Hub : Genes

ITGB1BP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1054	0.0433	1.8e-03	0.026	NA	0.034	NA	0.027	3.6e-03	NA	1.1e-03	NA	3.1e-03
2	GTEx	Cells Transformed fibroblasts	0.1070	0.0470	7.3e-03	0.000	NA	0.002	NA	0.003	3.2e-01	NA	2.0e-01	NA	1.7e-01
3	GTEx	Muscle Skeletal	0.0895	0.0345	2.6e-03	0.010	NA	0.011	NA	0.011	3.1e-02	NA	2.4e-02	NA	2.6e-02
4	GTEx	Testis	0.2740	0.0680	3.8e-07	0.216	NA	0.134	NA	0.214	6.1e-10	NA	1.5e-06	NA	7.5e-10
5	METSIM	Adipose	0.0655	0.0240	1.2e-05	0.004	0.028	0.046	0.028	0.009	8.2e-02	3.7e-05	1.8e-07	3.9e-05	1.2e-02
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0432	0.0282	8.2e-03	-0.002	0.004	0.001	NA	-0.002	7.8e-01	1.1e-01	2.4e-01	NA	8.9e-01
7	TCGA	Pheochromocytoma and Paraganglioma	0.1720	0.0920	1.2e-03	-0.006	0.091	0.033	NA	0.008	6.4e-01	1.9e-04	1.8e-02	NA	1.5e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.3	0.4	0.8	0.4	0.8	-0.9	-0.6	-0.0	-0.7	-0.8
Bipolar Disorder or Schizophrenia	0.4	0.9	3.2	-0.0	0.2	-1.8	-0.2	-1.3	-0.4	-1.2
Depressed Affect (Nagel 2018)	0.7	1.5	3.6	-1.9	-0.5	0.3	-1.4	1.1	-1.8	0.6
Depression (Nagel 2018)	0.2	0.4	1.8	-0.5	-1.4	-0.2	-0.0	-0.5	-0.2	0.5
Intelligence (Savage-Jansen 2018)	0.6	1.7	4.7	-0.1	-0.5	-1.5	0.1	-2.1	-2.2	-0.7
Neuroticism (Nagel 2018)	0.3	0.6	1.5	-0.6	0.2	-0.1	-1.0	1.2	-1.2	0.4
Schizophrenia (2018)	0.4	0.9	2.6	-0.3	-0.3	-1.6	0.2	-1.5	0.0	-0.9
Schizophrenia vs Biploar Disorder	0.3	0.4	1.2	0.2	-0.6	-0.7	0.0	-1.1	0.4	-0.8
Worry (Nagel 2018)	0.3	0.6	1.4	-0.2	-0.3	-0.9	-0.1	1.0	-1.2	0.7
Alzheimer’s Disease (in mother)	2.0	2.4	6.6	-1.2	-2.6	-2.0	-0.1	0.1	-2.1	0.3
Alzheimer’s Disease (in father)	0.8	0.9	2.7	-1.3	-0.7	-0.6	-0.8	-0.0	-1.6	0.6
Alzheimer’s Disease (including proxy)	2.6	3.8	8.5	-1.6	-2.8	-2.7	-0.1	-0.1	-2.9	0.6
Crohns Disease (2017)	0.2	0.5	2.4	-1.6	-0.1	0.5	-0.8	0.1	0.1	0.1
Irritable Bowel Disease (IBD)	1.3	3.0	10.0	-3.2	0.5	1.7	-2.5	1.2	-0.0	0.5
Ulcerative Colitis (UC)	2.2	4.1	8.0	-2.8	0.8	2.8	-2.7	1.8	0.5	1.3
Major Depression (MDD)	0.9	1.1	3.0	0.7	1.3	-1.2	0.3	-0.9	-0.3	-1.7
Reaction Time	0.7	1.4	4.1	1.1	1.2	0.7	1.5	0.6	2.0	0.2
Verbal and Numeric Reasoning (VNR)	0.7	1.8	6.7	-0.2	-0.9	-1.5	1.0	0.5	-2.6	1.2
Breast Cancer	0.5	1.3	4.6	0.5	-0.7	-1.6	0.7	-2.1	-0.0	-0.9
Ovarian Cancer	0.8	1.1	3.8	0.7	-0.7	-0.6	0.3	-1.5	-0.1	-2.0
Prostate Cancer	1.7	2.4	8.8	0.8	0.7	3.0	-0.1	0.0	2.6	0.1
Age at First Birth	2.0	2.8	7.7	0.9	1.4	2.6	1.1	1.1	2.8	0.6
Bipolar Disorder (2011)	0.4	0.4	1.9	0.4	0.5	0.2	-0.2	1.4	-0.1	0.5
Body Mass Index (BMI) (2010)	0.6	0.8	1.6	-1.1	-1.2	-0.1	-0.9	0.6	-1.2	0.3
Coronary Artery Disease (CAD)	1.9	2.2	5.8	-0.3	1.2	-1.4	-2.3	-0.7	-0.9	-2.4
Crohns Disease (2012)	0.1	0.2	0.4	-0.5	0.3	0.6	-0.6	-0.2	0.1	-0.2
Mean Putamen Volume	0.3	0.3	0.6	0.5	0.6	-0.3	-0.2	0.6	-0.8	-0.7
Fasting Glucose	0.7	0.8	1.9	-0.3	0.4	1.3	-0.2	-1.3	1.4	0.5
HbA1C	0.1	0.1	0.2	0.5	0.2	0.1	-0.0	-0.4	-0.4	0.2
HDL Cholesterol	0.5	0.9	1.9	1.1	-0.7	0.9	1.4	-0.0	1.1	0.8
LDL Cholesterol	0.7	1.1	4.3	-0.5	0.8	-0.1	-2.1	0.8	0.2	-1.2
Lupus	0.3	0.5	1.4	-0.7	0.8	-0.5	-0.5	-0.1	-1.2	-0.2
Neuroticism (2016)	0.2	0.3	0.9	-0.7	-0.0	-0.7	-0.2	0.4	-1.0	0.1
Primary Biliary Cirrhosis	1.3	1.9	4.5	1.9	2.1	1.3	1.3	0.8	0.7	0.7
Rheumatoid Arthritis	1.3	1.8	7.3	0.0	-0.4	1.7	1.0	-0.6	2.7	0.8
