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Traits
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Forced expiratory volume in 1-second (FEV1), Best measure
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chr4:144,230,902-146,788,825
Best TWAS P=1.14e-30 · Best GWAS P=5.97e-40 conditioned to 6.12e-08
144.5M
145M
145.5M
146M
146.5M
0
10
20
30
40
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Brain Hypothalamus
HHIP-AS1
0.12
0.02
enet
16
0.04
4.6e-02
8.9
11.5
1.1e-30
-0.61
0.06
0.20
TRUE
5
ROSMAP
Brain Pre-frontal Cortex
OTUD4
0.04
0.03
lasso
2
0.03
1.4e-04
8.2
-8.4
4.0e-17
0.26
0.35
0.48
TRUE
4
GTEx
Pancreas
ANAPC10
0.14
0.10
lasso
3
0.10
4.3e-05
-9.7
9.4
5.9e-21
-0.39
0.34
0.05
FALSE
2
CommonMind
Brain Pre-frontal Cortex
OTUD4
0.06
0.04
bslmm
272
0.04
2.6e-05
-9.3
-8.9
5.4e-19
0.35
0.24
0.73
FALSE
1
CommonMind
Brain Pre-frontal Cortex
GYPA
0.20
0.06
blup
293
0.10
4.0e-12
-3.0
-5.9
2.8e-09
0.34
1.00
0.00
FALSE