TWAS hub - SLC25A17

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.032	0.0170	3.3e-03	0.011	0.013	0.012	0.012	0.007	0.01500	0.0096	1.2e-02	0.012	0.03800
2	GTEx	Brain Frontal Cortex BA9	0.105	0.0478	3.4e-03	-0.008	NA	-0.004	NA	-0.001	0.58000	NA	4.4e-01	NA	0.35000
3	GTEx	Cells Transformed fibroblasts	0.086	0.0320	4.4e-05	0.033	NA	0.057	NA	0.045	0.00170	NA	4.2e-05	NA	0.00024
4	GTEx	Prostate	0.295	0.1210	5.9e-03	0.005	NA	0.006	NA	-0.004	0.24000	NA	2.2e-01	NA	0.42000
5	GTEx	Skin Sun Exposed Lower leg	0.056	0.0280	3.6e-03	0.040	NA	0.017	NA	0.023	0.00031	NA	1.4e-02	NA	0.00500
6	GTEx	Spleen	0.254	0.0870	8.3e-04	0.042	NA	0.066	NA	0.125	0.03100	NA	9.1e-03	NA	0.00043
7	TCGA	Ovarian Serous Cystadenocarcinoma	0.172	0.0940	3.2e-03	0.051	0.033	0.041	NA	0.045	0.00022	0.0025	8.7e-04	NA	0.00050

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	5	6	7
Bipolar Disorder or Schizophrenia	8.5	20.7	35.0	-5.1	-4.0	5.8	3.8	4.5	5.9
Bipolar Disorder (2018)	7.5	11.9	19.0	-4.3	-2.0	3.6	3.8	4.4	3.8
Mood swings	7.2	13.0	44.2	-3.6	-0.9	6.6	2.3	3.8	3.7
Worry (Nagel 2018)	6.6	14.0	43.0	-3.5	-0.7	6.6	2.0	4.0	4.8
Breast Cancer	6.1	14.7	61.6	-6.4	-7.8	-0.3	0.4	0.3	0.1
Schizophrenia (2014)	5.9	13.1	24.0	-4.1	-4.2	4.7	2.0	2.8	4.9
Neuroticism (Nagel 2018)	5.7	13.3	51.5	-3.7	-0.7	7.2	0.9	3.2	4.1
Irritability	5.2	8.7	28.6	-3.3	-1.6	5.3	0.9	2.6	3.4
Schizophrenia (2018)	4.9	10.2	20.4	-3.2	-3.6	4.5	1.8	2.2	4.5
Nervous feelings	4.5	8.3	22.4	-2.5	-0.0	4.7	2.7	3.8	2.8
Neuroticism (2016)	4.4	6.3	22.4	-2.6	-0.7	4.7	1.0	2.4	2.8
Tense / ‘highly strung’	4.4	7.2	24.0	-3.1	-1.2	4.9	0.8	2.7	2.8
Neuroticism	4.3	10.3	36.1	-3.7	-0.3	6.0	1.0	3.4	3.0
Breast cancer (self-reported)	4.3	5.1	12.9	3.6	2.7	0.4	-2.9	-2.5	-1.1
Neuroticism score	4.1	8.5	32.5	-2.9	-0.6	5.7	1.2	2.8	3.1
Alzheimer’s Disease (including proxy)	4.0	5.8	12.2	-2.7	-0.7	3.5	2.6	3.5	1.4
Allergy or Eczema	3.8	10.0	29.2	-3.1	-0.9	5.4	2.2	3.6	3.6
Age at first live birth	3.8	6.7	14.5	-3.0	-3.8	2.7	2.2	2.2	2.7
Basal cell carcinoma (self-reported)	3.7	4.4	15.0	-2.1	0.2	3.9	1.6	2.2	1.8
Worrier / anxious feelings	3.6	6.8	28.1	-1.7	-0.2	5.3	0.3	1.6	3.7
Blood Eosinophil Count	3.5	26.9	50.1	-7.1	-2.9	6.6	6.3	6.7	1.3
Current tobacco smoking	3.4	5.5	17.2	2.9	1.3	-4.1	-0.2	-1.9	-2.8
Diabetes (mother)	3.1	4.0	9.6	3.1	-0.2	-2.6	-1.5	-2.8	-1.1
Rheumatoid Arthritis	3.0	4.1	8.4	2.9	1.2	-2.5	-1.7	-2.3	-2.1
Number of full brothers	3.0	3.7	13.3	2.5	3.7	-1.9	0.4	-0.2	-1.7
Number of full sisters	3.0	3.7	9.0	2.8	2.1	-3.0	-0.2	-0.9	-2.0
Bipolar Disorder (2011)	2.9	2.8	7.6	-2.8	-1.9	1.4	1.3	1.6	1.5
Heel bone mineral density (BMD) T-score, automated (left)	2.9	6.7	15.1	-1.6	2.5	3.9	3.0	3.7	-0.3
Number of incorrect matches in round	2.9	4.8	10.8	-1.7	-2.6	3.3	0.9	1.3	3.3
Time employed in main current job	2.9	3.4	10.8	-0.6	-1.8	2.3	1.8	0.8	3.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.9	3.7	12.9	-2.3	-0.4	3.6	1.2	2.1	1.3
Age at First Birth	2.8	4.0	6.3	-2.5	-2.4	2.0	2.2	2.2	1.7
Age when periods started (menarche)	2.8	6.7	21.3	-1.9	0.1	2.0	3.8	4.6	2.0