Schizophrenia (2014)	0.7	1.5	4.1	0.3	0.0	-2.0	0.1	-1.8	0.1	-1.7
Triglycerides	1.2	2.0	6.4	-2.1	-0.2	-0.3	-2.5	0.1	-1.7	-0.5
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.0	0.1	-0.1	1.4	-1.1	1.1	-0.1	0.4
Ulcerative Colitis	2.0	2.9	7.5	-2.7	0.2	0.9	-2.6	1.5	-1.6	0.5
Blood Eosinophil Count	0.3	2.1	4.3	-2.1	-2.1	-0.5	-1.9	-0.2	-0.7	-1.3
Blood Platelet Count	0.1	1.0	2.9	1.7	0.2	-1.3	1.3	0.4	0.2	-0.5
Blood Red Count	0.1	0.7	3.2	0.1	0.3	1.2	0.0	0.2	-0.3	1.8
Blood White Count	0.2	1.5	8.5	-0.1	-2.9	-0.4	0.7	0.3	0.5	1.1
Heel T-Score	0.1	0.7	2.1	-1.3	0.2	-0.5	-0.2	-0.7	-1.4	-0.4
BMI	0.3	1.5	5.7	-0.3	-0.8	0.7	-0.4	1.7	-0.9	2.4
Height	1.2	23.4	73.8	-4.6	1.4	-1.8	-8.6	0.1	-4.7	-6.5
Waist Hip Ratio (WHR)	2.3	10.3	24.5	-5.0	-1.4	-1.7	-4.7	0.1	-3.5	-2.9
Systolic Blood Pressure	0.5	2.5	8.5	-0.9	-1.9	1.7	0.7	1.1	-0.2	2.9
Smoking Status	0.8	2.0	5.9	-0.5	-0.2	-2.2	-0.5	-2.4	-0.8	-1.4
Allergy or Eczema	1.0	2.5	4.7	-2.2	-1.5	-1.1	-1.9	-1.1	-2.1	-0.1
Cardiovascular Disease	0.7	2.2	7.7	-2.0	-2.8	0.3	-0.4	1.5	-0.2	1.2
Hypothyroidism (self reported)	0.9	2.0	8.5	0.9	-1.4	0.4	2.9	1.2	0.8	0.6
Respiratory disease	0.2	0.5	0.9	-0.5	-0.9	-0.6	-0.9	-0.7	0.1	-0.9
Type 2 Diabetes (T2D) (2018)	1.7	3.1	16.4	-1.5	-4.0	-1.5	-0.5	-0.6	-0.7	-0.1
Lung FEV1/FVC ratio	0.8	3.9	16.4	0.1	-0.2	-3.0	0.3	-4.0	-1.2	0.2
Lung FVC	0.6	3.0	7.8	2.0	1.7	0.9	1.6	-1.6	2.8	-0.0
Neuroticism	0.1	0.3	1.0	-0.3	-0.5	-0.0	-0.8	0.3	-1.0	-0.1
Chronotype (morning person)	0.6	1.5	4.2	-2.0	-0.7	-1.5	-0.9	-0.5	-1.5	0.1
Hair Pigment	0.0	1.4	3.7	0.6	-1.7	-1.3	1.9	-0.4	0.2	1.0
Tanning	0.0	0.6	1.8	0.9	-0.4	-0.8	1.4	-0.3	0.4	0.7
Hand grip strength (left)	1.0	2.7	5.8	2.4	1.1	0.7	0.8	-1.9	1.6	-2.1
Number of treatments/medications taken	1.3	2.4	5.4	-1.7	-1.6	-2.3	-1.2	0.3	-1.9	-0.4
Average weekly spirits intake	2.3	2.8	8.3	0.3	-0.7	-2.9	0.6	-2.1	-2.4	-0.7
Sensitivity / hurt feelings	0.3	0.5	1.2	0.8	0.0	-0.5	0.1	-1.1	0.1	-1.1
Frequency of depressed mood in last 2 weeks	0.5	0.6	2.2	0.0	-1.5	-0.2	0.8	-1.1	-0.1	0.6
Hearing difficulty/problems: Yes	2.0	3.1	8.6	-2.9	-1.4	0.3	-2.3	1.6	-1.7	0.3
Relative age of first facial hair	0.0	0.1	0.3	0.1	0.2	0.1	0.6	0.1	-0.3	0.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.3	-0.5	-0.9	-1.1	-0.2	0.0	-0.9	-0.3
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.9	-0.3	2.0	-1.1	-0.9	-0.3	-0.1	-1.7
Ever had hysterectomy (womb removed)	2.1	2.3	4.8	-1.8	0.9	-2.2	-1.6	-0.1	-1.2	-1.8
Systolic blood pressure, automated reading	0.5	1.5	4.7	-0.0	-1.4	0.2	1.1	1.7	-0.4	2.2
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	4.3	-2.1	-1.2	0.4	-1.1	0.4	0.0	0.1
Angina	0.7	0.9	2.6	-0.8	-1.0	-1.6	0.0	-1.0	-0.1	-0.9
Medication for hormone replacement therapy	0.8	0.9	3.1	-1.8	-0.8	-0.1	-0.9	0.3	-0.8	0.8
Vitamin and mineral supplements	0.8	1.1	3.4	-0.8	0.6	1.8	-0.0	0.5	1.2	1.3
Supplements: Zinc	0.5	0.5	1.6	0.5	-0.3	-1.0	0.0	-0.6	0.6	-1.3
Medication: Co-codamol	0.8	0.9	2.0	-1.0	0.1	-1.3	-0.8	1.4	-0.8	0.5
Medication: Metformin	1.5	2.1	6.0	-2.1	-2.4	-1.0	-0.9	0.6	-1.5	0.0
Diabetes (father)	0.2	0.2	0.6	0.2	0.3	0.8	-0.4	-0.5	-0.5	0.4
Diabetes (mother)	0.9	1.2	2.2	1.1	1.5	1.1	1.4	-0.0	0.5	1.3
Severe depression (siblings)	0.3	0.3	2.1	0.2	1.4	0.1	0.0	-0.2	0.0	-0.2
Pack years adult smoking proportion	0.4	0.7	2.1	0.9	-0.5	-1.4	0.9	-0.5	-0.6	0.2
