TWAS hub - PCDHB5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1300	0.0410	1.5e-06	0.041	0.045	0.050	0.049	0.043	8.7e-06	2.9e-06	1.0e-06	1.1e-06	5.1e-06
2	GTEx	Heart Left Ventricle	0.1116	0.0522	5.6e-04	0.051	NA	0.032	NA	0.057	1.1e-03	NA	8.1e-03	NA	5.3e-04
3	METSIM	Adipose	0.0303	0.0181	1.6e-02	0.007	0.007	0.002	0.013	0.005	2.3e-02	2.5e-02	1.4e-01	4.1e-03	4.8e-02
4	TCGA	Breast Invasive Carcinoma	0.0134	0.0071	4.1e-03	0.002	0.004	-0.001	NA	0.001	9.9e-02	3.9e-02	5.6e-01	NA	1.5e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Ever unenthusiastic/disinterested for a whole week	9.5	11.6	17.6	-0.2	4.1	4.2	3.4
Schizophrenia (2018)	6.9	14.3	25.9	-3.2	-5.1	-2.6	-3.8
Intelligence (Savage-Jansen 2018)	6.1	18.8	32.3	2.8	5.7	4.6	3.8
Eye problems/disorders: None of the above	6.1	7.1	14.5	-1.7	-3.8	-0.9	-3.2
Bipolar Disorder or Schizophrenia	5.7	13.9	25.4	-3.3	-5.0	-2.1	-3.9
Mouth/teeth dental problems: Bleeding gums	5.1	6.6	11.6	-1.0	-2.5	-3.4	-2.7
Forced expiratory volume in 1-second (FEV1), Best measure	5.0	15.9	38.4	3.7	6.2	1.4	3.1
Forced vital capacity (FVC), Best measure	4.7	17.2	36.2	4.3	6.0	1.5	3.5
Verbal and Numeric Reasoning (VNR)	4.6	11.1	16.6	3.0	4.1	2.6	3.5
Bipolar Disorder (2011)	4.3	4.2	8.7	-2.6	-3.0	-1.0	0.0
Blood White Count	4.1	30.2	50.6	-7.1	-5.9	-4.3	-4.2
Friendships satisfaction	4.1	5.1	14.0	0.6	3.7	2.3	0.8
Systolic Blood Pressure	4.0	19.9	41.3	-3.4	-6.4	-3.4	-3.9
Had other major operations	4.0	4.8	7.4	1.8	2.7	1.6	2.5
Long-standing illness, disability or infirmity	4.0	6.1	18.1	-0.3	0.7	4.3	2.4
Frequency of depressed mood in last 2 weeks	3.7	5.2	7.5	2.6	2.7	2.3	1.1
Depression (Nagel 2018)	3.6	5.4	8.5	1.8	2.9	2.8	1.5
Forced vital capacity (FVC)	3.6	13.7	31.7	3.9	5.6	0.4	2.8
Frequency of tiredness / lethargy in last 2 weeks	3.6	5.8	11.8	0.9	2.4	3.4	2.2
Unable to work because of sickness or disability	3.6	4.7	15.6	-4.0	-1.7	0.5	0.2
Schizophrenia (2014)	3.4	7.4	14.7	-2.1	-3.8	-1.9	-2.7
Forced expiratory volume in 1-second (FEV1)	3.4	11.6	29.4	3.3	5.4	-0.0	2.4
Happiness	3.3	4.0	7.4	-0.2	2.7	2.4	1.7
Birth weight	3.2	6.9	10.6	1.7	3.3	2.8	2.5
Miserableness	3.2	5.5	9.9	1.2	2.2	3.1	2.4
Supplements: Zinc	2.9	3.1	6.7	2.6	2.1	0.2	1.2
Serious illness, injury or assault of a close relative in last 2 years	2.8	3.2	5.9	2.3	2.4	-0.2	1.3
Number of operations (self-reported)	2.8	4.2	8.7	0.6	2.4	1.4	3.0
Wears glasses or contact lenses	2.7	3.1	7.6	1.1	2.8	0.9	1.7
Alcohol drinker status: Never	2.7	3.2	8.5	-2.0	-2.9	-0.0	-0.7
Neuroticism	2.6	6.2	9.3	2.4	3.0	3.0	0.9
Blood clot in the leg (DVT)	2.6	3.4	7.3	1.0	1.4	1.8	2.7