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.5	14.9	-3.0	-1.1	3.9	0.6	1.9	1.7
Medication for pain relief, constipation, heartburn	2.8	4.9	10.4	3.2	0.5	-3.2	-1.9	-3.0	-0.7
Age at last live birth	2.8	4.0	7.4	-2.7	-2.0	2.7	1.6	1.9	1.9
Glaucoma (self-reported)	2.6	3.0	10.5	-0.4	3.2	2.7	1.1	1.3	0.2
Family relationship satisfaction	2.6	3.2	9.9	-3.1	-2.4	1.9	1.5	1.0	0.4
Pack years of smoking	2.6	3.9	8.0	2.3	-0.1	-2.3	-1.8	-2.8	-2.2
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.7	12.5	-1.1	2.3	3.5	3.0	3.5	0.2
Medication: Paracetamol	2.5	4.1	6.2	-2.0	-2.5	2.3	1.7	2.3	2.2
Comparative body size at age 10	2.5	7.0	27.9	1.2	-5.3	-1.5	-0.6	-3.0	2.8
Alzheimer’s Disease (in mother)	2.4	2.8	6.9	-1.2	0.6	1.7	2.4	2.6	1.4
Smoking Status	2.4	5.7	14.1	3.1	2.6	-3.8	-0.1	-1.5	-2.7
Eye problems/disorders: Diabetes related eye disease	2.4	2.6	4.4	-1.6	-1.5	2.1	1.9	1.6	1.8
Pack years adult smoking proportion	2.4	3.7	8.0	2.5	-0.1	-2.2	-1.7	-2.8	-2.0
Hayfever, allergic rhinitis or eczema	2.4	5.3	14.9	-1.7	-0.1	3.9	1.9	2.7	2.9
Lung FEV1/FVC ratio	2.3	11.9	39.6	-3.9	-6.3	2.7	-1.4	-1.5	4.2
Maternal smoking around birth	2.3	3.3	9.3	1.8	0.6	-3.0	-0.9	-1.7	-2.5
Number of live births	2.3	3.3	12.1	2.1	3.5	-0.9	-1.3	-1.5	-1.3
Happiness	2.3	2.8	5.7	-2.4	-2.4	2.2	1.4	1.2	0.4
Smoking status: Current	2.3	3.6	12.1	2.5	0.9	-3.5	0.4	-1.4	-2.1
Depression (self-reported)	2.2	2.6	5.6	-2.4	-0.2	2.4	1.5	2.0	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.6	10.5	1.5	3.2	0.5	-1.8	-1.1	-0.8
Guilty feelings	2.2	3.3	12.6	-1.6	0.2	3.5	0.2	1.7	2.2
Medication: Paracetamol	2.2	3.4	5.8	-1.8	-2.2	1.8	2.1	2.4	1.4
Average weekly beer plus cider intake	2.2	3.2	9.7	1.8	1.2	-3.1	-1.4	-1.6	-1.9
Birth weight	2.1	4.6	14.7	-3.8	-2.7	0.9	1.9	2.1	-1.1
Eye problems/disorders: Glaucoma	2.1	2.5	8.7	-0.3	2.9	2.5	0.9	1.4	0.2
Heart attack/myocardial infarction (self-reported)	2.1	2.7	6.4	-2.5	-0.1	0.8	1.9	1.8	-2.3
Impedance of whole body	2.1	10.4	40.5	-0.7	6.4	2.9	1.5	4.4	-1.3
Heart attack	2.0	2.6	6.8	-2.6	-0.4	1.1	1.8	1.8	-1.9
Mouth/teeth dental problems: Mouth ulcers	2.0	3.2	6.5	-0.8	1.2	2.6	2.0	2.5	2.0
Wears glasses or contact lenses	2.0	2.3	6.3	-2.3	-1.7	2.5	-0.4	1.2	0.6
Alcohol drinker status: Never	2.0	2.4	5.1	-0.7	-1.4	2.1	1.7	1.2	2.3
Intelligence (Savage-Jansen 2018)	1.9	5.9	12.6	1.3	3.4	-3.5	1.6	-0.3	-3.5
Qualifications: CSEs or equivalent	1.9	2.5	6.5	2.6	1.7	-1.0	-1.9	-1.9	-0.4
Impedance of arm (right)	1.9	8.8	35.9	-0.5	6.0	3.0	1.1	3.8	-1.1
Medication: Ventolin 100micrograms inhaler	1.9	2.5	7.4	-1.5	0.3	2.7	1.2	2.1	1.3
Impedance of arm (left)	1.8	8.6	34.7	-0.5	5.9	3.3	0.6	3.6	-0.9
Mean time to correctly identify matches	1.8	3.4	10.0	3.2	0.8	-2.1	-1.2	-2.4	-1.1
Pulse rate, automated reading	1.8	6.0	10.1	-3.0	-2.7	2.0	3.2	2.9	1.7
Illnesses of father: High blood pressure	1.8	2.2	4.1	-1.5	-0.9	2.0	1.9	1.5	1.6
Major Depression (MDD)	1.7	2.0	3.7	-1.5	-1.4	1.9	1.5	1.3	1.5
Body Mass Index (BMI) (2010)	1.7	2.4	6.4	-1.5	-1.7	2.5	-0.1	1.0	2.0
Fed-up feelings	1.7	3.0	9.1	-3.0	-1.1	2.8	0.5	1.5	0.4
Allergy	1.7	4.0	14.7	1.6	-0.1	-3.8	-1.3	-2.3	-1.8
