[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), Best measure : ← →

chr3:48,618,666-50,620,043

Best TWAS P=3.38e-10 · Best GWAS P=9.14e-08 conditioned to 0.00593

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	RNF123	0.19	0.18	enet	29	0.18	2.1e-14	-4.6	-5.4	8.0e-08	-0.61	0.40	0.58	FALSE
2	GTEx	Artery Tibial	RNF123	0.08	0.08	enet	12	0.09	2.5e-07	-4.6	-5.6	2.0e-08	-0.68	0.41	0.58	FALSE
3	GTEx	Brain Caudate basal ganglia	RNF123	0.13	0.04	enet	20	0.02	1.2e-01	-4.6	-5.3	8.8e-08	-0.68	0.15	0.43	FALSE
4	GTEx	Brain Cerebellum	RNF123	0.36	0.31	enet	43	0.36	2.4e-11	-4.6	-5.4	6.5e-08	-0.49	0.40	0.59	FALSE
5	GTEx	Brain Cerebellum	GPX1	0.31	0.09	enet	19	0.23	2.0e-07	5.2	-5.9	3.1e-09	-0.82	0.05	0.95	FALSE
6	GTEx	Brain Frontal Cortex BA9	GPX1	0.16	0.06	lasso	6	0.15	7.9e-05	-4.6	-5.7	1.5e-08	-0.68	0.06	0.78	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	USP4	0.08	0.05	lasso	2	0.09	8.7e-04	-3.9	-5.3	9.3e-08	-0.71	0.10	0.64	FALSE
8	GTEx	Colon Sigmoid	RNF123	0.22	0.10	enet	23	0.20	1.1e-07	-4.8	-5.7	1.2e-08	-0.62	0.25	0.73	FALSE
9	GTEx	Colon Transverse	RNF123	0.16	0.05	enet	36	0.05	2.3e-03	-4.8	-6.3	3.4e-10	-0.46	0.13	0.52	TRUE
10	GTEx	Esophagus Gastroesophageal Junction	RNF123	0.14	0.13	enet	30	0.10	2.3e-04	-4.8	-5.8	7.1e-09	-0.57	0.21	0.70	FALSE
11	GTEx	Esophagus Muscularis	NICN1	0.11	0.03	enet	22	0.07	2.7e-05	5.0	5.5	4.4e-08	0.85	0.05	0.95	FALSE
12	GTEx	Esophagus Muscularis	MST1R	0.05	0.00	lasso	5	0.05	3.6e-04	3.1	-5.3	1.1e-07	-0.59	0.19	0.46	FALSE
13	GTEx	Esophagus Muscularis	GPX1	0.13	0.05	lasso	14	0.06	1.1e-04	5.1	-5.5	3.1e-08	-0.84	0.06	0.94	FALSE
14	GTEx	Heart Atrial Appendage	RNF123	0.06	0.04	lasso	2	0.02	4.0e-02	-4.6	-5.2	2.1e-07	-0.85	0.09	0.74	FALSE
15	GTEx	Lung	RNF123	0.13	0.05	enet	18	0.07	5.8e-06	-4.7	-5.9	3.1e-09	-0.77	0.23	0.74	FALSE
16	GTEx	Lung	GPX1	0.04	0.02	enet	13	0.04	5.7e-04	5.2	-6.0	2.1e-09	-0.86	0.06	0.76	FALSE
17	GTEx	Muscle Skeletal	FAM212A	0.05	0.08	lasso	3	0.07	4.9e-07	5.3	-5.5	3.4e-08	-0.96	0.03	0.97	FALSE
18	GTEx	Nerve Tibial	NICN1	0.13	0.15	enet	21	0.16	1.4e-11	-3.6	5.1	2.7e-07	0.67	0.87	0.11	FALSE
19	GTEx	Nerve Tibial	GPX1	0.05	0.01	enet	14	0.04	9.0e-04	-5.0	-5.2	1.6e-07	-0.40	0.14	0.34	FALSE
20	GTEx	Nerve Tibial	NICN1-AS1	0.15	0.11	lasso	5	0.13	1.1e-09	-3.6	5.3	1.0e-07	0.74	0.29	0.70	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	UBA7	0.07	0.03	lasso	6	0.06	2.9e-04	-5.0	5.6	1.7e-08	0.51	0.20	0.73	FALSE
22	GTEx	Skin Sun Exposed Lower leg	UBA7	0.04	0.01	lasso	8	0.00	2.9e-01	-4.6	5.2	2.5e-07	0.58	0.14	0.33	FALSE
23	GTEx	Stomach	RNF123	0.23	0.12	lasso	15	0.16	4.6e-08	-4.8	-5.5	3.1e-08	-0.56	0.25	0.74	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	RNF123	0.04	0.05	lasso	3	0.05	1.4e-06	-4.3	-5.3	1.4e-07	-0.63	0.39	0.60	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	AMIGO3	0.01	0.00	enet	13	0.01	5.7e-03	-4.8	-6.0	1.6e-09	-0.77	0.01	0.48	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	GMPPB	0.03	0.03	enet	12	0.03	3.0e-07	-4.8	-5.8	8.2e-09	-0.57	0.05	0.95	FALSE
27	The Cancer Genome Atlas	Glioblastoma Multiforme	AMIGO3	0.18	0.02	enet	24	0.07	2.9e-03	-4.8	-5.8	8.1e-09	-0.69	0.02	0.38	FALSE
28	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	APEH	0.02	0.02	blup	49	0.02	2.5e-03	5.3	5.2	2.6e-07	0.95	0.01	0.90	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	GMPPB	0.15	0.12	enet	17	0.13	1.2e-14	-4.8	-5.5	4.2e-08	-0.50	0.04	0.95	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	AMIGO3	0.02	0.00	blup	40	0.00	3.0e-01	-4.6	-5.4	5.9e-08	-0.67	0.04	0.39	FALSE
31	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GMPPB	0.04	0.02	blup	40	0.02	1.4e-02	-4.6	-5.4	5.9e-08	-0.61	0.03	0.33	FALSE
32	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	GMPPB	0.13	0.08	blup	40	0.09	2.7e-04	-4.8	-5.9	4.1e-09	-0.63	0.03	0.66	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	IP6K1	0.03	0.04	blup	55	0.04	9.2e-05	-5.0	-5.3	9.2e-08	-0.44	0.05	0.91	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBA7	0.05	0.04	enet	7	0.05	1.6e-05	-4.7	5.2	2.4e-07	0.65	0.03	0.96	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	AMIGO3	0.08	0.07	blup	40	0.06	1.3e-06	-4.8	-5.6	2.1e-08	-0.51	0.04	0.95	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	GMPPB	0.08	0.09	lasso	8	0.09	4.3e-09	-4.8	-5.3	9.0e-08	-0.44	0.05	0.95	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	UBA7	0.03	0.01	blup	30	0.02	2.0e-03	-4.7	5.3	1.2e-07	0.62	0.02	0.73	FALSE