Other serious medical condition/disability diagnosed by doctor	2.5	3.2	7.9	0.2	1.4	2.8	1.8
Emphysema/chronic bronchitis	2.4	2.7	6.9	-2.6	-0.6	1.8	0.7
Eye problems/disorders: Cataract	2.4	2.8	8.0	0.8	2.8	-0.1	1.6
Medication: Bendroflumethiazide	2.4	3.7	6.6	-1.8	-2.6	-1.2	-1.9
Depressed Affect (Nagel 2018)	2.3	4.9	7.2	2.5	2.7	2.3	1.0
Medication: Seretide 50 evohaler	2.3	2.7	5.9	-0.5	1.1	1.8	2.4
Chest pain or discomfort	2.3	3.3	6.5	-0.1	2.5	1.9	1.8
Qualifications: nursing, teaching	2.3	3.6	9.0	1.7	3.0	-1.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	4.8	16.3	1.1	4.0	-0.3	1.3
Allergy or Eczema	2.2	5.9	8.1	2.0	2.9	2.4	2.4
Heart attack	2.2	2.9	5.4	-2.3	-2.1	-0.1	-1.3
Deep venous thrombosis (DVT) (self-reported)	2.2	2.8	6.9	1.1	1.0	1.4	2.6
Lung FVC	2.1	10.7	23.1	1.4	4.8	1.7	3.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.9	6.9	1.1	1.7	2.6	0.6
Sitting height	2.1	15.2	25.9	4.0	5.1	2.1	3.9
Commuting to job workplace: Cycle	2.1	2.6	3.3	1.8	1.8	1.1	1.6
Systolic blood pressure, automated reading	2.0	5.8	11.3	-2.6	-3.4	-1.7	-1.4
Medication: Simvastatin	2.0	2.9	6.2	-2.5	-1.8	0.4	-1.4
Pulse wave peak to peak time	2.0	2.4	7.7	2.8	1.2	-0.5	0.3
Qualifications: College or University degree	2.0	6.3	16.9	2.0	4.1	1.4	1.5
Fed-up feelings	1.9	3.5	6.0	2.0	1.9	2.5	0.6
Fluid intelligence score	1.9	4.0	10.0	1.6	3.2	0.8	1.7
Neuroticism score	1.9	3.9	7.6	1.9	2.0	2.8	0.6
Father’s age at death	1.9	2.6	5.3	1.6	1.1	1.2	2.3
Lung cancer (father)	1.9	2.2	3.6	-1.0	-1.8	-1.9	-0.9
Family relationship satisfaction	1.9	2.3	5.3	0.0	2.3	2.0	0.3
Financial situation satisfaction	1.9	2.4	5.7	0.2	1.7	2.4	0.9
Heart attack/myocardial infarction (self-reported)	1.9	2.4	4.7	-2.2	-1.9	-0.2	-1.2
Type 2 Diabetes (T2D) (2018)	1.8	3.5	12.2	-1.0	-0.3	3.5	0.7
Medication: Ramipril	1.8	2.3	4.1	-1.4	-2.0	-1.2	-1.4
Neuroticism (Nagel 2018)	1.7	3.9	5.2	2.3	2.3	2.2	0.5
Overall health rating	1.7	3.6	7.3	-2.7	-1.8	2.0	-0.2
Diabetes diagnosed by doctor	1.7	2.8	6.3	-1.8	-0.9	2.5	0.8
Alzheimer’s Disease (in father)	1.6	1.7	5.7	2.4	1.0	0.2	0.3
Medication: Atenolol	1.6	2.0	3.2	-1.6	-1.4	-1.8	-0.4
Medication: Lansoprazole	1.6	1.8	5.8	0.3	0.4	2.4	1.1
Standing height	1.6	16.3	25.7	4.6	5.1	2.1	3.7
Length of working week for main job	1.6	1.8	3.6	1.9	1.6	0.9	-0.2
Medication: Gliclazide	1.6	1.8	4.8	-0.2	0.6	2.2	1.4
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	6.6	-2.6	-0.6	0.9	-0.2
Heart disease (siblings)	1.6	1.9	4.6	-1.2	-0.3	2.2	1.3
Stomach or abdominal pain in last month	1.5	1.8	3.5	-1.8	-1.9	0.9	-0.1
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	4.5	2.1	2.1	-0.9	0.6
Age at first live birth	1.5	2.7	5.7	2.4	2.0	-0.2	1.0