Pulse rate	1.7	2.8	6.2	-2.5	-2.5	1.1	1.7	1.8	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.3	12.7	-3.6	-1.1	1.8	2.6	3.2	1.7
Number of children fathered	1.7	2.0	4.6	1.2	0.9	-1.3	-2.1	-1.9	-1.2
Myopia	1.7	2.4	5.3	0.1	1.4	-1.8	2.3	1.5	-2.1
Depressed Affect (Nagel 2018)	1.6	3.3	14.2	-2.3	-0.1	3.8	-0.4	1.1	1.3
Verbal and Numeric Reasoning (VNR)	1.6	3.8	9.2	1.2	2.1	-2.9	1.9	0.0	-3.0
Crohns Disease (2012)	1.6	2.6	4.7	-1.5	-1.2	2.1	1.0	2.0	2.2
Impedance of leg (right)	1.6	8.0	32.5	-0.4	5.7	1.2	1.8	3.9	-1.9
Impedance of leg (left)	1.6	7.9	30.4	-0.6	5.5	1.5	1.9	4.0	-1.6
Mouth/teeth dental problems: Dentures	1.6	2.7	8.6	1.5	1.0	-2.6	0.3	-0.6	-2.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	7.9	-1.8	-0.0	2.8	0.7	2.1	1.0
Alcohol intake frequency.	1.6	3.7	10.0	-2.4	-1.7	3.2	0.1	1.0	2.5
Handedness (chirality/laterality): Left-handed	1.6	1.9	4.2	-1.3	-2.0	0.4	2.1	1.5	1.0
Crohns Disease (2017)	1.5	3.2	6.2	-2.4	-2.0	2.5	1.1	1.9	1.2
Taking other prescription medications	1.5	2.2	11.1	-1.0	0.3	3.3	0.1	1.0	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	6.0	0.3	1.4	-2.5	0.4	0.5	-1.8
Chest pain or discomfort	1.5	2.2	5.6	-2.2	-0.5	2.4	1.2	1.4	1.1
Irritable Bowel Disease (IBD)	1.4	3.4	7.4	-2.7	-0.9	2.4	1.6	2.7	0.4
Type 2 Diabetes (T2D) (2012)	1.4	1.6	5.1	1.6	-0.1	-0.4	-2.3	-1.7	0.6
Sensitivity / hurt feelings	1.4	2.4	11.1	-1.1	0.1	3.3	0.9	1.5	1.1
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	5.2	1.9	2.3	-0.4	-1.1	-0.9	-0.5
Hair/balding pattern: Pattern 4	1.4	3.3	13.1	3.6	0.9	-2.1	-0.4	-2.1	-0.2
Exposure to tobacco smoke outside home	1.4	1.9	4.3	2.1	1.6	-1.4	1.8	0.3	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	5.2	0.2	-1.1	1.0	1.6	1.4	2.3
Qualifications: College or University degree	1.4	4.5	10.0	-3.2	-1.7	1.1	2.7	2.6	1.9
Eye problems/disorders: Cataract	1.4	1.6	3.9	-2.0	-1.6	1.3	-0.1	0.8	1.6
High cholesterol (Self-reported)	1.4	2.5	7.5	1.7	-0.1	-0.5	-2.6	-2.7	0.1
Heel T-Score	1.3	10.7	21.9	-1.7	4.7	4.5	2.9	4.5	-1.1
Had menopause	1.3	1.6	3.1	1.8	1.7	-1.3	0.9	-0.5	-1.6
Standing height	1.3	13.0	37.0	-4.5	0.5	3.5	4.4	6.1	1.6
Eye problems/disorders: None of the above	1.3	1.4	2.7	1.6	1.4	-1.7	-0.6	-0.9	-1.3
Arm predicted mass (right)	1.3	6.6	28.7	-3.0	-5.4	0.6	1.4	0.5	2.4
Suffer from ‘nerves’	1.3	2.1	10.1	-0.5	0.8	3.2	-0.0	0.9	1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	5.6	-2.4	-1.4	1.0	1.6	2.3	1.4
Whole body water mass	1.3	7.2	28.3	-3.3	-5.3	1.2	1.5	0.8	2.6
Commuting to job workplace: Public transport	1.3	1.6	4.2	1.4	1.4	-1.3	2.0	0.5	-0.9
Ever smoked	1.3	2.3	7.5	1.7	2.7	-0.4	-0.7	-1.0	-2.0
Arm fat-free mass (left)	1.3	6.7	27.5	-3.1	-5.2	1.1	1.6	0.7	2.3
Diastolic blood pressure, automated reading	1.3	4.0	16.2	-2.8	-4.0	1.7	0.4	-0.0	1.0
Coronary Artery Disease (CAD)	1.2	1.4	2.8	1.6	0.6	-1.5	-0.7	-1.7	-1.2
Chronotype (morning person)	1.2	2.7	6.3	0.8	-1.7	1.0	-2.5	-2.5	1.4
Number of treatments/medications taken	1.2	2.1	8.6	-1.8	-0.9	2.9	-0.1	0.9	1.0
Ever used hormone-replacement therapy (HRT)	1.2	1.6	4.3	2.0	2.1	-0.6	-0.8	-0.9	-1.0
Angina	1.2	1.5	2.9	-1.4	1.3	0.9	1.7	1.3	-1.3
