[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), Best measure : ← →

chr17:60,821,100-63,531,331

Best TWAS P=3.56e-22 · Best GWAS P=1.22e-19 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Adipose Subcutaneous	CD79B	0.15	0.16	enet	9	0.17	3.5e-14	-8.96	9.7	3.6e-22	-0.98	0.00	1.00	TRUE
64	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMC5	0.04	0.03	lasso	1	0.03	5.6e-04	-8.35	-8.3	6.8e-17	0.76	0.01	0.96	TRUE
66	The Cancer Genome Atlas	Thyroid Carcinoma	PLEKHM1P	0.04	0.03	blup	7	0.05	1.2e-05	6.00	-6.7	2.9e-11	-0.02	0.00	0.99	TRUE
3	CommonMind	Brain Pre-frontal Cortex	SMARCD2	0.03	0.03	blup	330	0.03	1.1e-04	7.95	6.1	1.1e-09	-0.24	0.77	0.03	TRUE
20	GTEx	Cells Transformed fibroblasts	ICAM2	0.17	0.06	lasso	5	0.09	5.6e-07	3.11	-5.5	4.6e-08	0.29	0.94	0.01	TRUE
50	YFS	Blood	SMARCD2	0.03	0.04	lasso	7	0.05	7.6e-15	8.03	5.3	1.4e-07	-0.10	0.99	0.01	TRUE
10	GTEx	Brain Hippocampus	CYB561	0.33	0.24	enet	29	0.27	4.3e-07	-3.33	5.1	3.1e-07	-0.07	0.58	0.04	TRUE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD79B	0.02	0.02	lasso	2	0.01	3.0e-03	-9.07	9.1	9.1e-20	-0.99	0.00	0.89	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	SCN4A	0.04	0.01	blup	39	0.03	1.4e-07	-9.07	-8.8	1.9e-18	0.74	0.03	0.95	FALSE
15	GTEx	Breast Mammary Tissue (Female)	CD79B	0.04	0.07	lasso	2	0.03	4.2e-02	-8.68	8.3	7.1e-17	-0.70	0.03	0.45	FALSE
26	GTEx	Esophagus Muscularis	PSMC5	0.12	0.08	lasso	3	0.07	3.8e-05	-8.47	-8.3	1.1e-16	0.74	0.25	0.54	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KCNH6	0.04	0.02	enet	9	0.04	1.4e-05	7.65	8.0	1.7e-15	-0.49	0.64	0.17	FALSE
25	GTEx	Esophagus Mucosa	STRADA	0.05	0.07	lasso	2	0.05	1.9e-04	-7.92	-7.9	3.1e-15	0.74	0.18	0.44	FALSE
41	GTEx	Testis	PSMC5	0.14	0.13	lasso	6	0.14	6.0e-07	8.03	-7.9	3.3e-15	0.37	0.89	0.06	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	DDX42	0.23	0.04	lasso	12	0.07	8.1e-03	7.65	-7.9	3.4e-15	0.33	0.20	0.06	FALSE
54	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STRADA	0.05	0.03	lasso	1	0.02	1.7e-03	-7.86	-7.9	4.0e-15	0.75	0.00	0.85	FALSE
6	GTEx	Adipose Visceral Omentum	CD79B	0.15	0.00	lasso	6	0.02	4.1e-02	-8.96	7.7	1.3e-14	-0.89	0.01	0.95	FALSE
47	NTR	Blood	MAP3K3	0.02	0.01	lasso	2	0.01	2.0e-04	7.53	-7.7	1.5e-14	0.39	0.98	0.01	FALSE
13	GTEx	Breast Mammary Tissue	MAP3K3	0.10	0.11	lasso	8	0.08	8.9e-05	7.65	7.7	2.0e-14	-0.36	0.94	0.01	FALSE
32	GTEx	Nerve Tibial	MAP3K3	0.07	0.10	lasso	2	0.08	4.1e-06	7.65	7.7	2.1e-14	-0.35	0.95	0.02	FALSE
