[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), Best measure :

chr3:48,618,666-50,620,043

Best TWAS P=3.38e-10 · Best GWAS P=9.14e-08 conditioned to 0.00593

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous RNF123 0.19 0.18 enet 29 0.18 2.1e-14 -4.6 -5.4 8.0e-08 -0.61 0.40 0.58 FALSE
2 GTEx Artery Tibial RNF123 0.08 0.08 enet 12 0.09 2.5e-07 -4.6 -5.6 2.0e-08 -0.68 0.41 0.58 FALSE
3 GTEx Brain Caudate basal ganglia RNF123 0.13 0.04 enet 20 0.02 1.2e-01 -4.6 -5.3 8.8e-08 -0.68 0.15 0.43 FALSE
4 GTEx Brain Cerebellum RNF123 0.36 0.31 enet 43 0.36 2.4e-11 -4.6 -5.4 6.5e-08 -0.49 0.40 0.59 FALSE
5 GTEx Brain Cerebellum GPX1 0.31 0.09 enet 19 0.23 2.0e-07 5.2 -5.9 3.1e-09 -0.82 0.05 0.95 FALSE
6 GTEx Brain Frontal Cortex BA9 GPX1 0.16 0.06 lasso 6 0.15 7.9e-05 -4.6 -5.7 1.5e-08 -0.68 0.06 0.78 FALSE
7 GTEx Cells EBV-transformed lymphocytes USP4 0.08 0.05 lasso 2 0.09 8.7e-04 -3.9 -5.3 9.3e-08 -0.71 0.10 0.64 FALSE
8 GTEx Colon Sigmoid RNF123 0.22 0.10 enet 23 0.20 1.1e-07 -4.8 -5.7 1.2e-08 -0.62 0.25 0.73 FALSE
9 GTEx Colon Transverse RNF123 0.16 0.05 enet 36 0.05 2.3e-03 -4.8 -6.3 3.4e-10 -0.46 0.13 0.52 TRUE
10 GTEx Esophagus Gastroesophageal Junction RNF123 0.14 0.13 enet 30 0.10 2.3e-04 -4.8 -5.8 7.1e-09 -0.57 0.21 0.70 FALSE
11 GTEx Esophagus Muscularis NICN1 0.11 0.03 enet 22 0.07 2.7e-05 5.0 5.5 4.4e-08 0.85 0.05 0.95 FALSE
12 GTEx Esophagus Muscularis MST1R 0.05 0.00 lasso 5 0.05 3.6e-04 3.1 -5.3 1.1e-07 -0.59 0.19 0.46 FALSE
13 GTEx Esophagus Muscularis GPX1 0.13 0.05 lasso 14 0.06 1.1e-04 5.1 -5.5 3.1e-08 -0.84 0.06 0.94 FALSE
14 GTEx Heart Atrial Appendage RNF123 0.06 0.04 lasso 2 0.02 4.0e-02 -4.6 -5.2 2.1e-07 -0.85 0.09 0.74 FALSE
15 GTEx Lung RNF123 0.13 0.05 enet 18 0.07 5.8e-06 -4.7 -5.9 3.1e-09 -0.77 0.23 0.74 FALSE
16 GTEx Lung GPX1 0.04 0.02 enet 13 0.04 5.7e-04 5.2 -6.0 2.1e-09 -0.86 0.06 0.76 FALSE
17 GTEx Muscle Skeletal FAM212A 0.05 0.08 lasso 3 0.07 4.9e-07 5.3 -5.5 3.4e-08 -0.96 0.03 0.97 FALSE
18 GTEx Nerve Tibial NICN1 0.13 0.15 enet 21 0.16 1.4e-11 -3.6 5.1 2.7e-07 0.67 0.87 0.11 FALSE
19 GTEx Nerve Tibial GPX1 0.05 0.01 enet 14 0.04 9.0e-04 -5.0 -5.2 1.6e-07 -0.40 0.14 0.34 FALSE
