5	1.5	1.5	1.4	1.5	0.7
Chronic bronchitis/emphysema (father)	1.0	1.2	2.5	1.4	1.3	0.8	1.6	1.0	1.4	0.8	0.9	0.8	0.3	1.6	1.1
Had other major operations	1.0	1.2	2.9	1.2	1.1	1.1	1.0	1.4	1.0	1.0	1.2	1.7	0.9	0.5	1.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.4	1.2	1.1	0.4	1.8	1.5	1.4	1.0	1.3	1.5	0.7	1.0	0.4
Pulse wave reflection index	1.0	1.2	3.9	-0.4	-1.1	-2.0	-0.7	-1.2	-1.2	-1.4	-0.7	-1.0	-0.6	-1.3	-1.2
Emphysema/chronic bronchitis	1.0	1.1	2.4	0.8	1.3	1.1	1.1	1.5	1.0	0.9	1.4	0.7	0.7	0.9	1.3
Verbal and Numeric Reasoning (VNR)	0.9	2.1	4.6	1.9	1.3	0.8	1.5	1.4	1.6	1.2	1.9	2.1	1.1	1.4	1.5
Bipolar Disorder (2011)	0.9	0.9	3.8	-1.6	-0.6	-1.9	-1.1	-1.1	-1.0	-0.4	-0.9	-0.6	-0.3	-0.6	-0.0
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.8	1.7	1.2	0.5	1.1	1.2	1.2	0.7	1.2	0.6	0.2	1.3	0.9
Vitamin and mineral supplements	0.9	1.2	4.4	-1.3	-0.9	-1.5	-1.1	-0.7	-1.3	-0.0	-2.1	-0.4	-1.1	-1.5	-0.5
High blood pressure (siblings)	0.9	1.3	6.2	2.5	0.8	1.2	1.1	1.4	1.1	0.8	1.0	1.5	-0.4	0.1	0.9
Number of children fathered	0.9	1.0	4.9	0.3	0.7	0.8	0.3	1.1	0.2	1.5	0.8	2.2	1.1	0.1	1.2
Number of full sisters	0.9	1.0	3.0	1.7	0.8	1.2	1.5	1.1	1.2	1.6	0.7	0.4	0.3	0.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	4.0	-1.1	-1.9	-0.5	-1.1	-1.4	-1.5	-1.2	-2.0	-0.1	-1.2	-1.9	-1.8
Miserableness	0.9	1.5	4.5	0.9	1.7	1.1	1.1	1.1	0.9	1.1	1.2	0.8	1.3	1.4	2.1
Mother’s age at death	0.9	1.2	2.6	-0.4	-1.2	-0.7	-1.5	-1.3	-0.8	-1.6	-0.7	-1.6	-1.2	-0.6	-1.1
Heel T-Score	0.8	6.6	14.1	-1.2	-2.6	-2.8	-2.9	-3.8	-2.7	-1.8	-3.3	-3.4	-2.3	-1.8	-2.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.4	-0.9	-1.2	-0.3	-0.5	-1.2	-0.9	-1.0	-1.2	-1.1	-1.0	-1.0	-1.1
Serious illness, injury or assault to yourself	0.8	1.0	3.7	0.8	0.7	0.9	0.9	1.0	0.8	1.9	0.6	1.8	0.5	0.7	0.9
Past tobacco smoking	0.8	1.4	4.3	-0.5	-1.0	-0.8	-2.1	-1.6	-1.7	-0.9	-0.8	-0.7	-1.6	-1.2	-0.8
Hip circumference	0.8	3.5	8.4	2.9	1.8	1.0	1.4	2.2	1.2	2.6	2.0	2.3	1.2	1.4	2.4
Happiness	0.8	0.9	2.9	1.7	0.9	1.3	1.2	1.1	0.9	1.4	0.5	0.1	0.3	0.5	0.6
Osteoporosis (self-reported)	0.8	0.9	6.8	-0.7	-0.8	-0.7	-0.0	-0.3	-0.3	-2.6	-0.5	-0.7	-0.6	0.1	-1.5
Eye problems/disorders: Glaucoma	0.8	0.9	2.5	0.2	0.9	1.1	0.9	1.1	0.8	0.9	1.1	0.4	1.6	1.1	1.2
Schizophrenia (2018)	0.7	1.4	6.7	-1.4	-0.2	-0.6	-1.8	-1.1	-1.0	-0.7	-0.9	-2.6	-1.3	-0.5	-0.0
Ulcerative Colitis (UC)	0.7	1.3	3.8	1.6	1.4	1.6	0.2	1.1	1.1	1.2	0.9	0.7	0.8	0.4	1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.1	-0.1	-1.4	-1.6	-0.7	-1.7	-1.2	-0.9	-1.6	-2.0	-1.3	-1.3	-1.3
Fluid intelligence score	0.7	1.4	3.5	1.9	1.2	0.2	1.1	1.1	1.2	0.9	1.2	1.7	0.8	1.3	1.3