40	GTEx	Spleen	MAP3K3	0.21	0.14	lasso	10	0.10	1.4e-03	7.65	7.7	2.1e-14	-0.34	0.46	0.05	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	MAP3K3	0.12	0.13	enet	10	0.15	1.8e-08	7.65	7.6	2.8e-14	-0.36	0.99	0.00	FALSE
27	GTEx	Esophagus Muscularis	DCAF7	0.08	0.06	lasso	7	0.05	6.7e-04	7.57	7.6	2.9e-14	-0.35	0.68	0.02	FALSE
9	GTEx	Artery Tibial	MAP3K3	0.05	0.07	lasso	5	0.07	2.9e-06	7.42	7.6	3.1e-14	-0.39	0.83	0.02	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	DDX42	0.11	0.14	lasso	2	0.12	1.3e-04	7.54	-7.5	5.2e-14	0.36	0.32	0.04	FALSE
17	GTEx	Breast Mammary Tissue (Female)	MAP3K3	0.07	0.01	lasso	1	0.00	4.1e-01	7.50	7.5	6.2e-14	-0.36	0.05	0.15	FALSE
30	GTEx	Lung	MAP3K3	0.07	0.07	lasso	2	0.06	2.8e-05	7.44	7.5	8.6e-14	-0.36	0.93	0.02	FALSE
19	GTEx	Cells Transformed fibroblasts	PSMC5	0.19	0.09	lasso	5	0.10	7.1e-08	-7.86	-7.5	8.9e-14	0.68	0.30	0.69	FALSE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	STRADA	0.03	0.00	blup	57	0.01	5.2e-02	-7.86	7.3	2.5e-13	-0.73	0.01	0.72	FALSE
5	GTEx	Adipose Subcutaneous	MAP3K3	0.09	0.07	lasso	6	0.07	3.5e-06	7.48	7.3	3.2e-13	-0.34	0.99	0.01	FALSE
38	GTEx	Skin Sun Exposed Lower leg	MAP3K3	0.08	0.08	lasso	3	0.08	6.8e-07	7.65	7.2	4.2e-13	-0.34	0.96	0.01	FALSE
49	YFS	Blood	LIMD2	0.03	0.03	enet	11	0.03	3.6e-11	6.95	-7.2	4.8e-13	0.42	1.00	0.00	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	MAP3K3	0.02	0.02	blup	52	0.01	1.4e-02	7.44	7.0	3.0e-12	-0.27	0.03	0.60	FALSE
24	GTEx	Esophagus Mucosa	MAP3K3	0.05	0.01	enet	11	0.02	1.8e-02	4.63	6.9	6.8e-12	-0.29	0.28	0.06	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	SMARCD2	0.08	0.04	blup	28	0.04	5.1e-05	8.03	6.8	9.6e-12	-0.26	0.13	0.79	FALSE
56	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SCN4A	0.05	0.01	blup	41	0.04	2.2e-05	3.00	-6.7	2.1e-11	0.66	0.07	0.70	FALSE
16	GTEx	Breast Mammary Tissue (Female)	DCAF7	0.10	0.02	lasso	3	0.00	4.4e-01	6.95	6.7	2.5e-11	-0.29	0.07	0.06	FALSE
34	GTEx	Pancreas	MAP3K3	0.10	0.08	lasso	4	0.07	9.0e-04	7.65	6.5	5.6e-11	-0.27	0.14	0.16	FALSE
37	GTEx	Skin Sun Exposed Lower leg	DDX42	0.07	0.04	lasso	4	0.05	2.5e-05	8.03	-6.5	5.9e-11	0.22	0.98	0.01	FALSE
35	GTEx	Pituitary	MAP3K3	0.11	0.07	lasso	6	0.04	3.5e-02	7.50	6.5	6.6e-11	-0.28	0.13	0.05	FALSE
31	GTEx	Muscle Skeletal	SMARCD2	0.13	0.03	lasso	5	0.04	1.3e-04	-7.89	-6.5	7.6e-11	0.59	0.52	0.38	FALSE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	STRADA	0.07	0.01	blup	57	0.03	5.5e-04	2.55	6.4	1.2e-10	-0.70	0.02	0.84	FALSE
44	METSIM	Adipose	CD79B	0.04	0.01	lasso	5	0.01	4.3e-03	-4.23	6.4	1.7e-10	-0.56	0.03	0.91	FALSE
