Hub : Genes

SLC25A17

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.032 0.0170 3.3e-03 0.011 0.013 0.012 0.012 0.007 0.01500 0.0096 1.2e-02 0.012 0.03800
2 GTEx Brain Frontal Cortex BA9 0.105 0.0478 3.4e-03 -0.008 NA -0.004 NA -0.001 0.58000 NA 4.4e-01 NA 0.35000
3 GTEx Cells Transformed fibroblasts 0.086 0.0320 4.4e-05 0.033 NA 0.057 NA 0.045 0.00170 NA 4.2e-05 NA 0.00024
4 GTEx Prostate 0.295 0.1210 5.9e-03 0.005 NA 0.006 NA -0.004 0.24000 NA 2.2e-01 NA 0.42000
5 GTEx Skin Sun Exposed Lower leg 0.056 0.0280 3.6e-03 0.040 NA 0.017 NA 0.023 0.00031 NA 1.4e-02 NA 0.00500
6 GTEx Spleen 0.254 0.0870 8.3e-04 0.042 NA 0.066 NA 0.125 0.03100 NA 9.1e-03 NA 0.00043
7 TCGA Ovarian Serous Cystadenocarcinoma 0.172 0.0940 3.2e-03 0.051 0.033 0.041 NA 0.045 0.00022 0.0025 8.7e-04 NA 0.00050

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 7.5 11.9 19.0 -4.3 -2.0 3.6 0.0 3.8 4.4 3.8
Bipolar Disorder or Schizophrenia 8.5 20.7 35.0 -5.1 -4.0 5.8 0.0 3.8 4.5 5.9
Depressed Affect (Nagel 2018) 1.6 3.3 14.2 -2.3 -0.1 3.8 0.0 -0.4 1.1 1.3
Depression (Nagel 2018) 0.7 1.0 2.8 -1.7 -1.0 1.5 0.0 -0.0 0.6 0.9
Intelligence (Savage-Jansen 2018) 1.9 5.9 12.6 1.3 3.4 -3.5 0.0 1.6 -0.3 -3.5
Neuroticism (Nagel 2018) 5.7 13.3 51.5 -3.7 -0.7 7.2 0.0 0.9 3.2 4.1
Schizophrenia (2018) 4.9 10.2 20.4 -3.2 -3.6 4.5 0.0 1.8 2.2 4.5
Schizophrenia vs Biploar Disorder 0.5 0.7 2.2 -0.3 -1.5 0.4 0.0 -1.0 -0.7 0.9
Worry (Nagel 2018) 6.6 14.0 43.0 -3.5 -0.7 6.6 0.0 2.0 4.0 4.8
Alzheimer’s Disease (in mother) 2.4 2.8 6.9 -1.2 0.6 1.7 0.0 2.4 2.6 1.4
Alzheimer’s Disease (in father) 1.1 1.2 3.1 -1.8 -0.6 1.2 0.0 0.9 1.6 -0.4
Alzheimer’s Disease (including proxy) 4.0 5.8 12.2 -2.7 -0.7 3.5 0.0 2.6 3.5 1.4
Crohns Disease (2017) 1.5 3.2 6.2 -2.4 -2.0 2.5 0.0 1.1 1.9 1.2
Irritable Bowel Disease (IBD) 1.4 3.4 7.4 -2.7 -0.9 2.4 0.0 1.6 2.7 0.4
Ulcerative Colitis (UC) 1.1 2.0 5.5 -1.8 0.6 1.6 0.0 1.6 2.3 -0.3
Major Depression (MDD) 1.7 2.0 3.7 -1.5 -1.4 1.9 0.0 1.5 1.3 1.5
Reaction Time 0.7 1.3 4.3 2.1 0.5 -1.5 0.0 -0.7 -1.4 -0.2
Verbal and Numeric Reasoning (VNR) 1.6 3.8 9.2 1.2 2.1 -2.9 0.0 1.9 0.0 -3.0
Breast Cancer 6.1 14.7 61.6 -6.4 -7.8 -0.3 0.0 0.4 0.3 0.1
Ovarian Cancer 0.5 0.6 1.5 0.8 0.4 -0.6 0.0 -1.2 -1.2 -0.7
Prostate Cancer 0.8 1.2 3.6 0.8 1.6 1.9 0.0 0.7 0.8 0.5
Age at First Birth 2.8 4.0 6.3 -2.5 -2.4 2.0 0.0 2.2 2.2 1.7
Bipolar Disorder (2011) 2.9 2.8 7.6 -2.8 -1.9 1.4 0.0 1.3 1.6 1.5
Body Mass Index (BMI) (2010) 1.7 2.4 6.4 -1.5 -1.7 2.5 0.0 -0.1 1.0 2.0
Coronary Artery Disease (CAD) 1.2 1.4 2.8 1.6 0.6 -1.5 0.0 -0.7 -1.7 -1.2
Crohns Disease (2012) 1.6 2.6 4.7 -1.5 -1.2 2.1 0.0 1.0 2.0 2.2
Mean Putamen Volume 0.4 0.4 1.4 -1.2 -0.7 0.0 0.0 0.4 0.9 0.4
Fasting Glucose 0.9 1.1 3.1 0.7 1.1 0.2 0.0 -1.3 -1.0 -1.8
HbA1C 0.3 0.3 0.6 -0.7 -0.7 0.8 0.0 -0.6 -0.3 -0.3
HDL Cholesterol 0.2 0.4 0.9 0.6 0.8 -0.6 0.0 1.0 0.6 0.3
LDL Cholesterol 0.3 0.5 1.1 0.6 -1.0 0.5 0.0 -0.7 -1.0 0.3
Lupus 0.1 0.2 0.6 -0.3 0.3 0.7 0.0 -0.0 0.2 -0.6
Neuroticism (2016) 4.4 6.3 22.4 -2.6 -0.7 4.7 0.0 1.0 2.4 2.8
Primary Biliary Cirrhosis 0.4 0.6 1.9 -0.5 0.6 1.4 0.0 0.6 1.0 -0.4
Rheumatoid Arthritis 3.0 4.1 8.4 2.9 1.2 -2.5 0.0 -1.7 -2.3 -2.1
Schizophrenia (2014) 5.9 13.1 24.0 -4.1 -4.2 4.7 0.0 2.0 2.8 4.9