Weight	0.7	3.6	8.2	2.7	1.9	1.0	1.5	2.2	1.3	2.9	2.1	1.8	1.2	1.6	2.4
Number of full brothers	0.7	0.9	3.5	0.4	0.7	0.5	1.2	0.9	0.7	1.9	0.6	1.8	0.5	0.8	0.7
Medication: Aspirin	0.7	1.0	3.8	2.0	0.2	1.6	0.9	1.2	0.9	0.4	0.9	1.3	0.2	0.2	0.5
Back pain experienced in last month	0.7	1.0	3.1	1.6	0.9	1.2	1.8	1.1	1.1	0.8	1.0	0.7	0.4	0.1	0.5
Mineral and other dietary supplements	0.7	0.9	4.0	0.4	1.1	0.6	0.0	1.3	0.4	2.0	0.1	0.9	0.5	0.1	1.9
Irritability	0.7	1.1	3.2	0.6	1.0	0.4	1.3	1.1	0.5	1.4	1.0	1.8	1.6	0.5	1.0
Basal cell carcinoma (self-reported)	0.7	0.8	2.0	1.4	0.6	1.4	0.5	0.3	0.9	0.9	0.6	1.4	0.0	1.3	0.4
Pack years of smoking	0.7	1.0	2.5	1.3	1.1	1.0	0.7	1.0	0.7	1.6	1.1	1.4	0.5	0.7	1.2
Depressed Affect (Nagel 2018)	0.6	1.3	2.6	0.5	1.4	1.3	1.2	1.2	0.7	1.5	1.6	0.9	1.0	0.9	1.5
Schizophrenia vs Biploar Disorder	0.6	0.8	2.7	1.0	1.2	1.0	0.8	1.2	0.9	1.6	0.6	0.5	0.6	0.7	0.8
Major Depression (MDD)	0.6	0.7	3.1	1.7	0.6	1.5	-0.3	0.4	0.2	1.0	0.1	-0.7	-0.7	0.1	1.1
Prostate Cancer	0.6	0.9	3.3	-0.8	-0.7	-0.1	-1.8	-1.3	-1.4	0.3	-1.3	-0.1	-0.7	-1.1	-0.1
Coronary Artery Disease (CAD)	0.6	0.8	1.8	0.3	1.2	1.2	0.8	1.0	1.3	0.7	0.7	0.3	0.6	0.7	1.3
Triglycerides	0.6	0.9	3.3	0.0	-1.2	0.2	-1.0	-1.1	-0.9	-0.8	-1.1	-0.3	-1.3	-1.8	-1.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.4	-1.0	-1.0	-0.8	-0.7	-0.8	-1.2	-0.4	-1.2	-0.3	-0.4	-1.2	-0.8
Mouth/teeth dental problems	0.6	0.9	2.2	-1.1	-1.2	-1.4	-1.3	-1.1	-1.5	-0.6	-0.6	0.1	-0.3	-0.8	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	3.6	1.1	0.6	1.2	0.7	1.1	0.2	1.9	0.8	0.8	1.5	-0.1	0.3
Pulse rate	0.6	1.0	4.5	0.8	0.4	2.1	0.6	1.4	0.9	0.8	0.9	1.2	0.7	0.4	0.7
Tense / ‘highly strung’	0.6	1.1	3.3	0.4	1.2	0.1	0.8	1.2	0.5	1.8	0.9	1.4	1.3	0.8	1.2
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.3	-0.3	-1.2	-0.1	-1.8	-1.5	-0.9	-0.3	-1.0	-0.8	-1.4	-0.7	-0.6
Neck or shoulder pain in last month	0.6	0.8	2.3	0.3	1.0	0.5	0.6	0.8	0.3	1.2	1.5	1.2	1.0	0.6	1.4
Illnesses of siblings: Diabetes	0.6	0.8	2.9	0.7	0.9	0.7	1.7	1.3	1.1	0.4	0.6	1.1	0.2	0.6	0.5
Medication for cholesterol	0.6	0.9	2.9	0.9	1.4	-0.2	0.7	-0.0	1.4	-0.2	1.2	-0.3	1.3	1.7	0.8
Financial situation satisfaction	0.6	0.8	2.0	0.9	0.9	0.4	0.7	0.8	0.7	1.4	0.5	0.8	1.1	0.6	1.4
Arm fat-free mass (left)	0.6	3.2	8.3	2.9	1.9	1.2	1.3	2.1	1.0	2.8	1.9	1.7	1.0	1.2	2.2
Heart disease (siblings)	0.6	0.7	2.9	-0.7	-1.2	0.6	0.7	-0.6	0.0	-1.4	-1.2	-0.1	-0.3	-0.5	-1.7
Alzheimer’s Disease (including proxy)	0.5	0.7	4.1	0.3	1.0	-0.7	0.3	1.0	0.7	0.8	0.6	0.2	1.0	0.3	2.0
Reaction Time	0.5	1.0	4.5	-0.0	1.2	0.2	0.8	0.5	1.2	1.1	1.2	-0.4	1.0	1.1	2.1
Blood White Count	0.5	3.8	8.6	0.6	2.0	1.2	2.0	1.9	1.7	2.3	1.8	2.7	2.9	2.0	2.0
