Best TWAS P=7.03e-08 · Best GWAS P=9.69e-12 conditioned to 3.83e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ROSMAP | Brain Pre-frontal Cortex | RARB | 0.06 | 0.05 | enet | 14 | 0.04 | 1.7e-06 | 4.0 | -5.1 | 2.6e-07 | 0.09 | 0.01 | 0.84 | TRUE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | NKIRAS1 | 0.10 | 0.07 | enet | 16 | 0.07 | 2.5e-09 | -4.2 | -5.2 | 2.2e-07 | 0.51 | 0.92 | 0.08 | FALSE |
| 3 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NKIRAS1 | 0.14 | 0.05 | blup | 60 | 0.06 | 7.0e-07 | -4.7 | -5.4 | 7.0e-08 | 0.53 | 0.12 | 0.88 | TRUE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NR1D2 | 0.03 | 0.02 | enet | 4 | 0.04 | 5.5e-05 | -6.2 | -5.4 | 8.6e-08 | 0.85 | 0.00 | 0.97 | FALSE |
| 5 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RPL15 | 0.14 | 0.06 | lasso | 4 | 0.05 | 1.8e-04 | -4.9 | -5.4 | 7.4e-08 | 0.58 | 0.04 | 0.87 | FALSE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | UBE2E1 | 0.08 | 0.03 | lasso | 2 | 0.03 | 2.3e-03 | -5.1 | -5.2 | 2.3e-07 | 0.59 | 0.02 | 0.79 | FALSE |