TWAS hub - FAM109A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.208	0.0940	0.00730	0.005	NA	0.006	NA	0.008	1.8e-01	NA	0.1600	NA	1.3e-01
2	GTEx	Nerve Tibial	0.264	0.0719	0.00012	0.059	NA	0.034	NA	0.071	5.3e-05	NA	0.0019	NA	9.5e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Eosinophil Count	42.5	327.4	488.4	22.1	12.9
Blood White Count	22.3	165.4	243.4	15.6	9.3
Hypothyroidism (self reported)	22.3	51.2	89.1	9.4	3.6
Systolic Blood Pressure	20.2	101.1	127.7	11.3	8.6
Diastolic blood pressure, automated reading	19.4	60.2	67.9	8.2	7.2
Medication: Levothyroxine sodium	17.0	28.8	46.8	6.8	3.3
Hypothyroidism/myxoedema (self-reported)	16.4	32.1	54.6	7.4	3.1
High blood pressure	14.2	39.7	40.6	6.2	6.4
Cardiovascular Disease	13.1	43.2	50.9	7.1	6.0
Hypertension (Self-reported)	12.8	35.5	35.7	5.9	6.0
Illnesses of father: High blood pressure	12.6	15.6	17.9	3.6	4.2
Vascular/heart problems diagnosed by doctor	12.1	32.9	35.1	-5.9	-5.5
Systolic blood pressure, automated reading	10.4	30.3	38.3	6.2	4.7
Illnesses of siblings	10.3	14.4	16.0	-4.0	-3.6
Blood Red Count	9.5	91.4	131.9	11.5	7.1
Birth weight	9.5	20.5	28.8	-5.4	-3.5
Frequency of unenthusiasm / disinterest in last 2 weeks	8.0	10.7	11.2	-3.2	-3.4
Back pain experienced in last month	7.9	11.5	14.1	-3.8	-3.0
Medication: Blood pressure	7.9	15.0	22.9	4.8	2.7
Medication: Blood pressure	7.7	13.7	15.1	3.9	3.5
Rheumatoid Arthritis	7.4	10.2	14.6	3.8	2.4
Medication: Bendroflumethiazide	7.4	11.2	16.8	4.1	2.4
Medication: Ramipril	7.1	9.1	13.1	3.6	2.3
Ever depressed for a whole week	7.1	8.7	8.7	-3.0	-3.0
High blood pressure (mother)	6.8	9.5	12.8	2.5	3.6
Coronary Artery Disease (CAD)	6.7	8.0	14.8	3.9	1.0
Medication: Atenolol	6.4	7.9	9.8	3.1	2.5
Primary Biliary Cirrhosis	6.3	9.0	9.0	3.0	3.0
Father’s age at death	6.3	8.4	9.4	-2.7	-3.1
Blood Platelet Count	6.0	69.4	134.6	11.6	-2.0
Fed-up feelings	5.9	10.7	12.2	-3.5	-3.0
Medication: Allopurinol	5.9	7.8	12.5	3.5	1.8
Mouth/teeth dental problems: Mouth ulcers	5.9	9.4	10.7	-3.3	-2.8
Reaction Time	5.8	11.1	20.1	4.5	1.4
High blood pressure (siblings)	5.7	8.2	8.4	2.8	2.9
Comparative height size at age 10	5.7	31.4	44.2	-6.7	-4.3
Taking other prescription medications	5.6	8.6	13.9	3.7	1.8
Illnesses of father: None of the above (group 1)	5.6	6.9	7.6	-2.8	-2.5
Qualifications: NVQ or HND or HNC or equivalent	5.5	6.7	7.6	-2.8	-2.4
HbA1C	5.2	5.8	6.7	-2.2	-2.6
Gout (self-reported)	5.2	7.1	11.4	3.4	1.7
Medication for cholesterol, blood pressure or diabetes	5.1	8.5	10.2	-3.2	-2.6
Number of self-reported non-cancer illnesses	5.1	8.9	12.9	3.6	2.2
Birth weight of first child	5.0	9.1	13.9	-3.7	-2.1
Arm fat-free mass (left)	5.0	25.6	39.9	-6.3	-3.4
Allergy or Eczema	4.9	12.9	14.3	-3.8	-3.4
Neuroticism score	4.8	10.0	10.3	-3.1	-3.2
Trunk fat-free mass	4.8	27.5	42.1	-6.5	-3.6
Trunk predicted mass	4.8	27.5	42.1	-6.5	-3.6
Arm fat-free mass (right)	4.8	24.8	38.4	-6.2	-3.3
Pulse wave peak to peak time	4.8	5.6	9.2	-3.0	-1.4