Impedance of leg (right)	0.3	1.2	3.4	-0.2	0.8	0.2	1.8	-0.9	1.1	1.6
Leg fat-free mass (left)	0.5	2.8	10.9	-0.4	0.2	0.1	-3.3	1.4	-1.7	-1.9
Trunk fat percentage	0.7	2.9	10.0	-1.1	-1.6	1.0	-0.0	2.3	-0.6	3.2
Hand grip strength (right)	0.7	1.8	3.8	1.5	0.7	1.4	0.2	-2.0	1.6	-1.3
Townsend deprivation index at recruitment	0.2	0.3	0.9	0.5	0.8	0.5	0.3	0.9	-0.1	0.4
Current tobacco smoking	0.5	0.9	3.1	0.1	0.0	-1.5	0.4	-1.8	-0.6	-0.6
Average weekly fortified wine intake	0.3	0.3	1.3	-0.0	0.2	-0.4	0.4	1.1	0.6	-0.5
Maternal smoking around birth	0.5	0.7	2.0	-0.3	1.2	-0.8	0.2	1.4	-0.7	0.6
Fed-up feelings	0.7	1.3	2.7	-1.5	-0.9	1.6	-0.7	0.4	0.1	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.8	5.3	-0.4	-2.3	0.5	1.4	0.0	-0.6	2.1
Relative age voice broke	0.5	0.8	2.0	-1.0	-0.6	0.0	0.4	1.4	-0.6	1.3
Taking other prescription medications	0.6	1.0	2.7	0.5	-0.2	-1.6	-0.2	1.1	-0.5	-1.5
Age when periods started (menarche)	0.2	0.6	2.3	0.3	-1.5	0.4	0.3	1.0	0.3	-0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.7	-0.1	-0.1	-1.3	1.0	-0.2	0.0	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.0	-0.3	-0.7	-1.0	0.1	-0.8	-0.9	-0.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.2	0.2	-0.4	-0.7	0.2	-1.1	-1.1	-0.5
Qualifications: CSEs or equivalent	0.1	0.1	0.6	-0.2	-0.3	-0.1	-0.1	-0.3	0.0	0.8
Serious illness, injury or assault to yourself	0.4	0.5	1.4	0.4	-0.7	-1.2	0.1	0.0	0.3	-1.0
High blood pressure	1.0	2.7	10.3	-2.2	-3.2	0.2	-1.0	1.3	-0.1	0.7
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.4	-1.3	-0.8	-0.5	-1.3	-1.1	-1.6	0.4
Multivitamins +/- minerals	0.6	0.7	2.0	0.7	0.2	-1.4	0.3	-0.7	-0.3	-1.4
Stomach or abdominal pain in last month	0.7	0.9	1.5	-1.2	-0.7	-1.2	-1.1	-0.6	-0.5	-1.0
Supplements: Glucosamine	1.4	1.8	6.3	2.5	1.4	-0.1	1.3	0.0	1.5	-0.8
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	2.8	-1.7	-0.0	-1.6	-1.5	-1.7	-1.5	-0.8
Medication: Atenolol	0.7	0.8	3.3	-1.0	0.7	0.4	-0.7	1.8	0.3	0.5
Medication: Levothyroxine sodium	1.2	2.0	5.2	-0.8	-2.3	-1.3	1.3	1.7	-1.1	0.5
Sitting height	0.5	3.5	10.1	-0.8	2.3	-0.1	-2.8	-0.9	-0.5	-3.2
Chronic bronchitis/emphysema (father)	1.7	2.0	4.3	1.3	-0.7	0.7	1.8	1.0	1.8	2.1
High blood pressure (mother)	0.8	1.2	3.5	1.7	-0.1	0.2	1.9	-0.6	0.5	1.1
Body mass index (BMI)	0.3	1.2	3.7	-0.2	-0.9	0.4	-0.4	1.9	-0.7	1.8
Impedance of leg (left)	0.2	1.0	2.4	-0.8	0.3	-0.1	1.3	-1.2	0.6	1.6
Leg predicted mass (left)	0.5	2.7	10.4	-0.4	0.2	0.1	-3.2	1.3	-1.7	-1.9
Trunk fat mass	0.5	1.9	4.5	-1.2	-0.9	1.0	-1.2	2.1	-0.9	1.9
Waist circumference	0.5	1.9	4.8	-1.4	-0.9	0.3	-1.9	2.2	-1.3	0.5
Number of incorrect matches in round	0.4	0.7	2.5	-1.0	-1.6	-0.1	0.1	0.7	-0.2	1.0
Past tobacco smoking	0.4	0.7	1.6	1.1	1.0	0.4	0.8	0.6	1.3	0.1
Alcohol usually taken with meals	0.6	1.1	2.6	0.9	1.6	0.7	0.6	-0.1	1.3	-1.2
Nervous feelings	0.4	0.7	2.3	0.5	-1.5	-0.4	1.1	-0.0	-0.5	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.3	-0.0	0.1	0.0	0.0	-0.4	0.2	0.6
Hearing difficulty/problems with background noise	2.1	3.4	7.8	-2.6	-1.0	1.4	-2.3	2.8	-1.0	0.3
Hair/balding pattern: Pattern 2	1.1	1.4	3.5	1.7	0.3	-0.0	1.9	-0.7	0.3	1.7
Had menopause	0.6	0.7	2.0	0.8	0.4	-0.3	1.2	-1.4	0.4	0.5
Had other major operations	1.7	2.1	9.4	-0.3	-0.6	-3.1	-0.2	-0.2	-1.7	-1.3
