[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), Best measure :

chr2:23,453,834-25,889,403

Best TWAS P=1.49e-11 · Best GWAS P=9.13e-13 conditioned to 0.0346

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous ADCY3 0.07 0.04 lasso 6 0.01 3.2e-02 -5.4 -5.4 6.8e-08 -0.13 0.03 0.97 FALSE
2 GTEx Adipose Subcutaneous UBXN2A 0.06 0.04 lasso 5 0.04 5.2e-04 -5.5 -5.1 2.8e-07 -0.73 0.28 0.70 FALSE
3 GTEx Adipose Visceral Omentum UBXN2A 0.10 0.08 enet 29 0.03 9.8e-03 -5.8 -5.8 5.4e-09 -0.67 0.07 0.91 FALSE
4 GTEx Artery Tibial UBXN2A 0.12 0.06 enet 24 0.09 1.5e-07 -2.9 -5.6 2.7e-08 -0.72 0.78 0.22 FALSE
5 GTEx Cells EBV-transformed lymphocytes ADCY3 0.25 0.23 enet 10 0.12 9.2e-05 -5.4 6.3 2.4e-10 0.08 0.05 0.93 TRUE
6 GTEx Cells EBV-transformed lymphocytes RP11-443B20.1 0.13 0.13 enet 9 0.05 9.2e-03 -5.4 6.0 1.6e-09 0.11 0.04 0.90 FALSE
7 GTEx Colon Transverse UBXN2A 0.11 0.01 enet 8 0.03 8.7e-03 -5.4 -5.8 5.7e-09 -0.75 0.08 0.69 FALSE
8 GTEx Esophagus Muscularis NCOA1 0.11 0.01 enet 9 0.01 5.8e-02 -4.4 -5.9 2.8e-09 -0.30 0.06 0.28 FALSE
9 GTEx Lung UBXN2A 0.09 0.06 enet 7 0.07 6.1e-06 -3.1 -5.2 1.9e-07 -0.72 0.29 0.70 FALSE
10 GTEx Nerve Tibial ADCY3 0.09 0.05 enet 6 0.03 2.2e-03 -4.7 5.8 7.1e-09 0.15 0.04 0.96 FALSE
11 GTEx Nerve Tibial RP11-443B20.1 0.07 0.03 enet 6 0.02 1.1e-02 -4.7 5.2 1.5e-07 0.15 0.04 0.94 FALSE
12 GTEx Small Intestine Terminal Ileum UBXN2A 0.18 0.08 enet 33 0.16 2.5e-04 -5.8 -5.7 1.2e-08 -0.84 0.03 0.90 FALSE
13 GTEx Spleen UBXN2A 0.31 0.11 enet 19 0.17 4.1e-05 6.5 -6.8 1.5e-11 -0.80 0.03 0.93 TRUE
14 GTEx Whole Blood DNAJC27 0.08 0.10 lasso 1 0.10 2.2e-09 -5.3 -5.3 8.9e-08 -0.09 0.05 0.95 FALSE
15 GTEx Whole Blood ADCY3 0.23 0.24 enet 24 0.27 5.5e-25 -5.7 -5.5 3.1e-08 -0.12 0.02 0.98 FALSE
16 GTEx Whole Blood UBXN2A 0.17 0.07 lasso 8 0.09 2.1e-08 -3.1 -6.2 5.6e-10 -0.84 0.04 0.96 FALSE
17 GTEx Whole Blood RP11-443B20.1 0.21 0.17 enet 32 0.20 1.8e-18 -5.3 -5.2 2.4e-07 -0.13 0.03 0.97 FALSE
18 ROSMAP Brain Pre-frontal Cortex ADCY3 0.17 0.26 enet 32 0.26 6.8e-33 -5.7 6.2 6.5e-10 0.13 0.03 0.97 FALSE
19 The Cancer Genome Atlas Glioblastoma Multiforme ADCY3 0.36 0.14 enet 7 0.13 8.9e-05 -4.6 5.3 1.2e-07 0.05 0.02 0.56 FALSE
20 The Cancer Genome Atlas Brain Lower Grade Glioma ADCY3 0.03 0.02 blup 81 0.02 7.1e-04 -4.8 5.8 8.0e-09 0.07 0.06 0.88 FALSE