Hub : Genes

RANGAP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.070 0.0370 1.7e-03 0.022 NA 0.024 NA 0.025 0.0130 NA 8.9e-03 NA 8.6e-03
2 GTEx Nerve Tibial 0.521 0.0722 1.3e-10 0.017 NA 0.167 NA 0.125 0.0210 NA 6.2e-12 NA 3.9e-09
3 TCGA Stomach Adenocarcinoma 0.190 0.0890 6.0e-04 0.035 0.038 0.046 NA 0.023 0.0013 0.00093 2.8e-04 NA 7.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 3.9 6.2 9.1 -2.0 2.4 3.0
Bipolar Disorder or Schizophrenia 6.6 16.1 28.1 -4.0 2.0 5.3
Depressed Affect (Nagel 2018) 4.3 9.1 20.5 -4.5 0.1 2.6
Depression (Nagel 2018) 1.1 1.6 2.1 -1.1 1.4 1.3
Intelligence (Savage-Jansen 2018) 2.6 7.9 12.3 2.7 -2.0 -3.5
Neuroticism (Nagel 2018) 11.6 27.3 44.5 -6.7 1.4 6.0
Schizophrenia (2018) 5.1 10.7 19.2 -3.6 0.3 4.4
Schizophrenia vs Biploar Disorder 0.3 0.4 0.8 -0.5 -0.9 -0.2
Worry (Nagel 2018) 11.4 24.0 31.4 -5.6 3.3 5.4
Alzheimer’s Disease (in mother) 1.0 1.2 1.7 -1.0 0.8 1.3
Alzheimer’s Disease (in father) 1.6 1.8 3.1 -1.8 -1.5 0.3
Alzheimer’s Disease (including proxy) 3.9 5.7 9.0 -2.8 -0.3 3.0
Crohns Disease (2017) 2.1 4.6 10.6 -3.2 -0.3 1.8
Irritable Bowel Disease (IBD) 1.8 4.3 9.2 -3.0 0.0 1.9
Ulcerative Colitis (UC) 1.0 1.8 4.0 -2.0 -0.1 1.1
Major Depression (MDD) 0.4 0.4 0.6 -0.8 0.6 0.6
Reaction Time 0.8 1.6 2.7 1.7 -0.3 -1.4
Verbal and Numeric Reasoning (VNR) 2.7 6.4 6.7 2.6 -2.4 -2.5
Breast Cancer 0.5 1.2 2.9 0.1 1.7 -0.9
Ovarian Cancer 0.1 0.1 0.3 0.3 0.1 -0.6
Prostate Cancer 1.3 1.9 3.3 -1.4 -0.6 1.8
Age at First Birth 1.3 2.0 4.2 -1.2 0.3 2.1
Bipolar Disorder (2011) 0.7 0.7 1.0 -0.8 -0.6 1.0
Body Mass Index (BMI) (2010) 2.3 3.2 6.0 -2.5 -0.4 1.9
Coronary Artery Disease (CAD) 1.8 2.1 2.9 1.7 -1.2 -1.4
Crohns Disease (2012) 1.5 2.5 5.6 -2.4 -0.0 1.3
Mean Putamen Volume 0.2 0.2 0.3 0.6 -0.4 0.4
Fasting Glucose 0.9 1.1 2.6 -0.7 -1.6 0.3
HbA1C 0.5 0.6 0.9 -1.0 0.0 0.9
HDL Cholesterol 0.5 0.8 2.0 1.4 0.6 -0.3
LDL Cholesterol 0.4 0.6 1.6 0.3 -0.2 1.3
Lupus 0.1 0.1 0.2 -0.5 -0.3 0.1
Neuroticism (2016) 9.9 14.3 21.5 -4.1 2.0 4.6
Primary Biliary Cirrhosis 1.4 2.0 4.5 -2.1 -1.1 0.6
Rheumatoid Arthritis 1.9 2.6 4.8 2.2 -1.0 -1.4
Schizophrenia (2014) 4.5 9.9 18.1 -3.4 0.1 4.3
Triglycerides 1.1 1.8 3.3 -1.8 -0.4 1.4
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 0.5 -0.1 -0.4
Ulcerative Colitis 0.8 1.1 2.4 -1.6 -0.4 0.8
Blood Eosinophil Count 4.6 35.3 56.7 -7.5 2.0 6.7
Blood Platelet Count 0.2 2.0 3.2 1.8 -0.1 -1.7