Forced vital capacity (FVC)	1.0	4.0	9.1	1.1	2.6	0.8	-1.2	-2.4	1.7	-3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.6	-1.3	-1.2	0.2	-0.7	0.4	-0.8	0.3
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	3.5	-0.8	0.6	-1.1	-1.3	-0.4	-1.4	-1.9
Qualifications: None of the above	0.8	1.8	6.6	1.2	0.6	0.9	1.5	0.9	2.6	0.2
Financial difficulties in last 2 years	1.3	1.7	4.9	-1.6	-0.9	-0.9	-1.6	0.0	-2.2	-0.6
Mouth/teeth dental problems	0.3	0.5	1.3	-0.3	0.3	-0.6	0.0	-1.1	-0.3	-1.1
Heart attack	1.1	1.4	4.2	-0.3	-0.6	-2.0	-0.3	-1.4	0.5	-1.8
Allergy	0.3	0.8	1.6	1.0	0.2	1.1	1.2	0.9	0.9	-0.2
Pain all over the body in last month	0.6	0.6	1.8	-0.3	-1.1	0.8	-0.2	0.8	0.1	1.4
Diabetes (self-reported)	2.1	3.2	9.2	-2.4	-3.0	-1.6	-1.6	0.2	-1.6	-0.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.8	-0.6	-0.7	-0.5	-0.7	0.9	-1.4	1.3
Medication: Ramipril	0.8	1.1	4.2	-0.1	-1.4	0.8	-0.2	2.0	0.1	0.7
Medication: Simvastatin	0.5	0.7	3.1	-1.3	-0.2	-0.2	-0.4	-1.8	0.1	-0.2
Fluid intelligence score	0.6	1.3	3.6	0.7	-1.4	-0.2	1.9	-0.3	-0.7	1.6
Illnesses of siblings	0.5	0.7	3.1	0.4	-0.1	1.8	0.2	0.7	1.1	0.2
Neuroticism score	0.2	0.3	0.9	0.3	-0.9	0.1	0.4	-0.2	-0.5	0.9
Weight	0.4	1.9	7.3	-1.0	0.0	0.2	-2.7	1.6	-1.6	-0.5
Impedance of arm (right)	0.6	2.9	10.2	-0.3	-0.9	1.4	2.6	-0.3	0.8	3.2
Arm fat percentage (right)	0.9	3.6	14.2	-0.6	-1.8	1.4	0.9	2.1	-0.3	3.8
Trunk fat-free mass	1.0	5.6	17.1	-0.5	2.0	-0.2	-4.1	0.5	-1.6	-3.9
Hip circumference	0.4	1.6	3.5	1.2	0.2	1.6	0.1	1.9	0.9	1.8
Time employed in main current job	0.8	0.9	1.8	-0.5	0.6	1.4	-1.3	0.8	1.3	-0.3
Alcohol intake versus 10 years previously	0.4	0.6	1.5	0.1	-0.9	-1.2	0.3	0.8	-0.6	0.9
Father’s age at death	3.3	4.4	10.4	3.2	1.7	2.5	1.2	-0.1	3.1	0.3
Worrier / anxious feelings	0.2	0.4	1.4	0.4	0.7	0.5	-0.0	0.8	0.3	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.7	-1.6	-1.9	-0.7	-0.8	-0.8	-1.8	-0.3
Falls in the last year	0.5	0.6	1.5	-1.2	0.4	-0.0	-0.9	1.2	-0.3	-0.6
Hair/balding pattern: Pattern 3	0.7	1.1	2.9	-0.9	-0.6	-1.7	-1.0	0.3	-0.9	-1.2
Number of live births	2.1	3.0	8.6	1.8	-0.6	-0.8	0.4	-2.9	1.2	-2.6
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	7.7	0.9	2.0	0.1	-1.0	-2.8	1.3	-2.3
Pulse rate	0.4	0.6	1.5	-1.0	-0.3	0.4	0.1	1.1	-0.4	1.2
Happiness	1.0	1.3	3.6	-0.8	-1.9	-1.3	-0.2	-1.2	-1.2	-0.2
Noisy workplace	1.8	2.2	9.2	-3.0	-1.0	-0.7	-1.6	0.0	-1.4	0.0
Qualifications: A levels/AS levels or equivalent	0.7	1.5	4.6	0.3	2.1	-0.4	-0.7	-2.0	-0.7	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	3.9	0.7	0.7	-0.3	0.4	-2.0	0.2	-0.3
Mouth/teeth dental problems: Dentures	0.2	0.3	1.2	0.2	0.6	1.1	-0.1	0.1	0.5	0.0
Asthma	0.1	0.3	1.1	-0.7	-0.3	0.2	-1.1	0.3	-0.3	0.3
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	5.3	-1.4	-1.9	-0.0	-0.4	0.7	-2.1	2.3
Medication: Cholesterol lowering	1.7	2.6	4.4	-1.9	-1.2	-2.1	-1.9	-1.1	-1.1	-1.6
Depression (self-reported)	0.3	0.4	1.4	0.2	-1.2	0.4	0.1	1.0	0.1	0.2
Medication: Lansoprazole	1.8	2.0	5.8	-0.5	-1.0	-2.4	0.8	0.2	-2.4	0.6
Prospective memory result	1.9	2.3	8.7	-2.9	-0.9	-1.4	-1.5	-0.4	-1.2	-1.0
Lung cancer (father)	1.0	1.1	4.8	-0.4	-1.5	0.1	-0.4	2.2	0.5	0.6
Illnesses of mother	1.1	1.4	4.8	-1.7	0.3	0.8	-2.2	1.1	0.0	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.9	13.1	1.5	2.5	0.0	-0.6	-3.6	1.7	-3.0
Pulse wave Arterial Stiffness index	0.4	0.5	1.7	0.0	-0.2	-0.1	1.0	0.9	-0.0	1.3
