TWAS hub - HESX1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Gastroesophageal Junction	0.132	0.054	0.0055	0.017	NA	0.006	NA	0.018	0.078	NA	0.180	NA	0.070
2	TCGA	Pheochromocytoma and Paraganglioma	0.082	0.053	0.0086	0.047	0.039	0.035	NA	0.030	0.006	0.011	0.016	NA	0.023

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Forced expiratory volume in 1-second (FEV1), Best measure	6.2	19.8	26.9	3.5	5.2
Forced expiratory volume in 1-second (FEV1)	5.9	19.9	25.1	3.8	5.0
Exposure to tobacco smoke outside home	5.3	7.0	7.6	-2.5	-2.8
Hand grip strength (left)	4.0	10.5	12.9	3.6	2.8
Hair/balding pattern: Pattern 2	3.9	4.9	5.2	2.2	2.3
Birth weight of first child	3.9	7.0	8.2	2.9	2.4
Systolic blood pressure, automated reading	3.8	10.9	16.3	-4.0	-2.4
Neck or shoulder pain in last month	3.5	5.0	6.6	-2.6	-1.8
Lung FEV1/FVC ratio	3.4	17.2	26.1	2.9	5.1
Mouth/teeth dental problems	3.1	4.8	4.8	2.2	2.2
Gout (self-reported)	3.1	4.3	5.1	1.9	2.3
Number of full brothers	3.1	3.9	4.3	2.1	1.9
Illness, injury, bereavement, stress in last 2 years	3.1	3.8	4.8	1.7	2.2
Pain experienced in last month	3.1	5.2	5.4	2.2	2.3
Forced vital capacity (FVC)	3.0	11.5	14.1	3.0	3.8
Falls in the last year	2.9	3.9	7.1	-0.9	-2.7
Forced vital capacity (FVC), Best measure	2.9	10.5	14.2	2.6	3.8
Major Depression (MDD)	2.8	3.4	4.4	-1.6	-2.1
Chronic bronchitis/emphysema (father)	2.8	3.3	6.3	-2.5	0.6
Commuting to job workplace: Public transport	2.7	3.2	4.5	1.4	2.1
Mean Putamen Volume	2.6	2.9	3.1	1.7	1.8
Medication: Ibuprofen	2.6	3.1	3.9	-2.0	-1.5
Hand grip strength (right)	2.5	6.8	9.5	2.0	3.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.4	10.2	0.7	3.2
Friendships satisfaction	2.4	3.0	5.7	-2.4	-0.6
Eye problems/disorders: Cataract	2.4	2.8	4.0	-2.0	-1.2
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	3.4	-1.9	-1.5
Blood Platelet Count	2.2	25.9	27.8	-4.9	-5.3
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	3.7	-1.9	-1.2
Medication: Amlodipine	2.2	3.1	4.7	-2.2	-1.2
Overall health rating	2.2	4.8	7.6	-2.8	-1.4
Ever had hysterectomy (womb removed)	2.1	2.4	2.4	-1.6	-1.6
Mouth/teeth dental problems: Dentures	2.1	3.5	4.5	-2.1	-1.6
Ever had bowel cancer screening	2.1	2.5	3.2	-1.3	-1.8
Lupus	2.0	3.1	4.8	-1.2	-2.2
Mood swings	2.0	3.6	4.3	-1.7	-2.1
Back pain experienced in last month	2.0	2.9	4.6	-1.0	-2.1
Neuroticism (Nagel 2018)	1.9	4.4	6.8	-1.4	-2.6
Diabetes (father)	1.9	2.4	4.2	-2.0	-0.8
Alcohol intake versus 10 years previously	1.9	2.9	2.9	-1.7	-1.7
Length of working week for main job	1.9	2.1	3.1	-1.8	-1.1
Breast cancer (self-reported)	1.9	2.3	4.6	-0.2	-2.1
Ever used hormone-replacement therapy (HRT)	1.8	2.3	4.5	-2.1	-0.3
Ever highly irritable/argumentative for 2 days	1.8	2.1	4.2	-2.0	0.3
Shortness of breath walking on level ground	1.8	2.1	2.5	-1.6	-1.3
Depressed Affect (Nagel 2018)	1.7	3.6	5.0	-1.5	-2.2
Ulcerative Colitis (UC)	1.7	3.3	3.5	1.8	1.9
Prostate Cancer	1.7	2.3	4.7	-2.2	-0.1
Lung FVC	1.7	8.7	14.9	1.6	3.9
