Hub : Genes

CPZ

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Head and Neck Squamous Cell Carcinoma	0.0348	0.0154	4.0e-03	0.000	0.011	-0.001	NA	0.000	3.2e-01	1.9e-02	4.4e-01	NA	3.1e-01
2	TCGA	Lung Squamous Cell Carcinoma	0.0881	0.0317	3.0e-04	0.012	0.027	0.007	NA	0.009	1.5e-02	4.4e-04	4.9e-02	NA	3.0e-02
3	TCGA	Prostate Adenocarcinoma	0.1049	0.0266	1.7e-09	0.117	0.103	0.125	NA	0.127	3.4e-12	6.1e-11	4.9e-13	NA	3.1e-13

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.4	2.2	5.2	-1.0	-2.3	-0.6
Bipolar Disorder or Schizophrenia	0.4	1.0	2.9	-0.4	-1.7	-0.3
Depressed Affect (Nagel 2018)	0.4	0.7	1.6	-1.3	0.8	0.0
Depression (Nagel 2018)	0.1	0.1	0.2	0.2	0.4	-0.2
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.4	-1.5	-0.1	-0.3
Neuroticism (Nagel 2018)	0.3	0.6	1.0	-1.0	0.9	0.3
Schizophrenia (2018)	0.0	0.1	0.2	0.2	-0.4	-0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0
Worry (Nagel 2018)	0.2	0.5	1.3	-1.1	0.2	-0.4
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	-0.3	-0.4	-0.7
Alzheimer’s Disease (in father)	0.4	0.4	1.1	0.1	1.1	-0.4
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	-0.7	-0.1	-0.5
Crohns Disease (2017)	0.9	2.1	3.7	1.6	0.3	1.9
Irritable Bowel Disease (IBD)	0.8	1.9	4.7	2.2	0.0	1.1
Ulcerative Colitis (UC)	0.4	0.7	1.8	1.3	-0.5	-0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.1	0.3	0.5	0.2	-0.5	-0.7
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.7	-1.6	0.0	-0.3
Breast Cancer	0.4	1.0	2.2	-1.5	-0.8	-0.3
Ovarian Cancer	0.1	0.2	0.4	-0.1	-0.3	0.6
Prostate Cancer	0.5	0.7	1.5	0.3	0.7	1.2
Age at First Birth	0.2	0.3	0.5	-0.3	0.7	0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.6	1.1	-0.9	-1.0	0.1
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.8	1.0	2.6	1.6	-0.3	0.3
Fasting Glucose	0.6	0.7	1.3	-0.2	1.1	0.9
HbA1C	0.2	0.2	0.4	-0.1	-0.5	0.7
HDL Cholesterol	0.4	0.6	1.8	1.3	0.2	0.1
LDL Cholesterol	0.9	1.5	4.1	-2.0	-0.6	-0.2
Lupus	1.6	2.4	3.2	-1.7	-1.1	-1.8
Neuroticism (2016)	0.9	1.3	3.4	0.7	1.8	0.1
Primary Biliary Cirrhosis	1.5	2.1	3.6	-1.1	-1.2	-1.9
Rheumatoid Arthritis	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.1	0.2	0.3	0.3	-0.5	0.4
Triglycerides	0.8	1.2	1.7	-1.2	-1.3	-0.8
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.0	0.2	0.3	-0.3	-0.5	-0.5
Blood Platelet Count	0.3	3.5	6.1	-2.5	-1.4	-1.6
Blood Red Count	0.4	3.7	5.5	1.7	1.7	2.4
Blood White Count	0.1	0.8	2.0	-0.6	0.3	-1.4
Heel T-Score	0.1	0.5	1.1	0.6	0.1	-1.1
BMI	1.7	9.7	14.0	-3.7	-2.7	-2.8
Height	6.5	125.7	148.8	12.2	11.8	9.4
Waist Hip Ratio (WHR)	0.3	1.1	2.2	0.2	1.5	1.1
Systolic Blood Pressure	0.5	2.7	5.6	0.4	-1.6	-2.4
Smoking Status	0.1	0.3	0.4	-0.6	0.4	0.6
Allergy or Eczema	0.3	0.9	1.1	0.6	1.1	1.0
Cardiovascular Disease	0.1	0.4	0.9	0.5	-0.2	-0.9