Impedance of arm (left)	0.5	2.2	7.5	-0.2	-1.0	1.2	2.2	0.1	0.6	2.7
Arm fat mass (right)	0.4	1.6	4.0	-0.6	-0.9	1.1	-0.6	2.0	-0.8	2.0
Trunk predicted mass	1.0	5.8	17.9	-0.5	2.0	-0.3	-4.2	0.4	-1.7	-3.9
Standing height	0.9	8.5	26.1	-1.7	2.1	-0.4	-5.1	-0.7	-1.9	-4.6
Length of working week for main job	2.2	2.5	7.0	-0.8	-0.5	-2.6	-0.7	1.3	-2.6	-0.3
Exposure to tobacco smoke at home	1.3	1.4	4.2	0.3	-0.1	1.0	1.3	0.3	1.7	2.1
Breastfed as a baby	1.9	2.4	3.8	-1.9	-0.8	-1.5	-1.6	-1.4	-1.8	-1.5
Tense / ‘highly strung’	0.9	1.6	3.7	-1.1	-0.7	-0.4	-0.9	1.4	-1.6	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	1.0	-0.2	0.4	0.7	-0.2	-0.5	-0.3
Hair/balding pattern: Pattern 4	0.4	1.0	4.3	0.4	0.7	1.2	0.6	2.1	0.1	0.1
Birth weight of first child	2.1	3.8	14.6	-2.8	0.6	1.0	-3.8	0.0	-1.0	-1.3
Peak expiratory flow (PEF)	1.0	2.3	8.9	1.5	0.4	-1.2	0.8	-3.0	1.5	-0.6
Pulse wave reflection index	1.6	1.9	5.7	0.5	-1.2	-2.4	1.7	-1.5	-0.9	0.5
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.5	0.2	0.3	0.7	-0.7	0.1	0.3	-1.2
Loud music exposure frequency	0.7	0.8	2.9	0.4	0.6	1.7	0.3	0.7	0.6	1.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	2.7	-0.2	0.2	-0.2	-1.1	-1.7	-0.9	-0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.5	0.0	-0.5	0.6	-0.0	0.1	0.7	0.3
Blood clot in the leg (DVT)	0.5	0.6	1.8	0.3	1.4	-0.4	-0.4	-0.9	0.5	-0.9
Medication: Paracetamol	1.4	2.3	6.3	-2.5	-1.9	-0.8	-1.8	1.0	-1.1	0.4
Headache pain in last month	0.3	0.6	2.1	-0.4	-1.4	-1.0	-0.2	-0.7	-0.6	-0.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	3.7	1.7	0.8	0.4	1.9	-0.6	-0.0	0.0
Glaucoma (self-reported)	0.5	0.6	2.8	0.5	0.1	-1.7	0.6	-0.1	-0.3	-0.7
Gout (self-reported)	0.0	0.1	0.3	-0.6	0.2	0.0	0.0	0.0	-0.0	0.1
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	6.7	-0.4	-1.5	-0.3	1.1	2.6	-0.3	-0.1
Medication: Amlodipine	0.5	0.6	2.5	0.5	0.2	1.6	-0.5	0.5	1.1	0.2
Medication: Ventolin 100micrograms inhaler	1.7	2.2	4.9	2.2	0.9	2.1	0.7	0.0	2.1	0.0
Birth weight	9.1	19.8	48.2	-4.6	0.9	-2.6	-6.5	-2.8	-3.4	-6.9
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.5	1.2	0.7	-0.8	0.9	-0.2	0.0	-0.8
High blood pressure (siblings)	0.6	0.9	2.2	1.5	1.4	-0.2	1.1	-0.3	0.9	0.1
Forced vital capacity (FVC), Best measure	1.2	4.5	9.7	1.3	2.6	0.8	-0.6	-2.9	1.9	-3.1
Body fat percentage	0.7	2.9	11.2	-1.0	-1.6	0.9	0.3	2.1	-0.5	3.3
Leg fat percentage (right)	0.6	2.3	9.5	-0.0	-0.9	0.8	1.1	2.0	0.2	3.1
Arm fat-free mass (right)	1.0	5.0	18.0	-0.7	1.1	-0.5	-4.2	1.0	-1.6	-3.3
Exposure to tobacco smoke outside home	0.5	0.6	1.6	0.5	0.2	0.8	0.8	1.3	1.1	0.3
Comparative body size at age 10	0.3	0.7	2.7	0.7	0.9	-0.6	-0.7	-0.6	0.1	-1.6
Number of full brothers	0.7	0.9	3.4	-1.8	-0.3	-0.4	-1.4	0.1	-0.1	-0.5
Worry too long after embarrassment	1.1	1.9	4.4	2.1	0.3	-1.1	1.2	-2.0	-0.6	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.3	-0.1	0.1	-0.3	-0.5	1.5	-1.0	0.1
Wheeze or whistling in the chest in last year	0.2	0.4	1.5	0.2	-1.2	-0.1	0.3	0.8	-0.3	0.4
Number of children fathered	1.4	1.6	4.0	-2.0	-1.7	-0.8	-1.4	0.3	-1.1	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.8	0.1	-0.4	-0.6	-0.3	-0.9	-0.5	-0.0
Age at first live birth	0.7	1.2	3.4	-0.3	-0.1	1.4	1.1	-0.9	1.8	0.9
Pulse wave peak to peak time	0.6	0.7	2.4	-0.2	0.3	0.1	-1.3	-1.0	-0.0	-1.5