Arm predicted mass (left)	4.8	24.6	39.0	-6.2	-3.2
Arm predicted mass (right)	4.7	23.9	37.6	-6.1	-3.2
Ever unenthusiastic/disinterested for a whole week	4.4	5.3	6.6	-2.0	-2.6
Pulse wave Arterial Stiffness index	4.4	5.1	8.5	2.9	1.3
Hayfever, allergic rhinitis or eczema	4.3	9.3	11.0	-3.3	-2.8
Frequency of tenseness / restlessness in last 2 weeks	4.3	6.7	8.1	-2.8	-2.3
Illnesses of mother	4.3	5.3	8.5	-1.4	-2.9
Mean time to correctly identify matches	4.3	8.2	14.8	3.9	1.2
Number of treatments/medications taken	4.1	7.4	11.3	3.4	1.9
Loneliness, isolation	4.1	5.7	6.2	-2.5	-2.3
Whole body water mass	4.1	23.2	36.3	-6.0	-3.2
Depression (Nagel 2018)	4.0	6.0	6.4	-2.5	-2.4
Whole body fat-free mass	4.0	23.0	36.4	-6.0	-3.1
Medication for cholesterol	4.0	6.1	10.0	-3.2	-1.5
Heart attack/myocardial infarction (self-reported)	4.0	5.1	8.5	2.9	1.3
Depressed Affect (Nagel 2018)	3.9	8.2	8.2	-2.9	-2.9
Triglycerides	3.9	6.5	9.8	3.1	1.8
Basal metabolic rate	3.9	21.4	34.0	-5.8	-3.0
Ever highly irritable/argumentative for 2 days	3.8	4.6	5.8	-2.4	-1.8
Ever had hysterectomy (womb removed)	3.7	4.1	5.6	-1.6	-2.4
Lupus	3.6	5.5	7.3	1.9	2.7
Illnesses of father: Heart disease	3.6	5.0	5.8	2.1	2.4
Major Depression (MDD)	3.5	4.3	5.6	-2.4	-1.7
Blood clot in the leg (DVT)	3.4	4.4	7.3	2.7	1.2
Medication: Omeprazole (e.g. Zanprol)	3.4	4.2	7.3	2.7	1.0
LDL Cholesterol	3.2	5.0	8.2	-2.9	-1.4
Neuroticism	3.2	7.7	8.9	-2.6	-3.0
Heart attack	3.1	4.0	7.0	2.6	1.0
Frequency of depressed mood in last 2 weeks	3.0	4.2	5.5	-1.7	-2.3
Prospective memory result	3.0	3.7	5.7	-2.4	-1.3
Medication: Omeprazole	3.0	3.6	5.9	2.4	1.2
Deep venous thrombosis (DVT) (self-reported)	3.0	3.9	6.6	2.6	1.1
Allergy	2.9	6.6	7.6	2.8	2.4
Weight	2.9	14.2	22.1	-4.7	-2.5
Impedance of arm (left)	2.9	13.4	24.3	4.9	1.6
Angina	2.8	3.6	3.8	1.9	1.9
Leg fat-free mass (left)	2.8	14.6	23.6	-4.9	-2.4
Number of children fathered	2.8	3.2	5.9	-2.4	-0.7
Ever had bowel cancer screening	2.8	3.3	3.3	-1.8	-1.8
Leg predicted mass (left)	2.7	14.5	23.4	-4.8	-2.4
Medication: Cholesterol lowering	2.7	4.1	5.4	2.3	1.7
Exposure to tobacco smoke at home	2.7	3.0	4.1	2.0	1.4
Angina (self-reported)	2.7	3.6	3.8	2.0	1.8
Leg fat-free mass (right)	2.7	14.3	23.5	-4.8	-2.2
Age when periods started (menarche)	2.6	6.1	10.6	3.3	1.3
Impedance of arm (right)	2.6	12.2	22.1	4.7	1.5
Mood swings	2.6	4.8	6.8	-2.6	-1.7
Leg predicted mass (right)	2.6	13.7	22.6	-4.8	-2.2
Other serious medical condition/disability diagnosed by doctor	2.5	3.2	4.4	2.1	1.4
Townsend deprivation index at recruitment	2.5	3.5	5.2	2.3	1.3
Medication: Ventolin 100micrograms inhaler	2.5	3.2	4.2	-2.1	-1.5
Miserableness	2.5	4.4	5.8	-2.4	-1.7
Irritability	2.5	4.1	4.2	-2.0	-2.0
Neuroticism (Nagel 2018)	2.4	5.6	6.9	-2.1	-2.6
Exposure to tobacco smoke outside home	2.4	3.2	3.4	1.7	1.8
Commuting to job workplace: Public transport	2.4	2.9	4.8	2.2	1.0
Ever used hormone-replacement therapy (HRT)	2.3	2.9	5.7	-0.4	-2.4
Hip circumference	2.3	10.1	16.5	-4.1	-1.9