Hypothyroidism (self reported)	0.0	0.0	0.0	-0.2	-0.1	0.0
Respiratory disease	0.6	1.3	1.5	-0.9	1.2	-1.2
Type 2 Diabetes (T2D) (2018)	0.9	1.6	3.9	-2.0	-1.0	-0.2
Lung FEV1/FVC ratio	1.1	5.3	11.2	1.4	1.7	3.4
Lung FVC	2.9	14.9	28.3	-2.9	-2.8	-5.3
Neuroticism	0.5	1.1	1.5	-0.8	1.2	1.2
Chronotype (morning person)	0.4	0.9	2.2	-0.6	-0.3	-1.5
Hair Pigment	0.0	0.5	1.0	-0.0	0.8	1.0
Tanning	0.0	0.1	0.4	-0.6	-0.0	0.1
Hand grip strength (left)	0.8	2.2	4.6	2.1	1.4	-0.1
Number of treatments/medications taken	1.0	1.8	2.8	-1.7	-1.5	0.6
Average weekly spirits intake	1.6	1.9	4.4	1.1	2.1	0.2
Sensitivity / hurt feelings	0.6	1.1	2.5	0.2	1.6	0.8
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.4	-1.2	0.4	-0.1
Hearing difficulty/problems: Yes	0.7	1.0	1.9	1.4	0.7	0.8
Relative age of first facial hair	0.5	1.1	2.2	-0.4	1.5	0.9
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.3	-1.1	-0.1	1.0
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	-0.1	-0.2	0.1
Ever had hysterectomy (womb removed)	0.3	0.4	1.1	1.0	-0.2	-0.2
Systolic blood pressure, automated reading	1.7	4.8	7.3	-0.9	-2.7	-2.5
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	4.2	-1.0	-2.1	-0.1
Angina	0.5	0.7	1.6	-1.3	0.6	0.3
Medication for hormone replacement therapy	0.6	0.6	1.3	1.1	0.4	-0.6
Vitamin and mineral supplements	0.7	0.9	2.6	0.2	1.6	0.3
Supplements: Zinc	0.7	0.7	0.8	-0.9	0.8	0.9
Medication: Co-codamol	0.3	0.3	0.8	-0.4	0.9	0.3
Medication: Metformin	0.7	1.0	2.6	-1.6	0.1	-0.7
Diabetes (father)	1.0	1.3	1.8	-1.3	-1.3	-0.6
Diabetes (mother)	0.6	0.7	1.7	-1.3	0.3	0.6
Severe depression (siblings)	0.3	0.3	0.5	-0.4	0.5	-0.7
Pack years adult smoking proportion	1.4	2.2	4.4	-2.1	-1.4	0.2
Impedance of leg (right)	0.4	1.7	3.1	1.8	1.0	1.1
Leg fat-free mass (left)	0.2	1.2	2.0	1.3	1.4	0.2
Trunk fat percentage	0.1	0.3	0.7	-0.3	-0.1	-0.8
Hand grip strength (right)	0.5	1.2	2.6	0.9	-0.6	-1.6
Townsend deprivation index at recruitment	1.0	1.5	3.4	-1.8	-0.9	-0.3
Current tobacco smoking	0.6	0.9	2.8	-1.7	0.1	0.2
Average weekly fortified wine intake	0.4	0.5	1.2	-0.4	1.1	-0.1
Maternal smoking around birth	2.1	3.0	6.5	-2.5	-1.1	-1.1
Fed-up feelings	0.5	1.0	1.2	-1.1	1.1	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.1	-0.6	-0.5	-1.0
Relative age voice broke	0.6	0.9	2.2	-1.5	0.5	0.6
Taking other prescription medications	1.3	2.0	4.8	-2.2	-0.7	-0.8
Age when periods started (menarche)	0.0	0.1	0.2	-0.2	0.3	0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.9	0.5	0.4	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.7	0.6	0.8	-0.7
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.1	-0.8	-0.9	1.0
Qualifications: CSEs or equivalent	0.1	0.1	0.4	-0.1	0.1	0.6
Serious illness, injury or assault to yourself	0.0	0.0	0.1	0.0	-0.0	0.3
