[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), Best measure : ← →

chr4:105,373,669-107,622,327

Best TWAS P=5.57e-26 · Best GWAS P=1.67e-29 conditioned to 0.0765

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
13	GTEx	Esophagus Gastroesophageal Junction	PPA2	0.29	0.15	lasso	5	0.14	8.8e-06	-11.3	-10.5	5.6e-26	0.89	0.00	0.99	TRUE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	GSTCD	0.07	0.05	lasso	4	0.04	6.6e-05	8.8	9.0	2.8e-19	-0.09	0.02	0.98	TRUE
19	GTEx	Muscle Skeletal	PPA2	0.19	0.06	enet	28	0.11	8.7e-11	-7.8	-5.5	3.7e-08	0.60	0.67	0.33	TRUE
6	GTEx	Artery Aorta	PPA2	0.11	-0.01	enet	24	0.01	1.6e-01	-11.3	-9.2	3.0e-20	0.68	0.02	0.86	FALSE
14	GTEx	Esophagus Mucosa	PPA2	0.18	0.06	enet	14	0.12	2.5e-08	7.1	-9.0	1.7e-19	0.75	0.02	0.98	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	INTS12	0.04	0.03	blup	49	0.04	7.1e-08	7.5	-8.9	4.3e-19	0.09	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	INTS12	0.03	0.02	blup	49	0.02	6.4e-03	8.8	-8.9	5.9e-19	0.11	0.01	0.88	FALSE
30	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	INTS12	0.12	0.06	blup	50	0.08	1.2e-04	8.7	-8.9	7.2e-19	0.10	0.01	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	INTS12	0.06	0.06	enet	5	0.05	2.9e-07	8.8	-8.8	1.8e-18	0.08	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	INTS12	0.08	0.10	lasso	2	0.10	2.9e-11	8.7	-8.7	2.5e-18	0.08	0.01	0.99	FALSE
26	GTEx	Thyroid	INTS12	0.07	0.05	lasso	7	0.03	1.2e-03	8.7	-8.7	3.0e-18	0.08	0.86	0.00	FALSE
24	GTEx	Skin Sun Exposed Lower leg	GSTCD	0.08	0.02	lasso	6	0.01	3.8e-02	7.8	8.7	4.5e-18	-0.14	0.80	0.01	FALSE
34	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INTS12	0.32	0.00	blup	49	0.06	1.8e-04	7.5	-8.5	2.0e-17	0.09	0.01	0.80	FALSE
9	GTEx	Brain Cortex	PPA2	0.14	0.09	lasso	9	0.09	1.6e-03	-8.3	-8.4	3.3e-17	0.79	0.06	0.60	FALSE
12	GTEx	Cells Transformed fibroblasts	INTS12	0.15	0.16	lasso	9	0.17	9.5e-13	7.8	-8.4	3.9e-17	0.08	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	INTS12	0.08	0.10	enet	11	0.10	9.9e-12	8.8	-8.4	4.6e-17	0.10	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Stomach Adenocarcinoma	GSTCD	0.04	0.06	lasso	1	0.05	9.1e-05	8.3	8.3	9.7e-17	-0.09	0.03	0.91	FALSE
15	GTEx	Esophagus Muscularis	INTS12	0.12	0.10	lasso	15	0.10	1.3e-06	8.7	-8.3	1.0e-16	0.06	0.98	0.00	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	INTS12	0.11	0.09	blup	49	0.11	1.3e-10	8.7	-8.3	1.1e-16	0.13	0.01	0.99	FALSE
