TWAS
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Models
Genes
Traits
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Traits
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Forced expiratory volume in 1-second (FEV1), Best measure
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chr10:63,870,456-65,606,229
Best TWAS P=1.97e-09 · Best GWAS P=2.07e-09 conditioned to 0.0446
63.8M
64M
64.2M
64.4M
64.6M
64.8M
65M
65.2M
65.4M
65.6M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
ADO
0.03
0.02
blup
53
0.03
1.8e-06
4.8
6.0
2.0e-09
-0.80
0.04
0.96
TRUE
2
ROSMAP
Brain Pre-frontal Cortex
ADO
0.06
0.04
lasso
2
0.06
3.1e-08
-4.0
5.5
3.1e-08
-0.83
0.03
0.96
FALSE
4
The Cancer Genome Atlas
Pancreatic Adenocarcinoma
ADO
0.06
0.04
blup
55
0.01
1.4e-01
-4.0
5.5
3.2e-08
-0.87
0.02
0.56
FALSE
1
GTEx
Skin Sun Exposed Lower leg
NRBF2
0.06
0.01
lasso
3
0.00
4.0e-01
-5.5
5.5
3.8e-08
-0.67
0.05
0.46
FALSE