Medication: Blood pressure	1.5	2.6	5.7	-2.1	-2.4	0.2	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.4	-0.8	-1.6	-1.9	-0.8
Alcohol intake frequency.	1.5	3.4	6.0	-2.4	-2.3	0.8	-1.2
Mean Putamen Volume	1.4	1.6	2.7	-0.5	1.5	1.0	1.6
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	4.2	1.5	2.0	1.4	0.2
Illnesses of siblings	1.4	1.9	5.4	0.9	-0.5	-2.3	-1.1
Average weekly champagne plus white wine intake	1.4	1.9	4.1	-0.7	-0.4	-2.0	-1.7
Ever depressed for a whole week	1.4	1.8	4.2	-2.1	1.6	0.5	0.1
Height	1.3	24.7	33.2	5.7	5.8	2.4	5.2
Hearing difficulty/problems with background noise	1.3	2.1	6.0	-0.4	1.0	2.4	1.1
Pulse wave Arterial Stiffness index	1.3	1.5	5.2	-2.3	-0.7	0.7	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.1	3.8	-0.2	2.0	1.7	1.1
Gout (self-reported)	1.3	1.7	3.6	1.9	1.2	-1.1	0.8
Shortness of breath walking on level ground	1.3	1.6	2.2	-1.4	0.6	1.3	1.5
Mood swings	1.3	2.3	5.1	1.4	1.4	2.3	0.5
Asthma (self-reported)	1.3	2.7	4.8	0.0	2.2	1.6	1.8
Hearing aid user	1.3	1.5	3.9	-0.9	-0.9	0.7	2.0
Medication: Paracetamol	1.3	2.0	3.7	-1.0	-1.8	0.1	-1.9
Neuroticism (2016)	1.2	1.7	3.7	0.4	1.6	1.9	0.8
Respiratory disease	1.2	2.7	5.3	-0.5	2.3	1.9	1.2
Townsend deprivation index at recruitment	1.2	1.7	3.3	-1.3	0.0	1.8	-1.3
Taking other prescription medications	1.2	1.9	5.2	0.3	0.7	2.3	1.4
Hayfever, allergic rhinitis or eczema	1.2	2.7	4.9	1.8	2.2	1.0	1.2
Allergy	1.2	2.8	3.7	-0.8	-1.9	-1.9	-1.7
Alcohol intake versus 10 years previously	1.2	1.7	2.7	-1.6	-1.5	0.8	-1.2
Medication: Cholesterol lowering	1.2	1.8	4.6	-2.1	-1.0	1.2	0.4
Medication: Amlodipine	1.2	1.7	3.8	0.1	-2.0	-0.5	-1.6
Neck or shoulder pain in last month	1.2	1.7	3.2	0.8	1.5	0.7	1.8
Leg pain on walking	1.2	1.5	3.3	-0.7	0.8	1.3	1.8
Triglycerides	1.1	1.8	3.0	-1.6	-1.1	0.3	-1.7
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	2.5	-0.8	1.0	0.9	1.6
Supplements: Glucosamine	1.1	1.5	2.8	0.9	-1.5	-1.7	-0.3
Qualifications: None of the above	1.1	2.5	9.0	-0.7	-3.0	-0.5	-0.5
Diabetes (self-reported)	1.1	1.7	4.6	-1.2	-0.5	2.1	0.7
Qualifications: A levels/AS levels or equivalent	1.1	2.4	4.7	2.2	2.2	-0.1	0.2
Headache pain in last month	1.1	1.9	5.4	-1.4	-2.3	0.4	-0.4
Health satisfaction	1.1	1.4	3.6	-0.9	0.5	1.9	0.9
Heart disease (mother)	1.1	1.3	2.8	-0.7	1.7	1.3	-0.4
Average weekly red wine intake	1.1	1.7	3.1	1.7	0.9	-1.8	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.1	0.2	1.8	1.0	1.0
Bipolar Disorder (2018)	1.0	1.6	3.0	-1.3	-1.7	-0.1	-1.4
Mouth/teeth dental problems	1.0	1.5	4.0	0.6	1.2	2.0	0.7
Trunk fat-free mass	1.0	5.9	15.6	1.6	4.0	0.9	2.1
Hip circumference	1.0	4.2	7.6	-0.4	2.8	1.1	2.8