Cardiovascular Disease	0.5	1.5	4.8	0.8	0.7	2.2	0.9	1.8	0.4	1.6	1.1	2.1	0.4	0.4	1.2
Relative age of first facial hair	0.5	1.0	4.3	-0.9	-0.2	-1.1	-0.4	-1.2	-0.5	-1.6	-0.7	-2.1	-1.1	-0.4	-0.8
Trunk fat percentage	0.5	1.9	3.4	0.9	1.3	0.6	1.5	1.8	1.2	1.9	1.3	1.5	1.7	1.5	1.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.6	0.2	1.2	-0.4	0.9	0.5	0.8	0.3	1.0	0.2	0.8	0.4	1.3
Trunk fat mass	0.5	2.2	5.3	1.5	1.4	0.8	1.5	1.9	1.2	2.3	1.5	1.5	1.5	1.5	1.8
Number of incorrect matches in round	0.5	0.8	4.7	-0.9	-0.1	-1.2	-0.5	-1.0	-0.3	-0.9	-0.9	-2.2	-0.4	-0.2	-0.3
Nervous feelings	0.5	1.0	2.6	-1.6	-0.9	-0.8	-1.1	-1.3	-0.9	-0.7	-0.8	-1.6	-0.6	0.4	-0.8
Hearing difficulty/problems with background noise	0.5	0.7	1.6	-1.2	-0.6	-0.2	-0.8	-1.1	-0.8	-0.7	-1.2	-1.3	-1.0	-0.8	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.7	-0.4	0.6	1.3	0.4	0.3	0.4	1.3	0.6	0.9	0.9	0.9	0.9
Illnesses of mother	0.5	0.6	1.9	0.7	0.7	-0.1	0.3	0.5	0.7	0.8	0.7	0.1	1.4	1.2	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	3.7	0.9	0.8	0.5	0.3	0.2	0.6	1.9	0.1	0.7	0.6	0.2	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	3.5	-1.9	-0.3	-0.4	-0.7	-0.7	-0.7	0.7	-1.0	-0.9	-0.1	-0.8	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.5	0.2	-0.9	-0.4	-0.2	-0.4	-1.0	0.6	-1.6	-0.0	-1.3	-1.1	-0.6
Medication: Blood pressure	0.5	0.9	2.7	0.9	0.1	1.6	1.1	1.6	0.4	1.2	0.6	1.6	0.5	-0.1	0.3
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.8	-0.6	-1.0	-0.5	-0.2	-0.8	-0.4	-1.7	-0.0	-0.8	-0.5	0.2	-1.3
Medication: Bendroflumethiazide	0.5	0.8	2.2	0.1	-1.0	-0.2	-0.5	-0.6	-1.0	-0.2	-1.2	-1.1	-1.5	-1.5	-0.6
Ever depressed for a whole week	0.5	0.6	3.8	1.3	0.6	0.2	0.2	0.4	0.1	1.9	-0.5	0.1	-0.6	-0.1	0.8
Arm predicted mass (left)	0.5	2.6	8.3	2.9	1.6	1.0	0.9	1.7	0.7	2.7	1.6	1.4	0.7	0.9	2.1
Bipolar Disorder or Schizophrenia	0.4	1.0	5.6	-1.4	-0.0	-0.7	-1.5	-0.9	-0.7	-0.4	-0.8	-2.4	-1.0	-0.2	0.4
Alzheimer’s Disease (in father)	0.4	0.5	1.3	0.2	0.3	-1.2	-0.9	0.0	-0.6	1.0	-0.4	0.5	0.4	-0.8	1.1
Schizophrenia (2014)	0.4	1.0	4.4	-1.0	0.0	-0.4	-1.6	-0.8	-0.8	0.2	-0.9	-2.1	-1.3	-0.2	0.6
Sensitivity / hurt feelings	0.4	0.6	2.2	0.1	-0.7	-1.5	-0.6	-1.0	-0.9	0.7	-0.8	-0.9	0.1	-0.8	0.2
Systolic blood pressure, automated reading	0.4	1.2	3.0	1.3	0.8	1.7	0.8	1.3	0.9	1.2	0.2	1.4	1.5	0.5	1.2
Leg fat-free mass (left)	0.4	2.1	7.1	2.7	1.5	0.6	0.7	1.4	0.6	2.3	1.7	0.6	0.1	1.2	2.1
Multivitamins +/- minerals	0.4	0.5	1.9	0.8	0.3	1.4	0.5	0.4	0.5	0.1	1.3	1.0	0.3	0.4	0.3
Leg predicted mass (left)	0.4	2.0	6.7	2.6	1.6	0.5	0.6	1.4	0.6	2.3	1.7	0.6	0.1	1.2	2.1
Medication: Ramipril	0.4	0.5	1.5	0.7	1.0	0.6	0.4	1.1	0.2	0.8	0.7	0.3	0.2	-0.1	1.2