Blood Red Count 0.2 2.3 4.8 -0.4 -2.2 -1.4
Blood White Count 0.1 0.6 1.7 0.2 -0.3 -1.3
Heel T-Score 2.1 17.1 29.2 -5.4 -0.4 4.7
BMI 0.0 0.2 0.4 -0.6 0.3 0.4
Height 0.9 17.6 37.8 -3.7 -6.2 1.0
Waist Hip Ratio (WHR) 0.9 4.2 9.6 -0.7 -3.1 -1.6
Systolic Blood Pressure 0.2 1.1 2.1 -0.7 -0.8 1.5
Smoking Status 4.1 9.8 14.7 3.8 0.3 -3.8
Allergy or Eczema 5.8 15.3 25.5 -5.1 -1.1 4.4
Cardiovascular Disease 0.9 3.0 3.5 -1.9 1.6 1.8
Hypothyroidism (self reported) 2.6 5.9 11.9 3.4 -1.0 -2.2
Respiratory disease 2.4 5.4 15.1 -3.9 -0.7 0.8
Type 2 Diabetes (T2D) (2018) 1.0 1.8 3.3 -1.8 1.0 1.0
Lung FEV1/FVC ratio 1.1 5.6 6.8 -2.0 2.6 2.4
Lung FVC 0.7 3.6 5.9 2.1 0.7 -2.4
Neuroticism 8.8 21.2 38.1 -6.2 1.6 4.8
Chronotype (morning person) 0.7 1.6 2.6 -1.5 0.4 1.6
Hair Pigment 0.7 19.3 34.8 4.7 -0.7 -5.9
Tanning 0.3 3.8 4.9 2.0 -1.6 -2.2
Hand grip strength (left) 1.1 2.9 6.9 1.0 -2.6 -0.7
Number of treatments/medications taken 3.8 6.8 12.7 -3.6 -0.6 2.7
Average weekly spirits intake 2.2 2.7 3.7 1.9 -1.7 -1.2
Sensitivity / hurt feelings 4.8 8.2 14.0 -3.3 -0.2 3.7
Frequency of depressed mood in last 2 weeks 1.5 2.1 2.5 -1.6 1.1 1.6
Hearing difficulty/problems: Yes 0.9 1.3 2.0 1.2 -1.4 -0.7
Relative age of first facial hair 0.7 1.4 3.4 -1.8 -0.9 -0.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 0.8 -0.6 0.6 0.9
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.0 0.3 -1.0 -1.4
Ever had hysterectomy (womb removed) 0.6 0.7 1.1 -0.8 1.0 0.6
Systolic blood pressure, automated reading 0.1 0.3 0.7 0.2 0.2 0.9
Eye problems/disorders: Diabetes related eye disease 2.3 2.5 3.2 -1.2 1.7 1.8
Angina 0.9 1.1 1.9 -1.4 -1.2 0.3
Medication for hormone replacement therapy 0.2 0.2 0.5 0.7 -0.1 -0.2
Vitamin and mineral supplements 3.0 4.0 5.3 2.3 1.9 -1.8
Supplements: Zinc 0.5 0.6 1.1 -0.4 1.1 0.7
Medication: Co-codamol 0.2 0.3 0.4 -0.4 -0.4 0.7
Medication: Metformin 0.7 1.0 2.6 0.6 1.6 0.2
Diabetes (father) 0.3 0.4 0.7 -0.5 -0.5 0.9
Diabetes (mother) 3.6 4.7 8.8 3.0 -0.1 -2.3
Severe depression (siblings) 0.3 0.4 0.8 0.4 0.9 -0.5
Pack years adult smoking proportion 1.7 2.6 4.0 2.0 0.0 -2.0
Impedance of leg (right) 0.4 2.0 5.1 -2.3 -0.9 0.4
Leg fat-free mass (left) 0.3 1.7 2.6 -1.6 -0.1 1.6
Trunk fat percentage 3.1 12.3 24.8 -5.0 0.2 3.5
Hand grip strength (right) 1.1 2.9 5.5 1.5 -2.3 -0.9
Townsend deprivation index at recruitment 1.0 1.4 2.6 1.0 1.6 -0.8
Current tobacco smoking 9.0 14.7 23.3 4.8 0.2 -4.6
