Hub : Genes

CPZ

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Head and Neck Squamous Cell Carcinoma 0.0348 0.0154 4.0e-03 0.000 0.011 -0.001 NA 0.000 3.2e-01 1.9e-02 4.4e-01 NA 3.1e-01
2 TCGA Lung Squamous Cell Carcinoma 0.0881 0.0317 3.0e-04 0.012 0.027 0.007 NA 0.009 1.5e-02 4.4e-04 4.9e-02 NA 3.0e-02
3 TCGA Prostate Adenocarcinoma 0.1049 0.0266 1.7e-09 0.117 0.103 0.125 NA 0.127 3.4e-12 6.1e-11 4.9e-13 NA 3.1e-13

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.4 2.2 5.2 -1.0 -2.3 -0.6
Bipolar Disorder or Schizophrenia 0.4 1.0 2.9 -0.4 -1.7 -0.3
Depressed Affect (Nagel 2018) 0.4 0.7 1.6 -1.3 0.8 0.0
Depression (Nagel 2018) 0.1 0.1 0.2 0.2 0.4 -0.2
Intelligence (Savage-Jansen 2018) 0.3 0.8 2.4 -1.5 -0.1 -0.3
Neuroticism (Nagel 2018) 0.3 0.6 1.0 -1.0 0.9 0.3
Schizophrenia (2018) 0.0 0.1 0.2 0.2 -0.4 -0.0
Schizophrenia vs Biploar Disorder 0.0 0.0 0.0 0.0 0.0 0.0
Worry (Nagel 2018) 0.2 0.5 1.3 -1.1 0.2 -0.4
Alzheimer’s Disease (in mother) 0.2 0.2 0.5 -0.3 -0.4 -0.7
Alzheimer’s Disease (in father) 0.4 0.4 1.1 0.1 1.1 -0.4
Alzheimer’s Disease (including proxy) 0.2 0.3 0.5 -0.7 -0.1 -0.5
Crohns Disease (2017) 0.9 2.1 3.7 1.6 0.3 1.9
Irritable Bowel Disease (IBD) 0.8 1.9 4.7 2.2 0.0 1.1
Ulcerative Colitis (UC) 0.4 0.7 1.8 1.3 -0.5 -0.3
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.1 0.3 0.5 0.2 -0.5 -0.7
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.7 -1.6 0.0 -0.3
Breast Cancer 0.4 1.0 2.2 -1.5 -0.8 -0.3
Ovarian Cancer 0.1 0.2 0.4 -0.1 -0.3 0.6
Prostate Cancer 0.5 0.7 1.5 0.3 0.7 1.2
Age at First Birth 0.2 0.3 0.5 -0.3 0.7 0.6
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.6 1.1 -0.9 -1.0 0.1
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.0 0.0 0.0 0.0 0.0 0.0
Mean Putamen Volume 0.8 1.0 2.6 1.6 -0.3 0.3
Fasting Glucose 0.6 0.7 1.3 -0.2 1.1 0.9
HbA1C 0.2 0.2 0.4 -0.1 -0.5 0.7
HDL Cholesterol 0.4 0.6 1.8 1.3 0.2 0.1
LDL Cholesterol 0.9 1.5 4.1 -2.0 -0.6 -0.2
Lupus 1.6 2.4 3.2 -1.7 -1.1 -1.8
Neuroticism (2016) 0.9 1.3 3.4 0.7 1.8 0.1
Primary Biliary Cirrhosis 1.5 2.1 3.6 -1.1 -1.2 -1.9
Rheumatoid Arthritis 0.0 0.0 0.0 0.0 0.0 0.0
Schizophrenia (2014) 0.1 0.2 0.3 0.3 -0.5 0.4
Triglycerides 0.8 1.2 1.7 -1.2 -1.3 -0.8
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.0 0.0 0.0 0.0 0.0 0.0
Blood Eosinophil Count 0.0 0.2 0.3 -0.3 -0.5 -0.5
Blood Platelet Count 0.3 3.5 6.1 -2.5 -1.4 -1.6
Blood Red Count 0.4 3.7 5.5 1.7 1.7 2.4
Blood White Count 0.1 0.8 2.0 -0.6 0.3 -1.4
Heel T-Score 0.1 0.5 1.1 0.6 0.1 -1.1
BMI 1.7 9.7 14.0 -3.7 -2.7 -2.8
Height 6.5 125.7 148.8 12.2 11.8 9.4
Waist Hip Ratio (WHR) 0.3 1.1 2.2 0.2 1.5 1.1
Systolic Blood Pressure 0.5 2.7 5.6 0.4 -1.6 -2.4
Smoking Status 0.1 0.3 0.4 -0.6 0.4 0.6
Allergy or Eczema 0.3 0.9 1.1 0.6 1.1 1.0
