TWAS hub - RANGAP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.070	0.0370	1.7e-03	0.022	NA	0.024	NA	0.025	0.0130	NA	8.9e-03	NA	8.6e-03
2	GTEx	Nerve Tibial	0.521	0.0722	1.3e-10	0.017	NA	0.167	NA	0.125	0.0210	NA	6.2e-12	NA	3.9e-09
3	TCGA	Stomach Adenocarcinoma	0.190	0.0890	6.0e-04	0.035	0.038	0.046	NA	0.023	0.0013	0.00093	2.8e-04	NA	7.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Mood swings	12.3	22.2	36.6	-6.0	1.0	5.4
Neuroticism (Nagel 2018)	11.6	27.3	44.5	-6.7	1.4	6.0
Worry (Nagel 2018)	11.4	24.0	31.4	-5.6	3.3	5.4
Neuroticism (2016)	9.9	14.3	21.5	-4.1	2.0	4.6
Tense / ‘highly strung’	9.4	15.6	27.6	-5.3	1.8	4.0
Irritability	9.4	15.9	27.3	-5.2	0.1	4.5
Neuroticism score	9.2	19.1	30.1	-5.5	2.0	4.8
Current tobacco smoking	9.0	14.7	23.3	4.8	0.2	-4.6
Neuroticism	8.8	21.2	38.1	-6.2	1.6	4.8
Worrier / anxious feelings	8.6	16.2	26.2	-4.3	2.1	5.1
Frequency of tiredness / lethargy in last 2 weeks	7.3	11.8	21.7	-4.7	1.7	3.3
Smoking status: Current	7.3	11.6	18.9	4.4	0.3	-4.0
Bipolar Disorder or Schizophrenia	6.6	16.1	28.1	-4.0	2.0	5.3
Nervous feelings	6.6	12.2	18.9	-3.9	1.7	4.3
Seen a psychiatrist for nerves, anxiety, tension or depression	6.6	8.5	15.1	-3.9	0.8	3.1
Basal cell carcinoma (self-reported)	5.9	7.1	11.1	-3.3	0.9	3.1
Allergy or Eczema	5.8	15.3	25.5	-5.1	-1.1	4.4
Schizophrenia (2018)	5.1	10.7	19.2	-3.6	0.3	4.4
Number of full sisters	5.0	6.1	10.4	3.2	-0.5	-2.8
Sensitivity / hurt feelings	4.8	8.2	14.0	-3.3	-0.2	3.7
Glaucoma (self-reported)	4.8	5.7	10.4	-2.5	-0.6	3.2
Taking other prescription medications	4.7	7.2	10.6	-3.1	1.1	3.3
Number of incorrect matches in round	4.7	7.9	13.3	-1.8	2.7	3.6
Blood Eosinophil Count	4.6	35.3	56.7	-7.5	2.0	6.7
Maternal smoking around birth	4.6	6.6	9.8	3.0	-1.1	-3.1
Number of self-reported non-cancer illnesses	4.6	8.0	15.8	-4.0	-0.3	2.8
Schizophrenia (2014)	4.5	9.9	18.1	-3.4	0.1	4.3
Allergy	4.5	10.4	19.8	4.5	1.6	-3.0
Heel bone mineral density (BMD) T-score, automated (left)	4.4	10.1	17.2	-4.2	0.3	3.6
Depressed Affect (Nagel 2018)	4.3	9.1	20.5	-4.5	0.1	2.6
Smoking Status	4.1	9.8	14.7	3.8	0.3	-3.8
Medication: Ventolin 100micrograms inhaler	4.0	5.1	10.1	-3.2	-0.7	2.2
Guilty feelings	4.0	5.9	9.5	-2.7	0.9	3.1
Bipolar Disorder (2018)	3.9	6.2	9.1	-2.0	2.4	3.0
Alzheimer’s Disease (including proxy)	3.9	5.7	9.0	-2.8	-0.3	3.0
Heel bone mineral density (BMD) T-score, automated (right)	3.9	9.0	12.6	-3.5	1.5	3.5
Number of treatments/medications taken	3.8	6.8	12.7	-3.6	-0.6	2.7
Depression (self-reported)	3.8	4.6	6.4	-2.5	1.1	2.5
Suffer from ‘nerves’	3.8	6.0	7.7	-2.7	1.8	2.8
Average weekly beer plus cider intake	3.8	5.5	8.8	2.8	0.1	-3.0
Diabetes (mother)	3.6	4.7	8.8	3.0	-0.1	-2.3
Eye problems/disorders: Glaucoma	3.6	4.3	7.4	-2.3	-0.5	2.7
Wears glasses or contact lenses	3.5	4.0	5.3	-2.3	-1.3	2.3