Medication: Co-codamol	1.2	1.4	3.6	-1.9	-0.3	0.7	1.7	1.7	0.2
Leg fat-free mass (left)	1.2	6.1	22.4	-2.8	-4.7	2.0	0.9	0.4	2.7
Forced vital capacity (FVC)	1.2	4.6	13.0	-2.4	0.8	0.7	3.4	3.6	0.4
Trunk predicted mass	1.2	6.6	26.1	-3.3	-5.1	0.7	1.7	1.0	2.3
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	3.6	-1.6	0.0	1.9	1.2	1.6	0.9
Arm fat-free mass (right)	1.2	6.4	27.2	-3.0	-5.2	0.6	1.5	0.6	2.4
Worry too long after embarrassment	1.2	2.0	10.1	-0.3	0.4	3.2	-0.3	0.6	1.9
Mouth/teeth dental problems: Loose teeth	1.2	1.4	4.9	1.5	0.9	-2.2	-0.1	-0.9	-1.1
Neck or shoulder pain in last month	1.2	1.7	5.3	-2.3	-0.3	2.1	0.1	1.4	0.5
Medication: Ibuprofen	1.2	1.5	4.8	-1.0	0.6	0.7	1.7	2.2	-0.8
Whole body fat-free mass	1.2	6.9	27.1	-3.3	-5.2	1.2	1.4	0.7	2.5
Leg fat-free mass (right)	1.2	6.4	22.6	-2.9	-4.8	2.1	1.0	0.5	2.9
Leg predicted mass (right)	1.2	6.2	22.0	-2.8	-4.7	2.1	0.9	0.5	2.9
Number of self-reported non-cancer illnesses	1.2	2.1	8.6	-1.9	-1.0	2.9	-0.5	0.6	1.1
Tinnitus: Yes, now most or all of the time	1.2	1.4	6.3	-0.2	2.5	0.9	0.8	1.5	0.1
Basal metabolic rate	1.2	6.7	24.7	-3.2	-5.0	1.7	1.2	0.7	2.7
Cholesterol lowering medication	1.2	1.8	6.4	0.9	0.3	0.4	-2.5	-2.2	-0.5
Arm predicted mass (left)	1.2	6.0	25.2	-2.9	-5.0	0.9	1.4	0.6	2.3
Alzheimer’s Disease (in father)	1.1	1.2	3.1	-1.8	-0.6	1.2	0.9	1.6	-0.4
Ulcerative Colitis (UC)	1.1	2.0	5.5	-1.8	0.6	1.6	1.6	2.3	-0.3
BMI	1.1	6.4	27.4	-0.4	-5.2	-0.1	-2.4	-3.4	0.8
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.9	-1.7	-0.8	2.0	0.9	1.5	0.6
Medication: Atenolol	1.1	1.3	3.2	-0.2	0.5	-1.1	-1.8	-1.5	-1.6
Body mass index (BMI)	1.1	4.7	18.3	-0.5	-4.3	1.1	-1.7	-2.7	1.7
Leg predicted mass (left)	1.1	5.9	21.3	-2.8	-4.6	2.0	0.9	0.5	2.7
Qualifications: None of the above	1.1	2.3	6.0	2.5	0.9	-1.4	-1.9	-1.9	-0.6
Trunk fat-free mass	1.1	6.3	25.0	-3.2	-5.0	0.7	1.6	0.9	2.2
Hip circumference	1.1	4.8	11.7	-1.7	-2.7	3.4	0.4	0.5	3.3
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	9.0	-3.0	-0.6	1.3	2.4	2.7	1.4
Qualifications: A levels/AS levels or equivalent	1.1	2.5	10.9	-0.6	-0.5	0.0	3.3	2.2	0.8
Exposure to tobacco smoke at home	1.1	1.3	4.9	0.3	1.1	0.9	2.2	1.2	0.6
Long-standing illness, disability or infirmity	1.1	1.7	4.7	-0.6	-1.6	2.2	-0.3	0.1	2.0
Number of operations (self-reported)	1.1	1.6	4.4	1.1	0.8	-0.5	-2.1	-1.9	-1.1
Average weekly spirits intake	1.0	1.3	3.7	0.6	1.4	-1.9	-0.4	-0.7	-1.5
Medication for hormone replacement therapy	1.0	1.1	2.1	1.5	1.3	-0.6	-1.4	-1.2	-0.2
Vitamin and mineral supplements	1.0	1.4	3.2	1.6	-0.1	-1.8	-0.1	-1.6	-1.1
Mouth/teeth dental problems	1.0	1.5	3.9	0.3	-1.7	0.0	-2.0	-1.5	1.2
Diabetes (self-reported)	1.0	1.5	3.5	0.2	-1.8	0.6	-1.9	-1.3	1.5
Fluid intelligence score	1.0	2.0	6.8	0.3	1.2	-1.9	1.4	-0.2	-2.6
Weight	1.0	5.1	14.7	-2.6	-3.8	2.7	0.5	0.3	2.5
Pulse wave Arterial Stiffness index	1.0	1.2	5.8	-2.4	-0.9	0.9	0.2	0.7	-0.3
Loud music exposure frequency	1.0	1.1	4.6	0.4	0.8	-0.4	2.1	1.4	-0.0
Angina (self-reported)	1.0	1.3	2.6	-1.0	1.5	0.5	1.6	1.1	-1.4
Medication: Omeprazole	1.0	1.2	2.8	-0.9	1.7	1.1	0.9	1.4	-0.9