Average weekly fortified wine intake 0.7 0.8 1.6 0.7 -1.3 -0.6
Maternal smoking around birth 4.6 6.6 9.8 3.0 -1.1 -3.1
Fed-up feelings 2.6 4.7 12.1 -3.5 0.3 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 2.8 3.7 6.8 -1.3 2.6 1.6
Relative age voice broke 0.4 0.6 1.6 -0.3 -1.3 -0.4
Taking other prescription medications 4.7 7.2 10.6 -3.1 1.1 3.3
Age when periods started (menarche) 0.8 1.9 5.3 -0.5 -0.4 2.3
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.5 -0.2 -0.4 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 4.4 10.1 17.2 -4.2 0.3 3.6
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 0.4 0.2 0.2
Qualifications: CSEs or equivalent 0.3 0.4 0.8 0.9 0.3 -0.4
Serious illness, injury or assault to yourself 1.5 1.8 3.3 -1.8 -0.7 1.3
High blood pressure 0.3 1.0 1.5 -0.6 1.2 1.0
Hayfever, allergic rhinitis or eczema 3.3 7.2 12.3 -3.5 -1.3 2.8
Multivitamins +/- minerals 2.4 3.0 4.5 -2.1 -1.6 1.4
Stomach or abdominal pain in last month 0.7 0.9 1.5 -1.2 0.1 1.0
Supplements: Glucosamine 1.2 1.5 3.4 1.0 -1.9 -0.2
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.6 0.3 -0.0 -0.8
Medication: Atenolol 1.1 1.4 3.7 0.2 -1.9 -0.7
Medication: Levothyroxine sodium 1.2 2.0 5.6 2.4 -0.0 -0.6
Sitting height 1.0 6.7 19.6 -0.7 -4.4 -0.4
Chronic bronchitis/emphysema (father) 0.7 0.8 2.3 -0.3 0.1 -1.5
High blood pressure (mother) 0.9 1.3 2.6 1.1 0.3 -1.6
Body mass index (BMI) 0.3 1.4 2.8 -1.0 0.7 1.7
Impedance of leg (left) 0.5 2.3 5.8 -2.4 -1.0 0.5
Leg predicted mass (left) 0.3 1.7 2.7 -1.6 -0.1 1.6
Trunk fat mass 2.3 10.1 18.6 -4.3 -0.1 3.4
Waist circumference 0.6 2.4 3.9 -2.0 -0.1 1.8
Number of incorrect matches in round 4.7 7.9 13.3 -1.8 2.7 3.6
Past tobacco smoking 0.3 0.6 1.1 0.9 -0.3 -1.0
Alcohol usually taken with meals 0.7 1.2 1.8 -1.3 -1.1 0.7
Nervous feelings 6.6 12.2 18.9 -3.9 1.7 4.3
Frequency of tenseness / restlessness in last 2 weeks 2.2 3.4 4.5 -2.1 1.8 1.6
Hearing difficulty/problems with background noise 0.2 0.4 0.9 -0.2 -0.4 0.9
Hair/balding pattern: Pattern 2 1.6 2.0 5.0 0.0 -2.2 -1.0
Had menopause 0.6 0.7 1.3 0.9 -0.3 -1.1
Had other major operations 0.9 1.1 2.2 -1.5 0.1 1.0
Forced vital capacity (FVC) 0.2 0.8 1.5 -0.9 -1.2 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 3.9 9.0 12.6 -3.5 1.5 3.5
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 2.9 -1.7 -0.9 0.5
Qualifications: None of the above 1.0 2.2 4.3 1.3 2.1 -0.7
