Best TWAS P=3.13e-32 · Best GWAS P=3.73e-37 conditioned to 1.43e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Pituitary | LHFPL2 | 0.38 | 0.02 | lasso | 9 | 0.04 | 4.0e-02 | 1.7 | -7.2 | 6.7e-13 | 0.50 | 0.04 | 0.52 | FALSE |
| 2 | GTEx | Stomach | ARSB | 0.19 | 0.01 | lasso | 7 | 0.04 | 6.6e-03 | -5.0 | -5.8 | 7.6e-09 | 0.13 | 0.10 | 0.37 | TRUE |
| 3 | METSIM | Adipose | AP3B1 | 0.07 | 0.01 | blup | 556 | 0.02 | 2.4e-04 | 4.2 | -6.1 | 1.2e-09 | 0.54 | 0.09 | 0.81 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AP3B1 | 0.02 | 0.00 | blup | 126 | 0.01 | 1.8e-02 | -12.7 | -11.8 | 3.1e-32 | 0.85 | 0.01 | 0.91 | TRUE |
| 5 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | AP3B1 | 0.16 | 0.06 | enet | 18 | 0.09 | 2.2e-05 | 4.5 | -6.4 | 1.2e-10 | 0.52 | 0.06 | 0.28 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | AP3B1 | 0.08 | 0.01 | enet | 20 | 0.02 | 9.7e-04 | -12.6 | -7.2 | 7.3e-13 | 0.60 | 0.01 | 0.88 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DMGDH | 0.03 | 0.02 | lasso | 5 | 0.02 | 3.1e-03 | 6.0 | -5.7 | 1.6e-08 | -0.05 | 0.01 | 0.94 | TRUE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BHMT | 0.04 | 0.04 | enet | 9 | 0.02 | 2.4e-03 | 4.5 | -5.2 | 1.5e-07 | 0.04 | 0.02 | 0.92 | FALSE |
| 9 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ARSB | 0.22 | 0.00 | blup | 183 | 0.05 | 2.4e-03 | 4.2 | 5.2 | 1.8e-07 | 0.02 | 0.06 | 0.21 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AP3B1 | 0.05 | 0.02 | blup | 126 | 0.03 | 5.0e-04 | 5.2 | -10.0 | 1.5e-23 | 0.81 | 0.02 | 0.92 | FALSE |