Number of live births	1.0	1.4	2.9	-1.7	-1.7	-0.2	-0.0
Trunk predicted mass	1.0	5.9	15.5	1.6	3.9	1.0	2.1
Exposure to tobacco smoke at home	1.0	1.1	3.0	-1.7	-0.4	-1.0	-0.4
Peak expiratory flow (PEF)	1.0	2.3	8.1	0.1	1.0	-2.8	-0.2
Medication: Omeprazole	1.0	1.2	2.6	-1.6	0.2	1.5	0.4
Whole body fat-free mass	1.0	5.6	15.4	1.3	3.9	1.0	2.1
Osteoarthritis (self-reported)	1.0	1.3	3.5	-0.3	0.8	1.0	1.9
High cholesterol (Self-reported)	1.0	1.8	5.7	-2.4	-0.7	0.3	-0.9
Basal metabolic rate	1.0	5.3	14.1	1.0	3.8	1.1	2.2
Pain experienced in last month	1.0	1.7	2.7	1.1	1.6	-1.6	0.4
Supplements: Calcium	1.0	1.1	2.5	-1.6	-1.4	0.4	-0.0
Schizophrenia vs Biploar Disorder	0.9	1.2	4.7	0.3	-0.2	-2.2	-0.3
Alzheimer’s Disease (including proxy)	0.9	1.2	3.1	0.4	-1.8	-1.0	-0.8
Crohns Disease (2017)	0.9	1.9	3.6	-0.2	1.9	-1.2	1.5
Prostate Cancer	0.9	1.2	3.8	-0.4	0.8	-0.5	2.0
Number of treatments/medications taken	0.9	1.6	3.2	-1.3	-1.8	1.2	-0.1
Hearing difficulty/problems: Yes	0.9	1.4	4.4	0.4	0.8	2.1	0.6
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	1.3	0.5	1.1	1.1	1.1
Leg fat-free mass (left)	0.9	4.8	13.2	1.1	3.6	0.9	1.9
Trunk fat percentage	0.9	3.8	7.8	-1.6	1.0	1.9	2.8
Leg predicted mass (left)	0.9	4.8	13.4	1.1	3.7	0.9	2.0
Trunk fat mass	0.9	4.1	8.5	-1.1	1.9	1.8	2.9
Asthma	0.9	1.8	3.3	-0.4	1.8	1.5	1.3
Hair/balding pattern: Pattern 4	0.9	2.1	3.2	-0.3	-1.5	-1.7	-1.8
Loud music exposure frequency	0.9	1.0	1.9	-1.4	0.1	1.4	0.6
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.2	-1.5	-1.1	1.0	-0.2
High blood pressure (siblings)	0.9	1.4	2.3	-1.3	0.6	1.5	1.0
Migraine (self-reported)	0.9	1.2	2.2	-1.2	-0.9	-1.5	-0.5
Medication: Allopurinol	0.9	1.1	3.0	1.7	0.5	-1.1	-0.4
Comparative height size at age 10	0.9	5.1	7.8	2.6	2.8	1.5	1.8
Had major operations	0.9	1.0	2.2	0.9	0.6	0.9	1.5
Knee pain experienced in last month	0.9	1.4	3.2	-1.4	-0.3	1.8	0.5
Leg fat-free mass (right)	0.9	4.7	13.0	1.1	3.6	0.9	1.9
Loneliness, isolation	0.9	1.2	3.2	0.6	0.8	1.8	-0.8
Back pain experienced in last month	0.9	1.3	3.9	0.9	0.1	2.0	-0.7
Whole body water mass	0.9	5.4	14.8	1.2	3.9	1.0	2.1
Leg predicted mass (right)	0.9	4.9	13.2	1.1	3.6	1.1	2.0
Ever smoked	0.9	1.6	4.2	0.6	2.0	1.2	0.8
Major Depression (MDD)	0.8	0.9	1.8	-1.2	1.4	0.6	0.4
Body Mass Index (BMI) (2010)	0.8	1.1	2.0	-1.4	-0.1	-1.4	-0.6
Fasting Glucose	0.8	1.0	2.5	-0.4	0.1	-1.1	-1.6
Blood Red Count	0.8	7.5	18.5	-4.3	-2.9	-1.4	-0.9
Age when periods started (menarche)	0.8	2.0	5.0	-1.0	-2.2	-0.4	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	4.6	-0.3	-0.6	-2.2	-1.6
Alcohol usually taken with meals	0.8	1.3	3.3	-0.1	1.4	-1.8	-0.1
Pain all over the body in last month	0.8	0.9	2.6	-1.6	-0.6	-0.6	-0.5