Arm fat-free mass (right)	1.7	8.8	10.7	2.6	3.3
Reaction Time	1.6	3.1	4.8	1.2	2.2
HbA1C	1.6	1.8	2.6	1.0	1.6
Type 2 Diabetes (T2D) (2012)	1.6	1.9	3.7	1.9	0.2
Had menopause	1.6	2.0	3.3	-0.9	-1.8
Pain all over the body in last month	1.6	1.7	2.7	-1.6	-0.9
Fluid intelligence score	1.6	3.2	6.1	2.5	0.6
Exposure to tobacco smoke at home	1.6	1.8	3.4	1.9	0.4
Average weekly champagne plus white wine intake	1.6	2.3	3.6	1.9	0.9
Average weekly beer plus cider intake	1.6	2.3	4.6	-2.1	-0.3
Fasting Glucose	1.5	1.7	1.8	1.3	1.4
High blood pressure (mother)	1.5	2.1	2.1	-1.4	1.4
Trunk fat-free mass	1.5	8.8	11.4	2.5	3.4
Trunk predicted mass	1.5	8.4	11.3	2.3	3.4
Qualifications: O levels/GCSEs or equivalent	1.5	2.5	3.5	1.9	1.2
Arm predicted mass (right)	1.5	7.7	9.1	2.5	3.0
Alcohol drinker status: Previous	1.5	1.8	2.2	1.1	1.5
LDL Cholesterol	1.4	2.2	2.8	-1.3	-1.7
Medication: Co-codamol	1.4	1.7	2.9	-1.7	-0.6
Severe depression (siblings)	1.4	1.6	2.5	-1.6	0.8
Townsend deprivation index at recruitment	1.4	1.9	2.3	-1.2	1.5
Peak expiratory flow (PEF)	1.4	3.2	4.8	1.3	2.2
Emphysema/chronic bronchitis	1.4	1.6	2.6	-1.6	-0.7
Heart disease (mother)	1.4	1.7	2.1	-1.4	-1.2
Average weekly red wine intake	1.4	2.1	2.2	1.4	1.5
Supplements: Fish oil (including cod liver oil)	1.4	1.9	2.3	-1.5	-1.2
Medication: Atorvastatin	1.4	1.7	2.7	-0.9	-1.6
Arm fat-free mass (left)	1.4	7.1	8.9	2.3	3.0
Rheumatoid Arthritis	1.3	1.7	3.5	-1.9	-0.0
Heel T-Score	1.3	10.4	10.8	-3.3	3.2
Hypothyroidism (self reported)	1.3	2.9	5.8	-2.4	0.1
Current tobacco smoking	1.3	2.2	3.9	-2.0	-0.6
Age when periods started (menarche)	1.3	3.2	3.6	1.6	1.9
Mouth/teeth dental problems: Loose teeth	1.3	1.5	2.7	-0.6	-1.7
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	3.2	-0.1	-1.8
Whole body fat-free mass	1.3	7.7	9.9	2.3	3.1
Illnesses of father: None of the above (group 1)	1.3	1.6	2.8	1.7	-0.6
Whole body water mass	1.3	7.5	10.1	2.2	3.2
Mother’s age at death	1.3	1.7	3.3	0.0	-1.8
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.4	-0.7	-1.6
Arm predicted mass (left)	1.3	6.8	8.5	2.2	2.9
Bipolar Disorder (2018)	1.2	2.0	3.5	0.6	1.9
Alzheimer’s Disease (in mother)	1.2	1.4	2.7	0.1	-1.6
Ulcerative Colitis	1.2	1.7	2.2	1.1	1.5
Systolic Blood Pressure	1.2	5.8	11.0	-3.3	-0.8
Worrier / anxious feelings	1.2	2.2	3.2	-1.1	-1.8
Leg predicted mass (right)	1.2	6.6	7.6	2.4	2.8
Medication: Bendroflumethiazide	1.2	1.8	3.4	-1.8	-0.6
Blood White Count	1.1	8.0	13.1	3.6	1.7
Medication for hormone replacement therapy	1.1	1.3	1.6	-1.3	-1.0
Prospective memory result	1.1	1.4	2.8	-1.7	-0.0
Pulse wave Arterial Stiffness index	1.1	1.3	2.1	0.7	1.4
Glaucoma (self-reported)	1.1	1.3	1.6	0.9	1.3
Medication for pain relief, constipation, heartburn	1.1	1.9	3.6	1.9	0.5
Medication: Allopurinol	1.1	1.5	1.7	1.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	4.4	0.4	2.1
Leg fat-free mass (right)	1.1	6.0	6.9	2.3	2.6
Osteoarthritis (self-reported)	1.1	1.5	2.7	-0.5	-1.6
