[Hub]/) : Traits : Birth weight :

chr12:111,102,574-113,517,494

Best TWAS P=1.66e-10 · Best GWAS P=4.82e-21 conditioned to 4.5e-06

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ATXN2 0.02 0.03 enet 8 0.02 4.8e-04 4.9 -6.0 1.8e-09 0.56 0.24 0.66 FALSE
2 GTEx Adipose Subcutaneous HECTD4 0.06 0.00 enet 15 0.02 1.0e-02 4.3 -6.4 1.7e-10 0.65 0.06 0.85 TRUE
3 GTEx Artery Tibial HECTD4 0.05 0.02 lasso 3 0.01 3.1e-02 -7.1 -6.2 7.2e-10 0.78 0.01 0.93 FALSE
4 GTEx Brain Cerebellar Hemisphere ADAM1A 0.21 0.01 enet 29 0.03 6.8e-02 3.9 -5.8 7.3e-09 0.39 0.04 0.16 TRUE
5 GTEx Brain Putamen basal ganglia ALDH2 0.12 0.00 lasso 14 0.02 1.3e-01 4.6 -5.3 9.7e-08 0.39 0.16 0.18 FALSE
6 GTEx Colon Transverse FAM109A 0.21 0.00 lasso 4 0.01 1.3e-01 5.1 -5.4 7.8e-08 0.41 0.06 0.06 FALSE
7 GTEx Skin Not Sun Exposed Suprapubic MAPKAPK5-AS1 0.04 0.00 enet 30 0.00 7.0e-01 4.3 5.1 2.9e-07 -0.53 0.22 0.12 FALSE
8 GTEx Skin Sun Exposed Lower leg ALDH2 0.10 0.09 enet 13 0.13 6.7e-11 4.4 -5.8 8.2e-09 0.62 0.96 0.04 FALSE
9 GTEx Stomach TMEM116 0.13 0.03 lasso 7 0.03 1.6e-02 4.5 5.6 2.6e-08 -0.46 0.07 0.15 FALSE
10 YFS Blood SH2B3 0.05 0.01 enet 22 0.02 3.3e-07 3.5 -5.6 1.8e-08 0.64 0.51 0.49 FALSE
11 The Cancer Genome Atlas Brain Lower Grade Glioma TMEM116 0.03 0.03 blup 43 0.03 8.0e-05 4.0 5.3 1.1e-07 -0.43 0.52 0.21 FALSE
12 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ERP29 0.11 0.03 blup 25 0.05 5.0e-03 4.1 6.0 1.8e-09 -0.60 0.01 0.75 FALSE