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.7	0.9	0.3	1.6	0.2	0.5	0.3	1.6	0.3	-0.0	-0.4	-0.1	0.3
Leg pain on walking	0.4	0.5	1.8	0.3	0.2	-0.5	-0.4	-0.3	-0.8	-0.9	-0.5	-1.3	-1.3	-0.8	0.2
Supplements: Vitamin C	0.4	0.5	1.4	1.2	-0.2	-0.4	0.8	0.1	0.5	-0.7	0.9	-1.0	0.1	0.8	-1.1
Average weekly red wine intake	0.4	0.7	3.4	1.1	0.3	0.6	0.1	0.7	0.5	1.8	1.1	1.1	0.1	0.2	0.6
Breast cancer (self-reported)	0.4	0.5	2.3	0.8	-0.3	1.3	0.4	0.6	0.5	-0.0	0.4	1.5	0.2	-0.2	-0.4
Medication: Aspirin	0.4	0.5	2.3	1.5	-0.6	1.1	0.4	0.6	0.1	-0.4	0.4	1.0	-0.7	-0.7	-0.3
Illnesses of father: None of the above (group 1)	0.4	0.5	4.1	-0.5	-0.3	-2.0	-0.0	-0.8	0.1	-0.7	0.0	-0.4	0.4	0.3	-0.3
Leg predicted mass (right)	0.4	2.0	6.0	2.5	1.5	0.5	0.4	1.4	0.4	2.4	1.7	0.5	0.0	1.2	2.1
Guilty feelings	0.4	0.6	3.4	1.2	0.7	0.9	0.1	0.2	-0.0	1.8	1.1	0.7	0.3	0.1	0.6
Basal metabolic rate	0.4	2.1	7.0	2.6	1.5	0.7	0.7	1.6	0.6	2.4	1.6	1.0	0.3	1.0	2.0
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.4	-0.9	-0.4	-1.2	-1.1	-0.6	-1.0	-0.1	-0.2	0.1	-0.7	-0.9	-0.2
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.7	-1.2	0.1	-1.6	-1.2	-1.7	-0.4	-0.6	-0.7	-1.9	0.0	0.5	0.2
Supplements: Calcium	0.4	0.5	1.8	0.6	0.4	0.2	1.3	0.7	0.5	-0.8	1.1	0.6	0.4	0.0	-0.8
HDL Cholesterol	0.3	0.5	3.1	-0.4	0.2	-1.8	0.5	-0.3	-0.0	-0.9	0.1	-1.4	-0.2	0.2	-0.7
Blood Eosinophil Count	0.3	2.1	5.5	0.6	1.7	0.7	0.4	1.1	1.0	2.4	0.9	2.3	1.6	1.3	2.2
Blood Platelet Count	0.3	3.4	8.8	-1.5	-2.4	-1.5	-0.9	-2.0	-1.7	-2.3	-2.2	-0.3	-2.0	-1.6	-3.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.4	-0.3	0.5	1.2	0.7	0.7	0.3	0.0	0.5	1.0	1.2	-0.1	0.2
Age when periods started (menarche)	0.3	0.7	2.5	-1.6	-0.7	-0.8	0.5	-0.6	0.4	-0.6	-0.9	-1.0	-0.1	0.8	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	3.0	-0.2	-0.9	-0.9	-0.4	-1.5	-0.6	-1.0	-0.8	-1.7	-0.4	-0.3	-0.7
Medication: Levothyroxine sodium	0.3	0.5	1.4	0.9	0.5	1.2	-0.7	0.0	-0.4	1.2	-0.4	0.6	-0.6	-0.4	0.9
Had menopause	0.3	0.4	1.3	1.1	0.6	-0.3	0.3	-0.1	0.3	0.2	-0.0	1.1	1.0	0.3	0.7
Pain all over the body in last month	0.3	0.4	0.9	-0.8	-0.4	0.2	-0.7	-0.5	-0.9	-0.2	-0.9	0.6	0.1	-1.0	-0.3
Illnesses of siblings	0.3	0.4	2.0	-1.4	0.3	-0.3	-0.9	-0.3	-0.5	0.0	0.1	-0.8	1.2	0.2	0.3
Neuroticism score	0.3	0.7	3.0	0.7	0.7	0.8	0.4	0.4	0.1	1.7	1.0	0.6	0.8	0.4	1.4
Worrier / anxious feelings	0.3	0.6	1.4	1.1	-0.9	-0.2	-0.9	-1.2	-0.8	0.6	-0.7	-0.9	-1.2	-0.6	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.1	1.1	0.4	0.2	0.9	0.5	0.7	0.7	-0.0	0.3	0.7	0.6	-0.1
Medication: Cholesterol lowering	0.3	0.5	1.6	1.1	0.3	0.9	-0.0	0.8	0.2	0.9	-0.1	1.3	-0.5	-0.7	0.7
