[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), Best measure :

chr5:139,323,257-141,214,127

Best TWAS P=5.7e-10 · Best GWAS P=6.7e-08 conditioned to 0.445

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex NDUFA2 0.02 0.01 bslmm 343 0.01 7.8e-03 -5.3 5.2 2.3e-07 -0.89 0.08 0.71 FALSE
2 CommonMind Brain Pre-frontal Cortex PCDHA2 0.04 0.03 blup 478 0.03 5.0e-05 -4.8 -5.2 2.6e-07 0.83 0.11 0.89 FALSE
3 CommonMind Brain Pre-frontal Cortex PCDHA7 0.13 0.14 lasso 8 0.14 5.1e-17 -5.3 -5.2 2.0e-07 0.97 0.04 0.96 FALSE
4 CommonMind Brain Pre-frontal Cortex ZMAT2 0.06 0.10 blup 360 0.09 1.4e-11 -4.8 -5.7 1.2e-08 0.85 0.19 0.80 FALSE
5 GTEx Brain Hypothalamus HARS 0.14 -0.01 enet 15 -0.01 6.3e-01 4.5 5.2 1.5e-07 -0.70 0.06 0.37 FALSE
6 GTEx Cells Transformed fibroblasts ZMAT2 0.04 0.02 lasso 4 0.02 2.4e-02 -5.4 -5.5 3.6e-08 0.96 0.05 0.88 FALSE
7 GTEx Esophagus Mucosa ZMAT2 0.06 0.02 enet 16 0.02 1.1e-02 4.5 -5.3 1.2e-07 0.78 0.08 0.83 FALSE
8 GTEx Heart Left Ventricle TMCO6 0.05 0.01 lasso 5 0.00 6.2e-01 -5.2 -5.6 2.5e-08 0.91 0.05 0.78 FALSE
9 GTEx Heart Left Ventricle PCDHB5 0.11 0.05 lasso 3 0.06 5.3e-04 4.8 6.2 5.7e-10 -0.80 0.06 0.80 TRUE
10 GTEx Nerve Tibial HARS 0.07 0.01 enet 16 0.04 1.1e-03 -5.4 5.2 2.0e-07 -0.84 0.07 0.88 FALSE
11 METSIM Adipose DND1 0.08 0.11 lasso 5 0.10 7.3e-15 -5.4 5.3 9.7e-08 -0.98 0.06 0.94 FALSE
12 The Cancer Genome Atlas Breast Invasive Carcinoma PCDHA4 0.01 0.02 lasso 1 0.01 4.9e-04 -5.4 -5.4 6.8e-08 0.98 0.00 0.97 FALSE
13 The Cancer Genome Atlas Breast Invasive Carcinoma ZMAT2 0.03 0.03 enet 5 0.03 7.7e-07 5.0 -5.2 1.9e-07 0.84 0.02 0.98 FALSE
14 The Cancer Genome Atlas Lung Adenocarcinoma PCDHA13 0.02 0.01 enet 11 0.02 5.6e-03 4.8 5.2 1.6e-07 -0.64 0.01 0.83 FALSE
15 The Cancer Genome Atlas Prostate Adenocarcinoma HARS2 0.03 0.03 lasso 5 0.02 2.9e-03 5.0 -5.2 2.0e-07 0.77 0.02 0.85 FALSE
16 The Cancer Genome Atlas Prostate Adenocarcinoma ZMAT2 0.03 0.03 enet 6 0.04 1.3e-04 -4.7 -5.2 1.5e-07 0.90 0.02 0.89 FALSE