Triglycerides 0.3 0.5 2.7 -0.2 0.0 1.7 0.0 -0.8 0.1 0.2
Type 2 Diabetes (T2D) (2012) 1.4 1.6 5.1 1.6 -0.1 -0.4 0.0 -2.3 -1.7 0.6
Ulcerative Colitis 0.6 0.8 2.3 -1.5 -0.1 1.2 0.0 0.9 1.1 0.2
Blood Eosinophil Count 3.5 26.9 50.1 -7.1 -2.9 6.6 0.0 6.3 6.7 1.3
Blood Platelet Count 0.2 2.8 8.9 -1.8 -0.8 -1.2 0.0 3.0 2.4 0.2
Blood Red Count 0.3 2.9 9.8 -1.8 1.7 -1.0 0.0 1.3 1.3 -3.1
Blood White Count 0.1 1.0 2.4 -0.1 -1.5 -0.9 0.0 -0.6 -1.4 -1.2
Heel T-Score 1.3 10.7 21.9 -1.7 4.7 4.5 0.0 2.9 4.5 -1.1
BMI 1.1 6.4 27.4 -0.4 -5.2 -0.1 0.0 -2.4 -3.4 0.8
Height 0.5 9.8 27.2 -4.8 0.7 2.8 0.0 3.2 5.2 -0.5
Waist Hip Ratio (WHR) 0.9 4.1 13.9 1.3 0.8 -1.7 0.0 -1.9 -2.4 -3.7
Systolic Blood Pressure 0.5 2.4 4.2 1.8 2.1 1.1 0.0 -2.0 -1.5 1.2
Smoking Status 2.4 5.7 14.1 3.1 2.6 -3.8 0.0 -0.1 -1.5 -2.7
Allergy or Eczema 3.8 10.0 29.2 -3.1 -0.9 5.4 0.0 2.2 3.6 3.6
Cardiovascular Disease 0.7 2.5 8.9 0.2 -1.8 2.2 0.0 -0.3 -0.4 3.0
Hypothyroidism (self reported) 0.7 1.7 7.8 0.2 -0.3 -2.8 0.0 1.3 0.2 -1.5
Respiratory disease 0.5 1.1 2.7 0.2 1.5 1.6 0.0 -0.8 0.2 -1.4
Type 2 Diabetes (T2D) (2018) 0.5 1.0 2.2 -0.6 -1.5 1.1 0.0 -1.2 -0.4 1.3
Lung FEV1/FVC ratio 2.3 11.9 39.6 -3.9 -6.3 2.7 0.0 -1.4 -1.5 4.2
Lung FVC 0.4 1.9 4.7 -0.2 1.1 -2.0 0.0 2.2 0.8 -1.7
Neuroticism 4.3 10.3 36.1 -3.7 -0.3 6.0 0.0 1.0 3.4 3.0
Chronotype (morning person) 1.2 2.7 6.3 0.8 -1.7 1.0 0.0 -2.5 -2.5 1.4
Hair Pigment 0.4 12.1 35.0 4.0 3.9 -5.9 0.0 -0.8 -1.8 -3.8
Tanning 0.3 3.3 7.8 2.0 1.5 -2.8 0.0 -1.4 -2.1 -1.6
Hand grip strength (left) 0.1 0.3 1.0 -0.4 -0.1 -1.0 0.0 -0.2 -0.8 -0.2
Number of treatments/medications taken 1.2 2.1 8.6 -1.8 -0.9 2.9 0.0 -0.1 0.9 1.0
Average weekly spirits intake 1.0 1.3 3.7 0.6 1.4 -1.9 0.0 -0.4 -0.7 -1.5
Sensitivity / hurt feelings 1.4 2.4 11.1 -1.1 0.1 3.3 0.0 0.9 1.5 1.1
Frequency of depressed mood in last 2 weeks 1.1 1.5 3.9 -1.7 -0.8 2.0 0.0 0.9 1.5 0.6
Hearing difficulty/problems: Yes 0.4 0.6 2.1 0.4 0.2 -1.2 0.0 0.8 0.4 -1.5
Relative age of first facial hair 0.5 1.0 4.5 -0.5 2.1 0.8 0.0 0.1 0.5 -1.1
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.0 0.6 -1.0 0.6 0.0 -0.6 -0.6 0.4
Ever used hormone-replacement therapy (HRT) 1.2 1.6 4.3 2.0 2.1 -0.6 0.0 -0.8 -0.9 -1.0
Ever had hysterectomy (womb removed) 0.9 1.0 2.5 1.4 1.6 1.1 0.0 -0.6 -0.0 1.0
Systolic blood pressure, automated reading 0.9 2.6 7.3 1.9 0.7 0.1 0.0 -2.7 -2.6 0.1
Eye problems/disorders: Diabetes related eye disease 2.4 2.6 4.4 -1.6 -1.5 2.1 0.0 1.9 1.6 1.8
Angina 1.2 1.5 2.9 -1.4 1.3 0.9 0.0 1.7 1.3 -1.3
Medication for hormone replacement therapy 1.0 1.1 2.1 1.5 1.3 -0.6 0.0 -1.4 -1.2 -0.2
Vitamin and mineral supplements 1.0 1.4 3.2 1.6 -0.1 -1.8 0.0 -0.1 -1.6 -1.1
Supplements: Zinc 0.6 0.6 1.9 -0.3 -0.6 0.5 0.0 -1.4 -1.0 0.9
Medication: Co-codamol 1.2 1.4 3.6 -1.9 -0.3 0.7 0.0 1.7 1.7 0.2
Medication: Metformin 0.5 0.7 1.8 1.2 -0.6 -0.1 0.0 -1.2 -1.3 0.4
Diabetes (father) 0.3 0.3 1.4 -0.5 -0.2 0.1 0.0 -1.2 -0.5 -0.6
Diabetes (mother) 3.1 4.0 9.6 3.1 -0.2 -2.6 0.0 -1.5 -2.8 -1.1
Severe depression (siblings) 0.4 0.4 0.9 -1.0 -0.8 0.0 0.0 0.5 0.7 0.9
Pack years adult smoking proportion 2.4 3.7 8.0 2.5 -0.1 -2.2 0.0 -1.7 -2.8 -2.0
Impedance of leg (right) 1.6 8.0 32.5 -0.4 5.7 1.2 0.0 1.8 3.9 -1.9