Cardiovascular Disease 0.1 0.4 0.9 0.5 -0.2 -0.9
Hypothyroidism (self reported) 0.0 0.0 0.0 -0.2 -0.1 0.0
Respiratory disease 0.6 1.3 1.5 -0.9 1.2 -1.2
Type 2 Diabetes (T2D) (2018) 0.9 1.6 3.9 -2.0 -1.0 -0.2
Lung FEV1/FVC ratio 1.1 5.3 11.2 1.4 1.7 3.4
Lung FVC 2.9 14.9 28.3 -2.9 -2.8 -5.3
Neuroticism 0.5 1.1 1.5 -0.8 1.2 1.2
Chronotype (morning person) 0.4 0.9 2.2 -0.6 -0.3 -1.5
Hair Pigment 0.0 0.5 1.0 -0.0 0.8 1.0
Tanning 0.0 0.1 0.4 -0.6 -0.0 0.1
Hand grip strength (left) 0.8 2.2 4.6 2.1 1.4 -0.1
Number of treatments/medications taken 1.0 1.8 2.8 -1.7 -1.5 0.6
Average weekly spirits intake 1.6 1.9 4.4 1.1 2.1 0.2
Sensitivity / hurt feelings 0.6 1.1 2.5 0.2 1.6 0.8
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.4 -1.2 0.4 -0.1
Hearing difficulty/problems: Yes 0.7 1.0 1.9 1.4 0.7 0.8
Relative age of first facial hair 0.5 1.1 2.2 -0.4 1.5 0.9
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 1.3 -1.1 -0.1 1.0
Ever used hormone-replacement therapy (HRT) 0.0 0.0 0.0 -0.1 -0.2 0.1
Ever had hysterectomy (womb removed) 0.3 0.4 1.1 1.0 -0.2 -0.2
Systolic blood pressure, automated reading 1.7 4.8 7.3 -0.9 -2.7 -2.5
Eye problems/disorders: Diabetes related eye disease 1.6 1.8 4.2 -1.0 -2.1 -0.1
Angina 0.5 0.7 1.6 -1.3 0.6 0.3
Medication for hormone replacement therapy 0.6 0.6 1.3 1.1 0.4 -0.6
Vitamin and mineral supplements 0.7 0.9 2.6 0.2 1.6 0.3
Supplements: Zinc 0.7 0.7 0.8 -0.9 0.8 0.9
Medication: Co-codamol 0.3 0.3 0.8 -0.4 0.9 0.3
Medication: Metformin 0.7 1.0 2.6 -1.6 0.1 -0.7
Diabetes (father) 1.0 1.3 1.8 -1.3 -1.3 -0.6
Diabetes (mother) 0.6 0.7 1.7 -1.3 0.3 0.6
Severe depression (siblings) 0.3 0.3 0.5 -0.4 0.5 -0.7
Pack years adult smoking proportion 1.4 2.2 4.4 -2.1 -1.4 0.2
Impedance of leg (right) 0.4 1.7 3.1 1.8 1.0 1.1
Leg fat-free mass (left) 0.2 1.2 2.0 1.3 1.4 0.2
Trunk fat percentage 0.1 0.3 0.7 -0.3 -0.1 -0.8
Hand grip strength (right) 0.5 1.2 2.6 0.9 -0.6 -1.6
Townsend deprivation index at recruitment 1.0 1.5 3.4 -1.8 -0.9 -0.3
Current tobacco smoking 0.6 0.9 2.8 -1.7 0.1 0.2
Average weekly fortified wine intake 0.4 0.5 1.2 -0.4 1.1 -0.1
Maternal smoking around birth 2.1 3.0 6.5 -2.5 -1.1 -1.1
Fed-up feelings 0.5 1.0 1.2 -1.1 1.1 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.1 -0.6 -0.5 -1.0
Relative age voice broke 0.6 0.9 2.2 -1.5 0.5 0.6
Taking other prescription medications 1.3 2.0 4.8 -2.2 -0.7 -0.8
Age when periods started (menarche) 0.0 0.1 0.2 -0.2 0.3 0.4
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 0.9 0.5 0.4 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 0.7 0.6 0.8 -0.7
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 1.1 -0.8 -0.9 1.0
Qualifications: CSEs or equivalent 0.1 0.1 0.4 -0.1 0.1 0.6