Basal metabolic rate	1.1	6.3	7.8	2.2	2.8
Depression (Nagel 2018)	1.0	1.5	2.7	-0.5	-1.7
Alzheimer’s Disease (including proxy)	1.0	1.5	3.0	0.1	-1.7
Verbal and Numeric Reasoning (VNR)	1.0	2.4	4.6	2.1	0.4
Waist Hip Ratio (WHR)	1.0	4.4	6.4	1.6	2.5
Smoking Status	1.0	2.3	4.5	-2.1	-0.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	1.5	1.2	0.9
Medication: Atenolol	1.0	1.2	2.4	0.0	-1.6
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.3	-1.5	-1.0
Noisy workplace	1.0	1.3	1.3	-1.1	-1.2
Standing height	1.0	9.7	14.3	3.8	2.3
Had major operations	1.0	1.1	2.2	-1.5	0.2
Supplements: Vitamin C	1.0	1.1	2.2	1.5	-0.2
Primary Biliary Cirrhosis	0.9	1.2	1.9	-0.8	1.4
Neuroticism	0.9	2.2	2.8	-1.2	-1.7
Sensitivity / hurt feelings	0.9	1.5	2.2	-0.9	-1.5
Sitting height	0.9	6.5	9.2	3.0	1.9
Leg predicted mass (left)	0.9	4.5	5.4	1.9	2.3
Impedance of arm (right)	0.9	4.1	7.6	-0.7	-2.8
Father’s age at death	0.9	1.2	2.1	1.4	0.5
Happiness	0.9	1.1	1.6	-0.8	-1.3
Lung cancer (father)	0.9	1.1	1.6	0.7	1.3
Number of full sisters	0.9	1.1	2.2	-1.5	-0.1
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.9	0.4	-1.4
Medication for cholesterol	0.9	1.4	2.3	1.5	0.7
Diastolic blood pressure, automated reading	0.9	2.7	5.2	-2.3	-0.5
Irritable Bowel Disease (IBD)	0.8	1.9	2.9	1.7	0.9
Crohns Disease (2012)	0.8	1.3	2.5	1.6	0.1
Leg fat-free mass (left)	0.8	4.5	5.6	1.8	2.4
High blood pressure	0.8	2.2	3.6	-1.9	-0.9
Medication: Simvastatin	0.8	1.2	2.3	-0.2	1.5
Blood clot in the leg (DVT)	0.8	1.1	1.3	-0.9	-1.1
Smoking status: Current	0.8	1.3	2.6	-1.6	-0.2
Irritability	0.8	1.4	1.6	-1.2	-1.1
Ever depressed for a whole week	0.8	1.0	1.5	-1.2	-0.8
Supplements: Calcium	0.8	0.8	1.7	1.3	0.2
Ovarian Cancer	0.7	0.9	1.2	-0.8	-1.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.6	-1.3	-0.5
Number of incorrect matches in round	0.7	1.2	1.6	-0.9	-1.3
Qualifications: None of the above	0.7	1.6	3.2	-1.8	0.1
Illnesses of siblings	0.7	1.0	1.4	0.8	1.2
Suffer from ‘nerves’	0.7	1.0	1.9	1.4	0.4
Knee pain experienced in last month	0.7	1.1	1.8	-1.4	-0.6
Hypertension (Self-reported)	0.7	2.1	3.0	-1.7	-1.1
Long-standing illness, disability or infirmity	0.7	1.0	2.1	-1.4	-0.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.7	-1.3	0.3
Risk taking	0.7	1.0	2.0	-1.4	0.2
Fractured/broken bones in last 5 years	0.7	1.0	1.4	-1.2	0.7
Age started oral contraceptive pill	0.7	0.9	1.8	0.0	-1.4
Basal cell carcinoma (self-reported)	0.7	0.9	1.5	0.4	1.2
Height	0.6	11.1	16.9	4.1	2.3
Chronotype (morning person)	0.6	1.5	2.6	1.6	0.6
Impedance of leg (right)	0.6	2.8	5.4	-0.4	-2.3
Fed-up feelings	0.6	1.2	2.3	-0.0	-1.5
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.5	-1.2	-0.2
Medication: Cholesterol lowering	0.6	0.9	1.6	-0.6	1.3
Illnesses of mother	0.6	0.7	1.3	0.3	-1.1
Impedance of arm (left)	0.6	2.6	5.2	0.1	-2.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.5	-0.1	-1.2
Worry too long after embarrassment	0.6	1.0	1.3	0.8	-1.1
