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chr11:46,033,104-48,559,571

Best TWAS P=8.52e-13 · Best GWAS P=2.03e-10 conditioned to 0.0554

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MTCH2	0.03	0.00	bslmm	299	0.00	1.1e-01	2.9	-5.6	1.8e-08	0.75	0.03	0.77	FALSE
2	GTEx	Artery Tibial	ZNF408	0.10	0.00	lasso	6	0.04	2.0e-04	-3.4	5.4	7.5e-08	-0.15	0.10	0.62	FALSE
3	GTEx	Brain Cerebellar Hemisphere	RP11-750H9.5	0.17	0.25	lasso	6	0.21	3.5e-06	5.6	-5.6	2.4e-08	0.44	0.20	0.57	FALSE
4	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	-6.3	-5.9	3.4e-09	0.93	0.02	0.96	FALSE
5	GTEx	Brain Cortex	C1QTNF4	0.26	0.04	lasso	8	0.02	1.2e-01	5.0	6.0	1.7e-09	-0.76	0.04	0.36	FALSE
6	GTEx	Breast Mammary Tissue	C1QTNF4	0.10	0.06	lasso	2	0.03	8.5e-03	-5.3	5.2	2.2e-07	-0.84	0.05	0.85	FALSE
7	GTEx	Breast Mammary Tissue (Female)	MADD	0.13	0.04	lasso	3	0.05	1.3e-02	-5.3	-5.5	3.4e-08	0.83	0.04	0.50	FALSE
8	GTEx	Cells Transformed fibroblasts	FNBP4	0.11	0.05	lasso	8	0.08	1.6e-06	4.8	-5.6	2.1e-08	0.82	0.35	0.65	FALSE
9	GTEx	Colon Transverse	C1QTNF4	0.07	0.02	lasso	6	0.03	2.0e-02	-4.2	5.2	1.6e-07	-0.89	0.04	0.88	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	NUP160	0.18	0.02	enet	18	0.11	7.1e-05	3.6	-6.6	3.1e-11	0.57	0.13	0.55	FALSE
11	GTEx	Esophagus Muscularis	MTCH2	0.09	0.04	lasso	6	0.02	1.8e-02	-6.2	-7.0	3.1e-12	0.87	0.02	0.96	FALSE
12	GTEx	Liver	C1QTNF4	0.25	0.14	enet	16	0.20	2.3e-06	-4.1	6.0	2.6e-09	-0.81	0.04	0.93	FALSE
13	GTEx	Lung	C1QTNF4	0.18	0.15	lasso	6	0.13	3.2e-10	-5.2	5.5	3.8e-08	-0.88	0.03	0.97	FALSE
14	GTEx	Pituitary	MADD	0.42	0.32	lasso	6	0.39	8.9e-11	6.2	-7.2	8.5e-13	0.70	0.02	0.97	TRUE
15	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	-4.1	5.6	2.0e-08	-0.87	0.06	0.94	FALSE
16	GTEx	Spleen	C1QTNF4	0.31	0.28	enet	29	0.34	1.8e-09	-6.3	6.2	4.9e-10	-0.91	0.02	0.98	FALSE
17	GTEx	Testis	MTCH2	0.17	0.16	lasso	3	0.16	1.0e-07	-5.3	-5.3	1.4e-07	0.85	0.07	0.93	FALSE
18	GTEx	Testis	C1QTNF4	0.14	0.12	lasso	4	0.11	1.6e-05	5.0	5.8	6.7e-09	-0.65	0.69	0.18	FALSE
19	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	-6.2	6.2	6.2e-10	-0.95	0.02	0.97	FALSE
20	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	-6.3	6.1	8.5e-10	-0.92	0.02	0.98	FALSE
21	METSIM	Adipose	NR1H3	0.03	0.03	lasso	6	0.04	4.7e-06	4.8	-5.5	4.3e-08	0.25	0.15	0.79	FALSE
22	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	-6.2	6.2	4.3e-10	-0.92	0.02	0.98	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	-6.3	-6.1	1.2e-09	0.92	0.02	0.98	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	FNBP4	0.04	0.04	lasso	3	0.04	8.2e-06	5.1	-5.7	1.2e-08	0.62	0.89	0.10	FALSE
25	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	-6.3	5.8	4.8e-09	-0.91	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYBPC3	0.02	0.01	blup	43	0.01	3.4e-03	-5.2	5.5	3.7e-08	-0.77	0.07	0.70	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	NUP160	0.03	0.01	blup	44	0.01	1.9e-03	-6.4	-5.4	8.1e-08	0.84	0.01	0.72	FALSE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMC3	0.09	0.05	blup	39	0.05	1.0e-03	5.6	-6.1	9.7e-10	0.63	0.02	0.80	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	-6.3	6.2	4.0e-10	-0.92	0.00	1.00	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FNBP4	0.10	0.03	blup	45	0.05	7.7e-06	-6.2	-6.2	6.8e-10	0.80	0.00	0.99	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUP160	0.08	0.03	blup	42	0.04	6.7e-05	-6.3	-5.8	8.5e-09	0.87	0.01	0.96	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PSMC3	0.05	0.01	lasso	3	0.02	9.4e-04	3.7	-5.8	8.2e-09	0.64	0.03	0.19	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	-6.3	5.6	2.1e-08	-0.90	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	-6.2	6.2	4.2e-10	-0.92	0.00	1.00	FALSE
35	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMC3	0.07	0.07	enet	7	0.06	1.4e-04	-5.3	-5.3	9.2e-08	0.84	0.09	0.78	FALSE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	-6.3	-6.3	3.4e-10	0.92	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	-6.3	6.3	3.4e-10	-0.92	0.00	1.00	FALSE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	C1QTNF4	0.03	0.02	blup	15	0.02	1.3e-03	-4.1	5.2	1.8e-07	-0.85	0.00	0.96	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUP160	0.03	0.02	enet	7	0.02	6.3e-03	-6.3	-6.7	1.7e-11	0.96	0.01	0.91	FALSE
40	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	-6.3	5.8	5.4e-09	-0.92	0.00	0.93	FALSE