Depression (self-reported)	0.3	0.3	2.7	-1.6	0.1	0.8	0.2	-0.0	0.3	0.5	-0.5	0.1	0.5	0.2	-0.1
Prospective memory result	0.3	0.3	1.4	0.5	0.7	0.9	0.6	0.3	0.5	0.2	0.4	0.0	1.2	0.5	0.3
Birth weight of first child	0.3	0.5	4.3	-0.2	-0.5	-2.1	0.1	-0.3	-0.4	-0.8	-0.1	-0.1	-0.5	-0.4	-0.9
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.4	0.9	0.6	1.6	-0.0	0.4	0.0	0.9	-0.4	1.1	0.1	-0.2	1.2
Worry too long after embarrassment	0.3	0.4	1.9	-0.2	-0.3	-0.0	-1.4	-0.9	-0.9	-0.1	-0.4	-0.8	-1.1	-0.3	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.0	0.1	0.3	0.7	-0.6	-0.2	-0.1	-0.7	-1.0	0.7	0.1	-0.2	0.8
Smoking status: Previous	0.3	0.5	2.1	-0.1	0.3	-0.1	1.5	1.1	1.1	0.4	0.3	0.2	0.6	0.9	0.0
Leg fat-free mass (right)	0.3	1.8	5.9	2.4	1.4	0.5	0.4	1.3	0.4	2.3	1.6	0.5	-0.0	1.1	2.0
Ever had bowel cancer screening	0.3	0.3	1.6	0.2	-0.3	-0.7	-0.2	-0.8	-0.3	0.3	-1.0	0.4	-0.1	-1.3	0.3
Diabetes diagnosed by doctor	0.3	0.5	2.0	0.7	-0.4	0.3	-0.3	-0.1	-0.4	0.4	-1.1	1.2	-1.4	-0.9	-0.5
Qualifications: nursing, teaching	0.3	0.4	1.4	1.1	0.4	0.4	-0.6	0.4	0.2	1.2	0.4	0.9	-0.7	-0.1	0.5
Eye problems/disorders: Cataract	0.3	0.4	1.7	-0.2	-1.2	-0.4	0.3	-0.1	-0.0	0.3	-0.7	0.4	-0.8	-0.4	-1.3
Whole body water mass	0.3	1.5	6.4	2.5	1.2	0.4	0.3	1.2	0.2	2.1	1.3	0.6	-0.1	0.6	1.7
Ever smoked	0.3	0.5	1.3	0.2	0.5	0.5	1.1	1.1	0.8	0.8	0.4	0.6	1.0	0.3	0.3
Fractured/broken bones in last 5 years	0.3	0.3	1.6	0.5	-0.5	-0.5	-0.3	-0.1	-0.6	-0.9	-0.4	-0.3	-0.6	-1.3	-0.5
Unable to work because of sickness or disability	0.3	0.4	1.6	-0.2	-1.0	0.4	0.2	-0.4	-0.3	-0.5	-0.6	-0.1	-0.3	-1.2	-1.3
Cholesterol lowering medication	0.3	0.4	1.2	-0.6	-0.8	-0.1	-0.8	-0.8	-1.1	0.4	-0.9	0.5	-0.6	-0.7	-0.2
Bipolar Disorder (2018)	0.2	0.3	1.9	-0.8	0.3	-0.3	-0.1	-0.1	0.1	-0.3	-0.1	-1.4	0.0	0.3	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.1	1.5	0.5	0.4	1.3	0.8	1.0	0.7	1.1	1.2	0.2	0.6	0.0
Alzheimer’s Disease (in mother)	0.2	0.3	0.7	-0.8	0.7	-0.5	0.1	0.1	0.3	-0.3	0.3	-0.7	0.6	0.4	0.8
Crohns Disease (2017)	0.2	0.4	1.6	-0.2	-0.6	0.1	-0.2	-0.9	-0.3	0.2	-0.9	-1.2	-0.8	-0.9	-0.4
Breast Cancer	0.2	0.4	1.0	-0.9	-1.0	-1.0	-0.3	-0.5	-0.4	-0.4	-0.5	-0.6	-0.4	-0.5	-1.0
Primary Biliary Cirrhosis	0.2	0.3	0.9	-1.0	0.2	-0.6	-0.8	-0.3	-0.7	0.3	0.0	-0.4	0.8	-0.3	0.9
Waist Hip Ratio (WHR)	0.2	0.8	1.6	-0.1	1.0	1.0	1.3	1.2	1.0	0.7	0.3	1.3	1.1	0.9	0.6
Hypothyroidism (self reported)	0.2	0.5	2.2	0.6	0.3	1.5	-0.7	-0.0	-0.4	0.5	-0.9	0.5	-0.5	-0.4	1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.7	0.3	-0.2	-0.1	-0.1	0.1	-0.2	-0.2	-0.7	0.8	-1.3	-0.7	-0.6
Neuroticism	0.2	0.5	3.6	0.1	0.6	0.5	-0.4	0.1	-0.2	1.9	0.7	0.2	0.2	0.1	1.3