Financial difficulties in last 2 years 1.1 1.4 2.3 1.5 0.3 -1.4
Mouth/teeth dental problems 0.1 0.1 0.2 0.5 -0.1 0.3
Heart attack 1.0 1.2 1.8 -1.4 -0.3 1.3
Allergy 4.5 10.4 19.8 4.5 1.6 -3.0
Pain all over the body in last month 1.3 1.4 2.8 -1.2 1.7 0.2
Diabetes (self-reported) 0.2 0.2 0.3 -0.5 0.6 0.4
Hayfever/allergic rhinitis (self-reported) 1.9 2.6 4.7 -2.2 -1.5 0.9
Medication: Ramipril 1.1 1.4 2.9 -1.7 0.8 0.8
Medication: Simvastatin 0.2 0.3 0.8 0.2 0.9 -0.4
Fluid intelligence score 1.2 2.4 3.1 1.6 -1.3 -1.7
Illnesses of siblings 0.2 0.3 0.9 1.0 -0.1 0.3
Neuroticism score 9.2 19.1 30.1 -5.5 2.0 4.8
Weight 0.9 4.2 6.5 -2.6 -0.5 2.4
Impedance of arm (right) 2.1 10.0 27.2 -5.2 0.1 1.7
Arm fat percentage (right) 1.8 6.9 13.1 -3.6 1.0 2.6
Trunk fat-free mass 0.1 0.5 1.3 0.1 -1.2 0.5
Hip circumference 1.6 6.8 11.3 -2.6 1.5 3.4
Time employed in main current job 2.6 3.0 6.2 0.2 1.7 2.5
Alcohol intake versus 10 years previously 1.6 2.4 5.5 -0.9 -2.3 -0.9
Father’s age at death 0.0 0.0 0.1 0.0 -0.3 -0.2
Worrier / anxious feelings 8.6 16.2 26.2 -4.3 2.1 5.1
Frequency of tiredness / lethargy in last 2 weeks 7.3 11.8 21.7 -4.7 1.7 3.3
Falls in the last year 0.6 0.8 1.3 -1.0 -0.1 1.1
Hair/balding pattern: Pattern 3 1.2 1.7 2.5 -1.1 1.6 1.2
Number of live births 0.6 0.9 1.8 -0.2 1.3 -0.8
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.4 -1.6 -0.8 0.1
Pulse rate 0.3 0.5 0.7 -0.8 0.7 0.6
Happiness 2.7 3.3 5.4 -2.3 -0.3 2.1
Noisy workplace 0.5 0.7 1.3 0.8 1.2 0.1
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.5 0.7 0.2 0.1
Serious illness, injury or assault of a close relative in last 2 years 3.2 3.7 5.2 1.7 -2.3 -1.7
Mouth/teeth dental problems: Dentures 2.8 4.7 8.5 1.9 -1.4 -2.9
Asthma 2.7 5.3 12.1 -3.5 -1.1 1.6
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.0 -1.0 -1.0 0.1
Medication: Cholesterol lowering 0.2 0.3 0.7 0.2 0.9 0.1
Depression (self-reported) 3.8 4.6 6.4 -2.5 1.1 2.5
Medication: Lansoprazole 2.1 2.4 4.1 -2.0 -0.2 1.8
Prospective memory result 0.8 1.0 1.9 -0.6 1.4 0.8
Lung cancer (father) 1.5 1.7 3.9 2.0 -0.6 -1.0
Illnesses of mother 0.5 0.6 1.1 0.9 -1.0 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.7 3.8 -2.0 -0.9 0.7
Pulse wave Arterial Stiffness index 2.0 2.4 4.5 -1.0 -2.1 1.3
Impedance of arm (left) 2.6 12.0 33.4 -5.8 -0.2 1.6
Arm fat mass (right) 1.4 5.8 10.0 -3.2 0.3 2.7
Trunk predicted mass 0.1 0.4 1.1 0.1 -1.0 0.5