Health satisfaction	1.3	1.6	2.7	-1.3	-0.7	-1.6	-1.4	-1.1	-1.6	-0.9
Shortness of breath walking on level ground	1.7	2.0	6.5	-1.2	0.5	2.5	-1.3	1.3	1.5	0.2
Qualifications: College or University degree	0.2	0.6	2.2	0.2	1.5	0.7	-0.7	-0.5	0.4	-1.0
Eye problems/disorders: None of the above	1.0	1.1	4.4	0.5	-0.8	0.1	1.5	-0.5	-0.6	2.1
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.9	0.1	-0.3	0.6	-0.9	0.9	0.3	0.3
Emphysema/chronic bronchitis	0.4	0.4	1.5	-0.8	-0.5	-1.2	-0.1	0.1	-0.2	-0.9
Medication for pain relief, constipation, heartburn	2.7	4.6	13.7	3.7	2.3	1.5	2.2	-0.7	2.3	-0.3
Neck or shoulder pain in last month	1.2	1.8	5.0	-1.3	-1.9	-2.2	-0.9	-0.3	-0.4	-0.9
Medication: Blood pressure	0.8	1.5	3.7	-1.0	-0.6	1.3	-1.6	1.9	1.0	0.4
Angina (self-reported)	0.7	0.9	2.3	-1.1	-1.4	-1.5	-0.2	-0.6	-0.2	-0.7
Migraine (self-reported)	0.9	1.1	4.8	-1.3	-2.2	-0.5	-0.6	0.5	0.4	0.4
Medication: Ibuprofen	1.5	1.7	5.9	-0.4	-1.6	1.2	0.1	1.3	-0.6	2.4
Medication: Allopurinol	0.4	0.5	1.6	-1.3	-0.1	-0.6	-0.1	0.6	-1.0	0.4
Medication: Omeprazole	2.0	2.4	6.0	-1.9	1.2	-0.2	-2.2	2.5	-0.1	-0.8
Medication: Seretide 50 evohaler	0.8	0.9	1.6	1.3	0.8	1.0	0.5	-1.0	1.0	-0.8
Mean time to correctly identify matches	0.2	0.3	0.8	-0.2	0.8	-0.1	0.3	0.7	0.9	-0.2
Heart disease (mother)	3.0	3.7	13.4	1.3	0.3	-3.7	1.8	-2.1	-1.5	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.3	0.9	0.5	0.0	1.1	0.8	0.0	0.1
Whole body fat mass	0.4	1.8	5.0	-0.9	-0.9	0.9	-1.0	2.2	-0.8	1.9
Leg fat mass (right)	0.3	1.2	3.5	-0.8	-0.6	0.6	-0.8	1.9	-0.7	1.4
Arm predicted mass (right)	1.0	5.1	19.4	-0.8	1.1	-0.4	-4.4	0.8	-1.6	-3.4
Pulse rate, automated reading	2.4	7.9	24.0	1.1	-2.3	2.8	2.8	2.7	1.1	4.9
Alcohol intake frequency.	0.8	1.9	5.1	0.3	-1.0	0.9	0.9	2.2	1.2	1.9
Comparative height size at age 10	1.3	7.0	23.9	-3.0	-0.1	-0.4	-4.9	0.1	-1.7	-3.5
Number of full sisters	1.6	1.9	4.3	-0.9	-0.1	-1.8	-1.7	-0.6	-1.4	-2.1
Suffer from ‘nerves’	0.6	1.0	2.7	1.6	-0.2	-0.9	1.6	-0.7	0.4	-0.3
Overall health rating	0.9	2.0	6.1	-2.0	-2.5	-1.7	-0.5	0.6	-0.6	0.2
Chest pain or discomfort	0.3	0.5	1.7	0.6	0.3	-1.3	0.7	-0.3	-0.7	-0.1
Had major operations	1.6	1.8	4.6	-1.0	-0.1	-2.1	-1.4	-0.4	-1.7	-1.5
Age at last live birth	1.0	1.5	4.0	0.1	-1.3	1.8	0.7	-0.9	2.0	0.6
Family relationship satisfaction	0.4	0.5	1.4	-0.4	0.6	-1.0	0.4	-0.6	-1.2	-0.2
Leg pain on walking	0.5	0.6	2.4	-0.2	0.8	0.6	-1.5	0.5	0.2	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.9	0.4	0.2	-0.4	1.1	0.5	-0.9	1.4
Commuting to job workplace: Car/motor vehicle	1.7	2.0	5.5	2.3	0.6	0.4	0.5	-1.4	2.1	-0.9
Illness, injury, bereavement, stress in last 2 years	1.3	1.5	3.7	0.7	1.9	1.7	0.4	1.1	1.5	0.2
Medication: Aspirin	1.5	2.0	4.6	-1.6	-1.0	-2.1	-0.9	-1.0	-0.8	-1.9
Supplements: Vitamin C	1.0	1.2	2.4	0.8	-0.0	-1.6	-0.5	-1.1	-1.2	-1.4
Knee pain experienced in last month	0.6	0.9	2.6	-0.7	-1.4	-1.6	-0.4	-0.3	-0.7	-0.8
Hypertension (Self-reported)	0.6	1.8	7.3	-1.4	-2.7	0.3	-0.4	1.5	0.3	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	6.6	-0.3	-0.3	-0.2	-0.2	2.6	0.2	-0.4
Illnesses of father: Heart disease	1.6	2.2	9.9	0.8	-0.8	-3.1	0.9	-0.7	-1.3	-1.3
Illnesses of siblings: Diabetes	0.1	0.2	0.6	-0.1	0.0	-0.3	-0.4	0.8	0.2	-0.5