Chronotype (morning person)	0.2	0.5	2.0	0.9	0.7	0.6	0.8	0.7	0.7	0.6	0.6	0.3	1.4	0.4	0.5
Tanning	0.2	3.0	7.8	-1.6	-2.0	-0.2	-2.0	-1.9	-1.5	-2.8	-1.6	-1.8	-1.3	-0.8	-2.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.1	-0.4	0.7	0.7	0.2	0.3	0.1	0.8	0.3	0.5	1.0	0.4	0.8
Severe depression (siblings)	0.2	0.3	0.9	-0.3	-0.6	-0.1	-0.1	-0.2	-0.5	-0.2	-0.4	0.1	-0.9	-0.9	-1.0
Hand grip strength (right)	0.2	0.5	1.7	1.2	0.2	-0.0	-0.7	-0.9	-0.2	1.3	-0.0	-0.8	-0.6	0.4	0.8
High blood pressure	0.2	0.4	1.6	0.4	-0.9	0.5	0.3	0.7	-0.6	0.3	-0.1	1.0	-0.6	-1.2	-0.8
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.3	0.7	-0.0	-0.3	0.0	0.2	0.2	1.1	0.1	1.1	0.5	-0.1	0.1
Qualifications: None of the above	0.2	0.3	1.1	-0.7	0.4	-0.5	0.2	0.0	0.3	-0.8	-0.3	-1.0	1.0	0.2	0.7
Diabetes (self-reported)	0.2	0.3	1.2	0.8	-0.2	0.3	0.2	0.3	-0.2	0.5	-0.8	1.1	-0.7	-0.6	-0.3
Hair/balding pattern: Pattern 3	0.2	0.2	0.7	-0.2	-0.3	0.8	0.7	0.7	0.3	0.7	0.4	0.2	0.6	0.0	-0.3
Number of live births	0.2	0.3	0.8	0.6	-0.3	0.6	-0.1	0.3	-0.2	-0.4	-0.5	-0.8	-0.9	-0.5	-0.6
Noisy workplace	0.2	0.2	1.2	0.5	0.4	1.1	0.5	0.5	0.4	0.6	0.3	0.0	0.3	0.5	0.4
Mouth/teeth dental problems: Dentures	0.2	0.3	1.6	0.3	-0.1	0.1	0.3	-0.1	0.4	-0.6	-1.1	-1.2	-0.3	-0.2	0.0
Headache pain in last month	0.2	0.4	0.7	0.8	0.7	0.6	0.8	0.5	0.6	0.8	0.7	0.3	0.5	0.8	0.5
Gout (self-reported)	0.2	0.3	1.1	-0.5	-0.6	0.7	-1.0	-0.3	-0.6	-0.4	0.2	-0.8	-0.3	-0.1	-0.1
Medication: Amlodipine	0.2	0.3	0.8	-0.1	0.0	0.9	-0.9	-0.0	-0.6	0.4	-0.6	-0.5	-0.2	-0.8	0.8
Arm fat-free mass (right)	0.2	1.1	4.8	2.2	1.1	0.6	0.4	1.2	0.1	1.9	1.0	0.6	0.0	0.5	1.4
Shortness of breath walking on level ground	0.2	0.2	1.0	0.0	0.2	0.2	1.0	0.8	0.2	0.0	0.2	0.6	0.1	-0.5	0.3
Qualifications: College or University degree	0.2	0.6	1.7	0.9	0.7	0.3	-0.6	0.0	0.6	1.1	0.8	1.3	0.4	1.1	0.6
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.3	0.2	0.7	1.1	0.5	0.7	0.4	0.3	0.3	-0.3	0.2	-0.2	0.7
Migraine (self-reported)	0.2	0.3	0.7	0.6	-0.2	-0.7	-0.5	-0.8	-0.3	-0.5	-0.6	-0.8	-0.6	-0.2	-0.7
Medication: Omeprazole	0.2	0.2	0.7	0.0	0.4	-0.6	0.2	0.5	0.1	-0.5	0.8	-0.7	-0.4	0.2	0.5
Mean time to correctly identify matches	0.2	0.4	1.4	-0.7	0.2	-1.0	-0.3	-0.5	0.0	0.1	0.1	-1.2	0.6	0.0	1.1
Heart disease (mother)	0.2	0.2	1.3	-0.2	0.1	1.1	0.2	0.5	0.0	0.1	-0.3	0.8	0.1	-0.2	0.1
Arm predicted mass (right)	0.2	1.0	4.0	2.0	1.0	0.5	0.2	1.1	-0.0	1.8	0.8	0.7	-0.1	0.3	1.3
Suffer from ‘nerves’	0.2	0.3	1.3	0.1	0.1	0.0	-0.0	-0.2	-0.0	1.2	0.5	1.0	0.4	0.7	0.8
Hypertension (Self-reported)	0.2	0.4	1.9	0.4	-1.0	0.2	0.3	0.5	-0.7	0.0	-0.3	0.9	-0.7	-1.4	-0.8