Pulse wave peak to peak time	0.6	0.8	1.4	-0.3	-1.2
Medication: Seretide 50 evohaler	0.6	0.6	0.7	-0.8	-0.8
Comparative height size at age 10	0.6	3.4	6.6	2.6	0.5
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.0	1.0	0.7
Qualifications: nursing, teaching	0.6	0.9	1.2	-0.8	-1.1
Number of operations (self-reported)	0.6	1.0	1.1	-1.1	0.9
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.3	0.5	1.1
Impedance of whole body	0.6	3.1	6.2	0.2	-2.5
Schizophrenia vs Biploar Disorder	0.5	0.6	0.7	-0.7	-0.9
Cardiovascular Disease	0.5	1.7	2.8	-1.7	-0.8
Supplements: Glucosamine	0.5	0.7	1.2	0.4	-1.1
Had other major operations	0.5	0.6	1.1	-0.4	1.0
Neuroticism score	0.5	1.1	1.6	-0.8	-1.3
Weight	0.5	2.5	3.0	1.7	1.4
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.9	1.4	0.5
Breastfed as a baby	0.5	0.6	1.0	1.0	0.4
Headache pain in last month	0.5	0.8	1.6	-1.2	-0.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	1.7	-1.3	0.7
High blood pressure (siblings)	0.5	0.8	1.5	-1.2	0.1
Eye problems/disorders: None of the above	0.5	0.5	0.7	0.6	0.8
Medication: Aspirin	0.5	0.7	1.3	-1.1	0.0
Illnesses of father: Heart disease	0.5	0.6	0.8	0.7	0.9
Wears glasses or contact lenses	0.5	0.6	1.2	0.1	1.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.0	1.0	0.4
Alcohol drinker status: Never	0.5	0.6	0.7	-0.7	0.8
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.5	1.6	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	0.8	-0.6	-0.9
Heart disease (siblings)	0.5	0.6	1.0	-0.4	-1.0
Alzheimer’s Disease (in father)	0.4	0.5	0.9	-0.2	-1.0
Crohns Disease (2017)	0.4	0.8	1.6	1.2	-0.4
Body Mass Index (BMI) (2010)	0.4	0.5	0.6	-0.7	-0.8
Respiratory disease	0.4	0.8	1.3	0.6	-1.1
Angina	0.4	0.5	1.0	0.3	1.0
Vitamin and mineral supplements	0.4	0.5	0.5	-0.7	-0.6
Diabetes (mother)	0.4	0.6	0.9	1.0	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.3	-0.8	1.1
Qualifications: CSEs or equivalent	0.4	0.6	1.1	1.1	-0.2
Impedance of leg (left)	0.4	2.1	4.0	0.4	-2.0
Waist circumference	0.4	1.6	1.9	1.4	1.1
Nervous feelings	0.4	0.7	1.3	0.1	-1.1
Time employed in main current job	0.4	0.5	0.9	0.1	-1.0
Asthma	0.4	0.7	1.4	1.2	-0.3
Wheeze or whistling in the chest in last year	0.4	0.7	1.5	-1.2	-0.1
Health satisfaction	0.4	0.6	0.9	-0.5	-0.9
Leg pain on walking	0.4	0.5	1.0	-0.2	-1.0
Commuting to job workplace: Walk	0.4	0.4	0.8	0.2	0.9
Asthma (self-reported)	0.4	0.8	1.5	1.2	-0.3
Osteoporosis (self-reported)	0.4	0.5	0.9	-0.4	-1.0
Medication: Aspirin	0.4	0.5	0.9	-1.0	-0.1
Arm fat mass (left)	0.4	1.8	2.0	1.4	1.2
Medication: Paracetamol	0.4	0.7	0.9	-0.9	-0.7
Myopia	0.4	0.6	0.7	-0.9	0.6
Cholesterol lowering medication	0.4	0.5	1.0	-1.0	-0.2
Schizophrenia (2018)	0.3	0.5	0.8	-0.9	-0.5
Bipolar Disorder (2011)	0.3	0.3	0.6	0.2	-0.8
Triglycerides	0.3	0.6	1.0	-1.0	-0.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.4	-0.5	-0.6
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.5	0.0	1.2
Multivitamins +/- minerals	0.3	0.3	0.4	0.6	0.6
