[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), Best measure : ← →

chr16:2,741,812-5,510,848

Best TWAS P=2.79e-12 · Best GWAS P=1.34e-11 conditioned to 0.00431

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Adipose Subcutaneous	CLUAP1	0.42	0.32	enet	35	0.35	1.2e-29	-5.5	-7.0	2.8e-12	0.70	0.70	0.30	TRUE
9	GTEx	Brain Cerebellar Hemisphere	ZNF500	0.27	0.13	enet	13	0.12	4.4e-04	4.4	5.3	1.1e-07	0.03	0.03	0.88	TRUE
59	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NLRC3	0.03	0.01	lasso	3	0.00	3.3e-01	-5.6	6.3	2.4e-10	-0.73	0.00	0.88	FALSE
31	GTEx	Lung	ZSCAN32	0.08	0.02	lasso	3	0.02	6.3e-03	-5.6	-6.3	2.6e-10	0.58	0.10	0.24	FALSE
14	GTEx	Brain Hippocampus	CLUAP1	0.37	0.10	lasso	5	0.09	4.9e-03	-6.8	-6.3	3.5e-10	0.89	0.00	0.97	FALSE
41	GTEx	Skin Not Sun Exposed Suprapubic	CLUAP1	0.30	0.13	enet	18	0.23	8.1e-13	-5.2	-6.2	4.2e-10	0.70	0.39	0.61	FALSE
43	GTEx	Skin Sun Exposed Lower leg	CLUAP1	0.34	0.25	lasso	6	0.27	1.1e-22	-5.6	-6.2	6.9e-10	0.79	0.61	0.38	FALSE
30	GTEx	Lung	CLUAP1	0.16	0.10	enet	9	0.12	2.1e-09	-5.5	-6.2	7.2e-10	0.81	0.65	0.35	FALSE
5	GTEx	Artery Aorta	CLUAP1	0.40	0.33	enet	18	0.33	5.4e-19	-5.5	-6.1	9.1e-10	0.74	0.69	0.31	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CLUAP1	0.26	0.17	enet	24	0.17	2.9e-20	-5.5	-6.1	1.1e-09	0.66	0.70	0.30	FALSE
47	GTEx	Thyroid	CLUAP1	0.37	0.17	lasso	6	0.27	1.1e-20	-5.5	-6.1	1.2e-09	0.76	0.72	0.28	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NLRC3	0.13	0.12	blup	39	0.13	4.9e-14	-5.5	6.1	1.3e-09	-0.67	0.01	0.99	FALSE
7	GTEx	Artery Tibial	CLUAP1	0.45	0.29	enet	47	0.31	5.2e-25	-5.5	-6.0	1.5e-09	0.66	0.70	0.30	FALSE
28	GTEx	Heart Atrial Appendage	NLRC3	0.27	0.07	lasso	3	0.08	2.2e-04	-5.5	6.0	1.6e-09	-0.80	0.01	0.98	FALSE
32	GTEx	Muscle Skeletal	CLUAP1	0.21	0.19	lasso	6	0.20	3.8e-19	-5.5	-6.0	1.6e-09	0.79	0.69	0.31	FALSE
27	GTEx	Heart Atrial Appendage	CLUAP1	0.40	0.16	enet	13	0.29	2.3e-13	-5.2	-6.0	2.1e-09	0.79	0.71	0.29	FALSE
57	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	NLRC3	0.10	0.04	lasso	2	0.04	6.2e-03	-5.5	6.0	2.1e-09	-0.75	0.00	0.87	FALSE
25	GTEx	Esophagus Muscularis	CLUAP1	0.42	0.42	lasso	2	0.44	4.8e-29	-5.5	-5.9	4.2e-09	0.75	0.70	0.30	FALSE
29	GTEx	Heart Left Ventricle	CLUAP1	0.39	0.30	lasso	6	0.34	1.4e-18	-5.5	-5.8	5.3e-09	0.80	0.61	0.39	FALSE
21	GTEx	Colon Sigmoid	CLUAP1	0.47	0.32	lasso	9	0.34	1.1e-12	-5.2	-5.8	8.0e-09	0.78	0.75	0.25	FALSE