High blood pressure	0.3	0.9	2.2	-0.0	-1.5	-0.7
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.9	-0.1	0.2	0.9
Multivitamins +/- minerals	2.0	2.6	6.2	0.0	-2.5	-1.3
Stomach or abdominal pain in last month	0.1	0.1	0.4	0.2	0.1	0.6
Supplements: Glucosamine	0.4	0.6	0.9	0.7	-0.5	1.0
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	1.6	0.2	-1.2	1.3
Medication: Atenolol	0.5	0.6	1.1	1.0	0.9	-0.3
Medication: Levothyroxine sodium	0.9	1.6	3.3	-1.8	-1.1	-0.5
Sitting height	4.1	28.8	36.7	6.1	5.3	4.6
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	-0.5	0.9	0.1
High blood pressure (mother)	0.4	0.5	1.0	0.7	0.3	-1.0
Body mass index (BMI)	2.2	9.4	10.8	-3.3	-2.6	-3.2
Impedance of leg (left)	0.2	1.2	2.1	1.4	0.9	0.9
Leg predicted mass (left)	0.3	1.5	2.6	1.4	1.6	0.3
Trunk fat mass	0.0	0.2	0.6	-0.0	0.1	-0.8
Waist circumference	1.0	3.7	4.9	-2.2	-1.3	-2.2
Number of incorrect matches in round	0.3	0.5	0.6	0.8	0.5	-0.8
Past tobacco smoking	0.3	0.5	0.8	0.9	-0.6	0.5
Alcohol usually taken with meals	0.2	0.3	0.7	-0.1	0.8	-0.4
Nervous feelings	0.5	0.9	1.3	-1.1	-1.0	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.0	0.4	1.4	0.1
Hearing difficulty/problems with background noise	0.2	0.3	0.9	-0.0	-0.9	0.2
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	-0.9	-0.6	0.4
Had menopause	0.0	0.0	0.1	-0.3	0.1	0.2
Had other major operations	0.3	0.3	0.6	-0.8	0.6	0.2
Forced vital capacity (FVC)	0.5	2.1	3.9	1.4	2.0	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	0.6	1.0	-0.5
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.6	-0.8	-0.7	0.6
Qualifications: None of the above	0.8	1.8	4.4	-0.9	-2.1	-0.5
Financial difficulties in last 2 years	0.6	0.8	1.6	-0.9	0.0	1.3
Mouth/teeth dental problems	2.5	3.9	7.5	2.7	1.6	1.2
Heart attack	0.3	0.4	0.8	-0.9	-0.5	-0.3
Allergy	0.3	0.7	2.1	1.5	0.1	-0.2
Pain all over the body in last month	0.7	0.8	1.5	-1.2	0.3	-0.8
Diabetes (self-reported)	1.3	2.0	4.8	-2.2	-1.1	0.1
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.2	1.5	-0.2	1.0
Medication: Ramipril	0.5	0.6	1.4	1.2	-0.2	0.5
Medication: Simvastatin	0.0	0.1	0.1	-0.2	0.2	0.3
Fluid intelligence score	0.6	1.2	2.2	-1.5	-0.4	-1.1
Illnesses of siblings	0.5	0.7	1.6	1.3	-0.4	-0.6
Neuroticism score	0.3	0.6	0.9	-1.0	0.8	0.6
Weight	0.1	0.3	0.4	0.4	0.5	-0.6
Impedance of arm (right)	4.9	22.7	29.9	5.5	4.3	4.4
Arm fat percentage (right)	0.9	3.4	4.8	-1.9	-1.3	-2.2
Trunk fat-free mass	0.4	2.4	3.7	1.9	1.9	0.3
Hip circumference	0.5	2.1	4.0	-1.1	-1.1	-2.0
Time employed in main current job	0.7	0.8	0.9	1.0	0.8	-0.9
Alcohol intake versus 10 years previously	0.4	0.6	1.0	-0.9	0.0	-1.0
Father’s age at death	0.4	0.5	1.0	1.0	-0.5	-0.5
Worrier / anxious feelings	0.7	1.2	2.1	0.7	1.5	1.0
