Best TWAS P=3.18e-08 · Best GWAS P=2.86e-08 conditioned to 0.176
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Sigmoid | ZSWIM1 | 0.28 | 0.13 | lasso | 2 | 0.14 | 1.8e-05 | -5.2 | -5.2 | 1.7e-07 | 0.76 | 0.02 | 0.96 | FALSE |
| 2 | GTEx | Heart Atrial Appendage | DNTTIP1 | 0.09 | 0.10 | lasso | 2 | 0.08 | 1.6e-04 | -5.2 | 5.3 | 1.1e-07 | -0.78 | 0.03 | 0.96 | FALSE |
| 3 | GTEx | Testis | ZSWIM1 | 0.23 | 0.11 | lasso | 7 | 0.12 | 6.0e-06 | -5.3 | -5.4 | 6.7e-08 | 0.90 | 0.02 | 0.97 | FALSE |
| 4 | GTEx | Thyroid | SNX21 | 0.09 | 0.10 | lasso | 3 | 0.10 | 3.0e-08 | -5.4 | 5.5 | 3.2e-08 | -0.89 | 0.01 | 0.99 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZSWIM1 | 0.01 | 0.01 | blup | 41 | 0.01 | 2.4e-02 | -5.2 | -5.2 | 1.9e-07 | 0.84 | 0.03 | 0.90 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZSWIM1 | 0.04 | 0.07 | blup | 41 | 0.05 | 4.3e-06 | -4.8 | -5.3 | 1.1e-07 | 0.86 | 0.03 | 0.96 | FALSE |