Weight	0.8	3.9	8.0	-0.2	2.8	1.4	2.4
Time employed in main current job	0.8	0.9	1.6	1.2	1.0	0.1	1.0
Falls in the last year	0.8	1.1	3.1	-1.8	0.2	1.2	-0.1
Birth weight of first child	0.8	1.4	3.1	1.0	1.0	0.9	1.8
Body fat percentage	0.8	3.3	5.5	-2.0	0.6	1.8	2.3
Arm fat-free mass (right)	0.8	4.1	12.2	0.5	3.5	0.4	1.9
Wheeze or whistling in the chest in last year	0.8	1.5	4.2	-2.0	0.3	1.3	-0.3
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.0	0.2	-1.1	-0.7	-1.4
Mean time to correctly identify matches	0.8	1.5	3.1	-1.2	0.3	1.8	1.2
Arm predicted mass (right)	0.8	4.2	12.4	0.6	3.5	0.3	2.1
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.0	1.0	0.7	0.7	1.4
Commuting to job workplace: Public transport	0.8	0.9	3.3	-0.3	1.8	-0.4	0.3
Arm fat-free mass (left)	0.8	4.0	10.7	0.7	3.3	0.7	2.1
Ever had prostate specific antigen (PSA) test	0.8	1.0	3.6	0.4	1.9	0.3	0.1
Age started oral contraceptive pill	0.8	1.0	2.2	0.7	1.1	0.5	1.5
Arm predicted mass (left)	0.8	4.3	11.4	0.5	3.4	0.9	2.1
Primary Biliary Cirrhosis	0.7	0.9	3.2	0.6	1.8	-0.4	0.1
Rheumatoid Arthritis	0.7	1.0	2.1	0.3	0.5	1.5	1.3
Hypothyroidism (self reported)	0.7	1.7	3.1	-1.8	-1.1	1.2	-1.0
Average weekly spirits intake	0.7	0.8	2.4	-0.2	0.9	1.6	0.3
Serious illness, injury or assault to yourself	0.7	0.8	2.3	-1.5	-0.9	0.1	-0.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.2	0.3	1.5	0.9	0.5
Chronic bronchitis/emphysema (father)	0.7	0.8	1.9	-1.0	-1.4	0.5	0.3
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.8	0.9	1.7	0.1	0.3
Breastfed as a baby	0.7	0.9	2.8	-1.7	-0.3	0.8	0.1
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.7	-0.4	1.0	0.6	1.3
Glaucoma (self-reported)	0.7	0.8	1.1	0.7	1.0	1.0	0.9
Exposure to tobacco smoke outside home	0.7	0.9	1.6	-1.3	-1.0	1.1	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	1.6	-1.3	0.7	1.2	0.5
Whole body fat mass	0.7	3.0	5.7	-1.3	1.4	1.5	2.4
Age at last live birth	0.7	1.0	1.4	1.1	1.0	0.6	1.2
Osteoporosis (self-reported)	0.7	0.9	2.3	-1.5	-0.8	0.8	0.1
Leg fat percentage (left)	0.7	2.4	4.9	-2.2	0.1	1.1	1.8
Cholesterol lowering medication	0.7	1.0	2.9	-1.7	-0.8	0.0	-0.7
Crohns Disease (2012)	0.6	1.0	3.6	-0.2	0.6	-1.9	-0.3
Lupus	0.6	0.9	2.3	-0.1	1.0	1.5	0.6
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.7	1.3	0.9	0.5	-0.0
Chronotype (morning person)	0.6	1.5	3.5	1.5	1.9	0.0	0.4
Medication: Metformin	0.6	0.8	1.9	-1.4	-0.5	1.0	0.4
Diabetes (father)	0.6	0.7	2.7	-0.4	-1.6	0.2	-0.1
Diabetes (mother)	0.6	0.8	2.7	-0.4	0.5	1.6	0.4
Average weekly fortified wine intake	0.6	0.7	1.2	1.1	0.9	-0.6	0.6
Maternal smoking around birth	0.6	0.8	1.4	-0.8	-0.9	1.2	-0.7