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.7	4.6	-2.1	-0.6	-1.8
Falls in the last year	0.6	0.8	1.6	-0.7	0.4	1.3
Hair/balding pattern: Pattern 3	0.4	0.6	1.5	0.6	1.2	-0.1
Number of live births	0.5	0.7	1.3	-0.2	-0.8	1.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	3.2	1.8	1.4	-0.0
Pulse rate	1.1	1.9	2.3	1.4	1.5	-1.2
Happiness	0.9	1.1	1.6	0.1	-1.2	-1.3
Noisy workplace	1.0	1.2	1.8	-1.3	-1.3	0.4
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.9	1.7	0.2	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	-0.1	0.6	0.1
Mouth/teeth dental problems: Dentures	1.8	3.1	4.0	-2.0	-1.7	-1.6
Asthma	1.3	2.5	4.9	-1.5	0.5	-2.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.6	-0.6	-1.3	0.0
Medication: Cholesterol lowering	0.6	1.0	2.2	-0.1	-0.8	-1.5
Depression (self-reported)	0.2	0.3	0.3	-0.4	0.5	-0.6
Medication: Lansoprazole	2.7	3.1	3.7	-1.8	-1.9	-1.5
Prospective memory result	1.2	1.4	2.9	1.7	0.6	-1.0
Lung cancer (father)	0.3	0.3	0.6	-0.4	-0.3	0.8
Illnesses of mother	0.3	0.4	1.1	-0.2	0.2	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	4.7	2.2	1.5	0.4
Pulse wave Arterial Stiffness index	0.5	0.6	1.2	-0.5	0.6	1.1
Impedance of arm (left)	4.3	20.1	24.2	4.9	3.8	4.6
Arm fat mass (right)	0.5	2.0	3.3	-1.3	-1.0	-1.8
Trunk predicted mass	0.4	2.4	3.6	1.9	1.9	0.3
Standing height	4.6	45.3	61.9	7.9	6.8	5.3
Length of working week for main job	0.5	0.6	1.3	-0.6	-0.1	-1.1
Exposure to tobacco smoke at home	0.7	0.8	1.7	1.3	-0.9	0.2
Breastfed as a baby	0.9	1.1	2.7	0.6	0.4	1.6
Tense / ‘highly strung’	0.9	1.5	2.8	-1.7	-1.0	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.6	-0.2	-0.8	0.3
Hair/balding pattern: Pattern 4	0.4	1.0	2.7	-0.4	0.4	-1.7
Birth weight of first child	1.3	2.4	6.1	0.7	2.5	0.7
Peak expiratory flow (PEF)	0.6	1.4	3.3	1.8	0.4	0.8
Pulse wave reflection index	0.6	0.7	1.5	-1.2	-0.9	-0.1
Ever highly irritable/argumentative for 2 days	1.5	1.8	5.3	0.2	-2.3	0.5
Loud music exposure frequency	1.4	1.5	3.6	0.3	0.9	1.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.8	-0.8	-0.1	0.9
Mouth/teeth dental problems: Bleeding gums	1.4	1.9	3.5	-1.4	-1.9	-0.4
Blood clot in the leg (DVT)	0.3	0.4	0.8	-0.9	0.1	-0.8
Medication: Paracetamol	1.0	1.7	2.5	-1.6	-1.5	-0.5
Headache pain in last month	0.0	0.0	0.0	-0.1	-0.1	-0.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.4	-1.2	0.5	0.9
Glaucoma (self-reported)	0.8	0.9	1.9	-1.4	-0.7	-0.6
Gout (self-reported)	0.9	1.2	2.4	-1.1	-0.3	-1.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.0	-1.0	-0.7	-0.3
Medication: Amlodipine	0.6	0.8	1.4	-0.2	-0.9	-1.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.9	-1.4	0.4	-0.7
Birth weight	0.5	1.1	1.3	1.2	1.0	1.0
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.1	-0.2	0.1	1.0
