Best TWAS P=1.66e-10 · Best GWAS P=4.82e-21 conditioned to 4.5e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ATXN2 | 0.02 | 0.03 | enet | 8 | 0.02 | 4.8e-04 | 4.9 | -6.0 | 1.8e-09 | 0.56 | 0.24 | 0.66 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | HECTD4 | 0.06 | 0.00 | enet | 15 | 0.02 | 1.0e-02 | 4.3 | -6.4 | 1.7e-10 | 0.65 | 0.06 | 0.85 | TRUE |
| 3 | GTEx | Artery Tibial | HECTD4 | 0.05 | 0.02 | lasso | 3 | 0.01 | 3.1e-02 | -7.1 | -6.2 | 7.2e-10 | 0.78 | 0.01 | 0.93 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | ADAM1A | 0.21 | 0.01 | enet | 29 | 0.03 | 6.8e-02 | 3.9 | -5.8 | 7.3e-09 | 0.39 | 0.04 | 0.16 | TRUE |
| 5 | GTEx | Brain Putamen basal ganglia | ALDH2 | 0.12 | 0.00 | lasso | 14 | 0.02 | 1.3e-01 | 4.6 | -5.3 | 9.7e-08 | 0.39 | 0.16 | 0.18 | FALSE |
| 6 | GTEx | Colon Transverse | FAM109A | 0.21 | 0.00 | lasso | 4 | 0.01 | 1.3e-01 | 5.1 | -5.4 | 7.8e-08 | 0.41 | 0.06 | 0.06 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | MAPKAPK5-AS1 | 0.04 | 0.00 | enet | 30 | 0.00 | 7.0e-01 | 4.3 | 5.1 | 2.9e-07 | -0.53 | 0.22 | 0.12 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | ALDH2 | 0.10 | 0.09 | enet | 13 | 0.13 | 6.7e-11 | 4.4 | -5.8 | 8.2e-09 | 0.62 | 0.96 | 0.04 | FALSE |
| 9 | GTEx | Stomach | TMEM116 | 0.13 | 0.03 | lasso | 7 | 0.03 | 1.6e-02 | 4.5 | 5.6 | 2.6e-08 | -0.46 | 0.07 | 0.15 | FALSE |
| 10 | YFS | Blood | SH2B3 | 0.05 | 0.01 | enet | 22 | 0.02 | 3.3e-07 | 3.5 | -5.6 | 1.8e-08 | 0.64 | 0.51 | 0.49 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TMEM116 | 0.03 | 0.03 | blup | 43 | 0.03 | 8.0e-05 | 4.0 | 5.3 | 1.1e-07 | -0.43 | 0.52 | 0.21 | FALSE |
| 12 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ERP29 | 0.11 | 0.03 | blup | 25 | 0.05 | 5.0e-03 | 4.1 | 6.0 | 1.8e-09 | -0.60 | 0.01 | 0.75 | FALSE |