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chr12:111,102,574-113,517,494

Best TWAS P=1.66e-10 · Best GWAS P=4.82e-21 conditioned to 4.5e-06

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Adipose Subcutaneous	HECTD4	0.06	0.00	enet	15	0.02	1.0e-02	4.3	-6.4	1.7e-10	0.65	0.06	0.85	TRUE
4	GTEx	Brain Cerebellar Hemisphere	ADAM1A	0.21	0.01	enet	29	0.03	6.8e-02	3.9	-5.8	7.3e-09	0.39	0.04	0.16	TRUE
3	GTEx	Artery Tibial	HECTD4	0.05	0.02	lasso	3	0.01	3.1e-02	-7.1	-6.2	7.2e-10	0.78	0.01	0.93	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ATXN2	0.02	0.03	enet	8	0.02	4.8e-04	4.9	-6.0	1.8e-09	0.56	0.24	0.66	FALSE
12	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ERP29	0.11	0.03	blup	25	0.05	5.0e-03	4.1	6.0	1.8e-09	-0.60	0.01	0.75	FALSE
8	GTEx	Skin Sun Exposed Lower leg	ALDH2	0.10	0.09	enet	13	0.13	6.7e-11	4.4	-5.8	8.2e-09	0.62	0.96	0.04	FALSE
10	YFS	Blood	SH2B3	0.05	0.01	enet	22	0.02	3.3e-07	3.5	-5.6	1.8e-08	0.64	0.51	0.49	FALSE
9	GTEx	Stomach	TMEM116	0.13	0.03	lasso	7	0.03	1.6e-02	4.5	5.6	2.6e-08	-0.46	0.07	0.15	FALSE
6	GTEx	Colon Transverse	FAM109A	0.21	0.00	lasso	4	0.01	1.3e-01	5.1	-5.4	7.8e-08	0.41	0.06	0.06	FALSE
5	GTEx	Brain Putamen basal ganglia	ALDH2	0.12	0.00	lasso	14	0.02	1.3e-01	4.6	-5.3	9.7e-08	0.39	0.16	0.18	FALSE
11	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM116	0.03	0.03	blup	43	0.03	8.0e-05	4.0	5.3	1.1e-07	-0.43	0.52	0.21	FALSE
7	GTEx	Skin Not Sun Exposed Suprapubic	MAPKAPK5-AS1	0.04	0.00	enet	30	0.00	7.0e-01	4.3	5.1	2.9e-07	-0.53	0.22	0.12	FALSE