Worry too long after embarrassment	3.4	5.7	8.1	-2.8	1.4	2.6
Medication for pain relief, constipation, heartburn	3.4	5.9	10.4	3.2	-0.1	-2.7
Alcohol intake frequency.	3.4	7.9	13.7	-3.7	1.6	2.7
Hayfever, allergic rhinitis or eczema	3.3	7.2	12.3	-3.5	-1.3	2.8
Serious illness, injury or assault of a close relative in last 2 years	3.2	3.7	5.2	1.7	-2.3	-1.7
Trunk fat percentage	3.1	12.3	24.8	-5.0	0.2	3.5
Comparative body size at age 10	3.1	8.6	17.6	4.2	2.8	-0.3
Alcohol drinker status: Never	3.1	3.7	6.1	-1.4	2.5	1.7
Supplements: Calcium	3.1	3.4	5.5	-2.3	-1.3	1.8
Vitamin and mineral supplements	3.0	4.0	5.3	2.3	1.9	-1.8
Chest pain or discomfort	2.9	4.1	7.3	-2.7	-0.2	2.2
Age at last live birth	2.9	4.2	6.5	-2.6	0.9	2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.8	3.7	6.8	-1.3	2.6	1.6
Mouth/teeth dental problems: Dentures	2.8	4.7	8.5	1.9	-1.4	-2.9
Mouth/teeth dental problems: Loose teeth	2.8	3.3	6.7	2.6	0.4	-1.8
Verbal and Numeric Reasoning (VNR)	2.7	6.4	6.7	2.6	-2.4	-2.5
Happiness	2.7	3.3	5.4	-2.3	-0.3	2.1
Asthma	2.7	5.3	12.1	-3.5	-1.1	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	2.7	4.1	7.6	-2.8	-0.8	2.0
Hair/balding pattern: Pattern 4	2.7	6.6	13.8	3.7	2.1	-1.3
Neck or shoulder pain in last month	2.7	3.8	5.2	-2.3	-1.1	2.3
Intelligence (Savage-Jansen 2018)	2.6	7.9	12.3	2.7	-2.0	-3.5
Hypothyroidism (self reported)	2.6	5.9	11.9	3.4	-1.0	-2.2
Fed-up feelings	2.6	4.7	12.1	-3.5	0.3	1.4
Time employed in main current job	2.6	3.0	6.2	0.2	1.7	2.5
Impedance of arm (left)	2.6	12.0	33.4	-5.8	-0.2	1.6
Family relationship satisfaction	2.6	3.2	5.5	-2.4	-0.9	1.8
Respiratory disease	2.4	5.4	15.1	-3.9	-0.7	0.8
Multivitamins +/- minerals	2.4	3.0	4.5	-2.1	-1.6	1.4
Asthma (self-reported)	2.4	4.7	11.3	-3.4	-0.8	1.5
Commuting to job workplace: Public transport	2.4	2.9	5.2	2.3	0.7	-1.7
Body Mass Index (BMI) (2010)	2.3	3.2	6.0	-2.5	-0.4	1.9
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	3.2	-1.2	1.7	1.8
Trunk fat mass	2.3	10.1	18.6	-4.3	-0.1	3.4
Body fat percentage	2.3	9.0	16.8	-4.1	0.7	3.1
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	5.7	-2.4	0.2	1.7
Average weekly spirits intake	2.2	2.7	3.7	1.9	-1.7	-1.2
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	4.5	-2.1	1.8	1.6
Crohns Disease (2017)	2.1	4.6	10.6	-3.2	-0.3	1.8
Heel T-Score	2.1	17.1	29.2	-5.4	-0.4	4.7
Impedance of arm (right)	2.1	10.0	27.2	-5.2	0.1	1.7
Medication: Lansoprazole	2.1	2.4	4.1	-2.0	-0.2	1.8
Mouth/teeth dental problems: Mouth ulcers	2.1	3.3	6.4	-1.6	0.9	2.5
Tinnitus: Yes, now most or all of the time	2.1	2.4	4.6	-1.0	-2.2	1.2
Pulse wave Arterial Stiffness index	2.0	2.4	4.5	-1.0	-2.1	1.3
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	4.3	-2.1	0.9	1.7
Long-standing illness, disability or infirmity	2.0	3.0	4.4	-2.0	0.8	2.1