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.7	4.3	-2.1	-1.7
Worry too long after embarrassment	2.3	3.9	4.8	-1.7	-2.2
Impedance of whole body	2.2	11.0	19.2	4.4	1.7
Alcohol usually taken with meals	2.1	3.3	3.7	1.9	1.7
Alcohol intake versus 10 years previously	2.1	3.2	5.2	2.3	1.1
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.6	4.3	-2.1	-0.9
Mother’s age at death	2.1	2.6	3.2	-1.4	-1.8
Bipolar Disorder (2018)	2.0	3.1	3.6	-1.9	-1.6
Type 2 Diabetes (T2D) (2012)	2.0	2.3	3.1	1.8	1.2
Chronic bronchitis/emphysema (father)	2.0	2.4	2.7	-1.6	-1.4
Time employed in main current job	2.0	2.3	3.6	1.9	1.0
Breastfed as a baby	2.0	2.5	2.6	-1.6	-1.6
Diabetes (self-reported)	1.9	2.9	4.6	2.1	1.0
Emphysema/chronic bronchitis	1.9	2.2	4.1	-0.5	-2.0
Standing height	1.8	17.7	23.4	-4.8	-3.5
Diabetes diagnosed by doctor	1.8	3.0	4.9	2.2	1.0
Medication: Lisinopril	1.8	2.3	2.6	1.4	1.6
Ever smoked	1.8	3.2	3.9	2.0	1.6
Waist Hip Ratio (WHR)	1.7	7.7	14.7	3.8	0.9
Alcohol intake frequency.	1.7	3.9	4.8	2.2	1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	2.9	1.7	0.9
Medication: Gliclazide	1.7	1.9	2.2	1.5	1.2
Pain experienced in last month	1.7	2.9	3.9	2.0	1.4
Type 2 Diabetes (T2D) (2018)	1.6	3.0	4.3	2.1	1.3
Diabetes (father)	1.6	2.0	2.4	-1.6	1.3
Past tobacco smoking	1.6	2.9	4.2	-2.0	-1.3
Had menopause	1.6	2.0	3.7	-0.4	-1.9
Migraine (self-reported)	1.6	2.0	4.0	-0.3	-2.0
Relative age of first facial hair	1.5	3.0	4.1	2.0	1.4
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.3	-1.8	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	1.9	1.4	1.3
Smoking status: Previous	1.5	2.2	3.4	1.9	1.0
Had other major operations	1.4	1.7	1.8	1.3	1.3
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	3.6	-1.9	-0.4
Hair/balding pattern: Pattern 4	1.4	3.3	3.4	1.8	1.8
Suffer from ‘nerves’	1.4	2.2	3.2	-1.8	-1.1
High cholesterol (Self-reported)	1.4	2.6	2.8	1.7	1.5
Pain all over the body in last month	1.3	1.4	2.7	1.6	0.3
Pulse wave reflection index	1.3	1.6	2.7	1.6	0.7
Leg fat mass (right)	1.3	5.2	8.9	-3.0	-1.2
Medication: Aspirin	1.3	1.7	2.3	1.5	1.1
Alcohol drinker status: Previous	1.3	1.5	2.8	0.3	1.7
Leg fat mass (left)	1.3	5.0	8.9	-3.0	-1.1
Alzheimer’s Disease (in mother)	1.2	1.4	2.6	-1.6	0.5
Height	1.2	23.1	27.7	-5.3	-4.3
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.1	1.4	0.7
Relative age voice broke	1.2	1.8	3.4	1.9	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	3.2	-1.8	-1.5
Medication: Ibuprofen	1.2	1.5	1.8	-1.3	-1.1
Commuting to job workplace: Car/motor vehicle	1.2	1.3	1.8	-1.3	-0.9
Qualifications: nursing, teaching	1.2	1.8	2.6	-1.0	-1.6
Hearing aid user	1.2	1.4	2.7	1.6	0.3
Alcohol drinker status: Never	1.2	1.5	1.7	1.3	1.1
Alzheimer’s Disease (including proxy)	1.1	1.5	3.0	-1.7	-0.2
Smoking Status	1.1	2.7	4.7	2.2	0.8
Waist circumference	1.1	4.0	5.4	-2.3	-1.6
Number of full brothers	1.1	1.4	2.4	1.6	-0.6
Number of operations (self-reported)	1.1	1.6	3.3	1.8	-0.1
Fractured/broken bones in last 5 years	1.1	1.4	2.3	1.5	0.7
