Best TWAS P=1.98e-12 · Best GWAS P=1.87e-13 conditioned to 0.0282
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | HYKK | 0.08 | 0.01 | lasso | 2 | 0.01 | 3.0e-02 | 3.0 | 5.3 | 9.7e-08 | -0.80 | 0.04 | 0.81 | FALSE |
| 2 | GTEx | Liver | PSMA4 | 0.18 | 0.14 | lasso | 1 | 0.11 | 6.5e-04 | -7.0 | -7.0 | 2.0e-12 | 0.94 | 0.01 | 0.95 | TRUE |
| 3 | YFS | Blood | IREB2 | 0.18 | 0.20 | enet | 28 | 0.24 | 4.0e-78 | -6.6 | 6.1 | 1.3e-09 | -0.76 | 0.18 | 0.82 | FALSE |
| 4 | YFS | Blood | PSMA4 | 0.08 | 0.08 | lasso | 10 | 0.11 | 8.3e-35 | -7.4 | -6.8 | 1.1e-11 | 0.88 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Esophageal Carcinoma | CHRNA3 | 0.24 | 0.15 | enet | 5 | 0.16 | 6.5e-06 | -7.0 | 6.7 | 2.1e-11 | -0.90 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Esophageal Carcinoma | CHRNA5 | 0.17 | 0.15 | lasso | 4 | 0.14 | 3.1e-05 | -7.0 | 6.8 | 9.3e-12 | -0.93 | 0.00 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | CHRNA5 | 0.02 | 0.01 | blup | 50 | 0.02 | 2.6e-03 | 3.7 | 5.7 | 1.3e-08 | -0.83 | 0.01 | 0.77 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PSMA4 | 0.03 | 0.02 | blup | 40 | 0.02 | 3.1e-03 | 3.7 | -5.1 | 2.8e-07 | 0.81 | 0.02 | 0.65 | FALSE |
| 9 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CHRNA5 | 0.15 | 0.07 | blup | 50 | 0.09 | 2.5e-04 | 3.8 | 5.4 | 5.4e-08 | -0.64 | 0.18 | 0.54 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CHRNA5 | 0.04 | 0.01 | enet | 10 | 0.03 | 6.0e-04 | -7.0 | 5.3 | 9.0e-08 | -0.75 | 0.01 | 0.84 | FALSE |
| 11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CHRNA3 | 0.05 | 0.02 | blup | 44 | 0.02 | 7.6e-03 | -7.0 | 5.6 | 2.4e-08 | -0.86 | 0.00 | 0.98 | FALSE |