Rheumatoid Arthritis	1.9	2.6	4.8	2.2	-1.0	-1.4
Hayfever/allergic rhinitis (self-reported)	1.9	2.6	4.7	-2.2	-1.5	0.9
Age at first live birth	1.9	3.3	7.2	-1.6	0.3	2.7
Smoking status: Previous	1.9	2.9	4.6	-2.0	0.1	2.1
Irritable Bowel Disease (IBD)	1.8	4.3	9.2	-3.0	0.0	1.9
Coronary Artery Disease (CAD)	1.8	2.1	2.9	1.7	-1.2	-1.4
Arm fat percentage (right)	1.8	6.9	13.1	-3.6	1.0	2.6
Arm fat percentage (left)	1.8	7.2	14.6	-3.8	0.8	2.5
Pack years of smoking	1.8	2.6	4.3	2.1	0.0	-1.9
Pack years adult smoking proportion	1.7	2.6	4.0	2.0	0.0	-2.0
Pulse wave peak to peak time	1.7	2.0	4.7	0.7	2.2	-0.9
Whole body fat mass	1.7	7.1	12.0	-3.5	0.3	3.0
Overall health rating	1.7	3.6	7.0	-2.6	0.5	1.9
Average weekly red wine intake	1.7	2.4	3.4	1.9	-0.8	-1.8
Impedance of whole body	1.7	8.5	23.0	-4.8	-0.6	1.4
Alzheimer’s Disease (in father)	1.6	1.8	3.1	-1.8	-1.5	0.3
Hair/balding pattern: Pattern 2	1.6	2.0	5.0	0.0	-2.2	-1.0
Hip circumference	1.6	6.8	11.3	-2.6	1.5	3.4
Alcohol intake versus 10 years previously	1.6	2.4	5.5	-0.9	-2.3	-0.9
Miserableness	1.6	2.9	5.3	-2.3	0.6	1.7
Crohns Disease (2012)	1.5	2.5	5.6	-2.4	-0.0	1.3
Frequency of depressed mood in last 2 weeks	1.5	2.1	2.5	-1.6	1.1	1.6
Serious illness, injury or assault to yourself	1.5	1.8	3.3	-1.8	-0.7	1.3
Lung cancer (father)	1.5	1.7	3.9	2.0	-0.6	-1.0
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	5.9	2.4	-1.1	-1.3
Mineral and other dietary supplements	1.5	2.0	3.8	1.0	1.9	-1.1
Ever depressed for a whole week	1.5	1.8	3.1	-1.8	-0.8	1.3
Primary Biliary Cirrhosis	1.4	2.0	4.5	-2.1	-1.1	0.6
Arm fat mass (right)	1.4	5.8	10.0	-3.2	0.3	2.7
Length of working week for main job	1.4	1.6	4.4	-0.5	-2.1	-0.4
Headache pain in last month	1.4	2.3	4.3	-1.5	-2.1	0.7
Health satisfaction	1.4	1.8	3.7	-1.9	-0.4	1.3
Mean time to correctly identify matches	1.4	2.6	5.8	2.4	-0.1	-1.4
Back pain experienced in last month	1.4	2.1	3.8	-1.3	-0.8	2.0
Osteoarthritis (self-reported)	1.4	1.9	2.7	-1.6	-0.6	1.6
Supplements: Fish oil (including cod liver oil)	1.4	1.9	3.3	-1.4	-1.8	0.6
Myopia	1.4	2.0	3.6	1.9	0.3	-1.5
Prostate Cancer	1.3	1.9	3.3	-1.4	-0.6	1.8
Age at First Birth	1.3	2.0	4.2	-1.2	0.3	2.1
Pain all over the body in last month	1.3	1.4	2.8	-1.2	1.7	0.2
Number of full brothers	1.3	1.7	3.7	1.0	0.5	-1.9
Wheeze or whistling in the chest in last year	1.3	2.3	5.7	-2.4	0.0	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.0	0.6	1.7	1.0
Eye problems/disorders: None of the above	1.3	1.5	2.9	1.7	0.4	-1.2
Migraine (self-reported)	1.3	1.6	2.9	-1.7	-0.2	1.4
Arm fat mass (left)	1.3	5.2	9.4	-3.1	0.2	2.5
Alcohol drinker status: Previous	1.3	1.5	2.4	-1.2	0.8	1.5
Supplements: Glucosamine	1.2	1.5	3.4	1.0	-1.9	-0.2
Medication: Levothyroxine sodium	1.2	2.0	5.6	2.4	-0.0	-0.6
Fluid intelligence score	1.2	2.4	3.1	1.6	-1.3	-1.7