Heart disease (siblings)	1.1	1.4	1.8	1.0	1.3
Severe depression (siblings)	1.0	1.1	1.9	-1.4	-0.5
Body mass index (BMI)	1.0	4.2	7.2	-2.7	-1.1
Qualifications: None of the above	1.0	2.1	3.1	1.8	1.0
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	1.7	0.9	1.3
Whole body fat mass	1.0	4.1	6.8	-2.6	-1.2
Illnesses of siblings: Diabetes	1.0	1.3	2.4	0.3	1.6
Financial situation satisfaction	1.0	1.2	1.5	1.2	1.0
Unable to work because of sickness or disability	1.0	1.3	2.3	1.5	0.5
Cholesterol lowering medication	1.0	1.5	2.4	1.5	0.8
Basal cell carcinoma (self-reported)	1.0	1.2	2.3	-0.2	-1.5
Crohns Disease (2012)	0.9	1.4	1.7	1.3	1.1
Chronotype (morning person)	0.9	2.2	2.8	1.7	1.2
Tanning	0.9	10.8	14.7	2.6	3.8
Serious illness, injury or assault to yourself	0.9	1.0	2.1	1.4	0.1
Mouth/teeth dental problems	0.9	1.3	2.0	0.8	1.4
Medication: Simvastatin	0.9	1.3	1.6	1.0	1.3
Arm fat mass (right)	0.9	3.7	5.9	-2.4	-1.2
Tense / ‘highly strung’	0.9	1.5	2.7	-0.5	-1.7
Loud music exposure frequency	0.9	0.9	1.0	0.9	1.0
Eye problems/disorders: None of the above	0.9	1.0	2.0	-1.4	0.1
Long-standing illness, disability or infirmity	0.9	1.3	2.6	1.6	-0.1
Eye problems/disorders: Cataract	0.9	1.0	2.0	1.4	-0.2
Medication: Aspirin	0.9	1.2	1.9	1.4	0.7
Guilty feelings	0.9	1.4	2.0	-0.9	-1.4
Pack years of smoking	0.9	1.4	2.0	-1.4	-0.9
Impedance of leg (right)	0.8	3.9	7.2	2.7	0.7
Impedance of leg (left)	0.8	4.0	7.4	2.7	0.8
Trunk fat mass	0.8	3.3	5.4	-2.3	-1.1
Hearing difficulty/problems with background noise	0.8	1.3	2.6	-0.1	-1.6
Worrier / anxious feelings	0.8	1.6	3.2	-1.8	-0.2
Number of live births	0.8	1.2	2.1	0.5	-1.4
Pulse rate	0.8	1.3	2.1	1.5	0.7
Medication for pain relief, constipation, heartburn	0.8	1.4	2.4	-1.5	-0.7
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.2	-0.8	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	3.2	-1.8	-0.2
Arm fat mass (left)	0.8	3.3	5.4	-2.3	-1.1
Irritable Bowel Disease (IBD)	0.7	1.6	2.4	1.6	0.9
HDL Cholesterol	0.7	1.2	1.6	-1.2	0.9
Average weekly spirits intake	0.7	0.9	1.1	0.8	-1.0
Diabetes (mother)	0.7	0.9	1.9	-0.1	1.4
Hair/balding pattern: Pattern 3	0.7	1.0	2.0	-1.4	-0.3
Happiness	0.7	0.9	1.6	-0.3	-1.3
Headache pain in last month	0.7	1.2	1.7	-1.3	-0.9
Wheeze or whistling in the chest in last year	0.7	1.3	1.5	-1.0	1.2
Shortness of breath walking on level ground	0.7	0.8	1.1	-0.7	-1.1
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.4	0.5	-1.2
Overall health rating	0.7	1.6	2.6	-0.8	-1.6
Had major operations	0.7	0.8	1.6	-0.1	-1.3
Age at last live birth	0.7	1.1	1.6	0.7	1.3
Knee pain experienced in last month	0.7	1.0	1.2	-1.1	-0.9
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.4	-0.5	-1.2
Myopia	0.7	1.1	1.9	-0.5	-1.4
Worry (Nagel 2018)	0.6	1.3	1.4	-1.2	-1.1
Body Mass Index (BMI) (2010)	0.6	0.8	1.5	-1.2	-0.2
Fasting Glucose	0.6	0.7	1.3	0.2	1.1
BMI	0.6	3.2	5.8	-2.4	-0.8
Sensitivity / hurt feelings	0.6	1.0	1.0	-1.0	-1.0