Relative age voice broke	0.6	1.0	1.8	-0.4	-1.2	-1.4	-0.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	0.9	-0.9	0.9	0.5	0.8
Qualifications: CSEs or equivalent	0.6	0.8	1.8	1.3	0.8	-0.1	0.9
Nervous feelings	0.6	1.2	3.5	0.9	0.6	1.9	-0.1
Illnesses of mother	0.6	0.7	2.3	0.6	0.5	-1.5	0.1
Pulse wave reflection index	0.6	0.8	2.0	-1.4	-0.2	0.7	0.7
Medication: Paracetamol	0.6	1.0	2.5	-0.8	-1.6	0.3	-1.0
Chronic bronchitis/emphysema (mother)	0.6	0.7	3.0	-0.0	-0.1	1.7	0.1
Leg fat percentage (right)	0.6	2.1	4.8	-2.2	0.3	1.0	1.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.9	-1.4	-0.9	-0.0	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.8	2.4	0.1	1.6	0.2	-0.7
Illnesses of siblings: Diabetes	0.6	0.8	1.9	-1.4	-0.7	0.4	-0.8
Commuting to job workplace: Walk	0.6	0.6	1.9	-0.3	-0.7	-0.1	-1.4
Arm fat mass (left)	0.6	2.3	4.1	-1.2	1.6	1.2	2.0
Number of self-reported non-cancer illnesses	0.6	1.1	2.4	-0.8	0.0	1.6	1.1
Guilty feelings	0.6	0.8	2.1	0.9	0.7	1.4	0.0
Medication: Blood pressure	0.6	1.1	1.7	-0.9	-1.0	-0.9	-1.3
Alcohol drinker status: Previous	0.6	0.7	1.5	-0.8	-1.2	-0.8	-0.2
Irritable Bowel Disease (IBD)	0.5	1.2	2.2	0.0	1.5	-1.4	0.8
Ovarian Cancer	0.5	0.7	1.9	0.5	1.4	-0.5	0.7
HDL Cholesterol	0.5	0.8	1.6	1.2	-0.0	0.4	1.2
Cardiovascular Disease	0.5	1.6	3.3	-1.8	-1.6	0.5	-0.4
Lung FEV1/FVC ratio	0.5	2.6	6.4	1.6	2.5	-0.4	1.1
Sensitivity / hurt feelings	0.5	0.8	1.6	1.3	0.2	1.1	0.5
Ever had hysterectomy (womb removed)	0.5	0.5	1.0	-0.3	0.5	0.8	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.9	-0.5	-0.6	-1.3	-1.4
Financial difficulties in last 2 years	0.5	0.6	1.3	-0.0	1.1	0.9	-0.5
Arm fat percentage (right)	0.5	2.1	3.4	-1.8	0.5	1.6	1.5
Worrier / anxious feelings	0.5	0.9	1.8	1.4	0.1	1.3	-0.2
Pulse rate	0.5	0.8	2.2	-0.4	0.0	-0.9	-1.5
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.9	0.4	-0.2	0.8	1.4
Impedance of arm (left)	0.5	2.1	3.6	1.9	0.1	1.6	1.5
Arm fat mass (right)	0.5	2.3	3.5	-1.0	1.6	1.4	1.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.0	1.4	0.9	-0.6	0.3
Number of full brothers	0.5	0.6	1.4	-0.1	0.9	1.2	0.5
Medication for pain relief, constipation, heartburn	0.5	0.9	1.6	1.3	0.9	-1.0	0.1
Leg fat mass (right)	0.5	1.8	3.1	-1.2	1.4	0.8	1.8
Hypertension (Self-reported)	0.5	1.4	3.7	-1.3	-1.9	0.1	-0.6
Arm fat percentage (left)	0.5	2.1	3.2	-1.8	0.7	1.3	1.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.9	0.1	-0.9	0.9	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.2	-0.7	-0.7	0.4	1.1
Illnesses of father: None of the above (group 1)	0.5	0.7	1.6	-0.4	0.5	-0.7	-1.3
Eye problems/disorders: Glaucoma	0.5	0.6	1.2	-0.0	0.6	1.1	0.8