Hair/balding pattern: Pattern 3	1.2	1.7	2.5	-1.1	1.6	1.2
Qualifications: nursing, teaching	1.2	1.9	3.1	-1.8	-1.6	-0.4
Eye problems/disorders: Cataract	1.2	1.4	2.5	-1.6	-0.2	1.3
Average weekly champagne plus white wine intake	1.2	1.7	3.2	-1.3	-1.8	0.1
Depression (Nagel 2018)	1.1	1.6	2.1	-1.1	1.4	1.3
Triglycerides	1.1	1.8	3.3	-1.8	-0.4	1.4
Lung FEV1/FVC ratio	1.1	5.6	6.8	-2.0	2.6	2.4
Hand grip strength (left)	1.1	2.9	6.9	1.0	-2.6	-0.7
Hand grip strength (right)	1.1	2.9	5.5	1.5	-2.3	-0.9
Medication: Atenolol	1.1	1.4	3.7	0.2	-1.9	-0.7
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.9	-1.7	-0.9	0.5
Financial difficulties in last 2 years	1.1	1.4	2.3	1.5	0.3	-1.4
Medication: Ramipril	1.1	1.4	2.9	-1.7	0.8	0.8
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	5.0	0.5	-2.2	-0.3
Exposure to tobacco smoke outside home	1.1	1.5	2.8	1.7	-0.4	-1.2
Diabetes diagnosed by doctor	1.1	1.9	2.9	-1.1	1.7	1.2
Breast cancer (self-reported)	1.1	1.4	2.2	-1.0	-1.5	1.0
Illnesses of father: High blood pressure	1.1	1.3	2.5	-1.0	0.6	1.6
Risk taking	1.1	1.6	3.0	1.3	0.2	-1.7
Alzheimer’s Disease (in mother)	1.0	1.2	1.7	-1.0	0.8	1.3
Ulcerative Colitis (UC)	1.0	1.8	4.0	-2.0	-0.1	1.1
Type 2 Diabetes (T2D) (2018)	1.0	1.8	3.3	-1.8	1.0	1.0
Townsend deprivation index at recruitment	1.0	1.4	2.6	1.0	1.6	-0.8
Sitting height	1.0	6.7	19.6	-0.7	-4.4	-0.4
Qualifications: None of the above	1.0	2.2	4.3	1.3	2.1	-0.7
Heart attack	1.0	1.2	1.8	-1.4	-0.3	1.3
Medication: Paracetamol	1.0	1.6	2.6	-1.4	0.5	1.6
Medication: Allopurinol	1.0	1.4	2.4	-1.5	-0.8	1.1
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.9	-0.1	-1.7	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	1.5	0.5	1.2	-1.2
Osteoporosis (self-reported)	1.0	1.3	2.3	-1.0	-0.7	1.5
Illnesses of father: None of the above (group 1)	1.0	1.3	3.2	1.8	-0.1	-0.8
Medication: Paracetamol	1.0	1.5	1.8	-1.4	0.9	1.3
Ever had prostate specific antigen (PSA) test	1.0	1.1	1.7	-0.7	-1.1	1.3
Fasting Glucose	0.9	1.1	2.6	-0.7	-1.6	0.3
Height	0.9	17.6	37.8	-3.7	-6.2	1.0
Waist Hip Ratio (WHR)	0.9	4.2	9.6	-0.7	-3.1	-1.6
Cardiovascular Disease	0.9	3.0	3.5	-1.9	1.6	1.8
Hearing difficulty/problems: Yes	0.9	1.3	2.0	1.2	-1.4	-0.7
Angina	0.9	1.1	1.9	-1.4	-1.2	0.3
High blood pressure (mother)	0.9	1.3	2.6	1.1	0.3	-1.6
Had other major operations	0.9	1.1	2.2	-1.5	0.1	1.0
Weight	0.9	4.2	6.5	-2.6	-0.5	2.4
Breastfed as a baby	0.9	1.2	1.8	-1.4	-1.3	0.3
Pulse wave reflection index	0.9	1.1	1.6	-0.6	-1.3	1.2
Leg fat percentage (right)	0.9	3.3	4.8	-2.1	0.7	2.2
Medication: Ibuprofen	0.9	1.1	1.8	-1.2	-1.3	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.7	-0.7	-1.6	-0.2
Ever had bowel cancer screening	0.9	1.1	1.9	-1.1	-0.1	1.4
Ever taken oral contraceptive pill	0.9	1.0	2.2	1.5	0.1	-0.9