Pack years adult smoking proportion	0.6	0.9	1.5	-1.2	-0.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.2	-0.3	-1.1
Sitting height	0.6	4.2	7.6	-2.8	-0.9
Noisy workplace	0.6	0.7	0.9	0.8	0.9
Mouth/teeth dental problems: Dentures	0.6	0.9	1.5	1.2	-0.6
Peak expiratory flow (PEF)	0.6	1.3	1.7	-0.9	1.3
Chronic bronchitis/emphysema (mother)	0.6	0.7	0.8	0.9	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.0	1.0	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.4	-0.3	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	0.8	0.9	0.7
Friendships satisfaction	0.6	0.7	1.0	-1.0	-0.6
Commuting to job workplace: Cycle	0.6	0.7	0.9	0.9	0.7
Lung FEV1/FVC ratio	0.5	2.8	5.5	-2.4	-0.1
Lung FVC	0.5	2.7	4.5	1.0	2.1
Medication for hormone replacement therapy	0.5	0.6	1.2	0.0	-1.1
Multivitamins +/- minerals	0.5	0.7	0.8	-0.7	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	2.5	-1.6	0.8
Medication: Paracetamol	0.5	0.8	1.0	1.0	0.8
Medication: Amlodipine	0.5	0.7	1.0	0.6	1.0
Heart disease (mother)	0.5	0.6	0.8	0.9	0.7
Smoking status: Current	0.5	0.7	1.0	-0.7	-1.0
Average weekly champagne plus white wine intake	0.5	0.7	1.3	0.1	1.1
Bipolar Disorder or Schizophrenia	0.4	1.0	1.0	-1.0	-1.0
Schizophrenia vs Biploar Disorder	0.4	0.5	0.6	0.8	0.6
Ulcerative Colitis (UC)	0.4	0.8	1.4	1.2	0.4
Ovarian Cancer	0.4	0.5	0.5	0.7	0.7
Mean Putamen Volume	0.4	0.4	0.8	-0.9	-0.2
Ulcerative Colitis	0.4	0.5	0.8	0.9	0.5
Average weekly fortified wine intake	0.4	0.5	0.7	-0.6	-0.9
Qualifications: CSEs or equivalent	0.4	0.5	0.9	-0.4	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.0	-1.0	-1.0
Financial difficulties in last 2 years	0.4	0.6	0.8	-0.6	-0.9
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.7	-1.3	-0.3
Asthma	0.4	0.7	1.3	-1.1	-0.4
Lung cancer (father)	0.4	0.4	0.7	-0.4	-0.9
Leg fat percentage (right)	0.4	1.5	2.5	-1.6	-0.8
Chest pain or discomfort	0.4	0.6	0.7	-0.9	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.2	-1.1	-0.8
Ever taken oral contraceptive pill	0.4	0.4	0.5	-0.6	0.7
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.0	-1.0	0.0
Leg fat percentage (left)	0.4	1.4	2.4	-1.6	-0.7
Risk taking	0.4	0.6	0.9	-0.6	-1.0
Age started oral contraceptive pill	0.4	0.5	1.0	1.0	0.2
Crohns Disease (2017)	0.3	0.6	0.7	0.8	0.7
Bipolar Disorder (2011)	0.3	0.3	0.5	-0.3	-0.7
Neuroticism (2016)	0.3	0.4	0.5	-0.7	-0.5
Schizophrenia (2014)	0.3	0.6	1.1	0.0	-1.1
Heel T-Score	0.3	2.3	2.3	1.5	1.5
Hair Pigment	0.3	9.1	11.2	-2.6	-3.3
Hearing difficulty/problems: Yes	0.3	0.5	0.7	0.5	-0.8
Vitamin and mineral supplements	0.3	0.4	0.8	0.9	-0.2
Current tobacco smoking	0.3	0.5	0.7	-0.5	-0.8
Maternal smoking around birth	0.3	0.4	0.8	-0.0	-0.9
Nervous feelings	0.3	0.6	0.9	-0.6	-0.9
Falls in the last year	0.3	0.5	0.9	1.0	0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.3	-1.1	0.9
Depression (self-reported)	0.3	0.3	0.6	-0.8	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.0	-1.0	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.9	-1.0	-0.4