Illnesses of siblings: Diabetes	1.0	1.3	5.2	-1.6	-2.3	0.3	-0.7	-0.7	-0.5
Smoking status: Previous	1.0	1.4	4.0	0.5	1.7	1.4	-2.0	-1.0	-0.3
Diabetes diagnosed by doctor	1.0	1.7	4.1	-0.2	-1.5	1.3	-1.7	-0.8	2.0
Friendships satisfaction	1.0	1.2	2.7	-0.6	-1.7	0.7	-1.6	-1.4	-0.2
Arm fat mass (left)	1.0	4.0	13.7	-1.7	-3.7	2.6	-0.9	-0.9	1.8
Medication: Lisinopril	1.0	1.3	4.2	-0.3	-1.2	0.9	1.5	0.8	2.1
Fasting Glucose	0.9	1.1	3.1	0.7	1.1	0.2	-1.3	-1.0	-1.8
Waist Hip Ratio (WHR)	0.9	4.1	13.9	1.3	0.8	-1.7	-1.9	-2.4	-3.7
Ever had hysterectomy (womb removed)	0.9	1.0	2.5	1.4	1.6	1.1	-0.6	-0.0	1.0
Systolic blood pressure, automated reading	0.9	2.6	7.3	1.9	0.7	0.1	-2.7	-2.6	0.1
Multivitamins +/- minerals	0.9	1.2	2.7	-1.6	-0.7	1.6	-0.7	1.1	1.1
Stomach or abdominal pain in last month	0.9	1.2	4.3	-2.1	-0.6	0.9	0.7	1.5	0.1
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	3.7	0.2	1.9	-0.8	0.2	0.4	-1.5
Trunk fat mass	0.9	4.0	14.4	-2.4	-2.1	3.8	0.1	0.8	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	4.0	-1.0	0.7	2.0	1.0	1.8	0.7
Medication: Simvastatin	0.9	1.4	4.5	1.1	0.1	-0.6	-1.8	-2.1	-0.2
Arm fat mass (right)	0.9	3.9	12.1	-1.8	-3.5	2.7	-0.6	-0.7	1.9
Chronic bronchitis/emphysema (mother)	0.9	1.1	4.7	-2.2	-1.6	0.0	-0.6	0.5	0.3
High blood pressure (siblings)	0.9	1.3	2.8	-0.8	-1.2	0.9	1.6	0.9	1.7
Forced vital capacity (FVC), Best measure	0.9	3.3	10.1	-2.2	0.6	0.6	2.7	3.2	0.2
Whole body fat mass	0.9	3.6	10.4	-2.0	-2.7	3.2	-0.0	0.1	1.9
Had major operations	0.9	1.1	2.1	0.8	1.2	-0.7	-1.5	-1.3	-1.0
Commuting to job workplace: Car/motor vehicle	0.9	1.1	3.9	0.7	1.2	-0.6	-2.0	-0.8	-1.0
Ever had bowel cancer screening	0.9	1.0	2.7	-1.6	-0.6	1.4	0.7	1.2	0.5
Qualifications: nursing, teaching	0.9	1.4	4.5	-2.1	-0.9	0.4	1.3	1.6	-0.4
Osteoporosis (self-reported)	0.9	1.1	3.6	-1.4	-1.9	1.2	0.3	0.2	-0.8
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.9	-1.7	-1.7	0.6	-0.8	-0.4	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.2	-0.9	1.4	1.8	0.2	1.0	-0.6
Prostate Cancer	0.8	1.2	3.6	0.8	1.6	1.9	0.7	0.8	0.5
Trunk fat percentage	0.8	3.2	16.4	-1.7	-0.7	4.0	-0.3	0.7	1.3
Chronic bronchitis/emphysema (father)	0.8	0.9	2.3	-0.1	-0.5	-1.1	-1.4	-0.8	-1.5
Past tobacco smoking	0.8	1.5	4.8	-1.6	-2.2	-0.4	1.1	1.1	0.8
Falls in the last year	0.8	1.1	5.6	0.5	2.4	1.1	-0.1	0.6	-0.5
Hair/balding pattern: Pattern 3	0.8	1.2	2.1	-1.4	-1.4	1.2	0.6	1.1	1.2
Illnesses of mother	0.8	0.9	4.1	0.2	1.3	-0.8	0.1	0.3	-2.0
Birth weight of first child	0.8	1.4	3.5	-1.8	-1.9	1.0	0.8	1.0	0.6
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.6	0.7	1.9	-1.0	0.3	0.4	-1.9
Pulse wave peak to peak time	0.8	0.9	4.5	2.1	0.9	-0.4	-0.1	-0.3	0.8
Medication: Blood pressure	0.8	1.4	3.8	-0.8	-1.4	1.5	0.8	0.7	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.6	0.8	1.6	-0.3	-0.9	-0.6	-1.4
Arm fat percentage (left)	0.8	3.1	7.6	-1.3	-2.7	2.8	-1.5	-1.1	1.4
Commuting to job workplace: Walk	0.8	0.8	2.4	-0.2	1.0	0.6	1.6	1.4	0.4
Ever taken oral contraceptive pill	0.8	0.8	4.1	2.0	0.6	-0.7	-0.2	-0.4	0.9