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.4	0.6	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.3	-0.0	1.2
Financial difficulties in last 2 years	0.3	0.4	0.7	-0.8	-0.3
Heart attack	0.3	0.4	0.8	0.3	0.9
Number of live births	0.3	0.4	0.6	0.7	0.6
Depression (self-reported)	0.3	0.4	0.6	0.4	-0.8
Arm fat mass (right)	0.3	1.2	1.3	1.1	1.1
Medication: Paracetamol	0.3	0.5	0.5	-0.7	-0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	0.3	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	-0.2	-0.8
Angina (self-reported)	0.3	0.3	0.6	0.2	0.8
Mean time to correctly identify matches	0.3	0.6	0.9	1.0	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.5	-0.5	-0.7
Pulse rate, automated reading	0.3	1.0	2.0	0.2	-1.4
Chest pain or discomfort	0.3	0.5	0.8	-0.9	0.3
Illnesses of siblings: Diabetes	0.3	0.4	0.6	0.4	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.0	-1.0	0.2
Medication: Gliclazide	0.3	0.3	0.6	-0.7	-0.3
Ever taken oral contraceptive pill	0.3	0.4	0.7	-0.8	-0.1
Hearing aid user	0.3	0.3	0.6	-0.2	-0.8
High cholesterol (Self-reported)	0.3	0.6	1.2	-0.2	1.1
Medication: Lisinopril	0.3	0.4	0.5	-0.7	-0.5
Illnesses of father: High blood pressure	0.3	0.4	0.7	-0.9	-0.3
Ever smoked	0.3	0.5	1.0	0.2	1.0
Commuting to job workplace: Cycle	0.3	0.3	0.5	-0.3	-0.7
Pack years of smoking	0.3	0.5	0.9	-0.9	-0.2
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.9	0.9	0.4
Worry (Nagel 2018)	0.2	0.5	0.9	-0.4	-0.9
Neuroticism (2016)	0.2	0.4	0.6	0.3	-0.8
Relative age of first facial hair	0.2	0.5	0.5	0.7	-0.7
Supplements: Zinc	0.2	0.2	0.5	0.7	0.1
Pack years adult smoking proportion	0.2	0.3	0.6	-0.8	0.2
Trunk fat percentage	0.2	0.6	0.9	0.9	-0.6
Maternal smoking around birth	0.2	0.2	0.4	-0.2	0.6
Relative age voice broke	0.2	0.3	0.4	0.4	-0.6
Stomach or abdominal pain in last month	0.2	0.3	0.4	-0.4	0.7
Medication: Levothyroxine sodium	0.2	0.3	0.5	-0.7	0.3
Trunk fat mass	0.2	1.1	2.1	1.4	0.2
Medication: Ramipril	0.2	0.2	0.4	-0.0	0.6
Hip circumference	0.2	0.8	1.5	1.2	-0.1
Pulse rate	0.2	0.3	0.3	0.4	-0.6
Medication: Lansoprazole	0.2	0.3	0.6	0.7	0.0
Tense / ‘highly strung’	0.2	0.4	0.8	0.1	-0.9
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	-0.9	-0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.6	0.3	-0.8
Leg fat percentage (right)	0.2	0.8	1.3	-0.6	-1.1
Comparative body size at age 10	0.2	0.5	1.0	-1.0	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.6	0.2
Number of children fathered	0.2	0.2	0.4	0.0	0.6
Age at first live birth	0.2	0.3	0.5	0.4	-0.7
Whole body fat mass	0.2	0.6	1.1	1.0	0.5
Family relationship satisfaction	0.2	0.3	0.4	-0.6	0.3
Mineral and other dietary supplements	0.2	0.2	0.4	0.2	0.6
Number of self-reported non-cancer illnesses	0.2	0.4	0.5	0.7	0.5
Miserableness	0.2	0.4	0.5	-0.6	-0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	-0.3	0.8
Breast Cancer	0.1	0.3	0.5	0.7	-0.0
Schizophrenia (2014)	0.1	0.1	0.2	-0.5	-0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	0.5	0.4