High blood pressure (siblings)	0.5	0.8	2.1	-0.5	-1.4	-0.0
Forced vital capacity (FVC), Best measure	0.6	2.3	3.5	1.8	1.9	-0.2
Body fat percentage	0.6	2.5	3.6	-1.5	-1.2	-1.9
Leg fat percentage (right)	2.5	9.1	11.6	-2.8	-2.8	-3.4
Arm fat-free mass (right)	0.1	0.3	0.6	-0.1	0.5	-0.8
Exposure to tobacco smoke outside home	0.1	0.1	0.2	-0.4	0.4	0.2
Comparative body size at age 10	2.0	5.5	7.4	-2.7	-1.8	-2.4
Number of full brothers	0.6	0.7	1.3	-0.9	0.2	1.2
Worry too long after embarrassment	0.1	0.1	0.2	-0.2	-0.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	2.7	-1.6	-0.3	-1.7
Wheeze or whistling in the chest in last year	0.8	1.5	4.1	-2.0	-0.3	0.3
Number of children fathered	1.3	1.4	3.0	-0.7	0.9	1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.4	0.5	1.6	0.2
Age at first live birth	0.5	0.9	1.2	1.1	0.8	-0.9
Pulse wave peak to peak time	0.4	0.5	0.9	0.8	-0.1	-0.9
Health satisfaction	1.2	1.6	4.5	-0.2	-2.1	0.4
Shortness of breath walking on level ground	0.2	0.2	0.4	-0.1	-0.4	0.6
Qualifications: College or University degree	0.2	0.6	1.2	1.1	0.7	-0.3
Eye problems/disorders: None of the above	0.7	0.8	1.9	1.4	0.6	-0.3
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.3	-1.1	0.4	-0.3
Emphysema/chronic bronchitis	0.7	0.8	1.5	-0.5	0.9	1.2
Medication for pain relief, constipation, heartburn	2.2	3.8	6.2	2.0	2.5	1.1
Neck or shoulder pain in last month	0.1	0.2	0.6	-0.8	0.1	-0.0
Medication: Blood pressure	0.3	0.5	1.4	1.2	-0.1	0.0
Angina (self-reported)	0.6	0.7	1.4	-1.2	0.8	0.4
Migraine (self-reported)	0.6	0.7	1.8	-0.6	-0.2	1.3
Medication: Ibuprofen	0.3	0.4	0.4	-0.6	-0.6	0.6
Medication: Allopurinol	1.8	2.4	3.9	-1.5	-1.1	-2.0
Medication: Omeprazole	0.7	0.8	1.7	-0.8	-1.3	-0.2
Medication: Seretide 50 evohaler	2.3	2.7	6.8	-2.6	-0.9	-0.8
Mean time to correctly identify matches	0.1	0.1	0.2	-0.4	-0.5	-0.1
Heart disease (mother)	0.8	1.0	2.0	0.6	1.4	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.0	0.2	-0.3	1.4
Whole body fat mass	0.2	1.0	1.8	-0.9	-0.5	-1.3
Leg fat mass (right)	1.4	5.4	7.3	-2.2	-2.0	-2.7
Arm predicted mass (right)	0.1	0.4	0.9	0.0	0.7	-0.9
Pulse rate, automated reading	0.1	0.3	0.6	0.8	-0.0	-0.5
Alcohol intake frequency.	2.4	5.5	7.1	-2.7	-2.7	-1.5
Comparative height size at age 10	4.3	23.9	43.3	6.6	4.2	3.4
Number of full sisters	2.8	3.4	5.1	-2.2	-1.5	-1.7
Suffer from ‘nerves’	1.0	1.6	3.5	-1.9	-0.3	-1.1
Overall health rating	2.1	4.4	7.5	-2.1	-2.7	-1.1
Chest pain or discomfort	1.0	1.4	3.3	-0.8	0.4	1.8
Had major operations	1.2	1.4	3.7	0.2	0.7	1.9
Age at last live birth	0.2	0.2	0.4	0.7	-0.5	-0.2
Family relationship satisfaction	0.4	0.4	0.6	-0.8	-0.7	0.5
Leg pain on walking	0.7	0.9	2.0	-0.6	0.6	1.4
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	2.5	-1.6	-0.4	-1.3