Serious illness, injury or assault to yourself 0.0 0.0 0.1 0.0 -0.0 0.3
High blood pressure 0.3 0.9 2.2 -0.0 -1.5 -0.7
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.9 -0.1 0.2 0.9
Multivitamins +/- minerals 2.0 2.6 6.2 0.0 -2.5 -1.3
Stomach or abdominal pain in last month 0.1 0.1 0.4 0.2 0.1 0.6
Supplements: Glucosamine 0.4 0.6 0.9 0.7 -0.5 1.0
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 1.6 0.2 -1.2 1.3
Medication: Atenolol 0.5 0.6 1.1 1.0 0.9 -0.3
Medication: Levothyroxine sodium 0.9 1.6 3.3 -1.8 -1.1 -0.5
Sitting height 4.1 28.8 36.7 6.1 5.3 4.6
Chronic bronchitis/emphysema (father) 0.3 0.3 0.7 -0.5 0.9 0.1
High blood pressure (mother) 0.4 0.5 1.0 0.7 0.3 -1.0
Body mass index (BMI) 2.2 9.4 10.8 -3.3 -2.6 -3.2
Impedance of leg (left) 0.2 1.2 2.1 1.4 0.9 0.9
Leg predicted mass (left) 0.3 1.5 2.6 1.4 1.6 0.3
Trunk fat mass 0.0 0.2 0.6 -0.0 0.1 -0.8
Waist circumference 1.0 3.7 4.9 -2.2 -1.3 -2.2
Number of incorrect matches in round 0.3 0.5 0.6 0.8 0.5 -0.8
Past tobacco smoking 0.3 0.5 0.8 0.9 -0.6 0.5
Alcohol usually taken with meals 0.2 0.3 0.7 -0.1 0.8 -0.4
Nervous feelings 0.5 0.9 1.3 -1.1 -1.0 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 2.0 0.4 1.4 0.1
Hearing difficulty/problems with background noise 0.2 0.3 0.9 -0.0 -0.9 0.2
Hair/balding pattern: Pattern 2 0.3 0.4 0.7 -0.9 -0.6 0.4
Had menopause 0.0 0.0 0.1 -0.3 0.1 0.2
Had other major operations 0.3 0.3 0.6 -0.8 0.6 0.2
Forced vital capacity (FVC) 0.5 2.1 3.9 1.4 2.0 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.0 0.6 1.0 -0.5
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 0.6 -0.8 -0.7 0.6
Qualifications: None of the above 0.8 1.8 4.4 -0.9 -2.1 -0.5
Financial difficulties in last 2 years 0.6 0.8 1.6 -0.9 0.0 1.3
Mouth/teeth dental problems 2.5 3.9 7.5 2.7 1.6 1.2
Heart attack 0.3 0.4 0.8 -0.9 -0.5 -0.3
Allergy 0.3 0.7 2.1 1.5 0.1 -0.2
Pain all over the body in last month 0.7 0.8 1.5 -1.2 0.3 -0.8
Diabetes (self-reported) 1.3 2.0 4.8 -2.2 -1.1 0.1
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 2.2 1.5 -0.2 1.0
Medication: Ramipril 0.5 0.6 1.4 1.2 -0.2 0.5
Medication: Simvastatin 0.0 0.1 0.1 -0.2 0.2 0.3
Fluid intelligence score 0.6 1.2 2.2 -1.5 -0.4 -1.1
Illnesses of siblings 0.5 0.7 1.6 1.3 -0.4 -0.6
Neuroticism score 0.3 0.6 0.9 -1.0 0.8 0.6
Weight 0.1 0.3 0.4 0.4 0.5 -0.6
Impedance of arm (right) 4.9 22.7 29.9 5.5 4.3 4.4
Arm fat percentage (right) 0.9 3.4 4.8 -1.9 -1.3 -2.2
Trunk fat-free mass 0.4 2.4 3.7 1.9 1.9 0.3
Hip circumference 0.5 2.1 4.0 -1.1 -1.1 -2.0
Time employed in main current job 0.7 0.8 0.9 1.0 0.8 -0.9
Alcohol intake versus 10 years previously 0.4 0.6 1.0 -0.9 0.0 -1.0
Father’s age at death 0.4 0.5 1.0 1.0 -0.5 -0.5
Worrier / anxious feelings 0.7 1.2 2.1 0.7 1.5 1.0