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.3	-1.1	0.2	1.1	-0.1
Average weekly beer plus cider intake	0.5	0.7	1.9	0.1	-0.7	0.7	-1.4
Irritability	0.5	0.8	1.3	0.6	0.7	0.9	-1.2
Pack years of smoking	0.5	0.8	2.1	-1.4	-1.0	-0.2	-0.0
Leg fat mass (left)	0.5	1.9	3.3	-1.3	1.4	0.8	1.8
Worry (Nagel 2018)	0.4	0.9	2.1	1.5	0.6	1.0	-0.3
Alzheimer’s Disease (in mother)	0.4	0.5	1.9	-0.3	-1.4	-0.1	-0.2
Age at First Birth	0.4	0.6	1.4	1.2	0.9	-0.4	0.4
Blood Eosinophil Count	0.4	3.3	8.5	-2.9	-1.5	-0.4	-1.5
Heel T-Score	0.4	3.1	7.0	-1.0	-1.5	-2.6	-1.5
BMI	0.4	2.1	5.6	-2.4	1.6	0.5	0.5
Waist Hip Ratio (WHR)	0.4	1.7	3.5	1.5	-0.9	-0.4	-1.9
Relative age of first facial hair	0.4	0.8	1.8	1.1	1.4	-0.5	0.4
Angina	0.4	0.6	1.7	-1.3	-0.5	-0.4	0.5
Severe depression (siblings)	0.4	0.4	1.3	-0.5	-1.1	-0.3	0.1
Pack years adult smoking proportion	0.4	0.7	2.0	-1.4	-0.8	0.1	0.1
Hand grip strength (right)	0.4	1.0	3.4	-0.7	-0.1	-1.8	-0.5
Medication: Levothyroxine sodium	0.4	0.6	1.3	-0.8	-0.6	1.1	0.3
Body mass index (BMI)	0.4	1.7	5.8	-2.4	0.6	0.5	0.7
Past tobacco smoking	0.4	0.7	1.4	0.5	-1.0	-1.2	-0.4
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	-1.2	-0.2	-0.1	-1.1
Noisy workplace	0.4	0.5	1.1	-0.2	1.1	0.7	0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.7	-0.6	-0.1	1.6	0.4
Worry too long after embarrassment	0.4	0.7	2.3	-0.3	0.6	1.5	0.3
Angina (self-reported)	0.4	0.5	1.3	-1.2	-0.4	-0.7	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.3	1.2	0.6	1.0	0.8
Ever had bowel cancer screening	0.4	0.4	1.2	-0.0	0.2	1.1	-0.7
Mineral and other dietary supplements	0.4	0.6	1.2	-0.2	1.0	-0.0	-1.1
Medication: Aspirin	0.4	0.5	0.9	-1.0	-0.9	-0.3	-0.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.5	0.5	-1.2	-0.1	0.5
Medication: Lisinopril	0.4	0.5	0.8	-0.7	-0.8	0.9	-0.1
Reaction Time	0.3	0.5	0.8	-0.3	0.9	0.6	0.9
Tanning	0.3	3.6	8.1	2.8	0.2	-1.6	2.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.4	0.2	1.2	0.3	0.5
Medication for hormone replacement therapy	0.3	0.3	0.9	0.3	-0.5	0.2	0.9
Vitamin and mineral supplements	0.3	0.5	1.7	0.2	0.0	1.3	-0.3
High blood pressure	0.3	0.9	2.0	-1.1	-1.4	0.2	-0.5
Multivitamins +/- minerals	0.3	0.4	1.1	-0.1	0.6	-1.0	0.1
Waist circumference	0.3	1.2	2.3	-0.9	1.5	0.8	1.0
Impedance of arm (right)	0.3	1.5	2.6	1.6	-0.5	1.6	0.8
Mouth/teeth dental problems: Dentures	0.3	0.5	0.6	0.7	0.8	0.4	0.8
Prospective memory result	0.3	0.3	0.7	-0.3	-0.9	0.7	-0.1
Tense / ‘highly strung’	0.3	0.5	1.9	0.4	0.2	1.4	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.7	0.4	0.5	0.8	-0.7
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.1	-0.0	-0.6	-0.2	1.1