Leg fat-free mass (left) 1.2 6.1 22.4 -2.8 -4.7 2.0 0.0 0.9 0.4 2.7
Trunk fat percentage 0.8 3.2 16.4 -1.7 -0.7 4.0 0.0 -0.3 0.7 1.3
Hand grip strength (right) 0.1 0.3 1.3 -0.5 -0.4 -1.1 0.0 0.1 -0.5 -0.0
Townsend deprivation index at recruitment 0.6 0.9 2.3 1.5 0.3 -1.0 0.0 0.1 -1.3 -0.9
Current tobacco smoking 3.4 5.5 17.2 2.9 1.3 -4.1 0.0 -0.2 -1.9 -2.8
Average weekly fortified wine intake 0.4 0.5 1.4 0.7 1.2 -0.7 0.0 0.4 0.3 -0.7
Maternal smoking around birth 2.3 3.3 9.3 1.8 0.6 -3.0 0.0 -0.9 -1.7 -2.5
Fed-up feelings 1.7 3.0 9.1 -3.0 -1.1 2.8 0.0 0.5 1.5 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.9 -1.4 -0.6 1.4 0.0 -1.0 -0.2 0.6
Relative age voice broke 0.2 0.3 1.4 -0.1 0.7 -0.0 0.0 0.4 0.3 -1.2
Taking other prescription medications 1.5 2.2 11.1 -1.0 0.3 3.3 0.0 0.1 1.0 1.5
Age when periods started (menarche) 2.8 6.7 21.3 -1.9 0.1 2.0 0.0 3.8 4.6 2.0
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 5.2 1.9 2.3 -0.4 0.0 -1.1 -0.9 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 2.9 6.7 15.1 -1.6 2.5 3.9 0.0 3.0 3.7 -0.3
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 4.1 -0.1 -2.0 0.1 0.0 -0.4 -0.8 0.6
Qualifications: CSEs or equivalent 1.9 2.5 6.5 2.6 1.7 -1.0 0.0 -1.9 -1.9 -0.4
Serious illness, injury or assault to yourself 0.5 0.6 2.3 -0.5 0.2 1.5 0.0 0.8 1.0 -0.0
High blood pressure 0.6 1.6 4.9 -0.2 -1.9 1.4 0.0 0.7 0.1 2.2
Hayfever, allergic rhinitis or eczema 2.4 5.3 14.9 -1.7 -0.1 3.9 0.0 1.9 2.7 2.9
Multivitamins +/- minerals 0.9 1.2 2.7 -1.6 -0.7 1.6 0.0 -0.7 1.1 1.1
Stomach or abdominal pain in last month 0.9 1.2 4.3 -2.1 -0.6 0.9 0.0 0.7 1.5 0.1
Supplements: Glucosamine 0.7 0.9 1.9 0.9 1.1 -1.1 0.0 -0.5 -0.7 -1.4
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 3.7 0.2 1.9 -0.8 0.0 0.2 0.4 -1.5
Medication: Atenolol 1.1 1.3 3.2 -0.2 0.5 -1.1 0.0 -1.8 -1.5 -1.6
Medication: Levothyroxine sodium 0.3 0.6 2.6 1.0 -0.2 -1.6 0.0 0.2 -0.4 -0.5
Sitting height 0.7 5.3 15.3 -3.3 0.0 0.9 0.0 3.1 3.9 0.6
Chronic bronchitis/emphysema (father) 0.8 0.9 2.3 -0.1 -0.5 -1.1 0.0 -1.4 -0.8 -1.5
High blood pressure (mother) 0.6 0.8 2.2 0.9 -1.1 -1.5 0.0 -0.4 -1.3 0.2
Body mass index (BMI) 1.1 4.7 18.3 -0.5 -4.3 1.1 0.0 -1.7 -2.7 1.7
Impedance of leg (left) 1.6 7.9 30.4 -0.6 5.5 1.5 0.0 1.9 4.0 -1.6
Leg predicted mass (left) 1.1 5.9 21.3 -2.8 -4.6 2.0 0.0 0.9 0.5 2.7
Trunk fat mass 0.9 4.0 14.4 -2.4 -2.1 3.8 0.0 0.1 0.8 1.8
Waist circumference 0.7 2.4 9.7 -0.6 -3.1 1.6 0.0 -0.9 -1.6 1.0
Number of incorrect matches in round 2.9 4.8 10.8 -1.7 -2.6 3.3 0.0 0.9 1.3 3.3
Past tobacco smoking 0.8 1.5 4.8 -1.6 -2.2 -0.4 0.0 1.1 1.1 0.8
Alcohol usually taken with meals 0.4 0.7 1.9 -1.1 -0.5 0.7 0.0 0.8 1.4 0.4
Nervous feelings 4.5 8.3 22.4 -2.5 -0.0 4.7 0.0 2.7 3.8 2.8
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 4.0 -1.0 0.7 2.0 0.0 1.0 1.8 0.7
Hearing difficulty/problems with background noise 0.3 0.5 1.6 1.3 -0.4 0.4 0.0 -0.6 -0.6 1.0
Hair/balding pattern: Pattern 2 0.3 0.4 1.3 -1.1 -0.3 -0.5 0.0 -1.1 -0.4 -0.2
Had menopause 1.3 1.6 3.1 1.8 1.7 -1.3 0.0 0.9 -0.5 -1.6
Had other major operations 0.2 0.3 0.6 0.4 -0.4 0.8 0.0 -0.5 -0.8 0.2
Forced vital capacity (FVC) 1.2 4.6 13.0 -2.4 0.8 0.7 0.0 3.4 3.6 0.4
