Best TWAS P=2.53e-11 · Best GWAS P=5.82e-12 conditioned to 0.0785
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ZNF585A | 0.08 | 0.10 | lasso | 3 | 0.11 | 2.6e-13 | -5.5 | 5.6 | 2.3e-08 | 0.75 | 0.94 | 0.06 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | ZNF585A | 0.09 | 0.02 | lasso | 3 | 0.02 | 3.8e-03 | -4.6 | -5.6 | 2.0e-08 | -0.80 | 0.05 | 0.87 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | ZNF585B | 0.10 | 0.10 | lasso | 8 | 0.12 | 1.2e-09 | 6.3 | -6.0 | 2.1e-09 | -0.91 | 0.04 | 0.96 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | ZNF585B | 0.06 | 0.02 | enet | 8 | 0.00 | 2.5e-01 | -6.6 | -6.3 | 3.6e-10 | -0.93 | 0.04 | 0.74 | FALSE |
| 5 | GTEx | Artery Aorta | ZNF829 | 0.11 | 0.04 | lasso | 2 | 0.00 | 2.5e-01 | -6.6 | 6.4 | 1.2e-10 | 0.93 | 0.03 | 0.82 | FALSE |
| 6 | GTEx | Artery Tibial | AC092295.7 | 0.11 | 0.01 | enet | 25 | 0.07 | 3.6e-06 | 1.2 | -5.4 | 6.7e-08 | -0.60 | 0.30 | 0.62 | FALSE |
| 7 | GTEx | Artery Tibial | ZNF585B | 0.17 | 0.14 | lasso | 15 | 0.22 | 5.6e-17 | -5.5 | -5.4 | 7.0e-08 | -0.86 | 0.06 | 0.94 | FALSE |
| 8 | GTEx | Brain Cerebellum | ZNF793 | 0.23 | 0.02 | enet | 40 | 0.07 | 4.8e-03 | -6.6 | 5.2 | 2.5e-07 | 0.75 | 0.03 | 0.73 | FALSE |
| 9 | GTEx | Cells EBV-transformed lymphocytes | ZNF585B | 0.13 | 0.10 | enet | 20 | 0.13 | 4.3e-05 | -6.6 | -5.8 | 6.0e-09 | -0.71 | 0.03 | 0.92 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | ZNF585B | 0.17 | 0.20 | enet | 19 | 0.22 | 1.2e-16 | -6.6 | -5.8 | 5.9e-09 | -0.88 | 0.04 | 0.96 | FALSE |
| 11 | GTEx | Esophagus Mucosa | ZNF585B | 0.10 | 0.04 | lasso | 4 | 0.05 | 2.2e-04 | -6.5 | -5.1 | 2.8e-07 | -0.79 | 0.04 | 0.95 | FALSE |
| 12 | GTEx | Heart Atrial Appendage | ZNF850 | 0.08 | 0.03 | enet | 15 | 0.06 | 1.6e-03 | -5.6 | 5.2 | 1.7e-07 | 0.76 | 0.12 | 0.61 | FALSE |
| 13 | GTEx | Lung | ZNF585B | 0.06 | 0.08 | lasso | 5 | 0.07 | 7.0e-06 | 6.3 | -6.3 | 2.5e-10 | -0.94 | 0.04 | 0.96 | FALSE |
| 14 | GTEx | Nerve Tibial | ZNF585A | 0.06 | 0.07 | lasso | 9 | 0.06 | 6.9e-05 | -6.5 | -6.6 | 3.0e-11 | -0.95 | 0.04 | 0.96 | FALSE |
| 15 | GTEx | Pituitary | CTD-2630F21.1 | 0.14 | 0.02 | lasso | 7 | -0.01 | 4.6e-01 | 6.5 | -6.5 | 9.8e-11 | -0.96 | 0.02 | 0.71 | FALSE |
| 16 | GTEx | Spleen | ZNF585A | 0.23 | 0.10 | lasso | 8 | 0.07 | 5.9e-03 | -6.8 | -5.9 | 3.8e-09 | -0.88 | 0.04 | 0.74 | FALSE |
| 17 | GTEx | Stomach | ZNF585B | 0.07 | 0.07 | lasso | 5 | 0.05 | 1.4e-03 | -6.6 | -6.7 | 2.5e-11 | -0.95 | 0.04 | 0.91 | TRUE |
| 18 | GTEx | Thyroid | ZNF585B | 0.04 | 0.03 | lasso | 6 | 0.01 | 4.0e-02 | 6.9 | -6.6 | 4.2e-11 | -0.98 | 0.03 | 0.88 | FALSE |
| 19 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZNF568 | 0.01 | 0.01 | blup | 64 | 0.01 | 1.3e-03 | -5.1 | 6.3 | 2.2e-10 | 0.88 | 0.07 | 0.75 | FALSE |
| 20 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZNF585B | 0.03 | 0.02 | enet | 4 | 0.02 | 5.4e-06 | -6.8 | -5.3 | 1.4e-07 | -0.81 | 0.00 | 0.99 | FALSE |
| 21 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZNF585B | 0.11 | 0.04 | blup | 33 | 0.06 | 1.3e-07 | -5.5 | -5.7 | 1.5e-08 | -0.66 | 0.01 | 0.96 | FALSE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZNF585B | 0.12 | 0.04 | enet | 9 | 0.07 | 5.6e-08 | -6.8 | -6.0 | 2.3e-09 | -0.83 | 0.00 | 1.00 | FALSE |
| 23 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ZNF568 | 0.11 | 0.09 | blup | 63 | 0.09 | 4.1e-04 | 6.5 | 6.1 | 1.2e-09 | 0.96 | 0.02 | 0.92 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF568 | 0.20 | 0.14 | lasso | 2 | 0.14 | 9.3e-14 | -5.6 | 5.6 | 1.9e-08 | 0.70 | 0.90 | 0.10 | FALSE |