Heart disease (siblings)	0.8	1.0	5.8	0.4	2.4	-0.4	0.7	0.3	-0.7
Depression (Nagel 2018)	0.7	1.0	2.8	-1.7	-1.0	1.5	-0.0	0.6	0.9
Reaction Time	0.7	1.3	4.3	2.1	0.5	-1.5	-0.7	-1.4	-0.2
Cardiovascular Disease	0.7	2.5	8.9	0.2	-1.8	2.2	-0.3	-0.4	3.0
Hypothyroidism (self reported)	0.7	1.7	7.8	0.2	-0.3	-2.8	1.3	0.2	-1.5
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	4.1	-0.1	-2.0	0.1	-0.4	-0.8	0.6
Supplements: Glucosamine	0.7	0.9	1.9	0.9	1.1	-1.1	-0.5	-0.7	-1.4
Sitting height	0.7	5.3	15.3	-3.3	0.0	0.9	3.1	3.9	0.6
Waist circumference	0.7	2.4	9.7	-0.6	-3.1	1.6	-0.9	-1.6	1.0
Financial difficulties in last 2 years	0.7	0.9	2.5	1.2	0.7	-1.6	0.8	-0.5	-1.0
Arm fat percentage (right)	0.7	2.9	7.1	-1.3	-2.7	2.7	-1.2	-1.0	1.3
Body fat percentage	0.7	2.6	11.7	-1.5	-1.5	3.4	-0.6	-0.0	1.3
Medication: Seretide 50 evohaler	0.7	0.9	3.2	0.5	-0.7	0.6	-1.8	-1.3	0.3
Leg fat mass (right)	0.7	2.6	8.7	-1.3	-2.9	2.1	-0.5	-0.9	1.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.9	0.8	-0.1	1.0	-0.9	-0.9	1.7
Medication: Aspirin	0.7	0.9	2.5	-1.1	1.2	0.3	0.8	0.9	-1.6
Average weekly red wine intake	0.7	1.0	4.7	0.7	-0.7	-2.2	0.3	-0.5	-0.9
Medication: Aspirin	0.7	0.9	2.9	-0.6	1.5	-0.0	0.6	0.6	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	3.6	-1.7	-1.0	0.2	1.9	1.6	0.5
Miserableness	0.7	1.1	4.1	-0.1	1.0	2.0	-1.6	-0.6	0.3
Mother’s age at death	0.7	0.8	2.0	1.4	0.8	-1.2	1.0	-0.2	-0.8
Risk taking	0.7	1.0	2.5	1.6	-0.7	-1.4	-0.9	-1.0	-0.6
Ever depressed for a whole week	0.7	0.9	3.4	-1.3	0.1	1.8	0.3	1.1	0.4
Supplements: Calcium	0.7	0.8	2.3	0.2	0.9	1.5	-1.3	-0.9	-0.2
Leg fat mass (left)	0.7	2.8	9.4	-1.3	-3.1	2.2	-0.5	-0.8	1.7
Ulcerative Colitis	0.6	0.8	2.3	-1.5	-0.1	1.2	0.9	1.1	0.2
Supplements: Zinc	0.6	0.6	1.9	-0.3	-0.6	0.5	-1.4	-1.0	0.9
Townsend deprivation index at recruitment	0.6	0.9	2.3	1.5	0.3	-1.0	0.1	-1.3	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.9	-1.4	-0.6	1.4	-1.0	-0.2	0.6
High blood pressure	0.6	1.6	4.9	-0.2	-1.9	1.4	0.7	0.1	2.2
High blood pressure (mother)	0.6	0.8	2.2	0.9	-1.1	-1.5	-0.4	-1.3	0.2
Father’s age at death	0.6	0.8	3.8	1.2	2.0	-0.1	0.7	0.3	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.7	-1.1	-0.1	0.6	1.0	1.7	-0.1
Length of working week for main job	0.6	0.7	2.5	0.6	-0.7	-0.1	-1.6	-1.2	0.1
Shortness of breath walking on level ground	0.6	0.7	2.4	-0.1	0.2	0.5	1.5	1.5	0.6
Migraine (self-reported)	0.6	0.8	3.1	-1.8	-0.0	1.4	-0.5	0.5	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.2	0.5	-0.5	-0.9	-0.6	-1.5	-0.7
Back pain experienced in last month	0.6	0.9	2.9	-1.1	0.0	1.7	-0.1	1.1	1.1
Illnesses of father: None of the above (group 1)	0.6	0.8	2.8	1.7	0.8	-1.0	1.1	-0.1	0.3
Average weekly champagne plus white wine intake	0.6	0.9	2.6	-1.6	-1.0	0.4	0.6	1.4	0.1
Medication: Atorvastatin	0.6	0.7	1.9	0.7	-0.8	-0.1	-1.4	-1.3	0.1
Alcohol drinker status: Previous	0.6	0.7	1.3	-1.1	-1.1	0.8	0.2	0.6	1.1
Schizophrenia vs Biploar Disorder	0.5	0.7	2.2	-0.3	-1.5	0.4	-1.0	-0.7	0.9
Ovarian Cancer	0.5	0.6	1.5	0.8	0.4	-0.6	-1.2	-1.2	-0.7
Height	0.5	9.8	27.2	-4.8	0.7	2.8	3.2	5.2	-0.5
Systolic Blood Pressure	0.5	2.4	4.2	1.8	2.1	1.1	-2.0	-1.5	1.2