Heel bone mineral density (BMD) T-score, automated (right) 2.5 5.7 12.5 -1.1 2.3 3.5 0.0 3.0 3.5 0.2
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.0 -0.9 -0.5 1.0 0.0 -0.9 -0.8 -0.4
Qualifications: None of the above 1.1 2.3 6.0 2.5 0.9 -1.4 0.0 -1.9 -1.9 -0.6
Financial difficulties in last 2 years 0.7 0.9 2.5 1.2 0.7 -1.6 0.0 0.8 -0.5 -1.0
Mouth/teeth dental problems 1.0 1.5 3.9 0.3 -1.7 0.0 0.0 -2.0 -1.5 1.2
Heart attack 2.0 2.6 6.8 -2.6 -0.4 1.1 0.0 1.8 1.8 -1.9
Allergy 1.7 4.0 14.7 1.6 -0.1 -3.8 0.0 -1.3 -2.3 -1.8
Pain all over the body in last month 0.4 0.4 1.2 -0.3 0.5 0.6 0.0 0.7 1.1 -0.7
Diabetes (self-reported) 1.0 1.5 3.5 0.2 -1.8 0.6 0.0 -1.9 -1.3 1.5
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 2.4 -0.3 0.0 1.5 0.0 -0.9 0.1 0.4
Medication: Ramipril 0.4 0.5 1.4 -0.9 0.3 1.2 0.0 0.7 0.7 0.4
Medication: Simvastatin 0.9 1.4 4.5 1.1 0.1 -0.6 0.0 -1.8 -2.1 -0.2
Fluid intelligence score 1.0 2.0 6.8 0.3 1.2 -1.9 0.0 1.4 -0.2 -2.6
Illnesses of siblings 0.2 0.2 0.7 0.7 0.5 -0.2 0.0 -0.8 -0.1 -0.1
Neuroticism score 4.1 8.5 32.5 -2.9 -0.6 5.7 0.0 1.2 2.8 3.1
Weight 1.0 5.1 14.7 -2.6 -3.8 2.7 0.0 0.5 0.3 2.5
Impedance of arm (right) 1.9 8.8 35.9 -0.5 6.0 3.0 0.0 1.1 3.8 -1.1
Arm fat percentage (right) 0.7 2.9 7.1 -1.3 -2.7 2.7 0.0 -1.2 -1.0 1.3
Trunk fat-free mass 1.1 6.3 25.0 -3.2 -5.0 0.7 0.0 1.6 0.9 2.2
Hip circumference 1.1 4.8 11.7 -1.7 -2.7 3.4 0.0 0.4 0.5 3.3
Time employed in main current job 2.9 3.4 10.8 -0.6 -1.8 2.3 0.0 1.8 0.8 3.3
Alcohol intake versus 10 years previously 0.1 0.1 0.3 -0.6 0.3 0.3 0.0 -0.4 0.3 -0.1
Father’s age at death 0.6 0.8 3.8 1.2 2.0 -0.1 0.0 0.7 0.3 -0.1
Worrier / anxious feelings 3.6 6.8 28.1 -1.7 -0.2 5.3 0.0 0.3 1.6 3.7
Frequency of tiredness / lethargy in last 2 weeks 2.8 4.5 14.9 -3.0 -1.1 3.9 0.0 0.6 1.9 1.7
Falls in the last year 0.8 1.1 5.6 0.5 2.4 1.1 0.0 -0.1 0.6 -0.5
Hair/balding pattern: Pattern 3 0.8 1.2 2.1 -1.4 -1.4 1.2 0.0 0.6 1.1 1.2
Number of live births 2.3 3.3 12.1 2.1 3.5 -0.9 0.0 -1.3 -1.5 -1.3
Forced expiratory volume in 1-second (FEV1) 1.1 3.8 9.0 -3.0 -0.6 1.3 0.0 2.4 2.7 1.4
Pulse rate 1.7 2.8 6.2 -2.5 -2.5 1.1 0.0 1.7 1.8 0.5
Happiness 2.3 2.8 5.7 -2.4 -2.4 2.2 0.0 1.4 1.2 0.4
Noisy workplace 0.4 0.5 2.0 1.4 0.2 -0.3 0.0 -0.7 -0.5 0.8
Qualifications: A levels/AS levels or equivalent 1.1 2.5 10.9 -0.6 -0.5 0.0 0.0 3.3 2.2 0.8
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.7 6.0 0.3 1.4 -2.5 0.0 0.4 0.5 -1.8
Mouth/teeth dental problems: Dentures 1.6 2.7 8.6 1.5 1.0 -2.6 0.0 0.3 -0.6 -2.9
Asthma 0.4 0.9 5.3 -0.3 0.7 2.3 0.0 -0.3 0.3 -0.0
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 2.7 -1.1 -0.1 0.6 0.0 1.0 1.7 -0.1
Medication: Cholesterol lowering 0.2 0.4 1.0 -0.1 -0.7 -0.0 0.0 -1.0 -0.9 0.5
Depression (self-reported) 2.2 2.6 5.6 -2.4 -0.2 2.4 0.0 1.5 2.0 0.8
Medication: Lansoprazole 0.4 0.5 2.4 -0.4 0.5 1.5 0.0 -0.6 -0.6 -0.0
Prospective memory result 0.4 0.5 1.1 -0.4 0.1 1.0 0.0 0.8 1.1 0.9
Lung cancer (father) 0.5 0.6 2.1 0.3 -1.0 -1.5 0.0 -0.6 -0.5 -0.6
Illnesses of mother 0.8 0.9 4.1 0.2 1.3 -0.8 0.0 0.1 0.3 -2.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.7 5.3 12.7 -3.6 -1.1 1.8 0.0 2.6 3.2 1.7