Illnesses of father: Heart disease	0.2	0.3	3.1	-0.1	-0.1	1.8	-0.0	0.6	-0.2	-0.2	-0.1	0.4	-0.2	-0.4	-0.4
Whole body fat-free mass	0.2	1.4	6.0	2.4	1.2	0.3	0.3	1.1	0.1	2.0	1.3	0.5	-0.2	0.6	1.6
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.0	-0.8	-0.5	-0.1	0.8	0.1	0.2	-0.6	0.0	1.0	0.7	-0.3	-0.6
Friendships satisfaction	0.2	0.3	0.5	0.7	0.4	0.1	-0.6	-0.6	-0.3	0.7	-0.6	-0.7	-0.3	-0.5	0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.0	0.8	0.9	0.5	0.6	0.7	0.8	-0.2	1.0	-0.1	0.0	0.5	0.6
Wears glasses or contact lenses	0.2	0.2	0.6	0.5	0.2	-0.7	0.3	0.0	0.3	-0.5	0.4	-0.1	-0.8	0.5	-0.2
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.7	-0.1	0.1	-0.5	0.8	0.3	0.6	0.6	-0.2	0.4	0.7	0.7	0.7
Commuting to job workplace: Public transport	0.2	0.2	0.7	0.1	0.8	0.5	0.6	0.6	0.8	-0.2	0.5	0.1	0.0	0.6	0.3
Pain type(s) experienced in last month: Hip pain	0.2	0.2	1.7	-0.4	-0.4	0.4	-0.5	-0.1	-0.4	0.5	-0.2	1.3	0.5	-0.1	0.0
Risk taking	0.2	0.4	1.8	-0.2	0.6	-0.2	0.1	0.4	-0.4	1.4	0.4	0.8	-0.2	-0.1	1.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	1.0	0.3	0.2	-0.3	0.2	0.5	0.0	-0.2	1.0	-0.3	-0.6	-0.2	0.6
Depression (Nagel 2018)	0.1	0.2	0.6	-0.4	-0.3	-0.0	-0.6	-0.6	-0.8	-0.2	-0.2	-0.3	-0.5	-0.4	-0.4
Neuroticism (Nagel 2018)	0.1	0.1	0.9	0.4	0.3	-0.1	0.3	-0.3	-0.1	0.9	0.5	-0.4	-0.0	0.4	0.3
Worry (Nagel 2018)	0.1	0.1	0.5	-0.5	-0.1	-0.1	-0.2	-0.5	-0.2	0.7	0.1	-0.4	0.1	0.4	0.0
Irritable Bowel Disease (IBD)	0.1	0.2	0.8	0.6	0.2	0.9	-0.4	-0.2	0.2	0.7	-0.3	-0.4	-0.1	-0.6	0.6
Crohns Disease (2012)	0.1	0.2	0.9	0.7	-0.3	0.1	0.3	-0.0	-0.1	-0.1	-0.6	-0.3	-0.9	-0.8	-0.4
Mean Putamen Volume	0.1	0.1	0.3	0.4	0.5	0.0	-0.2	-0.3	0.0	-0.0	0.3	0.2	-0.4	0.3	0.6
Neuroticism (2016)	0.1	0.1	0.8	0.1	-0.0	0.1	0.3	-0.1	-0.1	0.9	-0.1	-0.3	0.1	-0.4	0.7
Blood Red Count	0.1	1.3	4.1	-1.1	0.8	-0.7	2.0	1.0	1.0	0.1	1.1	1.3	1.9	1.2	-0.0
Systolic Blood Pressure	0.1	0.6	2.2	-0.3	-0.7	1.5	-0.5	0.2	-0.7	0.8	-0.9	0.8	0.6	-1.3	-0.0
Allergy or Eczema	0.1	0.2	1.0	-0.3	-0.2	-0.9	0.5	0.2	0.3	1.0	0.2	0.7	0.1	0.2	-0.4
Hand grip strength (left)	0.1	0.2	1.1	0.9	0.3	0.1	-0.2	-0.2	0.0	1.0	0.4	0.5	-0.1	0.2	0.6
Number of treatments/medications taken	0.1	0.2	0.9	0.6	-0.0	0.9	0.6	0.5	0.3	1.0	0.1	0.6	-0.0	-0.2	-0.0
Hearing difficulty/problems: Yes	0.1	0.1	0.3	0.1	0.3	0.5	0.1	0.0	0.3	0.1	-0.4	-0.1	-0.2	0.2	0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.3	0.1	-0.5	0.2	0.2	-0.0	-0.3	-0.4	0.1	0.2	-0.3	0.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.7	0.1	0.2	-0.4	-0.0	0.2	-0.3	-0.3	0.1	0.6	0.2	-0.9	0.2
Medication: Metformin	0.1	0.2	0.9	0.4	-0.3	-0.1	0.0	0.1	-0.2	0.3	-0.7	0.5	-1.0	-0.1	-0.4
Diabetes (father)	0.1	0.2	0.7	0.4	0.6	-0.2	0.1	0.4	0.1	0.8	0.3	0.6	-0.1	0.1	0.6