Mother’s age at death	0.9	1.1	1.9	1.4	0.1	-1.2
Leg fat percentage (left)	0.9	3.4	5.1	-2.2	0.5	2.3
Reaction Time	0.8	1.6	2.7	1.7	-0.3	-1.4
Ulcerative Colitis	0.8	1.1	2.4	-1.6	-0.4	0.8
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.0	0.3	-1.0	-1.4
Age when periods started (menarche)	0.8	1.9	5.3	-0.5	-0.4	2.3
Prospective memory result	0.8	1.0	1.9	-0.6	1.4	0.8
Standing height	0.8	7.5	12.7	-3.6	-2.6	1.6
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.0	0.2	-1.4	-1.3
High blood pressure (siblings)	0.8	1.2	2.6	-0.8	1.6	0.6
Medication: Blood pressure	0.8	1.5	2.7	-0.4	1.3	1.6
Medication: Omeprazole	0.8	0.9	2.0	-1.4	0.0	0.8
Leg fat mass (right)	0.8	3.0	5.1	-1.9	0.3	2.3
Hearing aid user	0.8	0.9	1.0	1.0	-0.8	-1.0
Diastolic blood pressure, automated reading	0.8	2.4	3.7	-1.5	1.0	1.9
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.5	-1.2	-0.8	1.0
Leg fat mass (left)	0.8	3.3	5.5	-2.1	0.3	2.3
Bipolar Disorder (2011)	0.7	0.7	1.0	-0.8	-0.6	1.0
Lung FVC	0.7	3.6	5.9	2.1	0.7	-2.4
Chronotype (morning person)	0.7	1.6	2.6	-1.5	0.4	1.6
Hair Pigment	0.7	19.3	34.8	4.7	-0.7	-5.9
Relative age of first facial hair	0.7	1.4	3.4	-1.8	-0.9	-0.0
Medication: Metformin	0.7	1.0	2.6	0.6	1.6	0.2
Average weekly fortified wine intake	0.7	0.8	1.6	0.7	-1.3	-0.6
Stomach or abdominal pain in last month	0.7	0.9	1.5	-1.2	0.1	1.0
Chronic bronchitis/emphysema (father)	0.7	0.8	2.3	-0.3	0.1	-1.5
Alcohol usually taken with meals	0.7	1.2	1.8	-1.3	-1.1	0.7
Loud music exposure frequency	0.7	0.7	2.1	0.3	1.4	-0.1
Number of children fathered	0.7	0.8	1.3	1.1	-0.5	-0.9
Pulse rate, automated reading	0.7	2.2	2.9	-1.3	1.5	1.7
Financial situation satisfaction	0.7	0.8	2.3	-1.5	0.2	-0.2
Ever had hysterectomy (womb removed)	0.6	0.7	1.1	-0.8	1.0	0.6
Waist circumference	0.6	2.4	3.9	-2.0	-0.1	1.8
Had menopause	0.6	0.7	1.3	0.9	-0.3	-1.1
Falls in the last year	0.6	0.8	1.3	-1.0	-0.1	1.1
Number of live births	0.6	0.9	1.8	-0.2	1.3	-0.8
Emphysema/chronic bronchitis	0.6	0.7	1.6	-1.3	-0.5	0.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.3	0.1	0.9	1.2
Loneliness, isolation	0.6	0.8	2.2	-1.5	0.5	-0.3
Medication: Gliclazide	0.6	0.6	1.6	0.5	1.3	0.2
Breast Cancer	0.5	1.2	2.9	0.1	1.7	-0.9
HbA1C	0.5	0.6	0.9	-1.0	0.0	0.9
HDL Cholesterol	0.5	0.8	2.0	1.4	0.6	-0.3
Supplements: Zinc	0.5	0.6	1.1	-0.4	1.1	0.7
Impedance of leg (left)	0.5	2.3	5.8	-2.4	-1.0	0.5
Noisy workplace	0.5	0.7	1.3	0.8	1.2	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.0	-1.0	-1.0	0.1
Illnesses of mother	0.5	0.6	1.1	0.9	-1.0	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	3.8	-2.0	-0.9	0.7
Birth weight of first child	0.5	0.9	1.9	-0.8	1.4	0.3
Medication: Amlodipine	0.5	0.7	1.6	1.3	0.4	-0.6
Angina (self-reported)	0.5	0.7	1.2	-1.0	-1.1	0.0