Pulse wave Arterial Stiffness index 1.0 1.2 5.8 -2.4 -0.9 0.9 0.0 0.2 0.7 -0.3
Impedance of arm (left) 1.8 8.6 34.7 -0.5 5.9 3.3 0.0 0.6 3.6 -0.9
Arm fat mass (right) 0.9 3.9 12.1 -1.8 -3.5 2.7 0.0 -0.6 -0.7 1.9
Trunk predicted mass 1.2 6.6 26.1 -3.3 -5.1 0.7 0.0 1.7 1.0 2.3
Standing height 1.3 13.0 37.0 -4.5 0.5 3.5 0.0 4.4 6.1 1.6
Length of working week for main job 0.6 0.7 2.5 0.6 -0.7 -0.1 0.0 -1.6 -1.2 0.1
Exposure to tobacco smoke at home 1.1 1.3 4.9 0.3 1.1 0.9 0.0 2.2 1.2 0.6
Breastfed as a baby 0.3 0.4 1.3 -0.8 1.1 0.4 0.0 0.3 0.7 -0.3
Tense / ‘highly strung’ 4.4 7.2 24.0 -3.1 -1.2 4.9 0.0 0.8 2.7 2.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.6 2.4 7.9 -1.8 -0.0 2.8 0.0 0.7 2.1 1.0
Hair/balding pattern: Pattern 4 1.4 3.3 13.1 3.6 0.9 -2.1 0.0 -0.4 -2.1 -0.2
Birth weight of first child 0.8 1.4 3.5 -1.8 -1.9 1.0 0.0 0.8 1.0 0.6
Peak expiratory flow (PEF) 0.5 1.2 4.4 -1.3 -2.1 0.4 0.0 0.1 -0.2 1.3
Pulse wave reflection index 0.5 0.6 3.0 -1.7 -0.5 0.4 0.0 -0.0 0.6 0.6
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.7 0.3 0.8 0.5 0.0 0.1 0.0 -0.8
Loud music exposure frequency 1.0 1.1 4.6 0.4 0.8 -0.4 0.0 2.1 1.4 -0.0
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.7 0.6 1.3 -0.3 0.0 1.1 1.0 -0.4
Mouth/teeth dental problems: Bleeding gums 1.2 1.5 3.6 -1.6 0.0 1.9 0.0 1.2 1.6 0.9
Blood clot in the leg (DVT) 0.2 0.3 0.7 0.6 -0.4 -0.1 0.0 -0.3 -0.8 0.7
Medication: Paracetamol 2.5 4.1 6.2 -2.0 -2.5 2.3 0.0 1.7 2.3 2.2
Headache pain in last month 0.5 0.8 2.9 -1.7 -0.6 0.8 0.0 -0.5 1.2 0.4
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 3.6 0.7 1.9 -1.0 0.0 0.3 0.4 -1.9
Glaucoma (self-reported) 2.6 3.0 10.5 -0.4 3.2 2.7 0.0 1.1 1.3 0.2
Gout (self-reported) 0.3 0.5 1.2 0.2 0.4 0.9 0.0 1.1 1.0 0.4
Hypothyroidism/myxoedema (self-reported) 0.5 1.1 4.4 0.0 -0.1 -2.1 0.0 0.3 -0.1 -1.7
Medication: Amlodipine 0.4 0.6 1.9 0.5 -1.4 -0.8 0.0 -0.4 -0.9 0.5
Medication: Ventolin 100micrograms inhaler 1.9 2.5 7.4 -1.5 0.3 2.7 0.0 1.2 2.1 1.3
Birth weight 2.1 4.6 14.7 -3.8 -2.7 0.9 0.0 1.9 2.1 -1.1
Chronic bronchitis/emphysema (mother) 0.9 1.1 4.7 -2.2 -1.6 0.0 0.0 -0.6 0.5 0.3
High blood pressure (siblings) 0.9 1.3 2.8 -0.8 -1.2 0.9 0.0 1.6 0.9 1.7
Forced vital capacity (FVC), Best measure 0.9 3.3 10.1 -2.2 0.6 0.6 0.0 2.7 3.2 0.2
Body fat percentage 0.7 2.6 11.7 -1.5 -1.5 3.4 0.0 -0.6 -0.0 1.3
Leg fat percentage (right) 0.4 1.5 3.3 -0.6 -1.8 1.8 0.0 -1.1 -1.3 0.7
Arm fat-free mass (right) 1.2 6.4 27.2 -3.0 -5.2 0.6 0.0 1.5 0.6 2.4
Exposure to tobacco smoke outside home 1.4 1.9 4.3 2.1 1.6 -1.4 0.0 1.8 0.3 -1.1
Comparative body size at age 10 2.5 7.0 27.9 1.2 -5.3 -1.5 0.0 -0.6 -3.0 2.8
Number of full brothers 3.0 3.7 13.3 2.5 3.7 -1.9 0.0 0.4 -0.2 -1.7
Worry too long after embarrassment 1.2 2.0 10.1 -0.3 0.4 3.2 0.0 -0.3 0.6 1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 2.9 3.7 12.9 -2.3 -0.4 3.6 0.0 1.2 2.1 1.3
Wheeze or whistling in the chest in last year 0.3 0.5 2.7 0.5 0.1 1.6 0.0 0.0 0.4 0.8
Number of children fathered 1.7 2.0 4.6 1.2 0.9 -1.3 0.0 -2.1 -1.9 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.7 5.2 0.2 -1.1 1.0 0.0 1.6 1.4 2.3
Age at first live birth 3.8 6.7 14.5 -3.0 -3.8 2.7 0.0 2.2 2.2 2.7