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.7 4.6 -2.1 -0.6 -1.8
Falls in the last year 0.6 0.8 1.6 -0.7 0.4 1.3
Hair/balding pattern: Pattern 3 0.4 0.6 1.5 0.6 1.2 -0.1
Number of live births 0.5 0.7 1.3 -0.2 -0.8 1.2
Forced expiratory volume in 1-second (FEV1) 0.5 1.7 3.2 1.8 1.4 -0.0
Pulse rate 1.1 1.9 2.3 1.4 1.5 -1.2
Happiness 0.9 1.1 1.6 0.1 -1.2 -1.3
Noisy workplace 1.0 1.2 1.8 -1.3 -1.3 0.4
Qualifications: A levels/AS levels or equivalent 0.7 1.5 2.9 1.7 0.2 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.3 -0.1 0.6 0.1
Mouth/teeth dental problems: Dentures 1.8 3.1 4.0 -2.0 -1.7 -1.6
Asthma 1.3 2.5 4.9 -1.5 0.5 -2.2
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.6 -0.6 -1.3 0.0
Medication: Cholesterol lowering 0.6 1.0 2.2 -0.1 -0.8 -1.5
Depression (self-reported) 0.2 0.3 0.3 -0.4 0.5 -0.6
Medication: Lansoprazole 2.7 3.1 3.7 -1.8 -1.9 -1.5
Prospective memory result 1.2 1.4 2.9 1.7 0.6 -1.0
Lung cancer (father) 0.3 0.3 0.6 -0.4 -0.3 0.8
Illnesses of mother 0.3 0.4 1.1 -0.2 0.2 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.4 4.7 2.2 1.5 0.4
Pulse wave Arterial Stiffness index 0.5 0.6 1.2 -0.5 0.6 1.1
Impedance of arm (left) 4.3 20.1 24.2 4.9 3.8 4.6
Arm fat mass (right) 0.5 2.0 3.3 -1.3 -1.0 -1.8
Trunk predicted mass 0.4 2.4 3.6 1.9 1.9 0.3
Standing height 4.6 45.3 61.9 7.9 6.8 5.3
Length of working week for main job 0.5 0.6 1.3 -0.6 -0.1 -1.1
Exposure to tobacco smoke at home 0.7 0.8 1.7 1.3 -0.9 0.2
Breastfed as a baby 0.9 1.1 2.7 0.6 0.4 1.6
Tense / ‘highly strung’ 0.9 1.5 2.8 -1.7 -1.0 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.2 0.6 -0.2 -0.8 0.3
Hair/balding pattern: Pattern 4 0.4 1.0 2.7 -0.4 0.4 -1.7
Birth weight of first child 1.3 2.4 6.1 0.7 2.5 0.7
Peak expiratory flow (PEF) 0.6 1.4 3.3 1.8 0.4 0.8
Pulse wave reflection index 0.6 0.7 1.5 -1.2 -0.9 -0.1
Ever highly irritable/argumentative for 2 days 1.5 1.8 5.3 0.2 -2.3 0.5
Loud music exposure frequency 1.4 1.5 3.6 0.3 0.9 1.9
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.8 -0.8 -0.1 0.9
Mouth/teeth dental problems: Bleeding gums 1.4 1.9 3.5 -1.4 -1.9 -0.4
Blood clot in the leg (DVT) 0.3 0.4 0.8 -0.9 0.1 -0.8
Medication: Paracetamol 1.0 1.7 2.5 -1.6 -1.5 -0.5
Headache pain in last month 0.0 0.0 0.0 -0.1 -0.1 -0.1
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 1.4 -1.2 0.5 0.9
Glaucoma (self-reported) 0.8 0.9 1.9 -1.4 -0.7 -0.6
Gout (self-reported) 0.9 1.2 2.4 -1.1 -0.3 -1.6
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 1.0 -1.0 -0.7 -0.3
Medication: Amlodipine 0.6 0.8 1.4 -0.2 -0.9 -1.2
Medication: Ventolin 100micrograms inhaler 0.7 0.9 1.9 -1.4 0.4 -0.7
Birth weight 0.5 1.1 1.3 1.2 1.0 1.0
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.1 -0.2 0.1 1.0