Commuting to job workplace: Car/motor vehicle	1.4	1.6	3.8	2.0	0.2	-0.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	0.3	-0.5	-1.0
Medication: Aspirin	0.9	1.1	2.4	-0.9	-1.6	0.3
Supplements: Vitamin C	2.5	3.0	6.3	-1.6	-2.5	-0.2
Knee pain experienced in last month	3.3	5.1	8.0	-2.7	-2.8	-0.2
Hypertension (Self-reported)	0.2	0.6	1.4	0.5	-1.2	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	3.0	-1.7	-0.7	-1.6
Illnesses of father: Heart disease	0.2	0.3	0.7	0.4	-0.8	0.4
Illnesses of siblings: Diabetes	0.9	1.1	2.3	-1.5	1.0	0.3
Smoking status: Previous	0.2	0.3	0.4	-0.3	0.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	3.1	6.5	10.3	3.2	2.3	1.9
Whole body fat-free mass	0.3	1.7	2.9	1.5	1.7	0.2
Leg fat-free mass (right)	0.4	1.9	3.3	1.4	1.8	0.6
Arm fat percentage (left)	1.0	3.9	4.8	-2.2	-1.5	-2.1
Average weekly red wine intake	4.2	6.2	10.6	2.4	3.3	1.5
Handedness (chirality/laterality): Left-handed	1.3	1.5	2.4	0.9	1.2	1.5
Mood swings	0.4	0.7	1.4	-1.2	0.5	0.6
Loneliness, isolation	0.2	0.3	0.9	0.2	-0.9	-0.1
Long-standing illness, disability or infirmity	0.9	1.4	3.8	-1.9	-0.7	0.3
Ever had bowel cancer screening	1.7	2.0	2.9	1.2	1.2	1.7
Diabetes diagnosed by doctor	0.7	1.1	2.4	-1.5	-1.0	0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	4.0	0.3	2.0	-0.8
Friendships satisfaction	1.0	1.2	1.6	-1.0	-1.3	-1.0
Qualifications: nursing, teaching	1.1	1.8	5.0	2.2	0.5	0.1
Commuting to job workplace: Walk	0.0	0.1	0.1	0.1	0.3	0.3
Eye problems/disorders: Cataract	0.5	0.6	1.7	0.0	-0.1	1.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.1	-1.1	1.0	0.3
Medication for cholesterol	0.1	0.1	0.2	0.4	0.3	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	3.6	-1.9	0.8	-0.9
Back pain experienced in last month	2.4	3.5	6.3	-1.8	-2.5	-1.0
Mineral and other dietary supplements	0.5	0.7	1.4	-0.8	0.3	-1.2
Breast cancer (self-reported)	0.0	0.0	0.0	0.2	-0.2	-0.0
Asthma (self-reported)	1.3	2.6	4.6	-1.8	-0.0	-2.1
Osteoporosis (self-reported)	0.0	0.1	0.1	0.2	-0.3	-0.2
Osteoarthritis (self-reported)	0.2	0.2	0.6	-0.3	-0.7	-0.1
Medication: Aspirin	0.9	1.1	3.0	-0.5	-1.7	-0.3
Medication: Gliclazide	0.1	0.1	0.2	-0.1	-0.4	-0.4
Illnesses of father: None of the above (group 1)	0.2	0.3	0.4	-0.7	0.6	-0.1
Smoking status: Current	0.4	0.6	1.8	-1.3	0.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.0	1.0	-0.3	-0.6
Whole body water mass	0.3	1.4	2.4	1.4	1.6	0.1
Leg predicted mass (right)	0.3	1.8	3.0	1.4	1.7	0.5
Arm fat mass (left)	0.6	2.3	3.3	-1.5	-1.1	-1.8
Number of self-reported non-cancer illnesses	0.4	0.7	1.6	-1.2	-0.5	-0.4
Average weekly champagne plus white wine intake	0.1	0.1	0.2	0.2	0.4	0.2
Miserableness	0.5	0.9	1.7	-0.5	0.9	-1.3
Guilty feelings	0.2	0.3	0.4	-0.6	0.3	0.5