Pulse wave peak to peak time 0.8 0.9 4.5 2.1 0.9 -0.4 0.0 -0.1 -0.3 0.8
Health satisfaction 0.4 0.6 1.7 -0.7 -1.1 1.3 0.0 -0.6 -0.1 0.2
Shortness of breath walking on level ground 0.6 0.7 2.4 -0.1 0.2 0.5 0.0 1.5 1.5 0.6
Qualifications: College or University degree 1.4 4.5 10.0 -3.2 -1.7 1.1 0.0 2.7 2.6 1.9
Eye problems/disorders: None of the above 1.3 1.4 2.7 1.6 1.4 -1.7 0.0 -0.6 -0.9 -1.3
Mouth/teeth dental problems: Loose teeth 1.2 1.4 4.9 1.5 0.9 -2.2 0.0 -0.1 -0.9 -1.1
Emphysema/chronic bronchitis 0.2 0.3 0.6 0.8 0.7 0.3 0.0 -0.7 0.1 -0.3
Medication for pain relief, constipation, heartburn 2.8 4.9 10.4 3.2 0.5 -3.2 0.0 -1.9 -3.0 -0.7
Neck or shoulder pain in last month 1.2 1.7 5.3 -2.3 -0.3 2.1 0.0 0.1 1.4 0.5
Medication: Blood pressure 0.8 1.4 3.8 -0.8 -1.4 1.5 0.0 0.8 0.7 2.0
Angina (self-reported) 1.0 1.3 2.6 -1.0 1.5 0.5 0.0 1.6 1.1 -1.4
Migraine (self-reported) 0.6 0.8 3.1 -1.8 -0.0 1.4 0.0 -0.5 0.5 -0.1
Medication: Ibuprofen 1.2 1.5 4.8 -1.0 0.6 0.7 0.0 1.7 2.2 -0.8
Medication: Allopurinol 0.5 0.7 1.8 -1.2 0.5 1.3 0.0 0.1 1.0 -0.2
Medication: Omeprazole 1.0 1.2 2.8 -0.9 1.7 1.1 0.0 0.9 1.4 -0.9
Medication: Seretide 50 evohaler 0.7 0.9 3.2 0.5 -0.7 0.6 0.0 -1.8 -1.3 0.3
Mean time to correctly identify matches 1.8 3.4 10.0 3.2 0.8 -2.1 0.0 -1.2 -2.4 -1.1
Heart disease (mother) 0.2 0.2 0.6 -0.1 -0.7 0.0 0.0 -0.1 -0.5 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.2 2.6 10.5 1.5 3.2 0.5 0.0 -1.8 -1.1 -0.8
Whole body fat mass 0.9 3.6 10.4 -2.0 -2.7 3.2 0.0 -0.0 0.1 1.9
Leg fat mass (right) 0.7 2.6 8.7 -1.3 -2.9 2.1 0.0 -0.5 -0.9 1.6
Arm predicted mass (right) 1.3 6.6 28.7 -3.0 -5.4 0.6 0.0 1.4 0.5 2.4
Pulse rate, automated reading 1.8 6.0 10.1 -3.0 -2.7 2.0 0.0 3.2 2.9 1.7
Alcohol intake frequency. 1.6 3.7 10.0 -2.4 -1.7 3.2 0.0 0.1 1.0 2.5
Comparative height size at age 10 0.1 0.7 2.7 -1.3 0.7 0.4 0.0 0.3 1.6 -0.1
Number of full sisters 3.0 3.7 9.0 2.8 2.1 -3.0 0.0 -0.2 -0.9 -2.0
Suffer from ‘nerves’ 1.3 2.1 10.1 -0.5 0.8 3.2 0.0 -0.0 0.9 1.7
Overall health rating 0.4 0.8 3.1 -1.2 -0.0 1.8 0.0 -1.0 -0.1 0.0
Chest pain or discomfort 1.5 2.2 5.6 -2.2 -0.5 2.4 0.0 1.2 1.4 1.1
Had major operations 0.9 1.1 2.1 0.8 1.2 -0.7 0.0 -1.5 -1.3 -1.0
Age at last live birth 2.8 4.0 7.4 -2.7 -2.0 2.7 0.0 1.6 1.9 1.9
Family relationship satisfaction 2.6 3.2 9.9 -3.1 -2.4 1.9 0.0 1.5 1.0 0.4
Leg pain on walking 0.4 0.5 2.3 1.5 -0.6 -0.5 0.0 -0.2 -0.6 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 1.0 0.1 -1.0 -0.1 0.0 -0.3 0.2 0.6
Commuting to job workplace: Car/motor vehicle 0.9 1.1 3.9 0.7 1.2 -0.6 0.0 -2.0 -0.8 -1.0
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 2.9 0.8 -0.1 1.0 0.0 -0.9 -0.9 1.7
Medication: Aspirin 0.7 0.9 2.5 -1.1 1.2 0.3 0.0 0.8 0.9 -1.6
Supplements: Vitamin C 0.2 0.2 0.7 -0.2 0.4 -0.3 0.0 -0.8 -0.0 -0.7
Knee pain experienced in last month 0.4 0.6 1.7 0.6 -0.3 -0.7 0.0 -1.3 -0.9 -1.0
Hypertension (Self-reported) 0.5 1.5 4.8 -0.3 -1.6 1.5 0.0 0.7 0.2 2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.6 0.8 1.6 -0.3 0.0 -0.9 -0.6 -1.4
Illnesses of father: Heart disease 0.5 0.6 3.5 -1.9 -0.7 0.4 0.0 -0.4 0.0 -0.5
Illnesses of siblings: Diabetes 1.0 1.3 5.2 -1.6 -2.3 0.3 0.0 -0.7 -0.7 -0.5