11	GTEx	Brain Cerebellum	NLRC3	0.36	0.36	lasso	4	0.36	1.4e-11	-5.5	5.8	8.2e-09	-0.76	0.06	0.94	FALSE
12	GTEx	Brain Cerebellum	SLX4	0.33	0.14	lasso	3	0.10	6.8e-04	-5.6	5.7	1.1e-08	-0.75	0.03	0.82	FALSE
37	GTEx	Nerve Tibial	LA16c-306E5.3	0.19	0.12	lasso	2	0.10	2.5e-07	-5.5	5.7	1.2e-08	-0.77	0.06	0.94	FALSE
44	GTEx	Skin Sun Exposed Lower leg	NLRC3	0.16	0.17	lasso	3	0.18	1.7e-14	-5.2	5.7	1.5e-08	-0.74	0.81	0.19	FALSE
24	GTEx	Esophagus Mucosa	CLUAP1	0.30	0.18	lasso	7	0.19	1.3e-12	-5.5	-5.7	1.6e-08	0.75	0.77	0.23	FALSE
38	GTEx	Ovary	CLUAP1	0.29	0.14	lasso	3	0.11	1.4e-03	-5.5	-5.6	1.7e-08	0.74	0.05	0.70	FALSE
40	GTEx	Prostate	CLUAP1	0.44	0.36	lasso	3	0.35	1.1e-09	-5.5	-5.6	1.7e-08	0.73	0.29	0.61	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	CLUAP1	0.58	0.36	lasso	9	0.38	1.5e-14	-5.5	-5.6	1.8e-08	0.73	0.59	0.41	FALSE
58	The Cancer Genome Atlas	Lung Adenocarcinoma	NLRC3	0.09	0.08	enet	3	0.08	3.5e-09	-5.5	5.6	1.8e-08	-0.74	0.00	1.00	FALSE
35	GTEx	Nerve Tibial	CLUAP1	0.53	0.27	lasso	7	0.42	9.9e-32	-5.5	-5.6	1.9e-08	0.75	0.77	0.23	FALSE
4	GTEx	Adipose Visceral Omentum	CLUAP1	0.25	0.17	enet	16	0.16	7.7e-09	-5.5	-5.6	2.0e-08	0.69	0.27	0.72	FALSE
10	GTEx	Brain Cerebellar Hemisphere	NLRC3	0.40	0.39	lasso	2	0.40	2.1e-11	-5.5	5.6	2.0e-08	-0.76	0.03	0.97	FALSE
18	GTEx	Breast Mammary Tissue	CLUAP1	0.26	0.13	lasso	8	0.13	4.6e-07	-5.5	-5.6	2.4e-08	0.79	0.40	0.60	FALSE
49	GTEx	Uterus	CLUAP1	0.30	0.34	lasso	3	0.31	3.9e-07	-5.2	-5.6	2.8e-08	0.73	0.11	0.70	FALSE
20	GTEx	Cells Transformed fibroblasts	CLUAP1	0.56	0.35	lasso	10	0.39	1.7e-30	-5.5	-5.5	3.2e-08	0.69	0.70	0.30	FALSE
33	GTEx	Muscle Skeletal	NLRC3	0.16	0.11	lasso	2	0.11	7.9e-11	-5.5	5.5	3.6e-08	-0.74	0.66	0.34	FALSE
13	GTEx	Brain Cortex	NLRC3	0.30	0.34	lasso	1	0.31	2.3e-09	-5.5	5.5	3.8e-08	-0.73	0.07	0.92	FALSE
48	GTEx	Thyroid	LA16c-306E5.3	0.11	0.15	lasso	1	0.15	1.0e-11	-5.5	5.5	3.8e-08	-0.73	0.65	0.35	FALSE
62	The Cancer Genome Atlas	Soft Tissue Sarcoma	NLRC3	0.13	0.09	lasso	1	0.09	8.2e-06	-5.5	5.5	3.8e-08	-0.73	0.00	1.00	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	NLRC3	0.29	0.16	lasso	3	0.18	5.1e-07	-5.5	5.5	3.9e-08	-0.75	0.12	0.86	FALSE
16	GTEx	Brain Hypothalamus	CLUAP1	0.47	0.31	lasso	8	0.32	3.3e-08	-5.5	-5.5	4.0e-08	0.73	0.06	0.76	FALSE