Respiratory disease	0.5	1.1	2.7	0.2	1.5	1.6	-0.8	0.2	-1.4
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.2	-0.6	-1.5	1.1	-1.2	-0.4	1.3
Relative age of first facial hair	0.5	1.0	4.5	-0.5	2.1	0.8	0.1	0.5	-1.1
Medication: Metformin	0.5	0.7	1.8	1.2	-0.6	-0.1	-1.2	-1.3	0.4
Serious illness, injury or assault to yourself	0.5	0.6	2.3	-0.5	0.2	1.5	0.8	1.0	-0.0
Lung cancer (father)	0.5	0.6	2.1	0.3	-1.0	-1.5	-0.6	-0.5	-0.6
Peak expiratory flow (PEF)	0.5	1.2	4.4	-1.3	-2.1	0.4	0.1	-0.2	1.3
Pulse wave reflection index	0.5	0.6	3.0	-1.7	-0.5	0.4	-0.0	0.6	0.6
Headache pain in last month	0.5	0.8	2.9	-1.7	-0.6	0.8	-0.5	1.2	0.4
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	4.4	0.0	-0.1	-2.1	0.3	-0.1	-1.7
Medication: Allopurinol	0.5	0.7	1.8	-1.2	0.5	1.3	0.1	1.0	-0.2
Hypertension (Self-reported)	0.5	1.5	4.8	-0.3	-1.6	1.5	0.7	0.2	2.2
Illnesses of father: Heart disease	0.5	0.6	3.5	-1.9	-0.7	0.4	-0.4	0.0	-0.5
Mean Putamen Volume	0.4	0.4	1.4	-1.2	-0.7	0.0	0.4	0.9	0.4
Primary Biliary Cirrhosis	0.4	0.6	1.9	-0.5	0.6	1.4	0.6	1.0	-0.4
Lung FVC	0.4	1.9	4.7	-0.2	1.1	-2.0	2.2	0.8	-1.7
Hair Pigment	0.4	12.1	35.0	4.0	3.9	-5.9	-0.8	-1.8	-3.8
Hearing difficulty/problems: Yes	0.4	0.6	2.1	0.4	0.2	-1.2	0.8	0.4	-1.5
Severe depression (siblings)	0.4	0.4	0.9	-1.0	-0.8	0.0	0.5	0.7	0.9
Average weekly fortified wine intake	0.4	0.5	1.4	0.7	1.2	-0.7	0.4	0.3	-0.7
Alcohol usually taken with meals	0.4	0.7	1.9	-1.1	-0.5	0.7	0.8	1.4	0.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.0	-0.9	-0.5	1.0	-0.9	-0.8	-0.4
Pain all over the body in last month	0.4	0.4	1.2	-0.3	0.5	0.6	0.7	1.1	-0.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.4	-0.3	0.0	1.5	-0.9	0.1	0.4
Medication: Ramipril	0.4	0.5	1.4	-0.9	0.3	1.2	0.7	0.7	0.4
Noisy workplace	0.4	0.5	2.0	1.4	0.2	-0.3	-0.7	-0.5	0.8
Asthma	0.4	0.9	5.3	-0.3	0.7	2.3	-0.3	0.3	-0.0
Medication: Lansoprazole	0.4	0.5	2.4	-0.4	0.5	1.5	-0.6	-0.6	-0.0
Prospective memory result	0.4	0.5	1.1	-0.4	0.1	1.0	0.8	1.1	0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.7	0.6	1.3	-0.3	1.1	1.0	-0.4
Medication: Amlodipine	0.4	0.6	1.9	0.5	-1.4	-0.8	-0.4	-0.9	0.5
Leg fat percentage (right)	0.4	1.5	3.3	-0.6	-1.8	1.8	-1.1	-1.3	0.7
Health satisfaction	0.4	0.6	1.7	-0.7	-1.1	1.3	-0.6	-0.1	0.2
Overall health rating	0.4	0.8	3.1	-1.2	-0.0	1.8	-1.0	-0.1	0.0
Leg pain on walking	0.4	0.5	2.3	1.5	-0.6	-0.5	-0.2	-0.6	0.2
Knee pain experienced in last month	0.4	0.6	1.7	0.6	-0.3	-0.7	-1.3	-0.9	-1.0
Loneliness, isolation	0.4	0.5	1.9	-0.4	0.8	0.3	0.6	0.4	-1.4
Medication for cholesterol	0.4	0.6	1.8	-0.9	-0.6	-0.3	1.2	1.4	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.3	-0.2	0.7	1.2	0.6	0.8	0.3
Asthma (self-reported)	0.4	0.8	4.9	-0.3	0.6	2.2	-0.3	0.3	0.1
Medication: Gliclazide	0.4	0.4	1.4	-0.0	-1.2	-0.1	-0.7	-0.9	0.3
Financial situation satisfaction	0.4	0.5	1.7	-1.2	-1.3	0.4	0.1	0.0	-0.7
Leg fat percentage (left)	0.4	1.6	3.9	-0.7	-1.9	2.0	-1.0	-1.2	0.9
Age started oral contraceptive pill	0.4	0.5	1.6	0.8	0.5	-0.0	-0.7	-1.3	-0.5