Wears glasses or contact lenses	1.9	2.1	2.6	-1.4	-1.6	-1.4
Ever taken oral contraceptive pill	0.0	0.0	0.1	-0.2	0.0	-0.3
Hearing aid user	1.0	1.1	2.4	0.8	1.5	-0.5
Mother’s age at death	1.2	1.4	2.7	1.1	-0.7	-1.6
Financial situation satisfaction	1.2	1.5	3.9	-0.6	-0.4	2.0
Tinnitus: Yes, now most or all of the time	3.5	4.1	5.1	2.0	2.3	1.7
Commuting to job workplace: Public transport	0.8	1.0	1.7	-1.3	-0.1	1.1
Eye problems/disorders: Glaucoma	1.1	1.3	2.5	-1.6	0.4	-1.1
Medication: Blood pressure	0.2	0.3	0.8	0.1	-0.9	-0.4
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.4	-1.2	-0.3	-1.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.8	0.7	-0.1	0.9
High cholesterol (Self-reported)	0.6	1.1	2.0	-1.0	0.5	-1.4
Medication: Bendroflumethiazide	1.9	2.9	5.8	-1.3	-2.4	-1.1
Medication: Paracetamol	0.8	1.3	3.1	-1.8	-0.7	0.5
Medication: Lisinopril	0.4	0.5	0.7	0.8	0.2	-0.9
Medication: Atorvastatin	2.6	3.2	5.8	-1.9	-0.6	-2.4
Illnesses of father: High blood pressure	0.7	0.9	2.6	1.6	0.4	-0.2
Alcohol drinker status: Never	0.5	0.6	0.9	-0.3	-0.8	-1.0
Ever smoked	0.4	0.8	1.7	-1.3	0.7	-0.2
Basal metabolic rate	0.2	1.0	1.7	1.2	1.3	-0.2
Leg fat percentage (left)	2.8	10.2	12.5	-3.1	-2.9	-3.5
Arm fat-free mass (left)	0.1	0.7	1.0	0.2	1.0	-1.0
Number of operations (self-reported)	0.4	0.6	1.4	-0.6	-0.3	-1.2
Average weekly beer plus cider intake	2.6	3.8	5.0	-1.2	-2.2	-2.2
Irritability	1.4	2.4	4.4	0.9	2.1	1.4
Risk taking	0.8	1.2	2.1	-0.1	-1.4	-1.2
Ever had prostate specific antigen (PSA) test	2.3	2.7	3.0	1.4	1.7	1.7
Fractured/broken bones in last 5 years	0.2	0.2	0.5	0.3	0.7	0.3
Age started oral contraceptive pill	0.7	0.9	2.6	0.3	1.6	0.3
Diastolic blood pressure, automated reading	0.8	2.6	5.7	0.4	-2.4	-1.4
Ever depressed for a whole week	0.6	0.8	2.1	0.1	0.6	1.4
Unable to work because of sickness or disability	1.3	1.7	2.4	-1.0	-1.6	-1.3
Commuting to job workplace: Cycle	1.6	1.9	3.3	-1.8	-0.5	-1.5
Myopia	0.6	0.9	1.8	0.8	-1.4	-0.3
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.6	0.3	1.3	0.5
Cholesterol lowering medication	0.9	1.3	2.1	-1.4	0.9	1.0
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	3.0	-1.7	-1.7	-0.9
Pain experienced in last month	1.8	3.0	8.7	3.0	0.4	0.4
Supplements: Calcium	0.6	0.6	1.7	-0.3	-0.4	1.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.4	-0.0	0.1	0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	-1.0	-0.6	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	-0.6	-0.0	-0.6
Heart disease (siblings)	0.6	0.8	1.0	-1.0	-0.7	-0.9
Alcohol drinker status: Previous	2.9	3.3	5.3	-2.3	-1.9	-0.9
Pack years of smoking	1.4	2.1	4.3	-2.1	-1.3	0.4
Impedance of whole body	2.2	11.1	14.3	3.8	2.8	3.3
Leg fat mass (left)	1.5	5.9	7.8	-2.4	-2.1	-2.8
Arm predicted mass (left)	0.1	0.5	0.8	0.2	0.7	-0.9