20 GTEx Nerve Tibial NICN1-AS1 0.15 0.11 lasso 5 0.13 1.1e-09 -3.6 5.3 1.0e-07 0.74 0.29 0.70 FALSE
21 GTEx Skin Not Sun Exposed Suprapubic UBA7 0.07 0.03 lasso 6 0.06 2.9e-04 -5.0 5.6 1.7e-08 0.51 0.20 0.73 FALSE
22 GTEx Skin Sun Exposed Lower leg UBA7 0.04 0.01 lasso 8 0.00 2.9e-01 -4.6 5.2 2.5e-07 0.58 0.14 0.33 FALSE
23 GTEx Stomach RNF123 0.23 0.12 lasso 15 0.16 4.6e-08 -4.8 -5.5 3.1e-08 -0.56 0.25 0.74 FALSE
24 ROSMAP Brain Pre-frontal Cortex RNF123 0.04 0.05 lasso 3 0.05 1.4e-06 -4.3 -5.3 1.4e-07 -0.63 0.39 0.60 FALSE
25 The Cancer Genome Atlas Breast Invasive Carcinoma AMIGO3 0.01 0.00 enet 13 0.01 5.7e-03 -4.8 -6.0 1.6e-09 -0.77 0.01 0.48 FALSE
26 The Cancer Genome Atlas Breast Invasive Carcinoma GMPPB 0.03 0.03 enet 12 0.03 3.0e-07 -4.8 -5.8 8.2e-09 -0.57 0.05 0.95 FALSE
27 The Cancer Genome Atlas Glioblastoma Multiforme AMIGO3 0.18 0.02 enet 24 0.07 2.9e-03 -4.8 -5.8 8.1e-09 -0.69 0.02 0.38 FALSE
28 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma APEH 0.02 0.02 blup 49 0.02 2.5e-03 5.3 5.2 2.6e-07 0.95 0.01 0.90 FALSE
29 The Cancer Genome Atlas Brain Lower Grade Glioma GMPPB 0.15 0.12 enet 17 0.13 1.2e-14 -4.8 -5.5 4.2e-08 -0.50 0.04 0.95 FALSE
30 The Cancer Genome Atlas Lung Adenocarcinoma AMIGO3 0.02 0.00 blup 40 0.00 3.0e-01 -4.6 -5.4 5.9e-08 -0.67 0.04 0.39 FALSE
31 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma GMPPB 0.04 0.02 blup 40 0.02 1.4e-02 -4.6 -5.4 5.9e-08 -0.61 0.03 0.33 FALSE
32 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma GMPPB 0.13 0.08 blup 40 0.09 2.7e-04 -4.8 -5.9 4.1e-09 -0.63 0.03 0.66 FALSE
33 The Cancer Genome Atlas Prostate Adenocarcinoma IP6K1 0.03 0.04 blup 55 0.04 9.2e-05 -5.0 -5.3 9.2e-08 -0.44 0.05 0.91 FALSE
34 The Cancer Genome Atlas Prostate Adenocarcinoma UBA7 0.05 0.04 enet 7 0.05 1.6e-05 -4.7 5.2 2.4e-07 0.65 0.03 0.96 FALSE
35 The Cancer Genome Atlas Thyroid Carcinoma AMIGO3 0.08 0.07 blup 40 0.06 1.3e-06 -4.8 -5.6 2.1e-08 -0.51 0.04 0.95 FALSE
36 The Cancer Genome Atlas Thyroid Carcinoma GMPPB 0.08 0.09 lasso 8 0.09 4.3e-09 -4.8 -5.3 9.0e-08 -0.44 0.05 0.95 FALSE
37 The Cancer Genome Atlas Thyroid Carcinoma UBA7 0.03 0.01 blup 30 0.02 2.0e-03 -4.7 5.3 1.2e-07 0.62 0.02 0.73 FALSE