High blood pressure (siblings) 0.5 0.8 2.1 -0.5 -1.4 -0.0
Forced vital capacity (FVC), Best measure 0.6 2.3 3.5 1.8 1.9 -0.2
Body fat percentage 0.6 2.5 3.6 -1.5 -1.2 -1.9
Leg fat percentage (right) 2.5 9.1 11.6 -2.8 -2.8 -3.4
Arm fat-free mass (right) 0.1 0.3 0.6 -0.1 0.5 -0.8
Exposure to tobacco smoke outside home 0.1 0.1 0.2 -0.4 0.4 0.2
Comparative body size at age 10 2.0 5.5 7.4 -2.7 -1.8 -2.4
Number of full brothers 0.6 0.7 1.3 -0.9 0.2 1.2
Worry too long after embarrassment 0.1 0.1 0.2 -0.2 -0.5 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 2.7 -1.6 -0.3 -1.7
Wheeze or whistling in the chest in last year 0.8 1.5 4.1 -2.0 -0.3 0.3
Number of children fathered 1.3 1.4 3.0 -0.7 0.9 1.7
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 2.4 0.5 1.6 0.2
Age at first live birth 0.5 0.9 1.2 1.1 0.8 -0.9
Pulse wave peak to peak time 0.4 0.5 0.9 0.8 -0.1 -0.9
Health satisfaction 1.2 1.6 4.5 -0.2 -2.1 0.4
Shortness of breath walking on level ground 0.2 0.2 0.4 -0.1 -0.4 0.6
Qualifications: College or University degree 0.2 0.6 1.2 1.1 0.7 -0.3
Eye problems/disorders: None of the above 0.7 0.8 1.9 1.4 0.6 -0.3
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.3 -1.1 0.4 -0.3
Emphysema/chronic bronchitis 0.7 0.8 1.5 -0.5 0.9 1.2
Medication for pain relief, constipation, heartburn 2.2 3.8 6.2 2.0 2.5 1.1
Neck or shoulder pain in last month 0.1 0.2 0.6 -0.8 0.1 -0.0
Medication: Blood pressure 0.3 0.5 1.4 1.2 -0.1 0.0
Angina (self-reported) 0.6 0.7 1.4 -1.2 0.8 0.4
Migraine (self-reported) 0.6 0.7 1.8 -0.6 -0.2 1.3
Medication: Ibuprofen 0.3 0.4 0.4 -0.6 -0.6 0.6
Medication: Allopurinol 1.8 2.4 3.9 -1.5 -1.1 -2.0
Medication: Omeprazole 0.7 0.8 1.7 -0.8 -1.3 -0.2
Medication: Seretide 50 evohaler 2.3 2.7 6.8 -2.6 -0.9 -0.8
Mean time to correctly identify matches 0.1 0.1 0.2 -0.4 -0.5 -0.1
Heart disease (mother) 0.8 1.0 2.0 0.6 1.4 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.0 0.2 -0.3 1.4
Whole body fat mass 0.2 1.0 1.8 -0.9 -0.5 -1.3
Leg fat mass (right) 1.4 5.4 7.3 -2.2 -2.0 -2.7
Arm predicted mass (right) 0.1 0.4 0.9 0.0 0.7 -0.9
Pulse rate, automated reading 0.1 0.3 0.6 0.8 -0.0 -0.5
Alcohol intake frequency. 2.4 5.5 7.1 -2.7 -2.7 -1.5
Comparative height size at age 10 4.3 23.9 43.3 6.6 4.2 3.4
Number of full sisters 2.8 3.4 5.1 -2.2 -1.5 -1.7
Suffer from ‘nerves’ 1.0 1.6 3.5 -1.9 -0.3 -1.1
Overall health rating 2.1 4.4 7.5 -2.1 -2.7 -1.1
Chest pain or discomfort 1.0 1.4 3.3 -0.8 0.4 1.8
Had major operations 1.2 1.4 3.7 0.2 0.7 1.9
Age at last live birth 0.2 0.2 0.4 0.7 -0.5 -0.2
Family relationship satisfaction 0.4 0.4 0.6 -0.8 -0.7 0.5
Leg pain on walking 0.7 0.9 2.0 -0.6 0.6 1.4
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.5 2.5 -1.6 -0.4 -1.3
