Best TWAS P=1.36e-09 · Best GWAS P=5.35e-14 conditioned to 2.32e-07
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cerebellar Hemisphere | AFAP1-AS1 | 0.33 | 0.16 | lasso | 7 | 0.16 | 5.9e-05 | 5.97 | 5.7 | 1.4e-08 | 0.00 | 0.08 | 0.74 | FALSE |
2 | GTEx | Brain Cerebellum | AFAP1 | 0.47 | 0.19 | lasso | 4 | 0.19 | 2.8e-06 | -3.01 | 5.2 | 2.4e-07 | 0.00 | 0.10 | 0.82 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | AFAP1 | 0.26 | 0.10 | enet | 39 | 0.13 | 3.6e-10 | -5.04 | -6.0 | 2.3e-09 | -0.02 | 0.01 | 0.99 | TRUE |
4 | GTEx | Cells Transformed fibroblasts | AFAP1-AS1 | 0.20 | 0.09 | enet | 31 | 0.07 | 4.7e-06 | -7.01 | -5.5 | 3.1e-08 | -0.05 | 0.00 | 1.00 | FALSE |
5 | GTEx | Esophagus Mucosa | AFAP1 | 0.48 | 0.40 | enet | 29 | 0.43 | 3.9e-31 | 4.94 | 5.4 | 6.1e-08 | -0.02 | 0.98 | 0.02 | FALSE |
6 | GTEx | Skin Sun Exposed Lower leg | AFAP1-AS1 | 0.34 | 0.26 | lasso | 5 | 0.24 | 8.3e-20 | 4.94 | 5.1 | 2.8e-07 | -0.01 | 0.99 | 0.01 | FALSE |
7 | GTEx | Whole Blood | AFAP1-AS1 | 0.36 | 0.33 | lasso | 8 | 0.33 | 2.6e-31 | 4.94 | 5.2 | 2.5e-07 | -0.01 | 0.97 | 0.03 | FALSE |
8 | METSIM | Adipose | AFAP1 | 0.05 | 0.03 | enet | 13 | 0.03 | 1.3e-05 | 4.94 | 5.3 | 1.2e-07 | -0.01 | 0.35 | 0.62 | FALSE |
9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CPZ | 0.03 | 0.00 | blup | 80 | 0.01 | 1.9e-02 | -3.68 | 6.1 | 1.4e-09 | -0.55 | 0.03 | 0.23 | TRUE |
10 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CPZ | 0.09 | 0.01 | blup | 80 | 0.03 | 4.4e-04 | -0.28 | 5.3 | 9.7e-08 | -0.54 | 0.02 | 0.52 | FALSE |