TWAS
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Models
Genes
Traits
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Traits
:
Forced expiratory volume in 1-second (FEV1), Best measure
:
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chr5:130,936,652-132,401,730
Best TWAS P=3.4e-08 · Best GWAS P=2.72e-07 conditioned to 0.0354
131M
131.2M
131.4M
131.6M
131.8M
132M
132.2M
132.4M
0
2
4
6
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Whole Blood
SLC22A4
0.07
0.05
enet
16
0.05
4.6e-05
-4.7
-5.5
3.4e-08
0.64
0.04
0.90
TRUE
4
The Cancer Genome Atlas
Lung Adenocarcinoma
SLC22A5
0.06
0.03
lasso
4
0.02
9.3e-04
-4.7
-5.4
7.2e-08
0.66
0.00
0.90
FALSE
2
GTEx
Whole Blood
AC034220.3
0.08
0.05
enet
31
0.06
4.0e-06
3.5
-5.4
8.5e-08
0.59
0.16
0.76
FALSE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
PDLIM4
0.09
0.02
lasso
6
0.05
4.5e-06
-4.1
-5.2
2.0e-07
0.40
0.03
0.87
FALSE