Standing height 0.8 7.5 12.7 -3.6 -2.6 1.6
Length of working week for main job 1.4 1.6 4.4 -0.5 -2.1 -0.4
Exposure to tobacco smoke at home 0.1 0.2 0.2 0.3 -0.4 0.5
Breastfed as a baby 0.9 1.2 1.8 -1.4 -1.3 0.3
Tense / ‘highly strung’ 9.4 15.6 27.6 -5.3 1.8 4.0
Seen doctor (GP) for nerves, anxiety, tension or depression 2.7 4.1 7.6 -2.8 -0.8 2.0
Hair/balding pattern: Pattern 4 2.7 6.6 13.8 3.7 2.1 -1.3
Birth weight of first child 0.5 0.9 1.9 -0.8 1.4 0.3
Peak expiratory flow (PEF) 0.0 0.0 0.1 -0.3 -0.1 0.1
Pulse wave reflection index 0.9 1.1 1.6 -0.6 -1.3 1.2
Ever highly irritable/argumentative for 2 days 0.4 0.4 1.1 -1.1 0.2 -0.3
Loud music exposure frequency 0.7 0.7 2.1 0.3 1.4 -0.1
Qualifications: O levels/GCSEs or equivalent 1.1 1.8 5.0 0.5 -2.2 -0.3
Mouth/teeth dental problems: Bleeding gums 2.0 2.6 4.3 -2.1 0.9 1.7
Blood clot in the leg (DVT) 0.2 0.2 0.5 -0.0 0.7 0.3
Medication: Paracetamol 1.0 1.6 2.6 -1.4 0.5 1.6
Headache pain in last month 1.4 2.3 4.3 -1.5 -2.1 0.7
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 2.0 0.2 -1.4 -1.3
Glaucoma (self-reported) 4.8 5.7 10.4 -2.5 -0.6 3.2
Gout (self-reported) 0.1 0.2 0.4 -0.7 -0.1 0.3
Hypothyroidism/myxoedema (self-reported) 1.5 2.9 5.9 2.4 -1.1 -1.3
Medication: Amlodipine 0.5 0.7 1.6 1.3 0.4 -0.6
Medication: Ventolin 100micrograms inhaler 4.0 5.1 10.1 -3.2 -0.7 2.2
Birth weight 0.3 0.7 1.1 -1.1 -0.6 0.8
Chronic bronchitis/emphysema (mother) 0.4 0.5 0.8 -0.8 0.9 -0.3
High blood pressure (siblings) 0.8 1.2 2.6 -0.8 1.6 0.6
Forced vital capacity (FVC), Best measure 0.3 1.0 2.1 -0.8 -1.5 -0.3
Body fat percentage 2.3 9.0 16.8 -4.1 0.7 3.1
Leg fat percentage (right) 0.9 3.3 4.8 -2.1 0.7 2.2
Arm fat-free mass (right) 0.1 0.5 1.0 0.3 -1.0 0.5
Exposure to tobacco smoke outside home 1.1 1.5 2.8 1.7 -0.4 -1.2
Comparative body size at age 10 3.1 8.6 17.6 4.2 2.8 -0.3
Number of full brothers 1.3 1.7 3.7 1.0 0.5 -1.9
Worry too long after embarrassment 3.4 5.7 8.1 -2.8 1.4 2.6
Seen a psychiatrist for nerves, anxiety, tension or depression 6.6 8.5 15.1 -3.9 0.8 3.1
Wheeze or whistling in the chest in last year 1.3 2.3 5.7 -2.4 0.0 1.1
Number of children fathered 0.7 0.8 1.3 1.1 -0.5 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 3.0 0.6 1.7 1.0
Age at first live birth 1.9 3.3 7.2 -1.6 0.3 2.7
Pulse wave peak to peak time 1.7 2.0 4.7 0.7 2.2 -0.9
Health satisfaction 1.4 1.8 3.7 -1.9 -0.4 1.3