21	GTEx	Nerve Tibial	GSTCD	0.09	0.03	enet	16	0.02	1.3e-02	7.1	8.2	2.0e-16	-0.13	0.59	0.02	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	GSTCD	0.16	0.07	lasso	17	0.03	4.3e-02	7.8	8.1	8.3e-16	-0.08	0.39	0.04	FALSE
28	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	INTS12	0.04	0.03	blup	51	0.04	3.9e-04	7.8	-8.0	8.7e-16	0.13	0.01	0.96	FALSE
38	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	INTS12	0.22	0.15	lasso	6	0.16	2.3e-07	7.8	-8.0	1.7e-15	0.06	0.02	0.96	FALSE
7	GTEx	Artery Aorta	INTS12	0.13	0.14	lasso	3	0.14	6.5e-08	7.5	-7.7	1.4e-14	0.09	0.95	0.00	FALSE
3	GTEx	Adipose Subcutaneous	GSTCD	0.08	0.07	lasso	8	0.07	2.9e-06	6.0	7.6	2.8e-14	-0.13	0.97	0.00	FALSE
16	GTEx	Heart Atrial Appendage	PPA2	0.15	0.05	lasso	7	0.06	7.4e-04	-8.1	-7.2	4.1e-13	0.65	0.19	0.50	FALSE
22	GTEx	Ovary	PPA2	0.18	0.10	lasso	3	0.14	2.2e-04	-7.5	-7.2	5.9e-13	0.69	0.02	0.90	FALSE
20	GTEx	Nerve Tibial	PPA2	0.13	0.07	enet	23	0.07	2.1e-05	-7.5	-7.2	6.8e-13	0.59	0.25	0.63	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	PPA2	0.04	0.02	blup	84	0.04	6.1e-05	-7.8	-7.2	8.7e-13	0.72	0.14	0.65	FALSE
23	GTEx	Pituitary	GSTCD	0.28	0.14	lasso	5	0.09	2.8e-03	7.5	7.0	1.9e-12	-0.12	0.35	0.04	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	INTS12	0.15	0.11	lasso	3	0.17	2.1e-17	3.9	-6.8	8.4e-12	0.15	0.05	0.95	FALSE
37	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	INTS12	0.03	0.01	blup	49	0.03	6.0e-03	4.6	-6.7	1.6e-11	0.16	0.02	0.64	FALSE
5	GTEx	Adrenal Gland	INTS12	0.23	0.02	enet	21	0.04	1.4e-02	2.4	-6.7	3.0e-11	0.06	0.18	0.04	FALSE
17	GTEx	Lung	PPA2	0.09	0.02	enet	16	0.03	1.4e-03	3.2	-6.6	3.3e-11	0.49	0.13	0.56	FALSE
25	GTEx	Skin Sun Exposed Lower leg	TET2	0.09	0.01	enet	18	0.02	3.6e-03	-10.8	-6.1	1.2e-09	0.63	0.05	0.76	FALSE
4	GTEx	Adipose Visceral Omentum	PPA2	0.15	0.04	lasso	6	0.05	9.1e-04	4.9	-5.8	5.0e-09	0.37	0.12	0.20	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPA2	0.11	0.03	blup	84	0.03	4.7e-04	-7.5	-5.8	5.5e-09	0.55	0.24	0.58	FALSE
2	GTEx	Adipose Subcutaneous	PPA2	0.15	0.02	enet	36	0.06	7.0e-06	4.6	-5.7	9.6e-09	0.35	0.26	0.14	FALSE
18	GTEx	Lung	NPNT	0.07	0.02	enet	24	0.04	2.3e-04	8.7	-5.6	2.0e-08	0.00	0.03	0.94	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	PPA2	0.32	0.38	lasso	2	0.38	1.1e-51	4.9	-5.5	4.0e-08	0.38	1.00	0.00	FALSE
8	GTEx	Brain Cerebellum	PPA2	0.22	0.01	lasso	4	0.03	3.7e-02	-7.5	-5.4	5.8e-08	0.56	0.08	0.17	FALSE
11	GTEx	Cells Transformed fibroblasts	PPA2	0.11	0.03	lasso	3	0.01	6.5e-02	-4.9	-5.1	3.0e-07	0.59	0.29	0.38	FALSE