Medication: Seretide 50 evohaler	0.5	0.5	0.7	-0.5	0.8	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.2	-0.3	-0.8	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.5	0.4	-1.2	0.3
Supplements: Vitamin C	0.5	0.6	1.7	-0.0	-1.3	0.2
Hypertension (Self-reported)	0.5	1.3	1.6	-1.0	1.2	1.3
Friendships satisfaction	0.5	0.6	1.0	-0.8	-0.5	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.0	-0.9	0.1	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.1	-0.7	1.5	-0.9
Pain type(s) experienced in last month: Hip pain	0.5	0.6	0.9	0.6	-1.0	0.8
Pain experienced in last month	0.5	0.8	1.4	0.6	1.2	-0.8
Major Depression (MDD)	0.4	0.4	0.6	-0.8	0.6	0.6
LDL Cholesterol	0.4	0.6	1.6	0.3	-0.2	1.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.8	-0.6	0.6	0.9
Impedance of leg (right)	0.4	2.0	5.1	-2.3	-0.9	0.4
Relative age voice broke	0.4	0.6	1.6	-0.3	-1.3	-0.4
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.1	-1.1	0.2	-0.3
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.8	-0.8	0.9	-0.3
Qualifications: College or University degree	0.4	1.4	2.3	-0.7	-1.5	1.2
Comparative height size at age 10	0.4	1.9	4.0	-1.3	-2.0	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.2	-1.5	-0.6	0.1
High cholesterol (Self-reported)	0.4	0.6	0.9	0.9	0.9	-0.5
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	-0.5	-0.9	-0.2
Tanning	0.3	3.8	4.9	2.0	-1.6	-2.2
Diabetes (father)	0.3	0.4	0.7	-0.5	-0.5	0.9
Severe depression (siblings)	0.3	0.4	0.8	0.4	0.9	-0.5
Leg fat-free mass (left)	0.3	1.7	2.6	-1.6	-0.1	1.6
Qualifications: CSEs or equivalent	0.3	0.4	0.8	0.9	0.3	-0.4
High blood pressure	0.3	1.0	1.5	-0.6	1.2	1.0
Body mass index (BMI)	0.3	1.4	2.8	-1.0	0.7	1.7
Leg predicted mass (left)	0.3	1.7	2.7	-1.6	-0.1	1.6
Past tobacco smoking	0.3	0.6	1.1	0.9	-0.3	-1.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.4	-1.6	-0.8	0.1
Pulse rate	0.3	0.5	0.7	-0.8	0.7	0.6
Birth weight	0.3	0.7	1.1	-1.1	-0.6	0.8
Forced vital capacity (FVC), Best measure	0.3	1.0	2.1	-0.8	-1.5	-0.3
Knee pain experienced in last month	0.3	0.5	1.0	-0.7	-0.1	-1.0
Illnesses of siblings: Diabetes	0.3	0.4	0.7	-0.9	0.6	0.5
Leg fat-free mass (right)	0.3	1.6	2.5	-1.5	-0.3	1.6
Leg predicted mass (right)	0.3	1.7	2.5	-1.6	-0.2	1.6
Medication: Bendroflumethiazide	0.3	0.5	1.0	0.3	1.0	-0.5
Commuting to job workplace: Cycle	0.3	0.4	1.0	-0.3	1.0	0.3
Cholesterol lowering medication	0.3	0.4	1.3	-1.1	0.0	0.1
Mean Putamen Volume	0.2	0.2	0.3	0.6	-0.4	0.4
Blood Platelet Count	0.2	2.0	3.2	1.8	-0.1	-1.7
Blood Red Count	0.2	2.3	4.8	-0.4	-2.2	-1.4
Systolic Blood Pressure	0.2	1.1	2.1	-0.7	-0.8	1.5
Medication for hormone replacement therapy	0.2	0.2	0.5	0.7	-0.1	-0.2
Medication: Co-codamol	0.2	0.3	0.4	-0.4	-0.4	0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.2	-0.4	-0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	0.3	-0.0	-0.8
