Best TWAS P=1.75e-08 · Best GWAS P=1.91e-08 conditioned to 0.143
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Coronary | RHOT1 | 0.17 | 0.01 | lasso | 5 | 0.00 | 4.2e-01 | 4.5 | -5.2 | 1.6e-07 | -0.83 | 0.04 | 0.36 | FALSE |
2 | GTEx | Artery Tibial | UTP6 | 0.07 | 0.02 | lasso | 3 | 0.02 | 5.9e-03 | 5.3 | -5.3 | 1.3e-07 | -0.85 | 0.04 | 0.92 | FALSE |
3 | GTEx | Brain Cortex | LRRC37B | 0.14 | 0.06 | lasso | 8 | 0.02 | 9.5e-02 | 5.3 | 5.1 | 2.7e-07 | 0.90 | 0.04 | 0.74 | FALSE |
4 | GTEx | Breast Mammary Tissue | CTC-542B22.2 | 0.07 | 0.01 | enet | 8 | 0.03 | 1.7e-02 | 5.3 | 5.6 | 1.8e-08 | 0.87 | 0.04 | 0.87 | TRUE |
5 | GTEx | Cells EBV-transformed lymphocytes | RHOT1 | 0.10 | 0.01 | lasso | 13 | 0.01 | 1.1e-01 | 5.3 | -5.3 | 1.1e-07 | -0.85 | 0.04 | 0.71 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | CTC-542B22.2 | 0.12 | 0.03 | lasso | 6 | 0.05 | 2.1e-04 | 5.6 | 5.6 | 2.4e-08 | 0.96 | 0.01 | 0.99 | FALSE |
7 | GTEx | Esophagus Mucosa | RHOT1 | 0.07 | 0.00 | lasso | 14 | 0.00 | 1.5e-01 | 5.2 | -5.4 | 7.7e-08 | -0.88 | 0.04 | 0.46 | FALSE |
8 | GTEx | Esophagus Mucosa | COPRS | 0.23 | 0.21 | enet | 24 | 0.19 | 1.7e-12 | 5.2 | -5.1 | 3.0e-07 | -0.89 | 0.05 | 0.95 | FALSE |
9 | GTEx | Heart Left Ventricle | COPRS | 0.08 | 0.06 | lasso | 3 | 0.06 | 2.4e-04 | 5.3 | -5.3 | 1.3e-07 | -0.91 | 0.03 | 0.91 | FALSE |
10 | GTEx | Pancreas | COPRS | 0.14 | 0.12 | lasso | 1 | 0.07 | 7.2e-04 | 5.2 | -5.2 | 1.7e-07 | -0.89 | 0.05 | 0.90 | FALSE |
11 | GTEx | Skin Not Sun Exposed Suprapubic | COPRS | 0.29 | 0.26 | lasso | 3 | 0.24 | 2.6e-13 | 5.2 | -5.1 | 2.7e-07 | -0.89 | 0.05 | 0.94 | FALSE |
12 | GTEx | Testis | COPRS | 0.31 | 0.26 | enet | 11 | 0.28 | 4.3e-13 | 5.6 | 5.6 | 2.1e-08 | 0.97 | 0.01 | 0.99 | FALSE |
13 | YFS | Blood | RHOT1 | 0.04 | 0.05 | blup | 330 | 0.05 | 7.9e-17 | 4.8 | -5.2 | 1.5e-07 | -0.85 | 0.15 | 0.85 | FALSE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LRRC37B | 0.07 | 0.10 | enet | 5 | 0.09 | 1.0e-10 | 5.2 | 5.2 | 1.9e-07 | 0.85 | 0.02 | 0.98 | FALSE |
15 | The Cancer Genome Atlas | Lung Adenocarcinoma | LRRC37B | 0.02 | 0.02 | blup | 23 | 0.02 | 3.5e-03 | 5.2 | 5.3 | 1.3e-07 | 0.86 | 0.02 | 0.85 | FALSE |
16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C17orf79 | 0.07 | 0.04 | lasso | 2 | 0.03 | 1.5e-04 | 5.6 | -5.6 | 1.8e-08 | -0.99 | 0.00 | 1.00 | FALSE |