Shortness of breath walking on level ground 0.1 0.1 0.2 -0.5 -0.4 0.3
Qualifications: College or University degree 0.4 1.4 2.3 -0.7 -1.5 1.2
Eye problems/disorders: None of the above 1.3 1.5 2.9 1.7 0.4 -1.2
Mouth/teeth dental problems: Loose teeth 2.8 3.3 6.7 2.6 0.4 -1.8
Emphysema/chronic bronchitis 0.6 0.7 1.6 -1.3 -0.5 0.5
Medication for pain relief, constipation, heartburn 3.4 5.9 10.4 3.2 -0.1 -2.7
Neck or shoulder pain in last month 2.7 3.8 5.2 -2.3 -1.1 2.3
Medication: Blood pressure 0.8 1.5 2.7 -0.4 1.3 1.6
Angina (self-reported) 0.5 0.7 1.2 -1.0 -1.1 0.0
Migraine (self-reported) 1.3 1.6 2.9 -1.7 -0.2 1.4
Medication: Ibuprofen 0.9 1.1 1.8 -1.2 -1.3 0.1
Medication: Allopurinol 1.0 1.4 2.4 -1.5 -0.8 1.1
Medication: Omeprazole 0.8 0.9 2.0 -1.4 0.0 0.8
Medication: Seretide 50 evohaler 0.5 0.5 0.7 -0.5 0.8 0.8
Mean time to correctly identify matches 1.4 2.6 5.8 2.4 -0.1 -1.4
Heart disease (mother) 0.2 0.2 0.6 -0.2 0.1 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.2 -0.3 -0.8 1.1
Whole body fat mass 1.7 7.1 12.0 -3.5 0.3 3.0
Leg fat mass (right) 0.8 3.0 5.1 -1.9 0.3 2.3
Arm predicted mass (right) 0.1 0.4 1.0 0.4 -1.0 0.4
Pulse rate, automated reading 0.7 2.2 2.9 -1.3 1.5 1.7
Alcohol intake frequency. 3.4 7.9 13.7 -3.7 1.6 2.7
Comparative height size at age 10 0.4 1.9 4.0 -1.3 -2.0 -0.4
Number of full sisters 5.0 6.1 10.4 3.2 -0.5 -2.8
Suffer from ‘nerves’ 3.8 6.0 7.7 -2.7 1.8 2.8
Overall health rating 1.7 3.6 7.0 -2.6 0.5 1.9
Chest pain or discomfort 2.9 4.1 7.3 -2.7 -0.2 2.2
Had major operations 0.2 0.2 0.6 0.0 -0.3 -0.8
Age at last live birth 2.9 4.2 6.5 -2.6 0.9 2.3
Family relationship satisfaction 2.6 3.2 5.5 -2.4 -0.9 1.8
Leg pain on walking 0.2 0.2 0.7 0.2 0.1 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.5 0.4 -1.2 0.3
Commuting to job workplace: Car/motor vehicle 1.0 1.1 2.9 -0.1 -1.7 -0.7
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.3 0.1 0.9 1.2
Medication: Aspirin 0.2 0.3 0.6 -0.5 -0.2 0.8
Supplements: Vitamin C 0.5 0.6 1.7 -0.0 -1.3 0.2
Knee pain experienced in last month 0.3 0.5 1.0 -0.7 -0.1 -1.0
Hypertension (Self-reported) 0.5 1.3 1.6 -1.0 1.2 1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 2.7 -0.7 -1.6 -0.2
Illnesses of father: Heart disease 0.2 0.2 0.5 -0.4 -0.2 0.7
Illnesses of siblings: Diabetes 0.3 0.4 0.7 -0.9 0.6 0.5
Smoking status: Previous 1.9 2.9 4.6 -2.0 0.1 2.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.2 -1.5 -0.6 0.1