Hearing difficulty/problems with background noise	0.2	0.4	0.9	-0.2	-0.4	0.9
Forced vital capacity (FVC)	0.2	0.8	1.5	-0.9	-1.2	-0.5
Diabetes (self-reported)	0.2	0.2	0.3	-0.5	0.6	0.4
Medication: Simvastatin	0.2	0.3	0.8	0.2	0.9	-0.4
Illnesses of siblings	0.2	0.3	0.9	1.0	-0.1	0.3
Medication: Cholesterol lowering	0.2	0.3	0.7	0.2	0.9	0.1
Blood clot in the leg (DVT)	0.2	0.2	0.5	-0.0	0.7	0.3
Heart disease (mother)	0.2	0.2	0.6	-0.2	0.1	-0.8
Had major operations	0.2	0.2	0.6	0.0	-0.3	-0.8
Leg pain on walking	0.2	0.2	0.7	0.2	0.1	-0.8
Medication: Aspirin	0.2	0.3	0.6	-0.5	-0.2	0.8
Illnesses of father: Heart disease	0.2	0.2	0.5	-0.4	-0.2	0.7
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.4	-0.5	0.6
Medication: Atorvastatin	0.2	0.3	0.5	0.5	0.7	-0.2
Basal metabolic rate	0.2	1.2	2.0	-1.1	-0.7	1.4
Number of operations (self-reported)	0.2	0.2	0.4	-0.5	0.6	-0.0
Fractured/broken bones in last 5 years	0.2	0.3	0.9	0.0	-0.9	0.1
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.7	0.6	-0.8	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	0.3	0.8	0.2
Heart disease (siblings)	0.2	0.3	0.5	-0.2	-0.5	-0.7
Ovarian Cancer	0.1	0.1	0.3	0.3	0.1	-0.6
Lupus	0.1	0.1	0.2	-0.5	-0.3	0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.5	-0.1	-0.4
Blood White Count	0.1	0.6	1.7	0.2	-0.3	-1.3
Systolic blood pressure, automated reading	0.1	0.3	0.7	0.2	0.2	0.9
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.4	0.2	0.2
Mouth/teeth dental problems	0.1	0.1	0.2	0.5	-0.1	0.3
Trunk fat-free mass	0.1	0.5	1.3	0.1	-1.2	0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	0.7	0.2	0.1
Trunk predicted mass	0.1	0.4	1.1	0.1	-1.0	0.5
Exposure to tobacco smoke at home	0.1	0.2	0.2	0.3	-0.4	0.5
Gout (self-reported)	0.1	0.2	0.4	-0.7	-0.1	0.3
Arm fat-free mass (right)	0.1	0.5	1.0	0.3	-1.0	0.5
Shortness of breath walking on level ground	0.1	0.1	0.2	-0.5	-0.4	0.3
Arm predicted mass (right)	0.1	0.4	1.0	0.4	-1.0	0.4
Whole body fat-free mass	0.1	0.6	1.0	-0.5	-0.8	1.0
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	-0.1	0.6	0.1
Medication: Aspirin	0.1	0.1	0.2	-0.3	-0.2	0.4
Whole body water mass	0.1	0.6	0.9	-0.4	-0.8	1.0
Medication: Blood pressure	0.1	0.2	0.4	-0.2	0.6	-0.1
Medication: Lisinopril	0.1	0.2	0.3	-0.4	0.5	-0.1
Arm fat-free mass (left)	0.1	0.6	1.1	0.0	-0.9	1.1
Age started oral contraceptive pill	0.1	0.2	0.4	-0.7	0.2	0.3
Unable to work because of sickness or disability	0.1	0.1	0.3	-0.1	0.6	0.3
Arm predicted mass (left)	0.1	0.5	0.8	0.0	-0.9	0.9
BMI	0.0	0.2	0.4	-0.6	0.3	0.4
Father’s age at death	0.0	0.0	0.1	0.0	-0.3	-0.2
Peak expiratory flow (PEF)	0.0	0.0	0.1	-0.3	-0.1	0.1
Medication for cholesterol	0.0	0.1	0.1	0.4	0.2	-0.1
Ever smoked	0.0	0.1	0.2	-0.4	0.0	0.0

Hub : Genes

RANGAP1

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Trait associations