42	GTEx	Skin Not Sun Exposed Suprapubic	NLRC3	0.29	0.16	lasso	6	0.16	6.2e-09	-5.5	5.5	4.1e-08	-0.73	0.44	0.56	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	DNASE1	0.09	0.00	enet	12	0.05	3.4e-06	2.7	-5.5	4.6e-08	0.51	0.00	0.32	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	CLUAP1	0.03	0.02	enet	5	0.02	3.3e-05	-5.6	-5.5	4.7e-08	0.51	0.00	0.99	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	NLRC3	0.09	0.07	lasso	5	0.10	2.9e-19	-5.5	5.4	6.7e-08	-0.73	0.00	1.00	FALSE
51	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NLRC3	0.05	0.01	blup	39	0.02	9.8e-03	-5.1	5.4	7.1e-08	-0.72	0.00	0.90	FALSE
60	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NLRC3	0.14	0.11	enet	7	0.14	2.5e-06	-5.5	5.4	7.8e-08	-0.74	0.00	0.98	FALSE
15	GTEx	Brain Hippocampus	NLRC3	0.49	0.28	lasso	5	0.34	8.0e-09	-5.5	5.4	8.0e-08	-0.65	0.03	0.84	FALSE
17	GTEx	Brain Hypothalamus	NLRC3	0.38	0.15	lasso	6	0.17	8.3e-05	-5.5	5.4	8.2e-08	-0.74	0.06	0.63	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NLRC3	0.44	0.40	lasso	3	0.40	9.3e-53	-5.5	5.3	1.1e-07	-0.73	0.70	0.30	FALSE
19	GTEx	Breast Mammary Tissue (Female)	CLUAP1	0.35	0.14	lasso	8	0.12	2.3e-04	-5.5	-5.3	1.2e-07	0.69	0.10	0.64	FALSE
46	GTEx	Stomach	CLUAP1	0.19	0.10	enet	14	0.14	5.5e-07	-5.6	-5.3	1.2e-07	0.69	0.12	0.86	FALSE
8	GTEx	Brain Caudate basal ganglia	NLRC3	0.41	0.11	lasso	4	0.24	2.0e-07	-5.5	5.3	1.4e-07	-0.71	0.19	0.60	FALSE
34	GTEx	Muscle Skeletal	AC006111.1	0.29	0.07	enet	22	0.20	2.2e-19	2.7	-5.3	1.4e-07	0.57	0.24	0.76	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	C16orf71	0.01	0.01	blup	52	0.01	3.1e-03	5.0	5.3	1.4e-07	0.01	0.01	0.90	FALSE
6	GTEx	Artery Coronary	CLUAP1	0.31	0.26	enet	13	0.25	6.8e-09	-5.5	-5.3	1.5e-07	0.74	0.13	0.85	FALSE
36	GTEx	Nerve Tibial	NLRC3	0.29	0.24	lasso	3	0.32	8.7e-23	-5.5	5.2	1.5e-07	-0.72	0.71	0.29	FALSE
61	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NLRC3	0.36	0.20	enet	18	0.25	2.9e-10	-5.5	5.2	1.7e-07	-0.63	0.00	1.00	FALSE
26	GTEx	Esophagus Muscularis	NLRC3	0.48	0.29	lasso	6	0.36	5.1e-23	-5.5	5.2	1.8e-07	-0.71	0.71	0.29	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	NLRC3	0.31	0.21	lasso	3	0.26	8.4e-26	-5.5	5.2	1.8e-07	-0.71	0.00	1.00	FALSE
45	GTEx	Stomach	ZNF500	0.20	0.11	enet	10	0.08	1.5e-04	5.0	5.1	2.7e-07	0.00	0.02	0.97	FALSE
50	GTEx	Whole Blood	CLUAP1	0.07	0.02	lasso	3	0.01	6.5e-02	-5.1	-5.1	2.9e-07	0.75	0.07	0.59	FALSE
39	GTEx	Pancreas	CLUAP1	0.28	0.21	lasso	3	0.24	2.3e-10	-5.1	-5.1	3.1e-07	0.72	0.54	0.46	FALSE