Medication: Aspirin	0.3	0.4	1.2	-1.1	-0.7	-0.0	-0.1
Supplements: Vitamin C	0.3	0.3	0.5	0.7	-0.7	-0.4	0.5
Smoking status: Previous	0.3	0.4	1.0	-0.1	0.7	1.0	0.4
Breast cancer (self-reported)	0.3	0.4	1.3	-1.1	-0.2	-0.1	0.4
Mother’s age at death	0.3	0.3	0.5	0.6	0.7	0.3	0.5
Medication: Atorvastatin	0.3	0.4	0.8	-0.9	-0.5	-0.4	0.4
Illnesses of father: High blood pressure	0.3	0.4	0.8	0.9	0.7	-0.4	0.4
Fractured/broken bones in last 5 years	0.3	0.4	0.7	0.7	0.5	0.8	0.2
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.7	1.2	1.3	-0.5	0.4
Ulcerative Colitis (UC)	0.2	0.4	0.7	0.6	0.8	-0.8	0.2
Breast Cancer	0.2	0.6	1.8	0.6	0.3	1.3	0.3
HbA1C	0.2	0.2	0.6	-0.6	-0.8	-0.1	-0.2
LDL Cholesterol	0.2	0.4	0.6	-0.4	-0.7	0.4	-0.8
Smoking Status	0.2	0.4	1.0	-0.7	-0.2	1.0	-0.1
Hair Pigment	0.2	4.7	9.4	-3.1	-2.6	0.7	-1.5
Hand grip strength (left)	0.2	0.4	1.3	0.1	0.0	-1.1	-0.6
Current tobacco smoking	0.2	0.4	0.7	-0.8	-0.5	0.8	0.2
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	0.2	0.8	-0.2	0.7
Depression (self-reported)	0.2	0.3	1.1	-0.1	-0.1	1.1	0.2
Number of children fathered	0.2	0.2	0.3	0.4	0.6	-0.1	-0.5
Medication: Ibuprofen	0.2	0.3	0.8	0.1	-0.9	0.4	0.4
Illnesses of father: Heart disease	0.2	0.3	0.5	0.1	0.3	0.7	0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	-0.9	0.1	-0.6	0.1
Medication for cholesterol	0.2	0.4	1.0	1.0	0.6	0.0	0.4
Smoking status: Current	0.2	0.3	0.7	-0.8	-0.6	0.6	-0.0
Ever taken oral contraceptive pill	0.2	0.3	0.8	-0.3	-0.3	-0.9	-0.3
Risk taking	0.2	0.3	0.5	-0.6	-0.5	-0.3	0.7
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	-0.0	-0.7	-0.7	-0.3
Impedance of whole body	0.2	1.0	1.6	1.3	-0.9	0.9	0.9
Coronary Artery Disease (CAD)	0.1	0.2	0.5	-0.1	0.3	0.7	-0.3
Ulcerative Colitis	0.1	0.2	0.4	0.5	-0.1	-0.1	-0.6
Blood Platelet Count	0.1	1.7	4.1	-1.0	-2.0	-1.3	-0.2
Medication: Co-codamol	0.1	0.1	0.2	-0.4	0.3	-0.1	0.2
Impedance of leg (right)	0.1	0.4	1.3	0.5	-1.1	0.1	0.4
High blood pressure (mother)	0.1	0.2	0.6	0.2	0.4	0.8	0.1
Impedance of leg (left)	0.1	0.6	1.7	0.3	-1.3	0.4	0.7
Number of incorrect matches in round	0.1	0.2	0.6	0.3	-0.4	-0.8	-0.2
Had menopause	0.1	0.1	0.3	0.4	0.4	-0.5	0.1
Comparative body size at age 10	0.1	0.3	0.4	0.6	0.6	-0.3	-0.4
Pulse rate, automated reading	0.1	0.2	0.4	-0.3	-0.5	-0.3	-0.7
Number of full sisters	0.1	0.1	0.4	-0.2	0.6	0.2	0.2
Suffer from ‘nerves’	0.1	0.2	0.5	0.3	-0.7	0.5	-0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.5	-0.2	0.3	0.7	0.2
Myopia	0.1	0.2	0.5	0.3	-0.7	0.0	0.3
Diastolic blood pressure, automated reading	0.0	0.1	0.2	-0.4	-0.0	0.0	0.3

Hub : Genes

PCDHB5

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Trait associations