Unable to work because of sickness or disability	0.4	0.6	1.6	-0.1	0.1	0.5	1.3	1.3	0.7
Commuting to job workplace: Cycle	0.4	0.5	1.6	-0.4	-1.2	0.2	-0.3	-0.4	1.3
HbA1C	0.3	0.3	0.6	-0.7	-0.7	0.8	-0.6	-0.3	-0.3
LDL Cholesterol	0.3	0.5	1.1	0.6	-1.0	0.5	-0.7	-1.0	0.3
Triglycerides	0.3	0.5	2.7	-0.2	0.0	1.7	-0.8	0.1	0.2
Blood Red Count	0.3	2.9	9.8	-1.8	1.7	-1.0	1.3	1.3	-3.1
Tanning	0.3	3.3	7.8	2.0	1.5	-2.8	-1.4	-2.1	-1.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.0	0.6	-1.0	0.6	-0.6	-0.6	0.4
Diabetes (father)	0.3	0.3	1.4	-0.5	-0.2	0.1	-1.2	-0.5	-0.6
Medication: Levothyroxine sodium	0.3	0.6	2.6	1.0	-0.2	-1.6	0.2	-0.4	-0.5
Hearing difficulty/problems with background noise	0.3	0.5	1.6	1.3	-0.4	0.4	-0.6	-0.6	1.0
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	-1.1	-0.3	-0.5	-1.1	-0.4	-0.2
Breastfed as a baby	0.3	0.4	1.3	-0.8	1.1	0.4	0.3	0.7	-0.3
Gout (self-reported)	0.3	0.5	1.2	0.2	0.4	0.9	1.1	1.0	0.4
Wheeze or whistling in the chest in last year	0.3	0.5	2.7	0.5	0.1	1.6	0.0	0.4	0.8
Mineral and other dietary supplements	0.3	0.3	1.6	-0.1	-1.2	-0.4	0.4	-0.5	0.5
Hearing aid user	0.3	0.3	1.0	0.6	0.4	-1.0	-0.3	-0.5	-0.0
Medication: Blood pressure	0.3	0.5	1.6	0.1	-1.0	0.5	0.8	0.1	1.3
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.8	-0.6	-0.0	-0.0	0.8	0.8	-0.9
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.9	0.4	1.4	-1.1	-0.8	-0.2	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.1	1.1	-0.1	-0.1	-0.2	-0.8	1.0
HDL Cholesterol	0.2	0.4	0.9	0.6	0.8	-0.6	1.0	0.6	0.3
Blood Platelet Count	0.2	2.8	8.9	-1.8	-0.8	-1.2	3.0	2.4	0.2
Relative age voice broke	0.2	0.3	1.4	-0.1	0.7	-0.0	0.4	0.3	-1.2
Had other major operations	0.2	0.3	0.6	0.4	-0.4	0.8	-0.5	-0.8	0.2
Illnesses of siblings	0.2	0.2	0.7	0.7	0.5	-0.2	-0.8	-0.1	-0.1
Medication: Cholesterol lowering	0.2	0.4	1.0	-0.1	-0.7	-0.0	-1.0	-0.9	0.5
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	0.3	0.8	0.5	0.1	0.0	-0.8
Blood clot in the leg (DVT)	0.2	0.3	0.7	0.6	-0.4	-0.1	-0.3	-0.8	0.7
Emphysema/chronic bronchitis	0.2	0.3	0.6	0.8	0.7	0.3	-0.7	0.1	-0.3
Heart disease (mother)	0.2	0.2	0.6	-0.1	-0.7	0.0	-0.1	-0.5	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.0	0.1	-1.0	-0.1	-0.3	0.2	0.6
Supplements: Vitamin C	0.2	0.2	0.7	-0.2	0.4	-0.3	-0.8	-0.0	-0.7
Osteoarthritis (self-reported)	0.2	0.3	1.0	-1.0	0.1	0.9	-0.2	0.4	-0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.0	-0.7	0.3	0.3	-0.7	0.4	-1.0
Medication: Bendroflumethiazide	0.2	0.2	1.0	1.0	0.2	-0.3	0.1	-0.3	0.7
Pain experienced in last month	0.2	0.3	1.0	1.0	0.2	-0.2	1.0	-0.2	0.6
Lupus	0.1	0.2	0.6	-0.3	0.3	0.7	-0.0	0.2	-0.6
Blood White Count	0.1	1.0	2.4	-0.1	-1.5	-0.9	-0.6	-1.4	-1.2
Hand grip strength (left)	0.1	0.3	1.0	-0.4	-0.1	-1.0	-0.2	-0.8	-0.2
Hand grip strength (right)	0.1	0.3	1.3	-0.5	-0.4	-1.1	0.1	-0.5	-0.0
Alcohol intake versus 10 years previously	0.1	0.1	0.3	-0.6	0.3	0.3	-0.4	0.3	-0.1
Comparative height size at age 10	0.1	0.7	2.7	-1.3	0.7	0.4	0.3	1.6	-0.1
Fractured/broken bones in last 5 years	0.1	0.1	0.4	-0.1	-0.1	0.2	-0.6	-0.5	-0.1

Hub : Genes

SLC25A17

Models

Trait associations