61	The Cancer Genome Atlas	Lung Adenocarcinoma	SMARCD2	0.04	0.02	blup	28	0.01	1.6e-02	7.54	6.4	1.9e-10	-0.21	0.01	0.08	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PLEKHM1P	0.08	0.03	enet	4	0.04	4.0e-05	6.00	-6.3	2.1e-10	-0.05	0.00	0.98	FALSE
28	GTEx	Heart Atrial Appendage	CYB561	0.19	0.01	enet	28	0.06	1.3e-03	-1.44	6.2	4.2e-10	-0.28	0.06	0.26	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PLEKHM1P	0.24	0.26	lasso	6	0.27	8.0e-33	6.00	-6.1	1.0e-09	-0.02	0.00	1.00	FALSE
11	GTEx	Brain Hypothalamus	DDX42	0.15	0.18	lasso	3	0.09	4.2e-03	7.95	-6.1	1.1e-09	0.21	0.14	0.06	FALSE
23	GTEx	Esophagus Mucosa	DDX42	0.08	0.06	lasso	3	0.09	1.3e-06	7.61	-6.1	1.4e-09	0.19	0.95	0.01	FALSE
33	GTEx	Pancreas	DDX42	0.17	0.18	lasso	3	0.16	3.6e-07	7.50	-6.1	1.4e-09	0.20	0.98	0.00	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	PLEKHM1P	0.02	0.02	blup	7	0.02	6.7e-03	5.61	-6.0	1.6e-09	-0.02	0.00	0.78	FALSE
53	The Cancer Genome Atlas	Glioblastoma Multiforme	PLEKHM1P	0.08	0.04	blup	7	0.04	2.7e-02	5.90	-6.0	2.3e-09	-0.03	0.00	0.60	FALSE
39	GTEx	Skin Sun Exposed Lower leg	hsa-mir-6080	0.11	0.10	lasso	2	0.08	1.7e-07	5.62	-5.9	4.0e-09	-0.04	0.03	0.97	FALSE
43	GTEx	Vagina	SMURF2	0.32	0.00	enet	1	0.06	1.4e-02	5.58	5.6	2.3e-08	0.01	0.03	0.32	FALSE
48	YFS	Blood	ICAM2	0.06	0.03	enet	21	0.04	1.3e-11	3.01	-5.6	2.3e-08	0.35	1.00	0.00	FALSE
8	GTEx	Artery Tibial	DDX42	0.13	0.14	lasso	5	0.15	9.1e-12	7.64	-5.6	2.6e-08	0.13	0.99	0.01	FALSE
14	GTEx	Breast Mammary Tissue (Male)	MAP3K3	0.12	0.14	lasso	2	0.07	1.2e-02	7.44	5.5	3.0e-08	-0.13	0.15	0.06	FALSE
21	GTEx	Cells Transformed fibroblasts	SMURF2	0.17	0.13	enet	8	0.13	3.7e-10	5.54	5.5	3.0e-08	0.03	0.03	0.97	FALSE
7	GTEx	Adipose Visceral Omentum	MAP3K3	0.10	0.04	enet	12	0.05	9.0e-04	7.64	5.5	3.7e-08	-0.34	0.29	0.14	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	DDX42	0.07	0.07	enet	11	0.07	9.2e-08	7.49	-5.5	4.0e-08	0.14	0.83	0.16	FALSE
46	NTR	Blood	LIMD2	0.04	0.03	blup	304	0.03	2.2e-10	7.53	-5.4	6.0e-08	0.42	1.00	0.00	FALSE
42	GTEx	Testis	CCDC47	0.17	0.06	enet	28	0.09	1.0e-04	-8.35	5.4	7.3e-08	-0.68	0.02	0.96	FALSE
22	GTEx	Colon Sigmoid	CD79B	0.17	0.00	lasso	9	0.08	9.7e-04	7.52	5.3	9.6e-08	-0.23	0.09	0.12	FALSE
60	The Cancer Genome Atlas	Lung Adenocarcinoma	PLEKHM1P	0.02	0.01	blup	7	0.02	4.7e-03	5.61	-5.3	1.2e-07	-0.02	0.00	0.69	FALSE
29	GTEx	Lung	PSMC5	0.04	0.00	enet	5	0.01	4.1e-02	0.75	-5.2	2.0e-07	0.59	0.28	0.23	FALSE
45	METSIM	Adipose	RP11-214C8.2	0.03	0.00	blup	304	0.01	4.2e-03	-3.01	-5.2	2.5e-07	0.48	0.23	0.11	FALSE