Diabetes (mother)	0.1	0.1	0.5	0.7	0.3	0.2	0.1	-0.0	0.1	0.1	0.7	0.2	-0.2	0.1	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	-0.3	0.0	-0.1	0.7	-0.1	0.0	0.1	0.1	-0.3	0.5	0.2	-0.5
Relative age voice broke	0.1	0.1	0.6	0.2	0.4	-0.2	0.1	-0.5	0.2	0.3	0.1	-0.8	-0.5	0.6	0.1
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.9	-0.0	-0.0	-0.5	0.8	0.4	0.6	0.8	0.4	0.9	-0.1	0.4	-0.5
Alcohol usually taken with meals	0.1	0.1	0.6	0.5	-0.6	-0.1	-0.2	-0.4	-0.2	-0.2	0.3	-0.3	-0.5	-0.1	-0.7
Trunk fat-free mass	0.1	0.8	4.5	2.1	0.7	0.1	-0.0	0.7	-0.3	1.4	0.8	0.1	-0.6	-0.0	1.1
Alcohol intake versus 10 years previously	0.1	0.1	0.8	0.7	-0.1	-0.9	0.0	-0.3	-0.1	0.3	0.2	0.3	-0.4	-0.2	-0.3
Medication: Lansoprazole	0.1	0.1	0.6	0.1	-0.3	0.7	0.3	0.1	0.1	0.4	0.4	0.8	-0.1	-0.3	-0.3
Pulse wave Arterial Stiffness index	0.1	0.1	0.7	0.1	0.3	-0.4	0.1	-0.4	-0.2	-0.8	-0.1	-0.7	-0.2	-0.3	0.2
Trunk predicted mass	0.1	0.8	4.8	2.2	0.8	0.1	-0.0	0.8	-0.2	1.4	0.8	0.1	-0.6	-0.0	1.1
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	0.6	-0.3	0.6	-0.0	0.2	0.1	-0.2	-0.0	-0.5	-0.6	-0.4	-0.6
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.9	0.2	-0.3	-0.9	0.3	0.2	-0.2	-0.1	-0.3	0.0	-0.3	-0.5	-0.5
Comparative body size at age 10	0.1	0.4	1.2	1.1	0.5	0.7	0.9	0.5	0.7	0.6	0.7	-0.3	0.2	0.7	0.4
Pulse wave peak to peak time	0.1	0.1	0.3	-0.4	-0.6	0.1	-0.5	0.0	-0.2	0.5	-0.3	0.2	-0.3	0.0	-0.5
Eye problems/disorders: None of the above	0.1	0.1	0.4	0.4	0.6	0.2	0.2	0.1	0.4	-0.2	0.7	-0.0	0.2	0.6	0.2
Medication: Ibuprofen	0.1	0.1	0.8	0.9	0.1	0.1	0.5	0.3	0.5	0.6	-0.1	0.1	0.2	0.3	-0.2
Medication: Allopurinol	0.1	0.2	0.7	0.2	-0.5	0.7	-0.8	-0.2	-0.6	-0.1	0.3	-0.2	-0.7	-0.1	0.1
Pulse rate, automated reading	0.1	0.5	2.6	0.8	-0.2	1.6	0.3	0.8	0.2	0.5	0.5	1.2	0.2	-0.3	-0.4
Alcohol intake frequency.	0.1	0.3	0.7	0.5	0.2	0.8	0.5	0.4	0.3	0.5	0.7	0.5	0.5	0.6	0.4
Had major operations	0.1	0.1	0.8	0.9	0.1	-0.1	0.3	0.2	-0.0	0.1	0.3	0.7	-0.3	-0.5	-0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.6	0.2	-0.2	0.3	-0.3	0.0	-0.2	0.8	-0.5	-0.1	0.2	-0.3	0.5
Mood swings	0.1	0.2	0.7	0.8	0.2	0.5	0.3	0.0	-0.4	0.8	0.5	0.8	0.3	-0.4	0.5
Average weekly champagne plus white wine intake	0.1	0.2	1.2	0.0	0.1	0.3	1.1	0.5	0.3	-0.2	0.3	0.6	0.6	-0.0	0.0
High cholesterol (Self-reported)	0.1	0.3	0.7	-0.4	-0.4	-0.5	-0.4	-0.5	-0.8	0.8	-0.6	-0.1	-0.4	-0.7	0.2
Number of operations (self-reported)	0.1	0.2	0.8	0.4	0.0	-0.3	-0.9	-0.3	-0.6	0.0	-0.4	0.7	-0.3	-0.6	-0.1
Hair Pigment	0.0	0.7	1.7	0.3	-0.8	-1.0	-0.8	-0.9	-0.8	-0.9	-0.8	-0.6	-1.3	-1.3	-0.7

Hub : Genes

RHOT1

Models

Trait associations