Smoking status: Previous	0.4	0.6	1.4	-0.9	-1.2	-0.4	-0.3	0.1	-1.1	0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	6.0	0.2	2.5	-0.2	-2.1	-2.2	-1.0	-2.3
Whole body fat-free mass	0.8	4.7	16.6	-0.5	1.2	-0.3	-4.1	0.8	-1.9	-3.3
Leg fat-free mass (right)	0.6	3.2	12.7	-0.6	0.1	-0.1	-3.6	1.0	-2.0	-2.1
Arm fat percentage (left)	0.9	3.5	12.7	-0.6	-1.9	1.3	0.7	2.3	-0.5	3.6
Average weekly red wine intake	1.0	1.5	3.5	-1.2	-1.5	-1.3	-0.8	-1.9	-0.5	-1.0
Handedness (chirality/laterality): Left-handed	3.7	4.5	7.6	2.8	1.2	2.2	2.5	1.6	2.6	1.3
Mood swings	0.5	0.9	3.1	-0.6	-0.3	1.5	0.4	0.5	0.5	1.8
Loneliness, isolation	2.8	3.9	7.1	-2.6	-1.7	-1.7	-1.6	-2.1	-2.7	-0.5
Long-standing illness, disability or infirmity	0.6	0.9	1.9	-0.4	-0.9	-1.1	-0.7	1.4	0.2	-1.2
Ever had bowel cancer screening	0.4	0.4	1.0	-0.0	-0.7	-1.0	0.2	0.0	-1.0	0.5
Diabetes diagnosed by doctor	1.5	2.5	9.1	-2.1	-3.0	-1.3	-1.3	0.1	-1.0	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.4	4.5	1.8	2.1	1.7	-0.3	-0.6	2.0	-1.4
Friendships satisfaction	0.2	0.3	0.9	0.3	-0.1	0.8	-0.1	-0.2	0.9	0.4
Qualifications: nursing, teaching	0.7	1.1	2.8	-1.1	-0.8	-1.3	-0.3	-1.7	-0.9	-0.6
Commuting to job workplace: Walk	1.0	1.1	2.5	-1.3	-0.4	-0.4	0.1	1.6	-1.1	1.5
Eye problems/disorders: Cataract	0.5	0.6	1.5	-0.3	-1.0	0.9	-0.6	0.3	1.2	0.5
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	4.0	-0.8	-2.0	0.2	-0.7	0.5	-0.6	1.1
Medication for cholesterol	0.4	0.6	1.2	0.7	1.1	-0.2	-0.9	-0.6	0.7	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.1	3.6	13.0	-3.3	-0.0	0.5	-3.6	-0.1	-1.1	-0.5
Back pain experienced in last month	0.5	0.7	1.8	0.5	-1.0	-1.1	0.5	-1.3	0.6	0.0
Mineral and other dietary supplements	1.1	1.5	2.2	-1.5	0.5	1.4	-0.9	1.3	-1.2	1.5
Breast cancer (self-reported)	2.2	2.6	6.4	2.5	0.6	-0.6	2.2	-1.6	1.8	-0.8
Asthma (self-reported)	0.1	0.3	1.0	-0.8	-0.5	-0.0	-1.0	0.0	-0.4	0.2
Osteoporosis (self-reported)	0.7	0.9	2.5	0.6	0.5	-0.9	-0.9	0.8	-1.1	-1.6
Osteoarthritis (self-reported)	0.4	0.6	1.5	-0.8	0.7	-1.0	0.2	0.1	0.6	-1.2
Medication: Aspirin	1.7	2.2	3.9	-2.0	-1.6	-2.0	-1.1	-0.6	-1.1	-1.5
Medication: Gliclazide	1.0	1.1	2.5	-0.9	-0.6	-1.6	-0.4	0.4	-1.5	-1.1
Illnesses of father: None of the above (group 1)	0.7	0.9	2.0	-1.0	1.2	1.4	-1.0	0.5	-0.4	0.2
Smoking status: Current	0.6	1.0	3.5	-0.5	-0.3	-1.4	-0.4	-1.9	-0.6	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	4.2	0.4	1.0	-0.7	-0.2	-2.0	0.3	-0.7
Whole body water mass	0.8	4.7	16.5	-0.5	1.2	-0.3	-4.1	0.9	-1.8	-3.2
Leg predicted mass (right)	0.6	3.2	12.3	-0.5	0.2	-0.2	-3.5	1.0	-2.0	-2.2
Arm fat mass (left)	0.4	1.8	4.9	-0.8	-1.1	1.0	-0.9	2.2	-1.0	1.7
Number of self-reported non-cancer illnesses	1.1	1.9	5.6	-1.0	-1.2	-1.8	-1.1	2.4	-0.2	-0.6
Average weekly champagne plus white wine intake	1.8	2.4	7.0	1.1	2.6	1.9	-0.7	-0.3	1.8	-1.1
Miserableness	1.1	1.9	4.5	2.1	0.9	1.3	2.1	-0.3	0.8	1.0
Guilty feelings	1.1	1.6	4.5	1.8	0.9	1.4	0.6	0.5	2.1	-0.4
Wears glasses or contact lenses	0.5	0.6	1.8	-0.7	0.7	1.4	0.2	0.9	0.2	0.8
Ever taken oral contraceptive pill	0.4	0.5	1.1	0.9	0.7	-0.6	0.3	-0.7	0.2	-1.0
Hearing aid user	1.1	1.3	2.9	-1.5	-1.7	0.0	-0.2	1.4	-0.8	1.1
Mother’s age at death	0.6	0.8	1.7	1.2	-1.0	-0.4	1.3	0.1	1.0	-0.4
Financial situation satisfaction	2.1	2.6	5.1	-1.0	-2.2	-2.2	-0.3	-1.8	-1.8	-0.9
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.7	0.1	-0.8	0.2	-0.8	0.6	0.4	-0.1