Whole body fat-free mass 0.1 0.6 1.0 -0.5 -0.8 1.0
Leg fat-free mass (right) 0.3 1.6 2.5 -1.5 -0.3 1.6
Arm fat percentage (left) 1.8 7.2 14.6 -3.8 0.8 2.5
Average weekly red wine intake 1.7 2.4 3.4 1.9 -0.8 -1.8
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.3 -0.1 0.6 0.1
Mood swings 12.3 22.2 36.6 -6.0 1.0 5.4
Loneliness, isolation 0.6 0.8 2.2 -1.5 0.5 -0.3
Long-standing illness, disability or infirmity 2.0 3.0 4.4 -2.0 0.8 2.1
Ever had bowel cancer screening 0.9 1.1 1.9 -1.1 -0.1 1.4
Diabetes diagnosed by doctor 1.1 1.9 2.9 -1.1 1.7 1.2
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.0 1.5 0.5 1.2 -1.2
Friendships satisfaction 0.5 0.6 1.0 -0.8 -0.5 1.0
Qualifications: nursing, teaching 1.2 1.9 3.1 -1.8 -1.6 -0.4
Commuting to job workplace: Walk 0.2 0.2 0.4 -0.4 -0.5 0.6
Eye problems/disorders: Cataract 1.2 1.4 2.5 -1.6 -0.2 1.3
Mouth/teeth dental problems: Mouth ulcers 2.1 3.3 6.4 -1.6 0.9 2.5
Medication for cholesterol 0.0 0.1 0.1 0.4 0.2 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.0 -0.9 0.1 1.0
Back pain experienced in last month 1.4 2.1 3.8 -1.3 -0.8 2.0
Mineral and other dietary supplements 1.5 2.0 3.8 1.0 1.9 -1.1
Breast cancer (self-reported) 1.1 1.4 2.2 -1.0 -1.5 1.0
Asthma (self-reported) 2.4 4.7 11.3 -3.4 -0.8 1.5
Osteoporosis (self-reported) 1.0 1.3 2.3 -1.0 -0.7 1.5
Osteoarthritis (self-reported) 1.4 1.9 2.7 -1.6 -0.6 1.6
Medication: Aspirin 0.1 0.1 0.2 -0.3 -0.2 0.4
Medication: Gliclazide 0.6 0.6 1.6 0.5 1.3 0.2
Illnesses of father: None of the above (group 1) 1.0 1.3 3.2 1.8 -0.1 -0.8
Smoking status: Current 7.3 11.6 18.9 4.4 0.3 -4.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 2.1 -0.7 1.5 -0.9
Whole body water mass 0.1 0.6 0.9 -0.4 -0.8 1.0
Leg predicted mass (right) 0.3 1.7 2.5 -1.6 -0.2 1.6
Arm fat mass (left) 1.3 5.2 9.4 -3.1 0.2 2.5
Number of self-reported non-cancer illnesses 4.6 8.0 15.8 -4.0 -0.3 2.8
Average weekly champagne plus white wine intake 1.2 1.7 3.2 -1.3 -1.8 0.1
Miserableness 1.6 2.9 5.3 -2.3 0.6 1.7
Guilty feelings 4.0 5.9 9.5 -2.7 0.9 3.1
Wears glasses or contact lenses 3.5 4.0 5.3 -2.3 -1.3 2.3
Ever taken oral contraceptive pill 0.9 1.0 2.2 1.5 0.1 -0.9
Hearing aid user 0.8 0.9 1.0 1.0 -0.8 -1.0
Mother’s age at death 0.9 1.1 1.9 1.4 0.1 -1.2
Financial situation satisfaction 0.7 0.8 2.3 -1.5 0.2 -0.2
Tinnitus: Yes, now most or all of the time 2.1 2.4 4.6 -1.0 -2.2 1.2