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.1	-0.2	0.3
Hearing difficulty/problems: Yes	0.1	0.2	0.3	-0.5	0.2
Medication: Metformin	0.1	0.1	0.1	-0.3	0.2
Average weekly fortified wine intake	0.1	0.1	0.2	-0.4	0.1
Past tobacco smoking	0.1	0.1	0.2	0.4	-0.4
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.5	0.3
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.2	0.3	0.5
Loud music exposure frequency	0.1	0.1	0.2	-0.4	-0.2
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	0.2	0.3
Body fat percentage	0.1	0.4	0.6	0.5	-0.8
Medication: Blood pressure	0.1	0.1	0.2	-0.4	-0.0
Migraine (self-reported)	0.1	0.1	0.1	0.1	0.4
Smoking status: Previous	0.1	0.1	0.2	-0.4	0.3
Loneliness, isolation	0.1	0.1	0.2	-0.1	-0.4
Financial situation satisfaction	0.1	0.1	0.1	-0.2	-0.3
Medication: Blood pressure	0.1	0.2	0.4	-0.6	-0.3
Leg fat percentage (left)	0.1	0.4	0.7	-0.1	-0.8
Unable to work because of sickness or disability	0.1	0.1	0.2	0.5	0.1
Leg fat mass (left)	0.1	0.4	0.7	0.8	0.3
Age at First Birth	0.0	0.1	0.1	-0.3	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	-0.0	0.1
HDL Cholesterol	0.0	0.1	0.1	0.3	-0.1
Blood Eosinophil Count	0.0	0.3	0.6	-0.3	-0.7
Blood Red Count	0.0	0.5	0.9	0.0	1.0
BMI	0.0	0.3	0.3	0.4	0.6
Allergy or Eczema	0.0	0.0	0.0	0.2	-0.0
Hair Pigment	0.0	0.8	1.1	0.8	1.0
Tanning	0.0	0.0	0.1	0.3	-0.1
Number of treatments/medications taken	0.0	0.0	0.1	-0.2	0.2
Average weekly spirits intake	0.0	0.0	0.0	-0.1	0.1
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	-0.0	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.1	-0.1	-0.3
Taking other prescription medications	0.0	0.0	0.0	0.2	0.2
Serious illness, injury or assault to yourself	0.0	0.0	0.0	0.1	0.1
Body mass index (BMI)	0.0	0.2	0.4	0.1	0.6
Alcohol usually taken with meals	0.0	0.0	0.1	-0.2	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	0.1	0.3
Allergy	0.0	0.0	0.1	0.1	-0.3
Diabetes (self-reported)	0.0	0.0	0.0	0.1	-0.2
Arm fat percentage (right)	0.0	0.1	0.2	0.1	-0.4
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	-0.3	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.1	0.3
Pulse wave reflection index	0.0	0.1	0.1	-0.3	0.2
Birth weight	0.0	0.1	0.1	0.3	-0.1
Qualifications: College or University degree	0.0	0.1	0.2	-0.5	0.2
Medication: Omeprazole	0.0	0.0	0.1	-0.1	0.3
Leg fat mass (right)	0.0	0.2	0.4	0.6	0.1
Alcohol intake frequency.	0.0	0.1	0.2	-0.5	-0.1
Age at last live birth	0.0	0.1	0.1	-0.1	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.0	-0.1	0.2
Arm fat percentage (left)	0.0	0.1	0.1	0.4	-0.2
Diabetes diagnosed by doctor	0.0	0.0	0.0	-0.0	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	-0.0	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	-0.0	-0.2
Guilty feelings	0.0	0.1	0.1	0.3	-0.1
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	0.2	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.2	-0.1

Hub : Genes

HESX1

Models

Trait associations