Smoking status: Previous 1.0 1.4 4.0 0.5 1.7 1.4 0.0 -2.0 -1.0 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.6 5.6 -2.4 -1.4 1.0 0.0 1.6 2.3 1.4
Whole body fat-free mass 1.2 6.9 27.1 -3.3 -5.2 1.2 0.0 1.4 0.7 2.5
Leg fat-free mass (right) 1.2 6.4 22.6 -2.9 -4.8 2.1 0.0 1.0 0.5 2.9
Arm fat percentage (left) 0.8 3.1 7.6 -1.3 -2.7 2.8 0.0 -1.5 -1.1 1.4
Average weekly red wine intake 0.7 1.0 4.7 0.7 -0.7 -2.2 0.0 0.3 -0.5 -0.9
Handedness (chirality/laterality): Left-handed 1.6 1.9 4.2 -1.3 -2.0 0.4 0.0 2.1 1.5 1.0
Mood swings 7.2 13.0 44.2 -3.6 -0.9 6.6 0.0 2.3 3.8 3.7
Loneliness, isolation 0.4 0.5 1.9 -0.4 0.8 0.3 0.0 0.6 0.4 -1.4
Long-standing illness, disability or infirmity 1.1 1.7 4.7 -0.6 -1.6 2.2 0.0 -0.3 0.1 2.0
Ever had bowel cancer screening 0.9 1.0 2.7 -1.6 -0.6 1.4 0.0 0.7 1.2 0.5
Diabetes diagnosed by doctor 1.0 1.7 4.1 -0.2 -1.5 1.3 0.0 -1.7 -0.8 2.0
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 2.2 0.5 -0.5 -0.9 0.0 -0.6 -1.5 -0.7
Friendships satisfaction 1.0 1.2 2.7 -0.6 -1.7 0.7 0.0 -1.6 -1.4 -0.2
Qualifications: nursing, teaching 0.9 1.4 4.5 -2.1 -0.9 0.4 0.0 1.3 1.6 -0.4
Commuting to job workplace: Walk 0.8 0.8 2.4 -0.2 1.0 0.6 0.0 1.6 1.4 0.4
Eye problems/disorders: Cataract 1.4 1.6 3.9 -2.0 -1.6 1.3 0.0 -0.1 0.8 1.6
Mouth/teeth dental problems: Mouth ulcers 2.0 3.2 6.5 -0.8 1.2 2.6 0.0 2.0 2.5 2.0
Medication for cholesterol 0.4 0.6 1.8 -0.9 -0.6 -0.3 0.0 1.2 1.4 -0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 1.3 -0.2 0.7 1.2 0.0 0.6 0.8 0.3
Back pain experienced in last month 0.6 0.9 2.9 -1.1 0.0 1.7 0.0 -0.1 1.1 1.1
Mineral and other dietary supplements 0.3 0.3 1.6 -0.1 -1.2 -0.4 0.0 0.4 -0.5 0.5
Breast cancer (self-reported) 4.3 5.1 12.9 3.6 2.7 0.4 0.0 -2.9 -2.5 -1.1
Asthma (self-reported) 0.4 0.8 4.9 -0.3 0.6 2.2 0.0 -0.3 0.3 0.1
Osteoporosis (self-reported) 0.9 1.1 3.6 -1.4 -1.9 1.2 0.0 0.3 0.2 -0.8
Osteoarthritis (self-reported) 0.2 0.3 1.0 -1.0 0.1 0.9 0.0 -0.2 0.4 -0.5
Medication: Aspirin 0.7 0.9 2.9 -0.6 1.5 -0.0 0.0 0.6 0.6 -1.7
Medication: Gliclazide 0.4 0.4 1.4 -0.0 -1.2 -0.1 0.0 -0.7 -0.9 0.3
Illnesses of father: None of the above (group 1) 0.6 0.8 2.8 1.7 0.8 -1.0 0.0 1.1 -0.1 0.3
Smoking status: Current 2.3 3.6 12.1 2.5 0.9 -3.5 0.0 0.4 -1.4 -2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 3.6 -1.7 -1.0 0.2 0.0 1.9 1.6 0.5
Whole body water mass 1.3 7.2 28.3 -3.3 -5.3 1.2 0.0 1.5 0.8 2.6
Leg predicted mass (right) 1.2 6.2 22.0 -2.8 -4.7 2.1 0.0 0.9 0.5 2.9
Arm fat mass (left) 1.0 4.0 13.7 -1.7 -3.7 2.6 0.0 -0.9 -0.9 1.8
Number of self-reported non-cancer illnesses 1.2 2.1 8.6 -1.9 -1.0 2.9 0.0 -0.5 0.6 1.1
Average weekly champagne plus white wine intake 0.6 0.9 2.6 -1.6 -1.0 0.4 0.0 0.6 1.4 0.1
Miserableness 0.7 1.1 4.1 -0.1 1.0 2.0 0.0 -1.6 -0.6 0.3
Guilty feelings 2.2 3.3 12.6 -1.6 0.2 3.5 0.0 0.2 1.7 2.2
Wears glasses or contact lenses 2.0 2.3 6.3 -2.3 -1.7 2.5 0.0 -0.4 1.2 0.6
Ever taken oral contraceptive pill 0.8 0.8 4.1 2.0 0.6 -0.7 0.0 -0.2 -0.4 0.9
Hearing aid user 0.3 0.3 1.0 0.6 0.4 -1.0 0.0 -0.3 -0.5 -0.0
Mother’s age at death 0.7 0.8 2.0 1.4 0.8 -1.2 0.0 1.0 -0.2 -0.8
Financial situation satisfaction 0.4 0.5 1.7 -1.2 -1.3 0.4 0.0 0.1 0.0 -0.7
