[Hub]/) : Traits : Neuroticism score : ←

chr22:39,219,932-42,614,362

Best TWAS P=8.87e-09 · Best GWAS P=1.96e-09 conditioned to 0.393

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ATF4 0.18 0.16 lasso 2 0.16 3.3e-19 -5.6 -5.6 2.9e-08 -0.09 0.00 1.00 FALSE
2 GTEx Adipose Subcutaneous ATF4 0.12 0.08 lasso 6 0.07 3.7e-06 -5.5 -5.4 6.0e-08 -0.10 0.00 1.00 FALSE
3 GTEx Artery Aorta ATF4 0.27 0.18 lasso 3 0.18 3.6e-10 -5.5 -5.4 6.3e-08 -0.09 0.00 1.00 FALSE
4 GTEx Artery Tibial ATF4 0.22 0.18 lasso 5 0.16 5.9e-13 -5.5 -5.6 2.7e-08 -0.09 0.00 1.00 TRUE
5 GTEx Cells Transformed fibroblasts SLC25A17 0.09 0.03 enet 10 0.06 4.2e-05 5.5 5.7 1.2e-08 0.84 0.02 0.98 FALSE
6 GTEx Esophagus Mucosa RANGAP1 0.07 0.02 lasso 4 0.02 8.6e-03 5.7 -5.5 4.1e-08 -0.93 0.02 0.91 FALSE
7 GTEx Esophagus Muscularis ATF4 0.24 0.26 lasso 6 0.24 1.2e-14 -5.5 -5.5 3.8e-08 -0.09 0.00 1.00 FALSE
8 GTEx Muscle Skeletal ATF4 0.19 0.16 lasso 3 0.16 6.7e-16 -5.5 -5.5 3.3e-08 -0.09 0.00 1.00 FALSE
9 GTEx Nerve Tibial ACO2 0.06 0.05 lasso 5 0.04 8.5e-04 4.4 5.4 5.3e-08 0.80 0.40 0.55 FALSE
10 NTR Blood TEF 0.01 0.02 lasso 2 0.02 3.8e-06 5.1 5.2 1.6e-07 0.78 0.57 0.42 FALSE
11 YFS Blood ATF4 0.10 0.10 lasso 7 0.10 5.7e-31 -5.6 -5.5 3.3e-08 -0.09 0.00 1.00 FALSE
12 YFS Blood TEF 0.09 0.17 lasso 2 0.17 9.0e-53 5.1 5.1 2.9e-07 0.79 0.36 0.64 FALSE
13 The Cancer Genome Atlas Thyroid Carcinoma L3MBTL2 0.05 0.03 enet 9 0.04 1.8e-04 5.8 5.8 8.9e-09 0.89 0.01 0.97 TRUE