Best TWAS P=5.7e-10 · Best GWAS P=6.7e-08 conditioned to 0.445
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NDUFA2 | 0.02 | 0.01 | bslmm | 343 | 0.01 | 7.8e-03 | -5.3 | 5.2 | 2.3e-07 | -0.89 | 0.08 | 0.71 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PCDHA2 | 0.04 | 0.03 | blup | 478 | 0.03 | 5.0e-05 | -4.8 | -5.2 | 2.6e-07 | 0.83 | 0.11 | 0.89 | FALSE |
| 3 | CommonMind | Brain Pre-frontal Cortex | PCDHA7 | 0.13 | 0.14 | lasso | 8 | 0.14 | 5.1e-17 | -5.3 | -5.2 | 2.0e-07 | 0.97 | 0.04 | 0.96 | FALSE |
| 4 | CommonMind | Brain Pre-frontal Cortex | ZMAT2 | 0.06 | 0.10 | blup | 360 | 0.09 | 1.4e-11 | -4.8 | -5.7 | 1.2e-08 | 0.85 | 0.19 | 0.80 | FALSE |
| 5 | GTEx | Brain Hypothalamus | HARS | 0.14 | -0.01 | enet | 15 | -0.01 | 6.3e-01 | 4.5 | 5.2 | 1.5e-07 | -0.70 | 0.06 | 0.37 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | ZMAT2 | 0.04 | 0.02 | lasso | 4 | 0.02 | 2.4e-02 | -5.4 | -5.5 | 3.6e-08 | 0.96 | 0.05 | 0.88 | FALSE |
| 7 | GTEx | Esophagus Mucosa | ZMAT2 | 0.06 | 0.02 | enet | 16 | 0.02 | 1.1e-02 | 4.5 | -5.3 | 1.2e-07 | 0.78 | 0.08 | 0.83 | FALSE |
| 8 | GTEx | Heart Left Ventricle | TMCO6 | 0.05 | 0.01 | lasso | 5 | 0.00 | 6.2e-01 | -5.2 | -5.6 | 2.5e-08 | 0.91 | 0.05 | 0.78 | FALSE |
| 9 | GTEx | Heart Left Ventricle | PCDHB5 | 0.11 | 0.05 | lasso | 3 | 0.06 | 5.3e-04 | 4.8 | 6.2 | 5.7e-10 | -0.80 | 0.06 | 0.80 | TRUE |
| 10 | GTEx | Nerve Tibial | HARS | 0.07 | 0.01 | enet | 16 | 0.04 | 1.1e-03 | -5.4 | 5.2 | 2.0e-07 | -0.84 | 0.07 | 0.88 | FALSE |
| 11 | METSIM | Adipose | DND1 | 0.08 | 0.11 | lasso | 5 | 0.10 | 7.3e-15 | -5.4 | 5.3 | 9.7e-08 | -0.98 | 0.06 | 0.94 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PCDHA4 | 0.01 | 0.02 | lasso | 1 | 0.01 | 4.9e-04 | -5.4 | -5.4 | 6.8e-08 | 0.98 | 0.00 | 0.97 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZMAT2 | 0.03 | 0.03 | enet | 5 | 0.03 | 7.7e-07 | 5.0 | -5.2 | 1.9e-07 | 0.84 | 0.02 | 0.98 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | PCDHA13 | 0.02 | 0.01 | enet | 11 | 0.02 | 5.6e-03 | 4.8 | 5.2 | 1.6e-07 | -0.64 | 0.01 | 0.83 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HARS2 | 0.03 | 0.03 | lasso | 5 | 0.02 | 2.9e-03 | 5.0 | -5.2 | 2.0e-07 | 0.77 | 0.02 | 0.85 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZMAT2 | 0.03 | 0.03 | enet | 6 | 0.04 | 1.3e-04 | -4.7 | -5.2 | 1.5e-07 | 0.90 | 0.02 | 0.89 | FALSE |