Age at first live birth	0.3	0.6	0.7	-0.9	0.7
Health satisfaction	0.3	0.3	0.6	-0.2	-0.8
Family relationship satisfaction	0.3	0.4	0.6	0.8	-0.5
Breast cancer (self-reported)	0.3	0.4	0.8	-0.1	-0.9
Asthma (self-reported)	0.3	0.7	1.0	-1.0	-0.5
Osteoarthritis (self-reported)	0.3	0.4	0.6	0.8	-0.5
Medication: Atorvastatin	0.3	0.4	0.8	0.9	-0.1
Average weekly beer plus cider intake	0.3	0.4	0.6	-0.4	-0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.9	0.9	0.4
Age at First Birth	0.2	0.3	0.4	0.4	0.7
Hand grip strength (left)	0.2	0.6	1.2	-1.1	-0.1
Supplements: Zinc	0.2	0.2	0.3	-0.6	0.3
Medication: Co-codamol	0.2	0.2	0.3	-0.4	0.6
Supplements: Glucosamine	0.2	0.2	0.4	-0.3	-0.6
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	0.3	-0.6
Forced vital capacity (FVC)	0.2	0.9	1.9	-1.4	0.2
Fluid intelligence score	0.2	0.4	0.7	0.8	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	-0.0	0.7
Glaucoma (self-reported)	0.2	0.2	0.3	-0.4	-0.5
Forced vital capacity (FVC), Best measure	0.2	0.7	1.1	-1.1	0.5
Comparative body size at age 10	0.2	0.7	1.0	-0.6	1.0
Qualifications: College or University degree	0.2	0.7	1.4	-1.2	0.3
Number of full sisters	0.2	0.3	0.5	0.1	0.7
Average weekly red wine intake	0.2	0.3	0.4	0.7	-0.5
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.4	-0.4	-0.6
Commuting to job workplace: Walk	0.2	0.2	0.3	-0.3	0.6
Medication: Paracetamol	0.2	0.4	0.7	0.8	-0.2
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.6	0.8	-0.2
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.3	0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	-0.0	-0.3
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.4	-0.0
Number of incorrect matches in round	0.1	0.2	0.2	0.4	0.4
Medication: Lansoprazole	0.1	0.2	0.2	-0.3	0.5
Body fat percentage	0.1	0.4	0.6	-0.8	-0.4
Leg pain on walking	0.1	0.1	0.2	0.4	0.1
Osteoporosis (self-reported)	0.1	0.1	0.3	-0.5	-0.1
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.3	-0.6	0.0
Supplements: Calcium	0.1	0.1	0.3	0.0	0.5
Schizophrenia (2018)	0.0	0.0	0.1	0.3	-0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Respiratory disease	0.0	0.0	0.0	0.2	-0.2
Medication: Metformin	0.0	0.1	0.1	0.1	-0.3
Trunk fat percentage	0.0	0.2	0.3	-0.5	-0.2
Hand grip strength (right)	0.0	0.1	0.2	-0.4	0.3
Arm fat percentage (right)	0.0	0.0	0.1	-0.3	-0.0
Length of working week for main job	0.0	0.0	0.0	-0.1	0.0
Neck or shoulder pain in last month	0.0	0.1	0.1	0.1	0.3
Medication: Seretide 50 evohaler	0.0	0.0	0.0	-0.0	-0.0
Pulse rate, automated reading	0.0	0.0	0.1	0.0	-0.2
Supplements: Vitamin C	0.0	0.0	0.1	-0.3	-0.1
Arm fat percentage (left)	0.0	0.0	0.1	-0.3	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	0.2	-0.1
Mineral and other dietary supplements	0.0	0.0	0.0	0.2	-0.2
Wears glasses or contact lenses	0.0	0.0	0.0	-0.1	0.1
Eye problems/disorders: Glaucoma	0.0	0.0	0.0	0.1	-0.1
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	0.1	-0.1

Hub : Genes

FAM109A

Models

Trait associations