Commuting to job workplace: Car/motor vehicle 1.4 1.6 3.8 2.0 0.2 -0.9
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.0 0.3 -0.5 -1.0
Medication: Aspirin 0.9 1.1 2.4 -0.9 -1.6 0.3
Supplements: Vitamin C 2.5 3.0 6.3 -1.6 -2.5 -0.2
Knee pain experienced in last month 3.3 5.1 8.0 -2.7 -2.8 -0.2
Hypertension (Self-reported) 0.2 0.6 1.4 0.5 -1.2 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 2.0 3.0 -1.7 -0.7 -1.6
Illnesses of father: Heart disease 0.2 0.3 0.7 0.4 -0.8 0.4
Illnesses of siblings: Diabetes 0.9 1.1 2.3 -1.5 1.0 0.3
Smoking status: Previous 0.2 0.3 0.4 -0.3 0.6 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 3.1 6.5 10.3 3.2 2.3 1.9
Whole body fat-free mass 0.3 1.7 2.9 1.5 1.7 0.2
Leg fat-free mass (right) 0.4 1.9 3.3 1.4 1.8 0.6
Arm fat percentage (left) 1.0 3.9 4.8 -2.2 -1.5 -2.1
Average weekly red wine intake 4.2 6.2 10.6 2.4 3.3 1.5
Handedness (chirality/laterality): Left-handed 1.3 1.5 2.4 0.9 1.2 1.5
Mood swings 0.4 0.7 1.4 -1.2 0.5 0.6
Loneliness, isolation 0.2 0.3 0.9 0.2 -0.9 -0.1
Long-standing illness, disability or infirmity 0.9 1.4 3.8 -1.9 -0.7 0.3
Ever had bowel cancer screening 1.7 2.0 2.9 1.2 1.2 1.7
Diabetes diagnosed by doctor 0.7 1.1 2.4 -1.5 -1.0 0.2
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 4.0 0.3 2.0 -0.8
Friendships satisfaction 1.0 1.2 1.6 -1.0 -1.3 -1.0
Qualifications: nursing, teaching 1.1 1.8 5.0 2.2 0.5 0.1
Commuting to job workplace: Walk 0.0 0.1 0.1 0.1 0.3 0.3
Eye problems/disorders: Cataract 0.5 0.6 1.7 0.0 -0.1 1.3
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.1 -1.1 1.0 0.3
Medication for cholesterol 0.1 0.1 0.2 0.4 0.3 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 3.6 -1.9 0.8 -0.9
Back pain experienced in last month 2.4 3.5 6.3 -1.8 -2.5 -1.0
Mineral and other dietary supplements 0.5 0.7 1.4 -0.8 0.3 -1.2
Breast cancer (self-reported) 0.0 0.0 0.0 0.2 -0.2 -0.0
Asthma (self-reported) 1.3 2.6 4.6 -1.8 -0.0 -2.1
Osteoporosis (self-reported) 0.0 0.1 0.1 0.2 -0.3 -0.2
Osteoarthritis (self-reported) 0.2 0.2 0.6 -0.3 -0.7 -0.1
Medication: Aspirin 0.9 1.1 3.0 -0.5 -1.7 -0.3
Medication: Gliclazide 0.1 0.1 0.2 -0.1 -0.4 -0.4
Illnesses of father: None of the above (group 1) 0.2 0.3 0.4 -0.7 0.6 -0.1
Smoking status: Current 0.4 0.6 1.8 -1.3 0.2 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.0 1.0 -0.3 -0.6
Whole body water mass 0.3 1.4 2.4 1.4 1.6 0.1
Leg predicted mass (right) 0.3 1.8 3.0 1.4 1.7 0.5
Arm fat mass (left) 0.6 2.3 3.3 -1.5 -1.1 -1.8
Number of self-reported non-cancer illnesses 0.4 0.7 1.6 -1.2 -0.5 -0.4
Average weekly champagne plus white wine intake 0.1 0.1 0.2 0.2 0.4 0.2
Miserableness 0.5 0.9 1.7 -0.5 0.9 -1.3
Guilty feelings 0.2 0.3 0.4 -0.6 0.3 0.5