Tinnitus: Yes, now most or all of the time 1.2 1.4 6.3 -0.2 2.5 0.9 0.0 0.8 1.5 0.1
Commuting to job workplace: Public transport 1.3 1.6 4.2 1.4 1.4 -1.3 0.0 2.0 0.5 -0.9
Eye problems/disorders: Glaucoma 2.1 2.5 8.7 -0.3 2.9 2.5 0.0 0.9 1.4 0.2
Medication: Blood pressure 0.3 0.5 1.6 0.1 -1.0 0.5 0.0 0.8 0.1 1.3
Pain type(s) experienced in last month: Hip pain 0.3 0.3 0.8 -0.6 -0.0 -0.0 0.0 0.8 0.8 -0.9
Supplements: Fish oil (including cod liver oil) 0.2 0.3 1.0 -0.7 0.3 0.3 0.0 -0.7 0.4 -1.0
High cholesterol (Self-reported) 1.4 2.5 7.5 1.7 -0.1 -0.5 0.0 -2.6 -2.7 0.1
Medication: Bendroflumethiazide 0.2 0.2 1.0 1.0 0.2 -0.3 0.0 0.1 -0.3 0.7
Medication: Paracetamol 2.2 3.4 5.8 -1.8 -2.2 1.8 0.0 2.1 2.4 1.4
Medication: Lisinopril 1.0 1.3 4.2 -0.3 -1.2 0.9 0.0 1.5 0.8 2.1
Medication: Atorvastatin 0.6 0.7 1.9 0.7 -0.8 -0.1 0.0 -1.4 -1.3 0.1
Illnesses of father: High blood pressure 1.8 2.2 4.1 -1.5 -0.9 2.0 0.0 1.9 1.5 1.6
Alcohol drinker status: Never 2.0 2.4 5.1 -0.7 -1.4 2.1 0.0 1.7 1.2 2.3
Ever smoked 1.3 2.3 7.5 1.7 2.7 -0.4 0.0 -0.7 -1.0 -2.0
Basal metabolic rate 1.2 6.7 24.7 -3.2 -5.0 1.7 0.0 1.2 0.7 2.7
Leg fat percentage (left) 0.4 1.6 3.9 -0.7 -1.9 2.0 0.0 -1.0 -1.2 0.9
Arm fat-free mass (left) 1.3 6.7 27.5 -3.1 -5.2 1.1 0.0 1.6 0.7 2.3
Number of operations (self-reported) 1.1 1.6 4.4 1.1 0.8 -0.5 0.0 -2.1 -1.9 -1.1
Average weekly beer plus cider intake 2.2 3.2 9.7 1.8 1.2 -3.1 0.0 -1.4 -1.6 -1.9
Irritability 5.2 8.7 28.6 -3.3 -1.6 5.3 0.0 0.9 2.6 3.4
Risk taking 0.7 1.0 2.5 1.6 -0.7 -1.4 0.0 -0.9 -1.0 -0.6
Ever had prostate specific antigen (PSA) test 0.9 1.0 2.9 -1.7 -1.7 0.6 0.0 -0.8 -0.4 -0.5
Fractured/broken bones in last 5 years 0.1 0.1 0.4 -0.1 -0.1 0.2 0.0 -0.6 -0.5 -0.1
Age started oral contraceptive pill 0.4 0.5 1.6 0.8 0.5 -0.0 0.0 -0.7 -1.3 -0.5
Diastolic blood pressure, automated reading 1.3 4.0 16.2 -2.8 -4.0 1.7 0.0 0.4 -0.0 1.0
Ever depressed for a whole week 0.7 0.9 3.4 -1.3 0.1 1.8 0.0 0.3 1.1 0.4
Unable to work because of sickness or disability 0.4 0.6 1.6 -0.1 0.1 0.5 0.0 1.3 1.3 0.7
Commuting to job workplace: Cycle 0.4 0.5 1.6 -0.4 -1.2 0.2 0.0 -0.3 -0.4 1.3
Myopia 1.7 2.4 5.3 0.1 1.4 -1.8 0.0 2.3 1.5 -2.1
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.9 0.4 1.4 -1.1 0.0 -0.8 -0.2 -1.4
Cholesterol lowering medication 1.2 1.8 6.4 0.9 0.3 0.4 0.0 -2.5 -2.2 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 3.2 -0.9 1.4 1.8 0.0 0.2 1.0 -0.6
Pain experienced in last month 0.2 0.3 1.0 1.0 0.2 -0.2 0.0 1.0 -0.2 0.6
Supplements: Calcium 0.7 0.8 2.3 0.2 0.9 1.5 0.0 -1.3 -0.9 -0.2
Basal cell carcinoma (self-reported) 3.7 4.4 15.0 -2.1 0.2 3.9 0.0 1.6 2.2 1.8
Heart attack/myocardial infarction (self-reported) 2.1 2.7 6.4 -2.5 -0.1 0.8 0.0 1.9 1.8 -2.3
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.1 1.1 -0.1 -0.1 0.0 -0.2 -0.8 1.0
Heart disease (siblings) 0.8 1.0 5.8 0.4 2.4 -0.4 0.0 0.7 0.3 -0.7
Alcohol drinker status: Previous 0.6 0.7 1.3 -1.1 -1.1 0.8 0.0 0.2 0.6 1.1
Pack years of smoking 2.6 3.9 8.0 2.3 -0.1 -2.3 0.0 -1.8 -2.8 -2.2
Impedance of whole body 2.1 10.4 40.5 -0.7 6.4 2.9 0.0 1.5 4.4 -1.3
Leg fat mass (left) 0.7 2.8 9.4 -1.3 -3.1 2.2 0.0 -0.5 -0.8 1.7
Arm predicted mass (left) 1.2 6.0 25.2 -2.9 -5.0 0.9 0.0 1.4 0.6 2.3