Best TWAS P=9.83e-11 · Best GWAS P=9.76e-12 conditioned to 0.0733
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SRP19 | 0.08 | 0.06 | lasso | 5 | 0.07 | 1.3e-08 | 5.0 | -5.1 | 3.1e-07 | 0.63 | 0.76 | 0.24 | FALSE |
2 | GTEx | Adipose Subcutaneous | DCP2 | 0.21 | 0.11 | enet | 16 | 0.15 | 3.4e-12 | -5.0 | -5.2 | 2.6e-07 | 0.24 | 0.97 | 0.03 | TRUE |
3 | GTEx | Artery Aorta | REEP5 | 0.17 | 0.07 | lasso | 13 | 0.10 | 4.2e-06 | 6.1 | 5.7 | 1.0e-08 | -0.74 | 0.07 | 0.93 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | CTC-487M23.5 | 0.07 | 0.03 | lasso | 3 | 0.03 | 2.9e-03 | -5.4 | -6.0 | 2.7e-09 | 0.66 | 0.04 | 0.88 | FALSE |
5 | GTEx | Esophagus Gastroesophageal Junction | REEP5 | 0.18 | 0.03 | lasso | 3 | 0.03 | 3.7e-02 | 5.1 | 5.2 | 2.4e-07 | -0.61 | 0.06 | 0.79 | FALSE |
6 | GTEx | Esophagus Mucosa | REEP5 | 0.19 | 0.10 | lasso | 5 | 0.09 | 1.5e-06 | 5.1 | 5.2 | 1.9e-07 | -0.60 | 0.23 | 0.70 | FALSE |
7 | GTEx | Lung | DCP2 | 0.08 | 0.02 | enet | 12 | 0.02 | 8.9e-03 | 4.4 | -5.7 | 9.5e-09 | 0.43 | 0.31 | 0.10 | FALSE |
8 | GTEx | Nerve Tibial | XBP1P1 | 0.06 | 0.05 | lasso | 2 | 0.04 | 6.1e-04 | 4.3 | 5.2 | 1.8e-07 | -0.78 | 0.05 | 0.91 | FALSE |
9 | GTEx | Skin Not Sun Exposed Suprapubic | CTC-487M23.7 | 0.08 | 0.09 | enet | 7 | 0.10 | 3.9e-06 | 4.2 | 5.2 | 2.3e-07 | -0.65 | 0.13 | 0.83 | FALSE |
10 | GTEx | Testis | REEP5 | 0.22 | 0.14 | lasso | 5 | 0.14 | 6.6e-07 | 4.7 | 5.5 | 4.9e-08 | -0.59 | 0.11 | 0.87 | FALSE |
11 | NTR | Blood | REEP5 | 0.03 | 0.04 | lasso | 9 | 0.04 | 3.3e-12 | 6.1 | 6.5 | 9.8e-11 | -0.66 | 0.12 | 0.88 | TRUE |
12 | YFS | Blood | SRP19 | 0.02 | 0.01 | bslmm | 456 | 0.00 | 2.9e-02 | 5.3 | 5.3 | 9.0e-08 | -0.67 | 0.03 | 0.81 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | APC | 0.02 | 0.02 | enet | 5 | 0.02 | 4.2e-03 | -6.1 | 6.0 | 1.7e-09 | -0.74 | 0.03 | 0.85 | FALSE |