Wears glasses or contact lenses 1.9 2.1 2.6 -1.4 -1.6 -1.4
Ever taken oral contraceptive pill 0.0 0.0 0.1 -0.2 0.0 -0.3
Hearing aid user 1.0 1.1 2.4 0.8 1.5 -0.5
Mother’s age at death 1.2 1.4 2.7 1.1 -0.7 -1.6
Financial situation satisfaction 1.2 1.5 3.9 -0.6 -0.4 2.0
Tinnitus: Yes, now most or all of the time 3.5 4.1 5.1 2.0 2.3 1.7
Commuting to job workplace: Public transport 0.8 1.0 1.7 -1.3 -0.1 1.1
Eye problems/disorders: Glaucoma 1.1 1.3 2.5 -1.6 0.4 -1.1
Medication: Blood pressure 0.2 0.3 0.8 0.1 -0.9 -0.4
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.4 -1.2 -0.3 -1.1
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.8 0.7 -0.1 0.9
High cholesterol (Self-reported) 0.6 1.1 2.0 -1.0 0.5 -1.4
Medication: Bendroflumethiazide 1.9 2.9 5.8 -1.3 -2.4 -1.1
Medication: Paracetamol 0.8 1.3 3.1 -1.8 -0.7 0.5
Medication: Lisinopril 0.4 0.5 0.7 0.8 0.2 -0.9
Medication: Atorvastatin 2.6 3.2 5.8 -1.9 -0.6 -2.4
Illnesses of father: High blood pressure 0.7 0.9 2.6 1.6 0.4 -0.2
Alcohol drinker status: Never 0.5 0.6 0.9 -0.3 -0.8 -1.0
Ever smoked 0.4 0.8 1.7 -1.3 0.7 -0.2
Basal metabolic rate 0.2 1.0 1.7 1.2 1.3 -0.2
Leg fat percentage (left) 2.8 10.2 12.5 -3.1 -2.9 -3.5
Arm fat-free mass (left) 0.1 0.7 1.0 0.2 1.0 -1.0
Number of operations (self-reported) 0.4 0.6 1.4 -0.6 -0.3 -1.2
Average weekly beer plus cider intake 2.6 3.8 5.0 -1.2 -2.2 -2.2
Irritability 1.4 2.4 4.4 0.9 2.1 1.4
Risk taking 0.8 1.2 2.1 -0.1 -1.4 -1.2
Ever had prostate specific antigen (PSA) test 2.3 2.7 3.0 1.4 1.7 1.7
Fractured/broken bones in last 5 years 0.2 0.2 0.5 0.3 0.7 0.3
Age started oral contraceptive pill 0.7 0.9 2.6 0.3 1.6 0.3
Diastolic blood pressure, automated reading 0.8 2.6 5.7 0.4 -2.4 -1.4
Ever depressed for a whole week 0.6 0.8 2.1 0.1 0.6 1.4
Unable to work because of sickness or disability 1.3 1.7 2.4 -1.0 -1.6 -1.3
Commuting to job workplace: Cycle 1.6 1.9 3.3 -1.8 -0.5 -1.5
Myopia 0.6 0.9 1.8 0.8 -1.4 -0.3
Vascular/heart problems diagnosed by doctor 0.2 0.7 1.6 0.3 1.3 0.5
Cholesterol lowering medication 0.9 1.3 2.1 -1.4 0.9 1.0
Medication: Omeprazole (e.g. Zanprol) 1.8 2.2 3.0 -1.7 -1.7 -0.9
Pain experienced in last month 1.8 3.0 8.7 3.0 0.4 0.4
Supplements: Calcium 0.6 0.6 1.7 -0.3 -0.4 1.3
Basal cell carcinoma (self-reported) 0.1 0.1 0.4 -0.0 0.1 0.6
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.9 -1.0 -0.6 -0.0
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.4 -0.6 -0.0 -0.6
Heart disease (siblings) 0.6 0.8 1.0 -1.0 -0.7 -0.9
Alcohol drinker status: Previous 2.9 3.3 5.3 -2.3 -1.9 -0.9
Pack years of smoking 1.4 2.1 4.3 -2.1 -1.3 0.4
Impedance of whole body 2.2 11.1 14.3 3.8 2.8 3.3
Leg fat mass (left) 1.5 5.9 7.8 -2.4 -2.1 -2.8
Arm predicted mass (left) 0.1 0.5 0.8 0.2 0.7 -0.9