Best TWAS P=1.91e-09 · Best GWAS P=3.38e-09 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | PSMD5-AS1 | 0.63 | 0.49 | enet | 27 | 0.55 | 4.6e-23 | -4.0 | -5.2 | 1.6e-07 | 0.80 | 0.44 | 0.56 | FALSE |
2 | GTEx | Artery Aorta | RAB14 | 0.09 | 0.07 | lasso | 8 | 0.04 | 3.2e-03 | -5.9 | -6.0 | 1.9e-09 | 0.99 | 0.01 | 0.96 | TRUE |
3 | GTEx | Artery Coronary | PSMD5-AS1 | 0.56 | 0.50 | enet | 31 | 0.55 | 1.3e-21 | -4.0 | -5.2 | 1.9e-07 | 0.74 | 0.92 | 0.08 | FALSE |
4 | GTEx | Brain Cortex | PSMD5-AS1 | 0.67 | 0.45 | enet | 26 | 0.46 | 3.4e-14 | -3.8 | -5.2 | 2.3e-07 | 0.77 | 0.06 | 0.93 | FALSE |
5 | GTEx | Brain Hippocampus | PSMD5-AS1 | 0.61 | 0.40 | lasso | 6 | 0.53 | 1.4e-14 | -3.8 | -5.5 | 3.0e-08 | 0.84 | 0.01 | 0.99 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | PSMD5 | 0.25 | 0.18 | enet | 27 | 0.18 | 7.2e-14 | -3.8 | -5.5 | 3.9e-08 | 0.79 | 0.58 | 0.42 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | FBXW2 | 0.18 | 0.13 | lasso | 5 | 0.13 | 6.1e-10 | -5.9 | -5.9 | 2.9e-09 | 0.93 | 0.00 | 1.00 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | PSMD5-AS1 | 0.42 | 0.13 | lasso | 11 | 0.18 | 7.5e-14 | -3.8 | -5.4 | 6.3e-08 | 0.89 | 0.01 | 0.99 | FALSE |
9 | GTEx | Liver | PSMD5-AS1 | 0.62 | 0.35 | lasso | 5 | 0.49 | 1.2e-15 | -5.7 | -5.3 | 1.2e-07 | 0.79 | 0.03 | 0.97 | FALSE |
10 | GTEx | Prostate | PSMD5-AS1 | 0.63 | 0.33 | lasso | 9 | 0.47 | 2.2e-13 | -3.8 | -5.7 | 9.6e-09 | 0.82 | 0.04 | 0.96 | FALSE |
11 | GTEx | Testis | PSMD5-AS1 | 0.21 | 0.20 | lasso | 5 | 0.17 | 3.6e-08 | -5.3 | -5.4 | 8.1e-08 | 0.77 | 0.02 | 0.98 | FALSE |
12 | GTEx | Vagina | PSMD5-AS1 | 0.55 | 0.34 | lasso | 5 | 0.42 | 1.2e-10 | -5.3 | -5.4 | 5.8e-08 | 0.82 | 0.02 | 0.98 | FALSE |
13 | YFS | Blood | PHF19 | 0.05 | 0.03 | enet | 21 | 0.04 | 2.9e-14 | -3.8 | 5.3 | 1.1e-07 | -0.72 | 0.63 | 0.36 | FALSE |
14 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | LOC253039 | 0.18 | 0.09 | lasso | 4 | 0.12 | 2.6e-06 | -3.9 | -5.3 | 9.8e-08 | 0.88 | 0.00 | 1.00 | FALSE |
15 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TRAF1 | 0.05 | 0.00 | blup | 56 | 0.02 | 1.9e-02 | -4.1 | 5.6 | 1.7e-08 | -0.66 | 0.03 | 0.38 | FALSE |