Commuting to job workplace: Public transport	3.7	4.4	9.4	-3.1	-1.1	1.5	-1.3	2.8	-2.3	1.8
Eye problems/disorders: Glaucoma	0.7	0.9	2.3	0.3	1.1	-1.5	-0.7	-0.2	-0.1	-1.4
Medication: Blood pressure	0.5	1.0	3.2	0.1	-1.5	-0.0	1.8	0.3	-0.5	1.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.9	-0.5	-1.0	-0.9	0.1	-0.5	0.8	-0.6
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.0	1.1	0.2	-0.8	1.0	-1.7	1.6	-0.9
High cholesterol (Self-reported)	0.4	0.7	3.0	-1.7	-0.6	-0.3	-0.8	0.8	-0.2	0.1
Medication: Bendroflumethiazide	0.8	1.1	3.7	-0.0	-0.9	1.0	0.4	1.6	-0.2	1.9
Medication: Paracetamol	0.7	1.1	2.8	-1.5	-1.7	-1.1	-0.7	0.6	-0.6	0.3
Medication: Lisinopril	0.3	0.4	1.3	0.6	-1.0	0.0	0.3	-1.2	0.3	0.5
Medication: Atorvastatin	0.8	1.0	4.3	-0.3	-1.1	-0.7	-0.9	2.1	-0.6	-0.2
Illnesses of father: High blood pressure	0.5	0.7	1.3	1.1	-0.3	0.2	0.9	-1.1	1.1	-0.0
Alcohol drinker status: Never	1.1	1.4	4.3	0.6	1.1	0.8	0.1	-2.1	1.7	-0.4
Ever smoked	0.3	0.4	1.0	-0.8	-1.0	0.3	-0.9	-0.1	-0.8	-0.1
Basal metabolic rate	0.7	3.7	13.6	-0.5	0.9	-0.2	-3.7	1.2	-1.8	-2.5
Leg fat percentage (left)	0.6	2.1	9.1	-0.3	-1.1	0.5	0.8	1.9	-0.1	3.0
Arm fat-free mass (left)	0.7	3.6	13.4	-0.6	0.9	-0.5	-3.7	0.9	-1.6	-2.7
Number of operations (self-reported)	2.9	4.3	13.4	-1.6	-0.3	-3.7	-1.4	-0.3	-2.2	-2.6
Average weekly beer plus cider intake	0.3	0.5	1.8	-0.7	-0.7	0.3	0.4	-0.6	-0.3	1.3
Irritability	1.0	1.6	6.2	0.4	-0.5	1.4	0.4	1.6	0.0	2.5
Risk taking	1.2	1.8	7.0	-0.8	0.3	-0.3	-2.6	-0.4	-0.3	-2.1
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.1	-0.0	-0.8	-0.6	0.2	-1.0	-0.4	0.1
Fractured/broken bones in last 5 years	0.2	0.2	0.7	0.6	0.1	0.1	0.4	0.4	0.9	0.3
Age started oral contraceptive pill	1.5	1.8	4.6	-0.8	-1.5	-2.1	0.4	-1.0	-1.9	-0.7
Diastolic blood pressure, automated reading	0.7	2.0	5.2	-1.3	-1.1	-2.3	-0.9	-0.1	-2.3	0.4
Ever depressed for a whole week	1.0	1.2	3.7	-0.7	-0.6	-1.3	0.7	-1.9	-1.3	-0.2
Unable to work because of sickness or disability	0.9	1.2	4.9	-0.3	-1.4	-2.2	0.4	-0.6	-0.7	-0.3
Commuting to job workplace: Cycle	2.0	2.4	5.1	0.7	1.8	2.0	0.5	-1.8	2.3	0.1
Myopia	1.5	2.1	4.8	0.9	-0.3	-1.3	2.2	0.5	-1.5	2.2
Vascular/heart problems diagnosed by doctor	0.7	2.0	8.8	1.7	3.0	0.5	0.5	-1.0	0.2	-0.8
Cholesterol lowering medication	0.3	0.4	1.4	-0.2	-0.3	0.6	0.7	1.2	0.5	0.7
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	5.0	-1.5	1.1	-0.7	-1.9	2.2	-0.3	-0.9
Pain experienced in last month	2.1	3.5	11.5	2.6	3.4	1.4	1.1	1.5	0.6	-0.2
Supplements: Calcium	0.5	0.5	2.4	0.0	-0.6	-1.5	-0.4	-0.3	-0.2	-0.7
Basal cell carcinoma (self-reported)	1.4	1.7	4.1	1.7	2.0	-0.9	0.4	0.1	-0.9	-1.8
Heart attack/myocardial infarction (self-reported)	1.4	1.9	5.0	-0.2	-0.5	-2.2	-0.3	-1.7	0.6	-2.1
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.5	0.2	1.6	-0.6	-0.4	-1.5	0.5	-1.0
Heart disease (siblings)	4.0	4.9	16.9	-1.1	-0.4	-4.1	-0.4	-2.5	-2.1	-2.3
Alcohol drinker status: Previous	1.6	1.9	3.7	-1.2	-1.9	-1.1	0.0	1.9	-1.2	1.3
Pack years of smoking	0.5	0.8	3.1	0.8	-0.4	-1.8	0.9	-0.3	-0.7	-0.0
Impedance of whole body	0.3	1.7	5.3	-0.8	-0.4	0.8	1.9	-0.8	0.9	2.3
Leg fat mass (left)	0.3	1.2	3.2	-0.8	-0.7	0.5	-1.0	1.8	-0.7	1.4
Arm predicted mass (left)	0.9	4.5	17.1	-0.9	0.8	-0.3	-4.1	0.9	-1.9	-2.9