Commuting to job workplace: Public transport 2.4 2.9 5.2 2.3 0.7 -1.7
Eye problems/disorders: Glaucoma 3.6 4.3 7.4 -2.3 -0.5 2.7
Medication: Blood pressure 0.1 0.2 0.4 -0.2 0.6 -0.1
Pain type(s) experienced in last month: Hip pain 0.5 0.6 0.9 0.6 -1.0 0.8
Supplements: Fish oil (including cod liver oil) 1.4 1.9 3.3 -1.4 -1.8 0.6
High cholesterol (Self-reported) 0.4 0.6 0.9 0.9 0.9 -0.5
Medication: Bendroflumethiazide 0.3 0.5 1.0 0.3 1.0 -0.5
Medication: Paracetamol 1.0 1.5 1.8 -1.4 0.9 1.3
Medication: Lisinopril 0.1 0.2 0.3 -0.4 0.5 -0.1
Medication: Atorvastatin 0.2 0.3 0.5 0.5 0.7 -0.2
Illnesses of father: High blood pressure 1.1 1.3 2.5 -1.0 0.6 1.6
Alcohol drinker status: Never 3.1 3.7 6.1 -1.4 2.5 1.7
Ever smoked 0.0 0.1 0.2 -0.4 0.0 0.0
Basal metabolic rate 0.2 1.2 2.0 -1.1 -0.7 1.4
Leg fat percentage (left) 0.9 3.4 5.1 -2.2 0.5 2.3
Arm fat-free mass (left) 0.1 0.6 1.1 0.0 -0.9 1.1
Number of operations (self-reported) 0.2 0.2 0.4 -0.5 0.6 -0.0
Average weekly beer plus cider intake 3.8 5.5 8.8 2.8 0.1 -3.0
Irritability 9.4 15.9 27.3 -5.2 0.1 4.5
Risk taking 1.1 1.6 3.0 1.3 0.2 -1.7
Ever had prostate specific antigen (PSA) test 1.0 1.1 1.7 -0.7 -1.1 1.3
Fractured/broken bones in last 5 years 0.2 0.3 0.9 0.0 -0.9 0.1
Age started oral contraceptive pill 0.1 0.2 0.4 -0.7 0.2 0.3
Diastolic blood pressure, automated reading 0.8 2.4 3.7 -1.5 1.0 1.9
Ever depressed for a whole week 1.5 1.8 3.1 -1.8 -0.8 1.3
Unable to work because of sickness or disability 0.1 0.1 0.3 -0.1 0.6 0.3
Commuting to job workplace: Cycle 0.3 0.4 1.0 -0.3 1.0 0.3
Myopia 1.4 2.0 3.6 1.9 0.3 -1.5
Vascular/heart problems diagnosed by doctor 0.2 0.5 0.7 0.6 -0.8 -0.7
Cholesterol lowering medication 0.3 0.4 1.3 -1.1 0.0 0.1
Medication: Omeprazole (e.g. Zanprol) 2.3 2.8 5.7 -2.4 0.2 1.7
Pain experienced in last month 0.5 0.8 1.4 0.6 1.2 -0.8
Supplements: Calcium 3.1 3.4 5.5 -2.3 -1.3 1.8
Basal cell carcinoma (self-reported) 5.9 7.1 11.1 -3.3 0.9 3.1
Heart attack/myocardial infarction (self-reported) 0.8 1.0 1.5 -1.2 -0.8 1.0
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.7 0.3 0.8 0.2
Heart disease (siblings) 0.2 0.3 0.5 -0.2 -0.5 -0.7
Alcohol drinker status: Previous 1.3 1.5 2.4 -1.2 0.8 1.5
Pack years of smoking 1.8 2.6 4.3 2.1 0.0 -1.9
Impedance of whole body 1.7 8.5 23.0 -4.8 -0.6 1.4
Leg fat mass (left) 0.8 3.3 5.5 -2.1 0.3 2.3
Arm predicted mass (left) 0.1 0.5 0.8 0.0 -0.9 0.9